{"id":"https://openalex.org/W4386475659","doi":"https://doi.org/10.1016/j.cancergen.2023.09.002","title":"Paediatric B lymphoblastic leukaemia with hyperdiploidy and a false-positive KMT2A fluorescence in situ hybridization result","display_name":"Paediatric B lymphoblastic leukaemia with hyperdiploidy and a false-positive KMT2A fluorescence in situ hybridization result","publication_year":2023,"publication_date":"2023-09-06","ids":{"openalex":"https://openalex.org/W4386475659","doi":"https://doi.org/10.1016/j.cancergen.2023.09.002","pmid":"https://pubmed.ncbi.nlm.nih.gov/37742392"},"language":"en","primary_location":{"id":"doi:10.1016/j.cancergen.2023.09.002","doi":"https://doi.org/10.1016/j.cancergen.2023.09.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cancergen.2023.09.002","pdf_url":null,"source":{"id":"https://openalex.org/S4210168666","display_name":"Cancer Genetics","issn_l":"2210-7762","issn":["2210-7762","2210-7770"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.cancergen.2023.09.002","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015428138","display_name":"Jenna L. Nunn","orcid":"https://orcid.org/0000-0002-7790-9955","observed_orcids":["https://orcid.org/0000-0002-7790-9955"]},"institutions":[{"id":"https://openalex.org/I4210167058","display_name":"Children's Health Queensland Hospital and Health Service","ror":"https://ror.org/02t3p7e85","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131","https://openalex.org/I4210167058"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jenna Nunn","raw_affiliation_strings":["Oncology Service, Children's Health Queensland Hospital & Health Service, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Service, Children's Health Queensland Hospital & Health Service, Brisbane, Australia","institution_ids":["https://openalex.org/I4210167058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112026557","display_name":"Adayapalam Nandini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nandini Adayapalam","raw_affiliation_strings":["Genomics Discipline, Pathology Queensland, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Discipline, Pathology Queensland, Brisbane, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062164117","display_name":"Sarbjit Riyat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarbjit Riyat","raw_affiliation_strings":["Genomics Discipline, Pathology Queensland, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Discipline, Pathology Queensland, Brisbane, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018907932","display_name":"Louise Seymour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Louise Seymour","raw_affiliation_strings":["Pathology Queensland, Brisbane, Australia; The University of Queensland, Brisbane, Australia","Pathology Queensland, Brisbane, Australia","The University of Queensland, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Queensland, Brisbane, Australia; The University of Queensland, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"Pathology Queensland, Brisbane, Australia","institution_ids":[]},{"raw_affiliation_string":"The University of Queensland, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103492088","display_name":"Bronwyn Williams","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bronwyn Williams","raw_affiliation_strings":["Pathology Queensland, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Queensland, Brisbane, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016376415","display_name":"Jacqueline A. Rehn","orcid":"https://orcid.org/0000-0001-5043-6943","observed_orcids":["https://orcid.org/0000-0001-5043-6943"]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jacqueline Rehn","raw_affiliation_strings":["Precision Cancer Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Cancer Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, Australia","institution_ids":["https://openalex.org/I4210137740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026996624","display_name":"Deborah L. White","orcid":"https://orcid.org/0000-0003-4844-333X","observed_orcids":["https://orcid.org/0000-0003-4844-333X"]},"institutions":[{"id":"https://openalex.org/I4210137740","display_name":"South Australian Health and Medical Research Institute","ror":"https://ror.org/03e3kts03","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210137740"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Deborah White","raw_affiliation_strings":["Precision Cancer Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, Australia; Faculties of Health Science & Science, The University of Adelaide, Adelaide, South Australia, Australia","Faculties of Health Science & Science, The University of Adelaide, Adelaide, South Australia","Precision Cancer Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Cancer Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, Australia; Faculties of Health Science & Science, The University of Adelaide, Adelaide, South Australia, Australia","institution_ids":["https://openalex.org/I4210137740","https://openalex.org/I5681781"]},{"raw_affiliation_string":"Faculties of Health Science & Science, The University of