{"id":"https://openalex.org/W4386440853","doi":"https://doi.org/10.3389/fnins.2023.1263771","title":"Understanding neuropsychiatric symptoms in Alzheimer\u2019s disease: challenges and advances in diagnosis and treatment","display_name":"Understanding neuropsychiatric symptoms in Alzheimer\u2019s disease: challenges and advances in diagnosis and treatment","publication_year":2023,"publication_date":"2023-09-05","ids":{"openalex":"https://openalex.org/W4386440853","doi":"https://doi.org/10.3389/fnins.2023.1263771","pmid":"https://pubmed.ncbi.nlm.nih.gov/37732300","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10508352"},"language":"en","primary_location":{"id":"doi:10.3389/fnins.2023.1263771","doi":"https://doi.org/10.3389/fnins.2023.1263771","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2023.1263771","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2023.1263771/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnins.2023.1263771/pdf?isPublishedV2=False","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092756118","display_name":"Andrew Pless","orcid":"https://orcid.org/0009-0002-9659-3295","observed_orcids":["https://orcid.org/0009-0002-9659-3295"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Pless","raw_affiliation_strings":["Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112100633","display_name":"Destany Ware","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Destany Ware","raw_affiliation_strings":["Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063538128","display_name":"Shalini Saggu","orcid":"https://orcid.org/0000-0002-4058-3760","observed_orcids":["https://orcid.org/0000-0002-4058-3760"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shalini Saggu","raw_affiliation_strings":["Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081078523","display_name":"Hasibur Rehman","orcid":"https://orcid.org/0000-0003-1551-6520","observed_orcids":["https://orcid.org/0000-0003-1551-6520","https://orcid.org/0009-0007-1866-6256"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hasibur Rehman","raw_affiliation_strings":["Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078787421","display_name":"John C. Morgan","orcid":"https://orcid.org/0000-0001-5279-5026","observed_orcids":["https://orcid.org/0000-0001-5279-5026"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Morgan","raw_affiliation_strings":["Department of Neurology, Medical College of Georgia at Augusta University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical College of Georgia at Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100422801","display_name":"Qin Wang","orcid":"https://orcid.org/0000-0002-6269-6117","observed_orcids":["https://orcid.org/0000-0002-6269-6117"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qin Wang","raw_affiliation_strings":["Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, United States","institution_ids":["https://openalex.org/I25041050"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100422801"],"corresponding_institution_ids":["https://openalex.org/I25041050"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":4.6876,"has_fulltext":true,"cited_by_count":132,"citation_normalized_percentile":{"value":0.97254902,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"17","issue":null,"first_page":"1263771","last_page":"1263771"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuropsychiatric-symptoms","display_name":"neuropsychiatric symptoms","score":0.9879999756813049},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":1.0},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8510000109672546},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.8920000195503235},{"id":"https://openalex.org/keywords/agitation","display_name":"agitation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/aggression","display_name":"aggression","score":0.9810000061988831},{"id":"https://openalex.org/keywords/apathy","display_name":"apathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diagnosis","display_name":"diagnosis","score":0.4189999997615814},{"id":"https://openalex.org/keywords/treatment","display_name":"treatment","score":0.7950000166893005},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.6890000104904175},{"id":"https://openalex.org/keywords/caregiver-burden","display_name":"caregiver