{"id":"https://openalex.org/W4386475584","doi":"https://doi.org/10.1515/tnsci-2022-0298","title":"An interventional study of baicalin on neuronal pentraxin-1, neuronal pentraxin-2, and C-reactive protein in Alzheimer\u2019s disease rat model","display_name":"An interventional study of baicalin on neuronal pentraxin-1, neuronal pentraxin-2, and C-reactive protein in Alzheimer\u2019s disease rat model","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4386475584","doi":"https://doi.org/10.1515/tnsci-2022-0298","pmid":"https://pubmed.ncbi.nlm.nih.gov/37719746","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10500638"},"language":"en","primary_location":{"id":"doi:10.1515/tnsci-2022-0298","doi":"https://doi.org/10.1515/tnsci-2022-0298","is_oa":true,"landing_page_url":"https://doi.org/10.1515/tnsci-2022-0298","pdf_url":"https://www.degruyter.com/document/doi/10.1515/tnsci-2022-0298/pdf","source":{"id":"https://openalex.org/S136613190","display_name":"Translational Neuroscience","issn_l":"2081-3856","issn":["2081-3856","2081-6936"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","norway-1","oarl","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.degruyter.com/document/doi/10.1515/tnsci-2022-0298/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084320586","display_name":"Jingkun Zhao","orcid":"https://orcid.org/0000-0003-4096-3373","observed_orcids":["https://orcid.org/0000-0003-4096-3373"]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing-Kun Zhao","raw_affiliation_strings":["Department of Neurology, The First Affiliated Hospital of Harbin Medical University , No. 23 Postal Street, Nangang District , Harbin 150001 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The First Affiliated Hospital of Harbin Medical University , No. 23 Postal Street, Nangang District , Harbin 150001 , China","institution_ids":["https://openalex.org/I4210156501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113014110","display_name":"Si-Jia Hou","orcid":"https://orcid.org/0000-0003-3209-6409","observed_orcids":["https://orcid.org/0000-0003-3209-6409"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Si-Jia Hou","raw_affiliation_strings":["Department of Neurology, The General Hospital of Heilongjiang Province Land Reclamation Bureau , Harbin 150088 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The General Hospital of Heilongjiang Province Land Reclamation Bureau , Harbin 150088 , China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083969121","display_name":"Jiwei Zhao","orcid":"https://orcid.org/0000-0002-9298-9412","observed_orcids":["https://orcid.org/0000-0002-9298-9412"]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji-Wei Zhao","raw_affiliation_strings":["Department of Neurology, The First Affiliated Hospital of Harbin Medical University , No. 23 Postal Street, Nangang District , Harbin 150001 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The First Affiliated Hospital of Harbin Medical University , No. 23 Postal Street, Nangang District , Harbin 150001 , China","institution_ids":["https://openalex.org/I4210156501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100610660","display_name":"Hongli Yu","orcid":"https://orcid.org/0000-0003-4848-4756","observed_orcids":["https://orcid.org/0000-0003-4848-4756"]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Li Yu","raw_affiliation_strings":["Department of Neurology, The First Affiliated Hospital of Harbin Medical University , No. 23 Postal Street, Nangang District , Harbin 150001 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The First Affiliated Hospital of Harbin Medical University , No. 23 Postal Street, Nangang District , Harbin 150001 , China","institution_ids":["https://openalex.org/I4210156501"]}]},{"author_position":"last","author":{"id":null,"display_name":"Shu-Rong Duan","orcid":"https://orcid.org/0000-0001-9163-3732","observed_orcids":["https://orcid.org/0000-0001-9163-3732"]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shu-Rong Duan","raw_affiliation_strings":["Department of Neurology, The First Affiliated Hospital of Harbin Medical University , No. 23 Postal Street, Nangang District , Harbin 150001 , China"],"raw_orcid":"https://orcid.org/0000-0001-9163-3732","affiliations":[{"raw_affiliation_string":"Department of Neurology, The First Affiliated Hospital of Harbin Medical University , No. 23 Postal Street, Nangang District , Harbin 150001 , China","institution_ids":["https://openalex.org/I4210156501"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210156501"],"apc_list":{"value":1500,"currency":"EUR","value_usd":1623},"apc_paid":{"value":1500,"currency":"EUR","value_usd":1623},"fwci":1.494,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.81151007,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"14","issue":"1","first_page":"20220298","last_page":"20220298"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.4569999873638153,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.4569999873638153,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.4000999927520752,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.09769999980926514,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/baicalin","display_name":"baicalin","score":1.0},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/neuronal-pentraxin-2","display_name":"NPTX2","score":1.0},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":1.0},{"id":"https://openalex.org/keywords/spatial-learning-and-memory","display_name":"spatial learning and memory","score":0.8209999799728394},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.9110000133514404},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C2780113650","wikidata":"https://www.wikidata.org/wiki/Q2879368","display_name":"Baicalin","level":3,"score":0.9851810932159424},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.6530536413192749},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.5689762830734253},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4958725869655609},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47383174300193787},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4469800591468811},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38579514622688293},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3681691884994507},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3447021245956421},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3035743236541748},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1515/tnsci-2022-0298","doi":"https://doi.org/10.1515/tnsci-2022-0298","is_oa":true,"landing_page_url":"https://doi.org/10.1515/tnsci-2022-0298","pdf_url":"https://www.degruyter.com/document/doi/10.1515/tnsci-2022-0298/pdf","source":{"id":"https://openalex.org/S136613190","display_name":"Translational Neuroscience","issn_l":"2081-3856","issn":["2081-3856","2081-6936"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","norway-1","oarl","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10500638","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10500638","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10500638/pdf/tnsci-2022-0298.