{"id":"https://openalex.org/W4386475103","doi":"https://doi.org/10.1158/1535-7163.24089591.v1","title":"Figure 1 from Upregulation of Somatostatin Receptor Type 2 Improves 177Lu-DOTATATE Therapy in Receptor-Deficient Pancreatic Neuroendocrine Tumor Model","display_name":"Figure 1 from Upregulation of Somatostatin Receptor Type 2 Improves 177Lu-DOTATATE Therapy in Receptor-Deficient Pancreatic Neuroendocrine Tumor Model","publication_year":2023,"publication_date":"2023-09-06","ids":{"openalex":"https://openalex.org/W4386475103","doi":"https://doi.org/10.1158/1535-7163.24089591.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.24089591.v1","doi":"https://doi.org/10.1158/1535-7163.24089591.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.24089591.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1535-7163.24089591.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069800885","display_name":"Rupali Sharma","orcid":"https://orcid.org/0000-0002-0370-675X","observed_orcids":["https://orcid.org/0000-0002-0370-675X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rupali Sharma","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0370-675X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022252505","display_name":"Bhargav Earla","orcid":"https://orcid.org/0009-0000-4658-1945","observed_orcids":["https://orcid.org/0009-0000-4658-1945"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bhargav Earla","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-4658-1945","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018219579","display_name":"Kwamena E. Baidoo","orcid":"https://orcid.org/0009-0007-3726-1609","observed_orcids":["https://orcid.org/0009-0007-3726-1609"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kwamena E. Baidoo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-3726-1609","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025622172","display_name":"Martha A. Zeiger","orcid":"https://orcid.org/0000-0001-8998-0858","observed_orcids":["https://orcid.org/0000-0001-8998-0858"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martha A. Zeiger","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8998-0858","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014881195","display_name":"James P. Madigan","orcid":"https://orcid.org/0000-0002-0503-3704","observed_orcids":["https://orcid.org/0000-0002-0503-3704"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James P. Madigan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0503-3704","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078610086","display_name":"Freddy E. Escorcia","orcid":"https://orcid.org/0000-0002-0727-3242","observed_orcids":["https://orcid.org/0000-0002-0727-3242"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Freddy E. Escorcia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0727-3242","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050780818","display_name":"Samira Mercedes Sadowski","orcid":"https://orcid.org/0000-0002-7538-9431","observed_orcids":["https://orcid.org/0000-0002-7538-9431"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samira M. Sadowski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7538-9431","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatostatin-receptor-2","display_name":"somatostatin receptor 2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/pancreatic-neuroendocrine-tumors","display_name":"pancreatic neuroendocrine tumors","score":0.8330000042915344},{"id":"https://openalex.org/keywords/gastrointestinal-neuroendocrine-tumors","display_name":"gastrointestinal neuroendocrine tumors","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cpg-methylation","display_name":"CpG methylation","score":0.6690000295639038},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.753000020980835},{"id":"https://openalex.org/keywords/177lu-dotatate","display_name":"177Lu-DOTATATE","score":0.8289999961853027},{"id":"https://openalex.org/keywords/peptide-receptor-radionuclide-therapy","display_name":"peptide receptor radionuclide therapy","score":0.7649999856948853},{"id":"https://openalex.org/keywords/dna-demethylation","display_name":"DNA demethylation","score":0.6430000066757202},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9160000085830688},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.9430000185966492},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.7982879877090454},{"id":"https://openalex.org/C150008808","wikidata":"https://www.wikidata.org/wiki/Q18031731","display_name":"Somatostatin receptor 2","level":4,"score":0.6914812326431274},{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.5583714246749878},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5545821189880371},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.504330039024353},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.48660218715667725},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47776949405670166},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43553808331489563},{"id":"https://openalex.org/C80115893","wikidata":"https://www.wikidata.org/wiki/Q2067077","display_name":"Somatostatin receptor","level":3,"score":0.42214563488960266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37153780460357666},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36968013644218445},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1681031584739685},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1623593270778656},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06562873721122742}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.24089591.v1","doi":"https://doi.org/10.1158/1535-7163.24089591.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.24089591.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.24089591.v1","doi":"https://doi.org/10.1158/1535-7163.24089591.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.24089591.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2921972134","https://openalex.org/W4386485351","https://openalex.org/W4293236675","https://openalex.org/W4385212580","https://openalex.org/W4386485051","https://openalex.org/W4386475078","https://openalex.org/W4408091046","https://openalex.org/W7028155390","https://openalex.org/W4286457402","https://openalex.org/W4302022854"],"abstract_inverted_index":{"SSTR2":[0,52,101,120],"promoter":[1,102],"methylation":[2,34,43,48,60,103,154],"levels":[3,44,61,118],"in":[4,58,133],"GEP-NET":[5],"patients":[6,22,37,91],"(A":[7],"and":[8,10,33,65,72,77,80,99,113,119,125,130],"B)":[9],"three":[11,134],"NET":[12,135],"cell":[13,136],"lines":[14,137],"(C).":[15],"A,":[16],"An":[17],"NIH":[18],"cohort":[19],"of":[20,30,50,89,153],"96":[21],"with":[23,38,92,128],"GEP-NETs":[24],"was":[25,94],"analyzed":[26,95],"on":[27],"the":[28,46,51,59,106,111,151],"basis":[29],"tumor":[31],"grade":[32],"level.":[35],"Those":[36],"higher-grade":[39],"tumors":[40],"showed":[41],"increased":[42],"at":[45,168],"CpG":[47,169],"sites":[49],"promoter.":[53],"Significant":[54],"changes":[55,165],"were":[56,122,166],"observed":[57,167],"between":[62],"grades":[63,70,78],"1":[64,79],"2":[66,71],"(P":[67,74,82,172],"=":[68,75,83],"0.034),":[69],"3":[73,81],"0.044),":[76],"0.000014).":[84],"B,":[85],"The":[86,141,148,162],"GSE117852":[87],"dataset":[88],"32":[90],"PNETs":[93],"for":[96,145,158],"gene":[97],"expression":[98,121],"mean":[100],"levels,":[104],"using":[105],"Spearman":[107],"method":[108],"to":[109],"calculate":[110],"R":[112],"P":[114],"value.":[115],"C,":[116],"Methylation":[117],"measured":[123],"before":[124],"after":[126],"treatment":[127],"VPA":[129],"azacytidine":[131],"(TRTM)":[132],"(QGP-1,":[138],"BON-1,":[139],"GOT-1).":[140],"controls":[142],"are":[143],"untreated":[144],"comparison":[146],"(CTRL).":[147],"x-axis":[149],"represents":[150],"degree":[152],"(0\u20131),":[155],"adjusted":[156],"graphically":[157],"optimal":[159],"visual":[160],"display.":[161],"most":[163],"significant":[164],"island":[170],"cg14232289":[171],"<":[173],"0.0001).":[174]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-09-07T00:00:00"}