{"id":"https://openalex.org/W4386475160","doi":"https://doi.org/10.1038/s41598-023-41873-0","title":"HIV-1 Vpu protein forms stable oligomers in aqueous solution via its transmembrane domain self-association","display_name":"HIV-1 Vpu protein forms stable oligomers in aqueous solution via its transmembrane domain self-association","publication_year":2023,"publication_date":"2023-09-06","ids":{"openalex":"https://openalex.org/W4386475160","doi":"https://doi.org/10.1038/s41598-023-41873-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/37214796","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10197565"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-023-41873-0","doi":"https://doi.org/10.1038/s41598-023-41873-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-41873-0","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41598-023-41873-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053994968","display_name":"Saman Majeed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saman Majeed","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX, 79409, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX, 79409, USA","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lan Dang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lan Dang","raw_affiliation_strings":["Graduate Program in Quantitative and Computational Biosciences, Graduate School of Biomedical Sciences at Baylor College of Medicine, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Quantitative and Computational Biosciences, Graduate School of Biomedical Sciences at Baylor College of Medicine, Houston, TX, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101744502","display_name":"Md Majharul Islam","orcid":"https://orcid.org/0000-0001-6822-0585","observed_orcids":["https://orcid.org/0000-0001-6822-0585"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Md Majharul Islam","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX, 79409, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX, 79409, USA","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058057355","display_name":"Olamide Ishola","orcid":"https://orcid.org/0000-0002-1768-2664","observed_orcids":["https://orcid.org/0000-0002-1768-2664"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olamide Ishola","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX, 79409, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX, 79409, USA","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110035085","display_name":"Peter P. Borbat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter P. Borbat","raw_affiliation_strings":["Department of Chemistry and Chemical Biology and ACERT, Cornell University, Ithaca, NY, 14853, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology and ACERT, Cornell University, Ithaca, NY, 14853, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043428416","display_name":"Steven J. Ludtke","orcid":"https://orcid.org/0000-0002-1903-1574","observed_orcids":["https://orcid.org/0000-0002-1903-1574"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven J. Ludtke","raw_affiliation_strings":["Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, 77030, USA. sludtke@bcm.edu","Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, 77030, USA. sludtke@bcm.edu","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010730078","display_name":"Elka R. Georgieva","orcid":"https://orcid.org/0000-0001-9980-5260","observed_orcids":["https://orcid.org/0000-0001-9980-5260"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]},{"id":"https://openalex.org/I926076166","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93","country_code":"US","type":"education","lineage":["https://openalex.org/I926076166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elka R. Georgieva","raw_affiliation_strings":["Center for Membrane Protein Research, TTU Health Science Center, Lubbock, TX, 79430, USA. elgeorgi@ttu.edu","Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX, 79409, USA. elgeorgi@ttu.edu","Center for Membrane Protein Research, TTU Health Science Center, Lubbock, TX, 79430, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Membrane Protein Research, TTU Health Science Center, Lubbock, TX, 79430, USA. elgeorgi@ttu.edu","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX, 79409, USA. elgeorgi@ttu.edu","institution_ids":["https://openalex.org/I12315562"]},{"raw_affiliation_string":"Center for Membrane Protein Research, TTU Health Science Center, Lubbock, TX, 79430, USA","institution_ids":["https://openalex.org/I12315562","https://openalex.org/I926076166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010730078","https://openalex.org/A5043428416"],"corresponding_institution_ids":["https://openalex.org/I12315562","https://openalex.org/I181547552","https://openalex.org/I926076166"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":0.9166,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.73301304,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"13","issue":"1","first_page":"14691","last_page":"14691"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.5297999978065491,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.5297999978065491,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.2890999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0803999975323677,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-oligomerization","display_name":"protein oligomerization","score":0.9129999876022339},{"id":"https://openalex.org/keywords/soluble-oligomers","display_name":"soluble oligomers","score":0.8949999809265137},{"id":"https://openalex.org/keywords/membrane-protein-assembly","display_name":"membrane protein assembly","score":0.492000013589859},{"id":"https://openalex.org/keywords/c-terminal-flexibility","display_name":"C-terminal flexibility","score":0.7089999914169312},{"id":"https://openalex.org/keywords/hydrophobic-interactions","display_name":"hydrophobic interactions","score":0.8519999980926514},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.5759999752044678},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.7284845113754272},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.625541090965271},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6016527414321899},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.5926753282546997},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.5711430311203003},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4631599187850952},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.45486658811569214},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3456428050994873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3114233911037445},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.30778253078460693},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.24551263451576233},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24013644456863403},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09916335344314575},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07938686013221741},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07586324214935303},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":9,"locations":[{"id":"doi:10.1038/s41598-023-41873-0","doi":"https://doi.org/10.1038/s41598-023-41873-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-41873-0","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.1101/2023.05.08.539839","doi":"https://doi.org/10.1101/2023.05.08.539839","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.05.08.539839","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/05/08/2023.05.08.539839.