{"id":"https://openalex.org/W4386467525","doi":"https://doi.org/10.1002/adbi.202300233","title":"Rigorous Comparison of Extracellular Vesicle Processing to Enhance Downstream Analysis for Glioblastoma Characterization","display_name":"Rigorous Comparison of Extracellular Vesicle Processing to Enhance Downstream Analysis for Glioblastoma Characterization","publication_year":2023,"publication_date":"2023-09-05","ids":{"openalex":"https://openalex.org/W4386467525","doi":"https://doi.org/10.1002/adbi.202300233","pmid":"https://pubmed.ncbi.nlm.nih.gov/37670402","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12247158"},"language":"en","primary_location":{"id":"doi:10.1002/adbi.202300233","doi":"https://doi.org/10.1002/adbi.202300233","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adbi.202300233","pdf_url":null,"source":{"id":"https://openalex.org/S4210178898","display_name":"Advanced Biology","issn_l":"2701-0198","issn":["2701-0198"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12247158","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008205552","display_name":"Tiffaney Hsia","orcid":"https://orcid.org/0000-0003-4526-2605","observed_orcids":["https://orcid.org/0000-0003-4526-2605"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiffaney Hsia","raw_affiliation_strings":["Department of Neurosurgery Massachusetts General Hospital  185 Cambridge Street Boston MA 02114 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Massachusetts General Hospital  185 Cambridge Street Boston MA 02114 USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054638945","display_name":"Dong Gil You","orcid":"https://orcid.org/0000-0002-9508-6454","observed_orcids":["https://orcid.org/0000-0002-9508-6454"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Gil You","raw_affiliation_strings":["Department of Neurosurgery Massachusetts General Hospital  185 Cambridge Street Boston MA 02114 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Massachusetts General Hospital  185 Cambridge Street Boston MA 02114 USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093920876","display_name":"Michelle Garlin Politis","orcid":"https://orcid.org/0000-0003-2501-601X","observed_orcids":["https://orcid.org/0000-0003-2501-601X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Garlin Politis","raw_affiliation_strings":["Center for Systems Biology Massachusetts General Hospital  185 Cambridge Street Boston MA 02114 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Biology Massachusetts General Hospital  185 Cambridge Street Boston MA 02114 USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I4210155419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016411604","display_name":"Syeda Maheen Batool","orcid":"https://orcid.org/0000-0002-3264-1182","observed_orcids":["https://orcid.org/0000-0002-3264-1182"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syeda Maheen Batool","raw_affiliation_strings":["Department of Neurosurgery Massachusetts General Hospital  185 Cambridge Street Boston MA 02114 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Massachusetts General Hospital  185 Cambridge Street Boston MA 02114 USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111292773","display_name":"Emil Ekanayake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emil Ekanayake","raw_affiliation_strings":["Department of Neurosurgery Massachusetts General Hospital  185 Cambridge Street Boston MA 02114 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Massachusetts General Hospital  185 Cambridge Street Boston MA 02114 USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072782557","display_name":"Hakho Lee","orcid":"https://orcid.org/0000-0002-0087-0909","observed_orcids":["https://orcid.org/0000-0002-0087-0909","https://orcid.org/0000-0002-9236-157X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hakho Lee","raw_affiliation_strings":["Center for Systems Biology Massachusetts General Hospital  185 Cambridge Street Boston MA 02114 USA","Department of Radiology Massachusetts General Hospital  55 Fruit Street Boston MA 02114 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Biology Massachusetts General Hospital  185 Cambridge Street Boston MA 02114 USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Radiology Massachusetts General Hospital  55 Fruit Street Boston MA 02114 USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005526815","display_name":"Bob S. Carter","orcid":"https://orcid.org/0000-0002-3586-1324","observed_orcids":["https://orcid.org/0000-0002-3586-1324"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bob S. Carter","raw_affiliation_strings":["Department of Neurosurgery Harvard Medical School  25 Shattuck Street Boston MA 02115 USA","Department of Neurosurgery Massachusetts General Hospital  185 Cambridge Street Boston MA 02114 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Harvard Medical School  25 Shattuck Street Boston MA 02115 USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Neurosurgery Massachusetts General Hospital  