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Neurosci","raw_type":"Text"},{"id":"pmid:37719746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37719746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9e340668cfc64520bbf4633f11df6a46","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9e340668cfc64520bbf4633f11df6a46","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Neuroscience, Vol 14, Iss 1, Pp 1577-90 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1515/tnsci-2022-0298","doi":"https://doi.org/10.1515/tnsci-2022-0298","is_oa":true,"landing_page_url":"https://doi.org/10.1515/tnsci-2022-0298","pdf_url":"https://www.degruyter.com/document/doi/10.1515/tnsci-2022-0298/pdf","source":{"id":"https://openalex.org/S136613190","display_name":"Translational Neuroscience","issn_l":"2081-3856","issn":["2081-3856","2081-6936"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","norway-1","oarl","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5081575084","display_name":null,"funder_award_id":"2020-125","funder_id":"https://openalex.org/F4320317801","funder_display_name":"Health Commission of Heilongjiang Province"}],"funders":[{"id":"https://openalex.org/F4320317801","display_name":"Health Commission of Heilongjiang Province","ror":"https://ror.org/012pjba67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386475584.pdf","grobid_xml":"https://content.openalex.org/works/W4386475584.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1964065265","https://openalex.org/W1970567538","https://openalex.org/W1971053086","https://openalex.org/W2000908311","https://openalex.org/W2003841076","https://openalex.org/W2012801870","https://openalex.org/W2025894278","https://openalex.org/W2055190268","https://openalex.org/W2065281821","https://openalex.org/W2078165545","https://openalex.org/W2082429191","https://openalex.org/W2084060787","https://openalex.org/W2094640306","https://openalex.org/W2130945157","https://openalex.org/W2136199683","https://openalex.org/W2168334242","https://openalex.org/W2169473035","https://openalex.org/W2506432941","https://openalex.org/W2562584466","https://openalex.org/W2591323097","https://openalex.org/W2761517608","https://openalex.org/W2789287723","https://openalex.org/W2791391987","https://openalex.org/W2792619661","https://openalex.org/W2913751428","https://openalex.org/W4206046172","https://openalex.org/W4206631174","https://openalex.org/W4223591189","https://openalex.org/W4293771139","https://openalex.org/W4296077746","https://openalex.org/W4309507742","https://openalex.org/W4323035633","https://openalex.org/W4386065661"],"related_works":["https://openalex.org/W2084060787","https://openalex.org/W1963993567","https://openalex.org/W4404610245","https://openalex.org/W7117564768","https://openalex.org/W4401557798","https://openalex.org/W2058426031","https://openalex.org/W2761517608","https://openalex.org/W2025410841","https://openalex.org/W4324138147","https://openalex.org/W2364145281"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Baicalin":[2,172,223],"has":[3],"been":[4],"shown":[5],"to":[6,30,83,102],"promote":[7],"spatial":[8,93],"learning":[9,94],"and":[10,43,70,92,98,109,137,189,234],"neural":[11,19],"regeneration,":[12],"which":[13],"might":[14],"increase":[15],"the":[16,32,63,66,71,77,85,90,104,117,121,143,151,165,176,183,187,193,205,210],"differentiation":[17],"of":[18,34,87,95,106,160,178,207,213],"stem":[20],"cells":[21],"in":[22,47,111,142,192,209,237],"Alzheimer\u2019s":[23],"disease":[24],"(AD)":[25],"rat":[26],"models.":[27],"We":[28],"aimed":[29],"study":[31],"role":[33,228],"baicalin":[35,74,88,126,154,196],"on":[36,89],"neuronal":[37,40],"pentraxin-1":[38],"(NPTX-1),":[39],"pentraxin-2":[41],"(NPTX-2),":[42],"C-reactive":[44],"protein":[45],"(CRP)":[46],"AD":[48,67,72,118,122,152,166,184,194,214,238],"model":[49,68,119,167,185,239],"rats.":[50,96,240],"Methods":[51],"The":[52],"30":[53],"male":[54],"Sprague":[55],"Dawley":[56],"rats":[57,123,215],"were":[58,100],"divided":[59],"into":[60],"three":[61],"groups:":[62],"control":[64],"group,":[65,69,120,186],"+":[73,153,195],"group.":[75],"Then,":[76],"Morris":[78],"water":[79],"maze":[80],"was":[81,198,216],"used":[82,101],"verify":[84],"effect":[86],"memory":[91],"Immunohistochemistry":[97],"immunofluorescence":[99],"observe":[103],"expression":[105,191,206],"NPTX-1,":[107,231],"NPTX-2,":[108,233],"CRP":[110,190],"brain":[112,211],"tissue.":[113],"Results":[114],"Compared":[115],"with":[116,125,164,182],"treated":[124],"spent":[127],"significantly":[128,157,199,217],"less":[129],"time":[130],"finding":[131],"escape":[132],"latencies":[133],"(P":[134,146,169,201,219],"=":[135,147,202,220],"0.008)":[136],"had":[138,156],"longer":[139],"cross-platform":[140],"times":[141],"target":[144],"quadrant":[145],"0.015).":[148],"In":[149],"addition,":[150],"group":[155,168,197],"higher":[158],"numbers":[159],"hippocampal":[161],"neurons":[162],"compared":[163,181],"<":[170],"0.05).":[171],"also":[173],"obviously":[174],"decreased":[175],"apoptosis":[177],"neurons.":[179],"Moreover,":[180],"NPTX-1":[188],"reduced":[200],"0.000)":[203],"while":[204],"NPTX-2":[208],"tissue":[212],"increased":[218],"0.000).":[221],"Conclusions":[222],"can":[224],"play":[225],"a":[226],"therapeutic":[227],"by":[229],"downregulating":[230,235],"upregulating":[232],"CPR":[236]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-09-07T00:00:00"}