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10483038","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10483038","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10483038/pdf/41598_2023_Article_41873.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:37214796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37214796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:37673923","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37673923","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10197565","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10197565","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10197565/pdf/nihpp-2023.05.08.539839v2.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:baylor_docs-1122","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/baylor_docs/123","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty and Staff Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:752b4918c40d41d184ea0c0c60b17618","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/752b4918c40d41d184ea0c0c60b17618","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)","raw_type":"article"},{"id":"pmh:oai:ttu-ir.tdl.org:2346/96441","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2346/96441","pdf_url":null,"source":{"id":"https://openalex.org/S4306402519","display_name":"ThinkTech (Texas Tech University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12315562","host_organization_name":"Texas Tech University","host_organization_lineage":["https://openalex.org/I12315562"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1038/s41598-023-41873-0","doi":"https://doi.org/10.1038/s41598-023-41873-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-41873-0","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1476981552","display_name":"New Capabilities for Cancer Research in the TMC CryoEM Cores","funder_award_id":"RP190602","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"},{"id":"https://openalex.org/G767531880","display_name":"SUPPORT AND DEVELOPMENT OF EMAN FOR ELECTRON MICROSCOPY IMAGE PROCESSING","funder_award_id":"R01GM080139","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000886293","display_name":"National Biomedical Resource for Electron-Spin Resonance Spectroscopy (ACERT)","funder_award_id":"R24GM146107","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W176786823","https://openalex.org/W1539918506","https://openalex.org/W1555930389","https://openalex.org/W1814017524","https://openalex.org/W1824377481","https://openalex.org/W1891596881","https://openalex.org/W1953456383","https://openalex.org/W1984125372","https://openalex.org/W1998685200","https://openalex.org/W2001362053","https://openalex.org/W2001430278","https://openalex.org/W2003756762","https://openalex.org/W2010458160","https://openalex.org/W2010715944","https://openalex.org/W2014283693","https://openalex.org/W2021067210","https://openalex.org/W2033873142","https://openalex.org/W2035867814","https://openalex.org/W2045035889","https://openalex.org/W2045684019","https://openalex.org/W2058828092","https://openalex.org/W2066589127","https://openalex.org/W2071971425","https://openalex.org/W2080056514","https://openalex.org/W2086280683","https://openalex.org/W2091646550","https://openalex.org/W2098513990","https://openalex.org/W2099164564","https://openalex.org/W2100455255","https://openalex.org/W2104234755","https://openalex.org/W2112121524","https://openalex.org/W2128326592","https://openalex.org/W2133442602","https://openalex.org/W2134193705","https://openalex.org/W2139927157","https://openalex.org/W2149258763","https://openalex.org/W2155766451","https://openalex.org/W2172012533","https://openalex.org/W2198297310","https://openalex.org/W2233751927","https://openalex.org/W2278419621","https://openalex.org/W2466139738","https://openalex.org/W2493151343","https://openalex.org/W2520930511","https://openalex.org/W2565271894","https://openalex.org/W2802055049","https://openalex.org/W2883753771","https://openalex.org/W2891338881","https://openalex.org/W2911458485","https://openalex.org/W2970951657","https://openalex.org/W3037635279","https://openalex.org/W3121324275","https://openalex.org/W3137102412","https://openalex.org/W3184072622","https://openalex.org/W4320731530"],"related_works":["https://openalex.org/W4320731530","https://openalex.org/W4293864275","https://openalex.org/W2128326592","https://openalex.org/W2139927157","https://openalex.org/W2058376058","https://openalex.org/W3149084804","https://openalex.org/W4319936724","https://openalex.org/W7214131772","https://openalex.org/W4319937250","https://openalex.org/W2466139738"],"abstract_inverted_index":{"We":[0,100],"report":[1],"our":[2],"findings":[3],"on":[4],"the":[5,8,59,94,97,114,130,132,147,156,159,174,191,196],"assembly":[6],"of":[7,61,78,96,136,149,158,173,195],"HIV-1":[9,19,184],"protein":[10,35,79],"Vpu":[11,15,103,137,177],"into":[12],"soluble":[13,65,98],"oligomers.":[14,99],"is":[16,51,70,119,138],"a":[17,26,120],"key":[18],"protein.":[20,29],"It":[21],"has":[22],"been":[23],"considered":[24],"exclusively":[25],"single-pass":[27],"membrane":[28,67],"Previous":[30],"observations":[31,142],"show":[32],"that":[33,102,113],"this":[34,73,167],"forms":[36],"stable":[37],"oligomers":[38,46,160,178],"in":[39,183],"aqueous":[40],"solution,":[41],"but":[42],"details":[43],"about":[44,176,190],"these":[45],"still":[47],"remain":[48],"obscure.":[49],"This":[50],"an":[52],"interesting":[53],"and":[54,66,85,125,193],"rather":[55],"unique":[56],"observation,":[57],"as":[58],"number":[60],"proteins":[62],"transitioning":[63],"between":[64],"embedded":[68],"states":[69],"limited.":[71],"In":[72],"study":[74,168],"we":[75],"made":[76],"use":[77],"engineering,":[80],"size":[81,192],"exclusion":[82],"chromatography,":[83],"cryoEM":[84,124],"electron":[86],"paramagnetic":[87],"resonance":[88],"(EPR)":[89],"spectroscopy":[90],"to":[91],"better":[92],"elucidate":[93],"nature":[95,194],"found":[101],"oligomerizes":[104],"via":[105],"its":[106],"N-terminal":[107],"transmembrane":[108],"domain":[109],"(TM).":[110],"CryoEM":[111],"suggests":[112],"oligomeric":[115,197],"state":[116],"most":[117],"likely":[118],"hexamer/heptamer":[121],"equilibrium.":[122],"Both":[123],"EPR":[126],"suggest":[127],"that,":[128],"within":[129],"oligomer,":[131],"distal":[133],"C-terminal":[134],"region":[135],"highly":[139],"flexible.":[140],"Our":[141],"are":[143],"consistent":[144],"with":[145],"both":[146],"concept":[148],"specific":[150],"interactions":[151],"among":[152],"TM":[153],"helices":[154],"or":[155,179],"core":[157],"being":[161],"stabilized":[162],"by":[163],"hydrophobic":[164],"forces.":[165],"While":[166],"does":[169],"not":[170],"resolve":[171],"all":[172],"questions":[175],"their":[180],"functional":[181],"role":[182],"it":[185],"provides":[186],"new":[187],"fundamental":[188],"information":[189],"interactions.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-09-07T00:00:00"}