185 Cambridge Street Boston MA 02114 USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014953188","display_name":"Leonora Balaj","orcid":"https://orcid.org/0000-0003-0931-9715","observed_orcids":["https://orcid.org/0000-0003-0931-9715"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonora Balaj","raw_affiliation_strings":["Department of Neurosurgery Harvard Medical School  25 Shattuck Street Boston MA 02115 USA","Department of Neurosurgery Massachusetts General Hospital  185 Cambridge Street Boston MA 02114 USA"],"raw_orcid":"https://orcid.org/0000-0003-0931-9715","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery Harvard Medical School  25 Shattuck Street Boston MA 02115 USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Neurosurgery Massachusetts General Hospital  185 Cambridge Street Boston MA 02114 USA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":null,"fwci":0.0865,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.30849391,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"8","issue":"1","first_page":"e2300233","last_page":"e2300233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/ev-isolation","display_name":"EV isolation","score":0.6949999928474426},{"id":"https://openalex.org/keywords/size-exclusion-chromatography","display_name":"size exclusion chromatography","score":0.9819999933242798},{"id":"https://openalex.org/keywords/rna-extraction","display_name":"RNA extraction","score":0.7590000033378601},{"id":"https://openalex.org/keywords/rna-recovery","display_name":"RNA recovery","score":0.6819999814033508},{"id":"https://openalex.org/keywords/ev-heterogeneity","display_name":"EV heterogeneity","score":0.6140000224113464},{"id":"https://openalex.org/keywords/plasma","display_name":"plasma","score":0.3889999985694885},{"id":"https://openalex.org/keywords/spike-ins","display_name":"spike-ins","score":0.6480000019073486},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6010000109672546},{"id":"https://openalex.org/keywords/body-fluids","display_name":"biological fluids","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.8487504720687866},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6744409203529358},{"id":"https://openalex.org/C112190416","wikidata":"https://www.wikidata.org/wiki/Q2124450","display_name":"RNA extraction","level":4,"score":0.6711595058441162},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.607041597366333},{"id":"https://openalex.org/C2778120352","wikidata":"https://www.wikidata.org/wiki/Q3870163","display_name":"Nanoparticle tracking analysis","level":5,"score":0.5821598172187805},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.5699241757392883},{"id":"https://openalex.org/C2775941552","wikidata":"https://www.wikidata.org/wiki/Q25212305","display_name":"Isolation (microbiology)","level":2,"score":0.5552873611450195},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5208569169044495},{"id":"https://openalex.org/C67568554","wikidata":"https://www.wikidata.org/wiki/Q385442","display_name":"Downstream processing","level":2,"score":0.48339930176734924},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.4784843325614929},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47769930958747864},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40089917182922363},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.28837764263153076},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.21409901976585388},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18857821822166443},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.17872563004493713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15530624985694885},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.14158689975738525},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/adbi.202300233","doi":"https://doi.org/10.1002/adbi.202300233","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adbi.202300233","pdf_url":null,"source":{"id":"https://openalex.org/S4210178898","display_name":"Advanced Biology","issn_l":"2701-0198","issn":["2701-0198"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Biology","raw_type":"journal-article"},{"id":"pmid:37670402","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37670402","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12247158","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12247158","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Adv Biol (Weinh)","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:12247158","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12247158","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Adv Biol (Weinh)","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1589066665","display_name":"Molecular subtyping of brain tumors using a blood-based multiplexed assay","funder_award_id":"R01CA291826","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3063566657","display_name":null,"funder_award_id":"CA237500","funder_id":"https://openalex.org/F4320309684","funder_display_name":"Division of Cancer Prevention, National