{"id":"https://openalex.org/W4386414600","doi":"https://doi.org/10.1186/s13287-023-03469-3","title":"Transplanted ENSCs form functional connections with intestinal smooth muscle and restore colonic motility in nNOS-deficient mice","display_name":"Transplanted ENSCs form functional connections with intestinal smooth muscle and restore colonic motility in nNOS-deficient mice","publication_year":2023,"publication_date":"2023-09-04","ids":{"openalex":"https://openalex.org/W4386414600","doi":"https://doi.org/10.1186/s13287-023-03469-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/37667277","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10478362"},"language":"en","primary_location":{"id":"doi:10.1186/s13287-023-03469-3","doi":"https://doi.org/10.1186/s13287-023-03469-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-023-03469-3","pdf_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/s13287-023-03469-3","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/s13287-023-03469-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091865934","display_name":"Ryo Hotta","orcid":"https://orcid.org/0000-0001-9890-8241","observed_orcids":["https://orcid.org/0000-0001-9890-8241"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryo Hotta","raw_affiliation_strings":["Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078884127","display_name":"Ahmed Rahman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmed Rahman","raw_affiliation_strings":["Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051149813","display_name":"Sukhada M. Bhave","orcid":"https://orcid.org/0000-0002-5508-2571","observed_orcids":["https://orcid.org/0000-0002-5508-2571"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sukhada Bhave","raw_affiliation_strings":["Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024681677","display_name":"Rhian G Stavely","orcid":"https://orcid.org/0000-0002-5099-3704","observed_orcids":["https://orcid.org/0000-0002-5099-3704"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rhian Stavely","raw_affiliation_strings":["Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024394546","display_name":"Weikang Pan","orcid":"https://orcid.org/0000-0003-1400-7222","observed_orcids":["https://orcid.org/0000-0003-1400-7222"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weikang Pan","raw_affiliation_strings":["Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017962871","display_name":"Shriya S. Srinivasan","orcid":"https://orcid.org/0000-0002-2508-1324","observed_orcids":["https://orcid.org/0000-0002-2508-1324"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4390039253","display_name":"Koch Institute for Integrative Cancer Research At MIT","ror":"https://ror.org/01xd6q208","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shriya Srinivasan","raw_affiliation_strings":["David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA","Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA","Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","Society of Fellows, Harvard University, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4390039253","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Society of Fellows, Harvard University, Cambridge, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014169253","display_name":"Geoffrey de Couto","orcid":"https://orcid.org/0000-0002-1158-0560","observed_orcids":["https://orcid.org/0000-0002-1158-0560"]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]},{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Geoffrey de Couto","raw_affiliation_strings":["Gastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057259429","display_name":"Luis Rodr\u0131\u0301guez-Borlado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]},{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Luis Rodriguez-Borlado","raw_affiliation_strings":["Gastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richard Myers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]},{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Richard Myers","raw_affiliation_strings":["Gastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025418303","display_name":"Alan J. Burns","orcid":"https://orcid.org/0000-0002-1725-1071","observed_orcids":["https://orcid.org/0000-0002-1725-1071"]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]},{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB","JP","US"],"is_corresponding":false,"raw_author_name":"Alan J. Burns","raw_affiliation_strings":["Gastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, MA, USA","Stem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]},{"raw_affiliation_string":"Stem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027979899","display_name":"Allan M. Goldstein","orcid":"https://orcid.org/0000-0003-2106-847X","observed_orcids":["https://orcid.org/0000-0003-2106-847X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allan