{"id":"https://openalex.org/W4386433355","doi":"https://doi.org/10.55361/cmdlt.v15isuplemento.123","title":"Enfermedad de Cushing: An\u00e1lisis de morbimortalidad asociada en pacientes del Centro M\u00e9dico Docente la Trinidad","display_name":"Enfermedad de Cushing: An\u00e1lisis de morbimortalidad asociada en pacientes del Centro M\u00e9dico Docente la Trinidad","publication_year":2022,"publication_date":"2022-04-01","ids":{"openalex":"https://openalex.org/W4386433355","doi":"https://doi.org/10.55361/cmdlt.v15isuplemento.123"},"language":"es","primary_location":{"id":"doi:10.55361/cmdlt.v15isuplemento.123","doi":"https://doi.org/10.55361/cmdlt.v15isuplemento.123","is_oa":true,"landing_page_url":"http://dx.doi.org/10.55361/cmdlt.v15isuplemento.123","pdf_url":null,"source":{"id":"https://openalex.org/S4387279808","display_name":"Revista Cient\u00edfica CMDLT","issn_l":"2790-8305","issn":["2790-8305"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Cient\u00edfica CMDLT","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://dx.doi.org/10.55361/cmdlt.v15isuplemento.123","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081283219","display_name":"Valentina Balaustren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140747","display_name":"Centro M\u00e9dico Docente La Trinidad","ror":"https://ror.org/04yg3w958","country_code":"VE","type":"nonprofit","lineage":["https://openalex.org/I4210140747"]}],"countries":["VE"],"is_corresponding":false,"raw_author_name":"Valentina Balaustren","raw_affiliation_strings":["Centro M\u00e9dico Docente la Trinidad"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro M\u00e9dico Docente la Trinidad","institution_ids":["https://openalex.org/I4210140747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051191134","display_name":"Jes\u00fas Jaspe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140747","display_name":"Centro M\u00e9dico Docente La Trinidad","ror":"https://ror.org/04yg3w958","country_code":"VE","type":"nonprofit","lineage":["https://openalex.org/I4210140747"]}],"countries":["VE"],"is_corresponding":false,"raw_author_name":"Jes\u00fas Jaspe","raw_affiliation_strings":["Centro M\u00e9dico Docente la Trinidad"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro M\u00e9dico Docente la Trinidad","institution_ids":["https://openalex.org/I4210140747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004282091","display_name":"Paul Camperos","orcid":"https://orcid.org/0000-0003-2948-0813","observed_orcids":["https://orcid.org/0000-0003-2948-0813"]},"institutions":[{"id":"https://openalex.org/I4210140747","display_name":"Centro M\u00e9dico Docente La Trinidad","ror":"https://ror.org/04yg3w958","country_code":"VE","type":"nonprofit","lineage":["https://openalex.org/I4210140747"]}],"countries":["VE"],"is_corresponding":false,"raw_author_name":"Paul Camperos","raw_affiliation_strings":["Centro M\u00e9dico Docente la Trinidad"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro M\u00e9dico Docente la Trinidad","institution_ids":["https://openalex.org/I4210140747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210140747"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2728879,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"Suplemento","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cushing-disease","display_name":"Cushing's disease","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cushing-s-syndrome","display_name":"Cushing's syndrome","score":0.6240000128746033},{"id":"https://openalex.org/keywords/endogenous-hypercortisolism","display_name":"endogenous hypercortisolism","score":0.828000009059906},{"id":"https://openalex.org/keywords/pituitary-adenoma","display_name":"pituitary adenoma","score":0.8460000157356262},{"id":"https://openalex.org/keywords/transsphenoidal-surgery","display_name":"transsphenoidal surgery","score":0.8360000252723694},{"id":"https://openalex.org/keywords/diabetes-insipidus","display_name":"diabetes insipidus","score":0.7950000166893005},{"id":"https://openalex.org/keywords/morbidity-and-mortality","display_name":"morbidity and mortality","score":0.7580000162124634},{"id":"https://openalex.org/keywords/dexamethasone-suppression-test","display_name":"dexamethasone suppression