{"id":"https://openalex.org/W4386469710","doi":"https://doi.org/10.1021/acs.biomac.3c00523","title":"GSH-Responsive Polymeric Micelles for Remodeling the Tumor Microenvironment to Improve Chemotherapy and Inhibit Metastasis in Breast Cancer","display_name":"GSH-Responsive Polymeric Micelles for Remodeling the Tumor Microenvironment to Improve Chemotherapy and Inhibit Metastasis in Breast Cancer","publication_year":2023,"publication_date":"2023-09-06","ids":{"openalex":"https://openalex.org/W4386469710","doi":"https://doi.org/10.1021/acs.biomac.3c00523","pmid":"https://pubmed.ncbi.nlm.nih.gov/37672635"},"language":"en","primary_location":{"id":"doi:10.1021/acs.biomac.3c00523","doi":"https://doi.org/10.1021/acs.biomac.3c00523","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biomac.3c00523","pdf_url":null,"source":{"id":"https://openalex.org/S11629336","display_name":"Biomacromolecules","issn_l":"1525-7797","issn":["1525-7797","1526-4602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036329844","display_name":"Yingping Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingping Zeng","raw_affiliation_strings":["College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077792144","display_name":"Guangtao Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangtao Song","raw_affiliation_strings":["College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069207720","display_name":"Shufen Zhang","orcid":"https://orcid.org/0000-0003-3390-4199","observed_orcids":["https://orcid.org/0000-0003-3390-4199"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shufen Zhang","raw_affiliation_strings":["College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101477686","display_name":"Sufen Li","orcid":"https://orcid.org/0000-0002-2695-8263","observed_orcids":["https://orcid.org/0000-0002-2695-8263"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sufen Li","raw_affiliation_strings":["College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064867218","display_name":"Tingting Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Meng","raw_affiliation_strings":["College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015921335","display_name":"Hong Yuan","orcid":"https://orcid.org/0000-0002-0452-3189","observed_orcids":["https://orcid.org/0000-0002-0452-3189"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Yuan","raw_affiliation_strings":["College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China","Jinhua Institute of Zhejiang University, Jinhua 321299, China"],"raw_orcid":"https://orcid.org/0000-0002-0452-3189","affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Jinhua Institute of Zhejiang University, Jinhua 321299, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023586508","display_name":"Fuqiang Hu","orcid":"https://orcid.org/0000-0002-9847-134X","observed_orcids":["https://orcid.org/0000-0002-9847-134X"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fuqiang Hu","raw_affiliation_strings":["College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China","Jinhua Institute of Zhejiang University, Jinhua 321299, China"],"raw_orcid":"https://orcid.org/0000-0002-9847-134X","affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China","institution_ids":["https://openalex.org/I76130692"]},{"raw_affiliation_string":"Jinhua Institute of Zhejiang University, Jinhua 321299, China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023586508"],"corresponding_institution_ids":["https://openalex.org/I76130692"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":1.7185,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.82922293,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"24","issue":"11","first_page":"4731","last_page":"4742"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tumor-microenvironment-remodeling","display_name":"tumor microenvironment remodeling","score":0.7940000295639038},{"id":"https://openalex.org/keywords/polymeric-micelles","display_name":"polymeric micelles","score":0.8159999847412109},{"id":"https://openalex.org/keywords/glutathione-responsive-drug-release","display_name":"glutathione-responsive release","score":0.9070000052452087},{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.847000002861023},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.7689999938011169},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.7879999876022339},{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":0.8769999742507935},{"id":"https://openalex.org/keywords/octadecylamine","display_name":"octadecylamine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.6919999718666077},{"id":"https://openalex.org/keywords/m2-macrophage-infiltration","display_name":"M2 macrophage infiltration","score":0.6940000057220459},{"id":"https://openalex.org/keywords/m1-macrophage-infiltration","display_name":"M1 macrophage infiltration","score":0.7639999985694885},{"id":"https://openalex.org/keywords/metastasis-inhibition","display_name":"metastasis suppression","score":0.7630000114440918},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.625},{"id":"https://openalex.org/keywords/endothelial-targeting","display_name":"endothelial