burden","score":0.7049999833106995},{"id":"https://openalex.org/keywords/non-pharmacological-treatment","display_name":"non-pharmacological treatment","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2776509080","wikidata":"https://www.wikidata.org/wiki/Q309406","display_name":"Apathy","level":3,"score":0.813482940196991},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6697045564651489},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6596428751945496},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6188013553619385},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.6061674356460571},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.5564539432525635},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.5517402291297913},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5197972059249878},{"id":"https://openalex.org/C2779878486","wikidata":"https://www.wikidata.org/wiki/Q25053589","display_name":"Caregiver burden","level":4,"score":0.4657880365848541},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.4288485646247864},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4128151535987854},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0806381106376648},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnins.2023.1263771","doi":"https://doi.org/10.3389/fnins.2023.1263771","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2023.1263771","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2023.1263771/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10508352","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10508352","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10508352/pdf/fnins-17-1263771.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Neurosci","raw_type":"Text"},{"id":"pmid:37732300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37732300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f6e9c322863543ad8d81972d94d427b9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f6e9c322863543ad8d81972d94d427b9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Neuroscience, Vol 17 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnins.2023.1263771","doi":"https://doi.org/10.3389/fnins.2023.1263771","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2023.1263771","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnins.2023.1263771/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1945007101","display_name":"Alpha2 adrenergic signaling in AD pathogenesis","funder_award_id":"RF1AG056815","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3067815664","display_name":"Regulation of SORLA by beta-arrestin2","funder_award_id":"RF1AG067729","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3273197597","display_name":"Beta amyloid-adrenergic receptor interaction in Alzheimer's Disease","funder_award_id":"R01AG064664","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000000406","display_name":null,"funder_award_id":"AG067729","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386440853.pdf","grobid_xml":"https://content.openalex.org/works/W4386440853.grobid-xml"},"referenced_works_count":189,"referenced_works":["https://openalex.org/W71184711","https://openalex.org/W119570941","https://openalex.org/W218124021","https://openalex.org/W259292434","https://openalex.org/W563227684","https://openalex.org/W1514206567","https://openalex.org/W1583810538","https://openalex.org/W1606737956","https://openalex.org/W1705585006","https://openalex.org/W1777314638","https://openalex.org/W1879838490","https://openalex.org/W1889226804","https://openalex.org/W1910776655","https://openalex.org/W1964985810","https://openalex.org/W1969850569","https://openalex.org/W1970144812","https://openalex.org/W1970542719","https://openalex.org/W1971351343","https://openalex.org/W1976117775","https://openalex.org/W1989222460","https://openalex.org/W1992065178","https://openalex.org/W1992139786","https://openalex.org/W1995583689","https://openalex.org/W1996318924","https://openalex.org/W2001615218","https://openalex.org/W2004315874","https://openalex.org/W2009849318","https://openalex.org/W2010096675","https://openalex.org/W2011838459","https://openalex.org/W2013900285","https://openalex.org/W2014893226","https://openalex.org/W2015172698","https://openalex.org/W2018201647","https://openalex.org/W2019755331","https://openalex.org/W2022117805","https://openalex.org/W2022669291","https://openalex.org/W2030994918","https://openalex.org/W2031505047","https://openalex.org/W2031743984","https://openalex.org/W2032398247","https://openalex.org/W2039847173","https://openalex.org/W2042840116","https://openalex.org/W2044055673","https://openalex.org/W2044482065","https://openalex.org/W2044490369","https://openalex.org/W2054802697","https://openalex.org/W2059909188","https://openalex.org/W2060787282","https://openalex.org/W2061404811","https://openalex.org/W2061516663","https://openalex.org/W2064876313","https://openalex.org/W2072359531","https://openalex.org/W2073317794","https://openalex.org/W2079662917","https://openalex.org/W2082914293","https://openalex.org/W2084185169","https://openalex.org/W2085398207","https://openalex.org/W2087190235","https://openalex.org/W2088317481","https://openalex.org/W2088361570","https://openalex.org/W2090527899","https://openalex.org/W2091570747","https://openalex.org/W2091627651","https://openalex.org/W2094437177","https://openalex.org/W2097974458","https://openalex.org/W2101326230","https://openalex.org/W2102043105","https://openalex.org/W2105915837","https://openalex.org/W2106989122","https://openalex.org/W2107522606","https://openalex.org/W2108335346","https://openalex.org/W2112522819","https://openalex.org/W2112815097","https://openalex.org/W2115203342","https://openalex.org/W2122022552","https://openalex.org/W2125346945","https://openalex.org/W2132045663","https://openalex.org/W2132519124","https://openalex.org/W2136520115","https://openalex.org/W2137944397","https://openalex.org/W2139214514","https://openalex.org/W2145846347","https://openalex.org/W2146711959","https://openalex.org/W2149445867","https://openalex.org/W2149515427","https://openalex.org/W2151172140","https://openalex.org/W2152159914","https://openalex.org/W2167187896","https://openalex.org/W2167862712","https://openalex.org/W2168382654","https://openalex.org/W2169931561","https://openalex.org/W2176679799","https://openalex.org/W2178322525","https://openalex.org/W2190528560","https://openalex.org/W2197001618","https://openalex.org/W2273100370","https://openalex.org/W2287964010","https://openalex.org/W2289081216","https://openalex.org/W2412843828","https://openalex.org/W2444030416","https://openalex.org/W2460803101","https://openalex.org/W2468352757","https://openalex.org/W2476153917","https://openalex.org/W2497303700","https://openalex.org/W2525811719","https://openalex.org/W2547178450","https://openalex.org/W2565588177","https://openalex.org/W2568015492","https://openalex.org/W2570315135","https://openalex.org/W2572310047","https://openalex.org/W2574033184","https://openalex.org/W2574298159","https://openalex.org/W2589712282","https://openalex.org/W2592706033","https://openalex.org/W2604597656","https://openalex.org/W2612478467","https://openalex.org/W2612913686","https://openalex.org/W2737820018","https://openalex.org/W2741098376","https://openalex.org/W2758205666","https://openalex.org/W2777318152","https://openalex.org/W2780178134","https://openalex.org/W2782285351","https://openalex.org/W2799896517","https://openalex.org/W2804036901","https://openalex.org/W2865610681","https://openalex.org/W2885042050","https://openalex.org/W2888363961","https://openalex.org/W2896003185","https://openalex.org/W2901681921","https://openalex.org/W2912682745","https://openalex.org/W2916100289","https://openalex.org/W2946409369","https://openalex.org/W2947609328","https://openalex.org/W2960385417","https://openalex.org/W2973805821","https://openalex.org/W2978677315","https://openalex.org/W2987960305","https://openalex.org/W2990245974","https://openalex.org/W2992896690","https://openalex.org/W2994764796","https://openalex.org/W2999987844","https://openalex.org/W3004609956","https://openalex.org/W3007853567","https://openalex.org/W3008981973","https://openalex.org/W3009926870","https://openalex.org/W3014554116","https://openalex.org/W3018693245","https://openalex.org/W3022329051","https://openalex.org/W3034491166","https://openalex.org/W3049181194","https://openalex.org/W3080312596","https://openalex.org/W3083888882","https://openalex.org/W3084438809","https://openalex.org/W3086971346","https://openalex