M. Goldstein","raw_affiliation_strings":["Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA. amgoldstein@partners.org","Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA. amgoldstein@partners.org","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Pediatric Surgery, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5027979899"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":3.4038,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.92505769,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"232","last_page":"232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.8080999851226807,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.8080999851226807,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.16599999368190765,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-transplantation","display_name":"cell transplantation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/colonic-dysmotility","display_name":"colonic dysmotility","score":0.8090000152587891},{"id":"https://openalex.org/keywords/enteric-neuropathy","display_name":"enteric neuropathy","score":0.847000002861023},{"id":"https://openalex.org/keywords/neuromuscular-junction","display_name":"neuromuscular junction","score":0.7509999871253967},{"id":"https://openalex.org/keywords/intestinal-smooth-muscle","display_name":"intestinal smooth muscle","score":0.8730000257492065},{"id":"https://openalex.org/keywords/colonic-motility","display_name":"colonic motility","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.6460000276565552},{"id":"https://openalex.org/keywords/optogenetics","display_name":"optogenetics","score":0.6399999856948853},{"id":"https://openalex.org/keywords/channelrhodopsin","display_name":"channelrhodopsin","score":0.8410000205039978}],"concepts":[{"id":"https://openalex.org/C2777439022","wikidata":"https://www.wikidata.org/wiki/Q586582","display_name":"Enteric nervous system","level":2,"score":0.6178779006004333},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.5260874032974243},{"id":"https://openalex.org/C2780512811","wikidata":"https://www.wikidata.org/wiki/Q11829360","display_name":"Gastrointestinal tract","level":2,"score":0.48893681168556213},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4860668480396271},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.44496914744377136},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.43912434577941895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4343092441558838},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37436285614967346},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3359748125076294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.315915048122406},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1565638780593872}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/s13287-023-03469-3","doi":"https://doi.org/10.1186/s13287-023-03469-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-023-03469-3","pdf_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/s13287-023-03469-3","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10478362","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10478362","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10478362/pdf/13287_2023_Article_3469.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Res Ther","raw_type":"Text"},{"id":"pmid:37667277","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37667277","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:dspace.mit.edu:1721.1/152255","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1721.1/152255","pdf_url":"https://dspace.mit.edu/bitstream/1721.1/152255/1/13287_2023_Article_3469.pdf","source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Springer","raw_type":"Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt2rx682wj","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/2rx682wj","pdf_url":"https://escholarship.org/content/qt2rx682wj/qt2rx682wj.pdf?t=s1fmgv","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cell Research and Therapy, vol 14, iss 1","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:3507b616264b4da0a5ab836cf0ab4178","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3507b616264b4da0a5ab836cf0ab4178","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13287-023-03469-3","doi":"https://doi.org/10.1186/s13287-023-03469-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-023-03469-3","pdf_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/s13287-023-03469-3","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research & Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310030","display_name":"Takeda Pharmaceuticals U.S.A.","ror":"https://ror.org/03bygaq51"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386414600.pdf","grobid_xml":"https://content.openalex.org/works/W4386414600.