targeting","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6671912670135498},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.660660445690155},{"id":"https://openalex.org/C11268172","wikidata":"https://www.wikidata.org/wiki/Q421110","display_name":"Micelle","level":3,"score":0.6331889629364014},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.612532377243042},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5869536399841309},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5526759624481201},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5124833583831787},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48830389976501465},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.334805428981781},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2734847962856293},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.21583425998687744},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.07581937313079834},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.biomac.3c00523","doi":"https://doi.org/10.1021/acs.biomac.3c00523","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biomac.3c00523","pdf_url":null,"source":{"id":"https://openalex.org/S11629336","display_name":"Biomacromolecules","issn_l":"1525-7797","issn":["1525-7797","1526-4602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"journal-article"},{"id":"pmid:37672635","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37672635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4555268585","display_name":null,"funder_award_id":"81973267","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4892740476","display_name":"\u8840\u8111\u5c4f\u969c\u8c03\u63a7\u4e0e\u8111\u90e8\u80bf\u7624\u9776\u5411\u6cbb\u7597","funder_award_id":"LD19H300001","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1536583711","https://openalex.org/W1962872293","https://openalex.org/W2000241906","https://openalex.org/W2052444415","https://openalex.org/W2075453630","https://openalex.org/W2100231368","https://openalex.org/W2111429259","https://openalex.org/W2123894943","https://openalex.org/W2134579258","https://openalex.org/W2284089480","https://openalex.org/W2291205197","https://openalex.org/W2342488790","https://openalex.org/W2511897228","https://openalex.org/W2516429875","https://openalex.org/W2612358593","https://openalex.org/W2760277446","https://openalex.org/W2945136360","https://openalex.org/W2954433902","https://openalex.org/W2956024695","https://openalex.org/W2960078024","https://openalex.org/W2980093890","https://openalex.org/W2981803901","https://openalex.org/W2988346767","https://openalex.org/W2997852206","https://openalex.org/W3000669373","https://openalex.org/W3010186562","https://openalex.org/W3014077431","https://openalex.org/W3019306048","https://openalex.org/W3022686384","https://openalex.org/W3043696309","https://openalex.org/W3046886884","https://openalex.org/W3082056328","https://openalex.org/W3082328907","https://openalex.org/W3087753599","https://openalex.org/W3096240000","https://openalex.org/W3119549591","https://openalex.org/W3120831468","https://openalex.org/W3143895078","https://openalex.org/W3150393082","https://openalex.org/W3155924509","https://openalex.org/W3164268320","https://openalex.org/W3173665490","https://openalex.org/W3179658109","https://openalex.org/W4205724345","https://openalex.org/W4223431213","https://openalex.org/W4283654015","https://openalex.org/W4283709165","https://openalex.org/W4284971625","https://openalex.org/W4296534905","https://openalex.org/W4296821587","https://openalex.org/W4308350244"],"related_works":["https://openalex.org/W4404368966","https://openalex.org/W4318694111","https://openalex.org/W4399212593","https://openalex.org/W7168130901","https://openalex.org/W3193899347","https://openalex.org/W2602597722","https://openalex.org/W4378364364","https://openalex.org/W3145770461","https://openalex.org/W4394935910","https://openalex.org/W4400747342"],"abstract_inverted_index":{"The":[0,78,109,146,164,181,247],"tumor":[1,12,71,131,144,179,209,241,245],"microenvironment":[2],"(TME)":[3],"of":[4,22,106,162,167,186,196,214,222,238],"breast":[5,107,258],"cancer":[6],"is":[7],"hypoxic,":[8],"which":[9,39,158,199],"can":[10,28,207,233],"promote":[11],"progression,":[13],"including":[14],"invasion":[15],"and":[16,18,35,52,61,73,94,138,193,227,242],"metastasis,":[17],"limit":[19],"the":[20,37,41,45,58,62,104,123,133,168,187,201,212,220,229,236,239],"efficacy":[21],"anti-tumor":[23,46],"treatment.":[24],"Nitric":[25],"oxide":[26],"(NO)":[27],"dilate":[29],"blood":[30],"vessels,":[31],"effectively":[32,142,243,256],"alleviate":[33,208],"hypoxia,":[34,210],"regulate":[36],"TME,":[38],"has":[40],"potential":[42,253],"to":[43,88,127,141,152,170,178,204],"improve":[44],"therapeutic":[47],"efficacy.":[48],"Here,":[49],"chitosan":[50],"(CO)":[51],"octadecylamine":[53],"(ODA)":[54],"were":[55,101],"linked":[56,66],"by":[57],"disulfide":[59,134,147],"bond,":[60],"LinTT1":[63],"peptide":[64],"was":[65,86,92,149,173],"onto":[67],"CO\u2013SS\u2013ODA":[68],"for":[69,103,255],"targeting":[70],"cells":[72,75,172],"endothelial":[74,121,156,171],"in":[76,116,155,217,225],"tumors.":[77],"NO":[79],"donor":[80],"S":[81],"-nitroso-":[82],"N":[83],"-acetylpenicillamine":[84],"(SNAP)":[85],"connected":[87],"CO.":[89],"Doxorubicin":[90],"(DOX)":[91],"encapsulated,":[93],"GSH":[95,118,153],"hierarchically":[96],"responsive":[97,113],"polymer":[98],"micelles":[99,110,124,169],"(TSCO\u2013SS\u2013ODA/DOX)":[100],"constructed":[102],"treatment":[105,195],"cancer.":[108,259],"had":[111,159,200],"differently":[112],"drug":[114,184,188,248],"release":[115,128,161,185],"different":[117],"concentrations.":[119],"In":[120,130],"cells,":[122,132,157],"rapidly":[125,136],"responded":[126],"NO.":[129],"bond":[135,148],"broke":[137],"released":[139],"DOX":[140],"kill":[143],"cells.":[145,180],"not":[150],"sensitive":[151],"concentration":[154],"less":[160],"DOX.":[163],"killing":[165],"effect":[166],"much":[174],"lower":[175],"than":[176],"that":[177],"cell":[182],"selective":[183],"delivery":[189,249],"systems":[190],"enabled":[191],"safe":[192],"effective":[194],"drugs.":[197],"TSCO\u2013SS\u2013ODA/DOX,":[198],"excellent":[202],"ability":[203],"target":[205],"tumors,":[206,218,226],"decrease":[211],"infiltration":[213,221],"M2":[215],"macrophages":[216,224],"increase":[219],"M1":[223],"remodel":[228],"TME.":[230],"Notably,":[231],"TSCO\u2013SS\u2013ODA/DOX":[232],"significantly":[234],"inhibit":[235,244],"growth":[237],"primary":[240],"metastasis.":[246],"system":[250],"provided":[251],"a":[252],"solution":[254],"treating":[257]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-09-07T00:00:00"}