Adelaide, Adelaide, South Australia","institution_ids":["https://openalex.org/I5681781"]},{"raw_affiliation_string":"Precision Cancer Medicine Theme, South Australian Health & Medical Research Institute, Adelaide, Australia","institution_ids":["https://openalex.org/I4210137740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035808651","display_name":"Andrew S. Moore","orcid":"https://orcid.org/0000-0001-8062-1779","observed_orcids":["https://orcid.org/0000-0001-8062-1779"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4210167058","display_name":"Children's Health Queensland Hospital and Health Service","ror":"https://ror.org/02t3p7e85","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1302211766","https://openalex.org/I2801244131","https://openalex.org/I4210167058"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrew S. Moore","raw_affiliation_strings":["Oncology Service, Children's Health Queensland Hospital & Health Service, Brisbane, Australia; Child Health Research Centre, The University of Queensland, Brisbane, Australia","Child Health Research Centre, The University of Queensland, Brisbane, Australia","Oncology Service, Children's Health Queensland Hospital & Health Service, Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Service, Children's Health Queensland Hospital & Health Service, Brisbane, Australia; Child Health Research Centre, The University of Queensland, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4210167058"]},{"raw_affiliation_string":"Child Health Research Centre, The University of Queensland, Brisbane, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"Oncology Service, Children's Health Queensland Hospital & Health Service, Brisbane, Australia","institution_ids":["https://openalex.org/I4210167058"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058581049","display_name":"Karen D. Tsuchiya","orcid":"https://orcid.org/0000-0003-1406-5000","observed_orcids":["https://orcid.org/0000-0003-1406-5000"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]},{"id":"https://openalex.org/I2801852214","display_name":"University of Washington Medical Center","ror":"https://ror.org/00wbzw723","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801852214"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Karen Tsuchiya","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, University of Washington Medical Center, Seattle, WA, United States. Electronic address: Karen.tsuchiya@nationwidechildrens.org","Current affiliation: Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH","Department of Laboratory Medicine and Pathology, University of Washington Medical Center, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington Medical Center, Seattle, WA, United States. Electronic address: Karen.tsuchiya@nationwidechildrens.org","institution_ids":["https://openalex.org/I2801852214"]},{"raw_affiliation_string":"Current affiliation: Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH","institution_ids":["https://openalex.org/I1314135232"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, University of Washington Medical Center, Seattle, Washington","institution_ids":["https://openalex.org/I2801852214"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5058581049"],"corresponding_institution_ids":["https://openalex.org/I1314135232","https://openalex.org/I2801852214"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":0.5096,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.65338619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"278-279","issue":null,"first_page":"80","last_page":"83"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperdiploidy","display_name":"hyperdiploidy","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mll-rearrangement","display_name":"MLL rearrangement","score":0.972000002861023},{"id":"https://openalex.org/keywords/chromothripsis","display_name":"chromothripsis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/chromosome-11","display_name":"chromosome 11","score":0.9539999961853027},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.6830000281333923},{"id":"https://openalex.org/keywords/misclassification","display_name":"misclassification","score":0.5460000038146973},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism-array","display_name":"single nucleotide polymorphism array","score":0.8059999942779541},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.7330955862998962},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6552188396453857},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.5962940454483032},{"id":"https://openalex.org/C122060243","wikidata":"https://www.wikidata.org/wiki/Q7391885","display_name":"SNP array","level":5,"score":0.4553152024745941},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.445684552192688},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.43802914023399353},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4260391592979431},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4126279354095459},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3966137170791626},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.39518773555755615},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38898155093193054},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2811228036880493},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.27079683542251587},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2065315544605255},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15942510962486267},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008228","descriptor_name":"Lymphoma, Non-Hodgkin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015452","descriptor_name":"Precursor B-Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cancergen.2023.09.002","doi":"https://doi.org/10.1016/j.cancergen.2023.09.