.org/W3093472860","https://openalex.org/W3111862849","https://openalex.org/W3112948680","https://openalex.org/W3127760363","https://openalex.org/W3134426402","https://openalex.org/W3153068183","https://openalex.org/W3153069590","https://openalex.org/W3159530258","https://openalex.org/W3164808835","https://openalex.org/W3169518878","https://openalex.org/W3184429840","https://openalex.org/W3187274454","https://openalex.org/W4200058882","https://openalex.org/W4205106947","https://openalex.org/W4205624181","https://openalex.org/W4206055706","https://openalex.org/W4210702981","https://openalex.org/W4211242662","https://openalex.org/W4220953436","https://openalex.org/W4221041873","https://openalex.org/W4225157619","https://openalex.org/W4233442272","https://openalex.org/W4238233446","https://openalex.org/W4239288979","https://openalex.org/W4285491083","https://openalex.org/W4286356016","https://openalex.org/W4306177181","https://openalex.org/W4310461604","https://openalex.org/W4311986794","https://openalex.org/W4315632151","https://openalex.org/W4321014450","https://openalex.org/W4322730368","https://openalex.org/W4323045057","https://openalex.org/W4366083986"],"related_works":["https://openalex.org/W4410373985","https://openalex.org/W4403654605","https://openalex.org/W4408922071","https://openalex.org/W7165916982","https://openalex.org/W4399177495","https://openalex.org/W4416083639","https://openalex.org/W1785160854","https://openalex.org/W2115559222","https://openalex.org/W7128715861","https://openalex.org/W2743290174"],"abstract_inverted_index":{"Neuropsychiatric":[0],"symptoms":[1,56,202],"(NPS)":[2],"in":[3,39,63,93,107,135,171,181,220],"Alzheimer's":[4],"disease":[5],"(AD)":[6],"affect":[7],"up":[8],"to":[9,44,142,148,190,210],"97%":[10],"of":[11,18,37,51,88,112,161,185,197,206,214,218],"AD":[12,20,40,130,152],"patients,":[13],"with":[14,115,129],"an":[15],"estimated":[16],"80%":[17],"current":[19],"patients":[21],"experiencing":[22],"these":[23,55,201],"symptoms.":[24],"Common":[25],"AD-associated":[26,186],"NPS":[27,38,92,113,127,145,170,219],"include":[28],"depression,":[29],"anxiety,":[30],"agitation,":[31],"aggression,":[32],"and":[33,48,72,80,100,109,123,179,183,199,208],"apathy.":[34],"The":[35],"severity":[36],"is":[41,84,139],"typically":[42],"linked":[43],"the":[45,49,102,126,159,177,195,204,215],"disease's":[46],"progression":[47],"extent":[50],"cognitive":[52],"decline.":[53],"Additionally,":[54],"are":[57,146,154],"responsible":[58],"for":[59,169],"a":[60,85,132,211],"significant":[61,81],"increase":[62],"morbidity,":[64],"mortality,":[65],"caregiver":[66],"burden,":[67],"earlier":[68],"nursing":[69],"home":[70],"placement,":[71],"greater":[73],"healthcare":[74],"expenditure.":[75],"Despite":[76],"their":[77],"high":[78],"prevalence":[79],"impact,":[82],"there":[83],"notable":[86],"lack":[87],"clinical":[89,136],"research":[90],"on":[91],"AD.":[94,116,221],"In":[95],"this":[96],"article,":[97],"we":[98,188],"explore":[99],"analyze":[101],"prevalence,":[103],"symptom":[104],"manifestations,":[105],"challenges":[106,180],"diagnosis,":[108],"treatment":[110,184],"options":[111],"associated":[114,128],"Our":[117],"literature":[118],"review":[119],"reveals":[120],"that":[121],"distinguishing":[122],"accurately":[124],"diagnosing":[125],"remains":[131,173],"challenging":[133],"task":[134],"settings.":[137],"It":[138],"often":[140],"difficult":[141],"discern":[143],"whether":[144],"secondary":[147],"pathophysiological":[149],"changes":[150],"from":[151],"or":[153],"comorbid":[155],"psychiatric":[156],"conditions.":[157],"Furthermore,":[158],"availability":[160],"effective":[162],"pharmaceutical":[163],"interventions,":[164],"as":[165,167],"well":[166],"non-pharmacotherapies":[168],"AD,":[172,207],"limited.":[174],"By":[175],"highlighting":[176],"advance":[178],"diagnosis":[182],"NPS,":[187],"aspire":[189],"offer":[191],"new":[192],"insights":[193],"into":[194],"complexity":[196],"identifying":[198],"treating":[200],"within":[203],"context":[205],"contribute":[209],"deeper":[212],"understanding":[213],"multifaceted":[216],"nature":[217]},"counts_by_year":[{"year":2026,"cited_by_count":47},{"year":2025,"cited_by_count":53},{"year":2024,"cited_by_count":31},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-09-06T00:00:00"}