{"id":"https://openalex.org/W4386400985","doi":"https://doi.org/10.1101/2023.09.01.23294957","title":"Pathway-Specific Polygenic Scores Improve Cross-Ancestry Prediction of Psychosis and Clinical Outcomes","display_name":"Pathway-Specific Polygenic Scores Improve Cross-Ancestry Prediction of Psychosis and Clinical Outcomes","publication_year":2023,"publication_date":"2023-09-02","ids":{"openalex":"https://openalex.org/W4386400985","doi":"https://doi.org/10.1101/2023.09.01.23294957","pmid":"https://pubmed.ncbi.nlm.nih.gov/37790317","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10543247"},"language":"en","primary_location":{"id":"doi:10.1101/2023.09.01.23294957","doi":"https://doi.org/10.1101/2023.09.01.23294957","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.09.01.23294957","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2023/09/19/2023.09.01.23294957.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2023/09/19/2023.09.01.23294957.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021456485","display_name":"Justin D. Tubbs","orcid":"https://orcid.org/0000-0002-6671-6816","observed_orcids":["https://orcid.org/0000-0002-6671-6816"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4392738323","display_name":"Stanley Center for Psychiatric Research","ror":"https://ror.org/01tm9b530","country_code":"US","type":"facility","lineage":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK","US"],"is_corresponding":false,"raw_author_name":"Justin D. Tubbs","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, Boston, MA, USA","Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR","Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA","Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-6671-6816","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101798504","display_name":"Perry B.M. Leung","orcid":"https://orcid.org/0000-0002-5292-5641","observed_orcids":["https://orcid.org/0000-0002-5292-5641"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["GB","HK"],"is_corresponding":false,"raw_author_name":"Perry B.M. Leung","raw_affiliation_strings":["Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR","Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027376381","display_name":"Yuanxin Zhong","orcid":"https://orcid.org/0000-0003-0865-6525","observed_orcids":["https://orcid.org/0000-0003-0865-6525"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yuanxin Zhong","raw_affiliation_strings":["Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001276935","display_name":"Na Zhan","orcid":"https://orcid.org/0000-0003-1200-9582","observed_orcids":["https://orcid.org/0000-0003-1200-9582"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Na Zhan","raw_affiliation_strings":["Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018369422","display_name":"Tomy C.K. Hui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Tomy C.K. Hui","raw_affiliation_strings":["Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109379601","display_name":"Karen K. Y. Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801059291","display_name":"Castle Peak Hospital","ror":"https://ror.org/05w7tpg32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2801059291"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Karen K.Y. Ho","raw_affiliation_strings":["Department of General Adult Psychiatry, Castle Peak Hospital, Hong Kong SAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Adult Psychiatry, Castle Peak Hospital, Hong Kong SAR","institution_ids":["https://openalex.org/I2801059291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020904279","display_name":"Karen S. Y. Hung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801059291","display_name":"Castle Peak Hospital","ror":"https://ror.org/05w7tpg32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2801059291"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Karen S.Y. Hung","raw_affiliation_strings":["Department of General Adult Psychiatry, Castle Peak Hospital, Hong Kong SAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Adult Psychiatry, Castle Peak Hospital, Hong Kong SAR","institution_ids":["https://openalex.org/I2801059291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046554805","display_name":"Eric F.C. Cheung","orcid":"https://orcid.org/0000-0002-6854-8991","observed_orcids":["https://orcid.org/0000-0002-6854-8991"]},"institutions":[{"id":"https://openalex.org/I2801059291","display_name":"Castle Peak Hospital","ror":"https://ror.org/05w7tpg32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2801059291"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Eric F.C. Cheung","raw_affiliation_strings":["Department of General Adult Psychiatry, Castle Peak Hospital, Hong Kong SAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Adult Psychiatry, Castle Peak Hospital, Hong Kong SAR","institution_ids":["https://openalex.org/I2801059291"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010652735","display_name":"Hon\u2010Cheong So","orcid":"https://orcid.org/0000-0002-7102-833X","observed_orcids":["https://orcid.org/0000-0002-7102-833X"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Hon-Cheong So","raw_affiliation_strings":["Department of Psychiatry, The Chinese University of Hong Kong, Shatin, Hong Kong SAR","School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, The Chinese University of Hong Kong, Shatin, Hong Kong SAR","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064976374","display_name":"Simon S. Y. Lui","orcid":"https://orcid.org/0000-0001-9360-6244","observed_orcids":["https://orcid.org/0000-0001-9360-6244"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Simon S.Y. Lui","raw_affiliation_strings":["Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018516395","display_name":"Pak Chung Sham","orcid":"https://orcid.org/0000-0002-2533-7270","observed_orcids":["https://orcid.org/0000-0002-2533-7270"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Pak C. Sham","raw_affiliation_strings":["Centre for PanorOmic Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR","Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR","State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong SAR"],"raw_orcid":"https://orcid.org/0000-0002-2533-7270","affiliations":[{"raw_affiliation_string":"Centre for PanorOmic Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong SAR","institution_ids":["https://openalex.org/I889458895"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5010652735","https://openalex.org/A5018516395","https://openalex.org/A5064976374"],"corresponding_institution_ids":["https://openalex.org/I177725633","https://openalex.org/I889458895"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5102999806404114,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5102999806404114,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.4636000096797943,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10565","display_name":"Psychopathy, Forensic