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cancergen.2023.09.002","pdf_url":null,"source":{"id":"https://openalex.org/S4210168666","display_name":"Cancer Genetics","issn_l":"2210-7762","issn":["2210-7762","2210-7770"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Genetics","raw_type":"journal-article"},{"id":"pmid:37742392","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37742392","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer genetics","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1016/j.cancergen.2023.09.002","doi":"https://doi.org/10.1016/j.cancergen.2023.09.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cancergen.2023.09.002","pdf_url":null,"source":{"id":"https://openalex.org/S4210168666","display_name":"Cancer Genetics","issn_l":"2210-7762","issn":["2210-7762","2210-7770"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1556688334","https://openalex.org/W1569839307","https://openalex.org/W1978709366","https://openalex.org/W2015158272","https://openalex.org/W2015501589","https://openalex.org/W2036282932","https://openalex.org/W2063821902","https://openalex.org/W2092925278","https://openalex.org/W2104910696","https://openalex.org/W2109158187","https://openalex.org/W2111246279","https://openalex.org/W2114340167","https://openalex.org/W2148802388","https://openalex.org/W2161199883","https://openalex.org/W2286866866","https://openalex.org/W2405220018","https://openalex.org/W2595838441","https://openalex.org/W2770081349","https://openalex.org/W2916162780","https://openalex.org/W2985264430","https://openalex.org/W2995586576","https://openalex.org/W3181438909","https://openalex.org/W3210124852","https://openalex.org/W4225907047","https://openalex.org/W4306632239"],"related_works":["https://openalex.org/W4408147068","https://openalex.org/W4306320763","https://openalex.org/W2947527521","https://openalex.org/W2062424815","https://openalex.org/W4408169247","https://openalex.org/W4408169242","https://openalex.org/W2943279900","https://openalex.org/W2624157698","https://openalex.org/W2168760347","https://openalex.org/W4403554618"],"abstract_inverted_index":{"The":[0,39],"dramatic":[1],"improvement":[2],"in":[3,56,65],"the":[4,100,130,145,150],"event-free":[5],"survival":[6],"of":[7,20,27,37,41,67,129,136,156,171],"paediatric":[8],"B-lymphoblastic":[9],"leukaemia":[10],"(B-ALL)":[11],"has":[12],"led":[13,133],"to":[14,33,105,134,180],"risk-stratified":[15],"treatment.":[16,68],"Through":[17],"a":[18,48,61,71,76,174],"combination":[19],"clinical":[21],"features,":[22],"cytogenetic":[23,147],"abnormalities":[24],"and":[25,82,114,153],"assessment":[26],"treatment":[28],"response,":[29],"patients":[30],"are":[31,58],"stratified":[32],"receive":[34],"different":[35],"intensities":[36],"therapy.":[38],"presence":[40],"high":[42,77],"hyperdiploidy":[43],"(>50":[44],"chromosomes)":[45,81],"is":[46],"considered":[47],"favourable":[49],"genetic":[50],"feature.":[51],"Conversely,":[52],"KMT2A":[53,83,101,124,175],"fusion":[54,92,112,176],"genes":[55],"B-ALL":[57],"associated":[59],"with":[60,74,89,139,144],"poor":[62],"prognosis,":[63],"resulting":[64],"intensification":[66],"We":[69],"present":[70],"seven-year-old":[72],"female":[73],"B-ALL,":[75],"hyperdiploid":[78,141,146],"karyotype":[79],"(56":[80],"rearrangement":[84,102],"detected":[85],"on":[86],"FISH,":[87],"but":[88],"no":[90],"productive":[91],"identified.":[93],"Single":[94],"nucleotide":[95],"polymorphism":[96],"(SNP)":[97],"array":[98],"suggested":[99],"was":[103],"due":[104],"chromosome":[106,162],"11":[107],"chromothripsis.":[108],"Subsequent":[109],"targeted":[110],"RNA":[111],"panel":[113],"whole":[115],"transcriptomic":[116],"sequencing":[117],"(mRNA-seq)":[118],"did":[119],"not":[120],"detect":[121],"an":[122],"expressed":[123],"fusion.":[125],"Differential":[126],"expression":[127],"analyses":[128],"mRNA-seq":[131],"data":[132],"clustering":[135],"this":[137],"case":[138],"other":[140],"cases,":[142],"consistent":[143],"results.":[148],"Given":[149],"additional":[151],"intensity":[152],"potential":[154],"toxicity":[155],"high-risk":[157],"treatment,":[158],"unusual":[159],"findings":[160],"by":[161,177],"analysis,":[163],"FISH":[164],"and/or":[165],"chromosomal":[166],"microarray":[167],"should":[168],"prompt":[169],"consideration":[170],"testing":[172],"for":[173],"another":[178],"method":[179],"avoid":[181],"misclassification.":[182]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-09-07T00:00:00"}