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W217485018","https://openalex.org/W1542569637","https://openalex.org/W1576122756","https://openalex.org/W1612411512","https://openalex.org/W1894973918","https://openalex.org/W1914423920","https://openalex.org/W1990736267","https://openalex.org/W1991218946","https://openalex.org/W2010051583","https://openalex.org/W2010843219","https://openalex.org/W2019240380","https://openalex.org/W2029487190","https://openalex.org/W2055055525","https://openalex.org/W2063549311","https://openalex.org/W2063885235","https://openalex.org/W2070379597","https://openalex.org/W2084400434","https://openalex.org/W2090012397","https://openalex.org/W2104677947","https://openalex.org/W2113493830","https://openalex.org/W2120131466","https://openalex.org/W2122810775","https://openalex.org/W2136781148","https://openalex.org/W2137069217","https://openalex.org/W2144941656","https://openalex.org/W2173856182","https://openalex.org/W2216654280","https://openalex.org/W2252541578","https://openalex.org/W2264853099","https://openalex.org/W2274531174","https://openalex.org/W2320275480","https://openalex.org/W2344997643","https://openalex.org/W2404056201","https://openalex.org/W2568033066","https://openalex.org/W2572852851","https://openalex.org/W2598617076","https://openalex.org/W2727727649","https://openalex.org/W2799377086","https://openalex.org/W2803823517","https://openalex.org/W2890105461","https://openalex.org/W2937445474","https://openalex.org/W2941576001","https://openalex.org/W2944005288","https://openalex.org/W2950460839","https://openalex.org/W2990928265","https://openalex.org/W2995068836","https://openalex.org/W3000600077","https://openalex.org/W3043855203","https://openalex.org/W3157095589","https://openalex.org/W3159463265","https://openalex.org/W3165320667","https://openalex.org/W3211806559","https://openalex.org/W4221116922","https://openalex.org/W4223479227","https://openalex.org/W4281481726","https://openalex.org/W4283585347","https://openalex.org/W4307968322","https://openalex.org/W4322767169"],"related_works":["https://openalex.org/W2727727649","https://openalex.org/W2572852851","https://openalex.org/W4393011262","https://openalex.org/W2083823230","https://openalex.org/W2120131466","https://openalex.org/W1987293615","https://openalex.org/W4303940458","https://openalex.org/W2997970864","https://openalex.org/W2803137695","https://openalex.org/W2024544528"],"abstract_inverted_index":{"BACKGROUND:":[0],"Enteric":[1],"neuropathies,":[2],"which":[3],"result":[4],"from":[5],"abnormalities":[6],"of":[7,49,100,108,158,163,191,200],"the":[8,34,209],"enteric":[9,38],"nervous":[10],"system,":[11],"are":[12,24],"associated":[13,117],"with":[14,118],"significant":[15],"morbidity":[16],"and":[17,40,90,115,140,161,183,194],"high":[18],"health-care":[19],"costs,":[20],"but":[21],"current":[22],"treatments":[23],"unsatisfactory.":[25],"Cell-based":[26],"therapy":[27],"offers":[28],"an":[29,205],"innovative":[30],"approach":[31],"to":[32,78,111,169,204],"replace":[33],"absent":[35],"or":[36,58],"abnormal":[37],"neurons":[39],"thereby":[41],"restore":[42],"gut":[43],"function.":[44],"METHODS:":[45],"mouse,":[46],"a":[47,104,119,189],"model":[48,190],"colonic":[50,123,129,185,192],"dysmotility,":[51,193],"using":[52,82],"either":[53],"1":[54],"(n":[55,60],"=":[56,61],"12)":[57,62],"3":[59],"injections":[63,99],"(30":[64],"NS":[65],"per":[66],"injection)":[67],"targeted":[68],"longitudinally":[69],"1-2":[70],"mm":[71],"apart.":[72],"Functional":[73],"outcomes":[74],"were":[75,116],"assessed":[76],"up":[77],"6":[79],"weeks":[80],"later":[81],"electromyography":[83],"(EMG),":[84],"electrical":[85],"field":[86],"stimulation":[87,157],"(EFS),":[88],"optogenetics,":[89],"by":[91,126,132,155],"measuring":[92],"colorectal":[93],"motility.":[94],"RESULTS:":[95],"recipient":[96],"colon.":[97],"Multiple":[98],"ENSCs":[101,160,177],"resulted":[102],"in":[103,122,146,167,188],"significantly":[105],"larger":[106],"area":[107],"coverage":[109],"compared":[110],"single":[112],"injection":[113],"alone":[114],"marked":[120],"improvement":[121],"function,":[124],"demonstrated":[125],"(1)":[127],"increased":[128,142],"muscle":[130,165],"activity":[131],"EMG":[133],"recording,":[134],"(2)":[135],"faster":[136],"rectal":[137],"bead":[138],"expulsion,":[139],"(3)":[141],"fecal":[143],"pellet":[144],"output":[145],"vivo.":[147],"Organ":[148],"bath":[149],"studies":[150],"revealed":[151],"direct":[152],"neuromuscular":[153,181],"communication":[154],"optogenetic":[156],"channelrhodopsin-expressing":[159],"restoration":[162],"smooth":[164],"relaxation":[166],"response":[168],"EFS.":[170],"CONCLUSIONS:":[171],"These":[172],"results":[173],"demonstrate":[174],"that":[175,197],"transplanted":[176],"can":[178],"form":[179],"effective":[180],"connections":[182],"improve":[184],"motor":[186],"function":[187],"additionally":[195],"reveal":[196],"multiple":[198],"sites":[199],"cell":[201],"delivery":[202],"led":[203],"improved":[206],"response,":[207],"paving":[208],"way":[210],"for":[211],"optimized":[212],"clinical":[213],"trial":[214],"design.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-09-05T00:00:00"}