test","score":0.7850000262260437},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8519039154052734},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.5376120805740356},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.40802013874053955},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.06734400987625122}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.55361/cmdlt.v15isuplemento.123","doi":"https://doi.org/10.55361/cmdlt.v15isuplemento.123","is_oa":true,"landing_page_url":"http://dx.doi.org/10.55361/cmdlt.v15isuplemento.123","pdf_url":null,"source":{"id":"https://openalex.org/S4387279808","display_name":"Revista Cient\u00edfica CMDLT","issn_l":"2790-8305","issn":["2790-8305"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Cient\u00edfica CMDLT","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.55361/cmdlt.v15isuplemento.123","doi":"https://doi.org/10.55361/cmdlt.v15isuplemento.123","is_oa":true,"landing_page_url":"http://dx.doi.org/10.55361/cmdlt.v15isuplemento.123","pdf_url":null,"source":{"id":"https://openalex.org/S4387279808","display_name":"Revista Cient\u00edfica CMDLT","issn_l":"2790-8305","issn":["2790-8305"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Cient\u00edfica CMDLT","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7156278825","https://openalex.org/W4402610527","https://openalex.org/W3132275608","https://openalex.org/W7206947450","https://openalex.org/W4200313043","https://openalex.org/W2050236826","https://openalex.org/W4383337486","https://openalex.org/W6996501587","https://openalex.org/W3090156447","https://openalex.org/W2756246853"],"abstract_inverted_index":{"Resumen:":[0],"La":[1],"enfermedad":[2],"de":[3,9,15,17,20,41,43,54,61,71,80,92,101,111,144,178,183,193,224,226,236],"cushing":[4],"es":[5,220,232],"la":[6,18,26,29,163],"principal":[7],"causa":[8],"hipercortisolismo":[10],"end\u00f3geno":[11],"neopl\u00e1sico.":[12],"Del":[13],"registro":[14],"tumores":[16],"Consulta":[19],"Endocrinolog\u00eda":[21],"del":[22],"Centro":[23],"M\u00e9dico":[24],"Docente":[25],"Trinidad":[27],"analizamos":[28],"morbimortalidad.":[30],"Materiales":[31],"y":[32,77,94,132,153,187,207,218,222,230],"m\u00e9todos:estudio":[33],"observacional-descriptivo,":[34],"retrospectivo,":[35],"transversal.":[36],"Doce":[37],"pacientes":[38,52,102,148,211],"con":[39,57,140],"diagn\u00f3stico":[40,99,217,235],"Enfermedad":[42],"Cushing":[44,112,194,237],"en":[45,146,160,162,195,209],"el":[46,98,124,135,137,216,234],"per\u00edodo":[47],"2017-2020.":[48],"Resultados:":[49],"todos":[50],"los":[51,142],"fueron":[53,69,87,149,170,176],"sexo":[55],"femenino":[56],"una":[58],"edad":[59],"media":[60],"35,75\u00b110,17,":[62],"las":[63,81,84,243],"caracter\u00edsticas":[64],"cl\u00ednicas":[65],"discriminativas":[66,83],"m\u00e1s":[67,85],"frecuentes":[68,86],"hematomas":[70],"aparici\u00f3n":[72],"f\u00e1cil,":[73],"estr\u00edas":[74],"viol\u00e1ceas,":[75],"depresi\u00f3n":[76],"pl\u00e9toral":[78],"facial,":[79],"no":[82],"hirsutismo,":[88],"calvicie":[89],"femenina,":[90],"ganancia":[91],"peso/obesidad":[93],"giba":[95],"dorsocervical.":[96],"Para":[97],"40%":[100,114],"present\u00f3":[103],"cortisol":[104,117],"s\u00e9rico":[105],"mayor":[106],"a":[107,171],">36":[108],"\u03bcg/dL":[109],"calific\u00e1ndose":[110],"Severo,":[113],"tuvo":[115],"un":[116],"libre":[118],"urinario":[119],"24":[120],"horas":[121],"4":[122,154],"veces":[123,134],"valor":[125],"superior":[126],"normal":[127],"(VSN),":[128],"30%":[129],"entre":[130,150],"1.5":[131],"2.7":[133],"VSN;":[136],"83,3%":[138],"suprimieron":[139],"dexametasona,":[141],"valores":[143],"ACTH":[145],"5":[147],"6-76":[151],"pg/ml":[152],">76":[155],"pg/ml,":[156],"82%":[157],"microadenomas":[158],"evidenciando":[159],"75%":[161],"cirug\u00eda":[164],"anatom\u00eda":[165],"patol\u00f3gica":[166],"macrosc\u00f3picamente.":[167],"El":[168],"66,6%":[169],"Cirug\u00eda":[172],"Transesfenoidal":[173],"cuyas":[174],"complicaciones":[175],"f\u00edstula":[177],"LCR":[179],"25%,":[180,203],"diabetes":[181,213],"ins\u00edpida":[182],"forma":[184],"permanente":[185],"25%":[186,206],"eventos":[188],"hemorr\u00e1gicos":[189],"25%.":[190],"Hubo":[191],"recurrencia":[192],"41,6%,":[196],"persistencia":[197],"33,3%,":[198],"mejor\u00eda":[199],"parcial":[200],"cl\u00ednicamente":[201],"significativa":[202],"remisi\u00f3n":[204],"completa":[205],"muerte":[208],"1/12":[210],"por":[212],"ins\u00edpida.":[214],"Conclusiones:":[215],"tratamiento":[219,227],"complejo":[221],"requiere":[223],"combinaci\u00f3n":[225],"m\u00e9dico,":[228],"quir\u00fargico":[229],"radioterapia,":[231],"frecuente":[233],"severo,":[238],"tratarlo":[239],"oportunamente":[240],"podr\u00eda":[241],"reducir":[242],"complicaciones.":[244]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2023-09-05T00:00:00"}