Cancer Institute"},{"id":"https://openalex.org/G3657812728","display_name":"Standardized Molecular Analyses of Glioma EVs","funder_award_id":"R01CA237500","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3717810449","display_name":null,"funder_award_id":"CA239078","funder_id":"https://openalex.org/F4320309684","funder_display_name":"Division of Cancer Prevention, National Cancer Institute"},{"id":"https://openalex.org/G4511912346","display_name":"Imaging and Liquid Biopsy for Glioma Diagnosis and Treatment Monitoring","funder_award_id":"R01CA239078","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8262508392","display_name":"Liquid Biopsy for treatment stratification of IDH1.R132H and EGFRvIII mutant gliomas","funder_award_id":"U01CA230697","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309684","display_name":"Division of Cancer Prevention, National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320313380","display_name":"Rappaport Foundation","ror":"https://ror.org/054wncf73"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1959468401","https://openalex.org/W2020863352","https://openalex.org/W2030701238","https://openalex.org/W2067416068","https://openalex.org/W2128111546","https://openalex.org/W2134812217","https://openalex.org/W2283764701","https://openalex.org/W2540034041","https://openalex.org/W2582368205","https://openalex.org/W2593629244","https://openalex.org/W2619136320","https://openalex.org/W2736407666","https://openalex.org/W2767654638","https://openalex.org/W2770740914","https://openalex.org/W2782865844","https://openalex.org/W2789992655","https://openalex.org/W2905270996","https://openalex.org/W2939856144","https://openalex.org/W2975786428","https://openalex.org/W2980742761","https://openalex.org/W3001058124","https://openalex.org/W3010132504","https://openalex.org/W3023102949","https://openalex.org/W3041185714","https://openalex.org/W3096879739","https://openalex.org/W3109744624","https://openalex.org/W3115511975","https://openalex.org/W3125322167","https://openalex.org/W3184374917","https://openalex.org/W3193641608","https://openalex.org/W4210933394","https://openalex.org/W4285800402","https://openalex.org/W4296805213","https://openalex.org/W4300089610","https://openalex.org/W4309654083"],"related_works":["https://openalex.org/W2783823932","https://openalex.org/W3043045961","https://openalex.org/W4415606398","https://openalex.org/W3139758770","https://openalex.org/W7124852509","https://openalex.org/W4396997888","https://openalex.org/W4306828719","https://openalex.org/W3009054832","https://openalex.org/W7045433050","https://openalex.org/W2007499410"],"abstract_inverted_index":{"Extracellular":[0],"vesicles":[1],"(EVs)":[2],"are":[3],"highly":[4],"sought":[5],"after":[6],"as":[7,164,166],"a":[8,73,100],"source":[9],"of":[10,75,94,123,193,199,202],"biomarkers":[11],"for":[12,142],"disease":[13],"detection":[14],"and":[15,21,30,33,68,83,86,89,113,140,162,182],"monitoring.":[16],"Tumor":[17],"EV":[18,28,46,66,125,138,148,180],"isolation,":[19,169],"processing,":[20],"evaluation":[22,93],"from":[23,156],"biofluids":[24],"is":[25,34,70,97,132,151,170],"convoluted":[26],"by":[27,36],"heterogeneity":[29],"biological":[31,109],"contaminants":[32],"limited":[35],"technical":[37,114],"processing":[38,194],"efficacy.":[39],"This":[40,176],"study":[41,122,177],"rigorously":[42],"compares":[43],"common":[44],"bulk":[45,167],"isolation":[47,141,181],"workflows":[48],"(size":[49],"exclusion":[50],"chromatography,":[51],"SEC;":[52],"membrane":[53],"affinity,":[54],"MA)":[55],"alongside":[56],"downstream":[57],"RNA":[58,87,160,183],"extraction":[59,184],"protocols":[60],"to":[61,77,134,196],"investigate":[62],"molecular":[63],"analyte":[64,96,188,201],"recovery.":[65,90],"integrity":[67,150],"recovery":[69,161,198],"evaluated":[71],"using":[72],"variety":[74],"technologies":[76],"quantify":[78],"total":[79,82],"intact":[80],"EVs,":[81,158],"surface":[84,149],"proteins,":[85],"purity":[88,139],"A":[91],"comprehensive":[92],"each":[95],"performed,":[98],"with":[99],"specific":[101],"emphasis":[102],"on":[103],"maintaining":[104],"user":[105],"(n":[106,110],"=":[107,111],"2),":[108],"3),":[112],"replicates":[115],"(n\u22653)":[116],"under":[117],"in":[118,154,173],"vitro":[119],"conditions.":[120],"Subsequent":[121],"tumor":[124],"spike-in":[126],"into":[127],"healthy":[128],"donor":[129],"plasma":[130],"samples":[131],"performed":[133],"further":[135],"validate":[136],"biofluid-derived":[137],"clinical":[143],"application.":[144],"Results":[145],"show":[146],"that":[147,179],"considerably":[152],"preserved":[153],"eluates":[155],"SEC-derived":[157],"but":[159],"purity,":[163],"well":[165],"protein":[168],"significantly":[171],"improved":[172],"MA-isolated":[174],"EVs.":[175],"concludes":[178],"pipelines":[185],"govern":[186],"recovered":[187],"integrity,":[189],"necessitating":[190],"careful":[191],"selection":[192],"modality":[195],"enhance":[197],"the":[200],"interest.":[203]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-09-07T00:00:00"}