Psychiatry, Sexual Offending","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psychosis","display_name":"psychosis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.7310000061988831},{"id":"https://openalex.org/keywords/chinese-ancestry","display_name":"Chinese ancestry","score":0.8500000238418579},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.7039999961853027},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/ion-channel-complex","display_name":"ion channel complex","score":0.9700000286102295},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.890999972820282},{"id":"https://openalex.org/keywords/psychiatric-hospitalization","display_name":"psychiatric hospitalization","score":0.6190000176429749},{"id":"https://openalex.org/keywords/clinical-outcomes","display_name":"clinical outcomes","score":0.6209999918937683},{"id":"https://openalex.org/keywords/genetic-risk-prediction","display_name":"genetic risk prediction","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.7775533199310303},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.6850242018699646},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6249064207077026},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.5178937911987305},{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.4797200560569763},{"id":"https://openalex.org/C84201533","wikidata":"https://www.wikidata.org/wiki/Q7256235","display_name":"Psychiatric genetics","level":3,"score":0.4400981664657593},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3669523298740387},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.35459327697753906},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34455782175064087},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.34273287653923035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33348649740219116},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2961787283420563},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11093765497207642},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1061873733997345},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.09897914528846741}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2023.09.01.23294957","doi":"https://doi.org/10.1101/2023.09.01.23294957","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.09.01.23294957","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2023/09/19/2023.09.01.23294957.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},{"id":"pmid:37790317","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37790317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"medRxiv : the preprint server for health sciences","raw_type":"Preprint"},{"id":"pmh:oai:pubmedcentral.nih.gov:10543247","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10543247","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10543247/pdf/nihpp-2023.09.01.23294957v2.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2023.09.01.23294957","doi":"https://doi.org/10.1101/2023.09.01.23294957","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.09.01.23294957","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2023/09/19/2023.09.01.23294957.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2905555334","display_name":"Unraveling the genetic bases of clinical and neurocognitive phenotypes of schizophrenia","funder_award_id":"07180376","funder_id":"https://openalex.org/F4320335055","funder_display_name":"Health and Medical Research Fund"},{"id":"https://openalex.org/G9000914901","display_name":"Mass General Brigham Training Program in Precision and Genomic Medicine","funder_award_id":"T32HG010464","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320335055","display_name":"Health and Medical Research Fund","ror":"https://ror.org/03qh32912"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386400985.pdf","grobid_xml":"https://content.openalex.org/works/W4386400985.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W21879210","https://openalex.org/W1963673462","https://openalex.org/W1980862554","https://openalex.org/W2009139403","https://openalex.org/W2009638223","https://openalex.org/W2019813370","https://openalex.org/W2088395061","https://openalex.org/W2097572674","https://openalex.org/W2099085143","https://openalex.org/W2130780062","https://openalex.org/W2156976492","https://openalex.org/W2166739899","https://openalex.org/W2183016022","https://openalex.org/W2252725895","https://openalex.org/W2580377516","https://openalex.org/W2624404469","https://openalex.org/W2739175229","https://openalex.org/W2751739125","https://openalex.org/W2770518716","https://openalex.org/W2792823656","https://openalex.org/W2809567684","https://openalex.org/W2895599024","https://openalex.org/W2898134536","https://openalex.org/W2911487850","https://openalex.org/W2916226351","https://openalex.org/W2932671560","https://openalex.org/W2951553270","https://openalex.org/W2983765585","https://openalex.org/W2999532514","https://openalex.org/W3134617067","https://openalex.org/W3160614037","https://openalex.org/W3162259891","https://openalex.org/W3176569519","https://openalex.org/W4210845685","https://openalex.org/W4223520055","https://openalex.org/W4280538862","https://openalex.org/W4319334383","https://openalex.org/W4392858938"],"related_works":["https://openalex.org/W7222925662","https://openalex.org/W7166846440","https://openalex.org/W6891633132","https://openalex.org/W7213921875","https://openalex.org/W7221764839","https://openalex.org/W4296691245","https://openalex.org/W4411579414","https://openalex.org/W7172540832","https://openalex.org/W7214132520","https://openalex.org/W2486515975"],"abstract_inverted_index":{"Psychotic":[0],"disorders":[1],"are":[2],"debilitating":[3],"conditions":[4],"with":[5,140,152,222],"disproportionately":[6],"high":[7,14],"public":[8],"health":[9],"burden.":[10],"Genetic":[11],"studies":[12],"indicate":[13],"heritability,":[15],"but":[16,250],"current":[17],"polygenic":[18],"scores":[19],"(PGS)":[20],"account":[21,164],"for":[22,108,130,165,204,245],"only":[23,184,234],"a":[24,93,159,166],"fraction":[25],"of":[26,63,85,97,111,122,145,155,168,186,200,210,226],"variance":[27,188,215],"in":[28,41,76,92,127,171,189,193,228],"psychosis":[29,99,192],"risk.":[30],"PGS":[31,45,49,87,181,227],"often":[32],"show":[33],"poor":[34],"portability":[35],"across":[36],"ancestries,":[37],"performing":[38],"significantly":[39],"worse":[40],"non-European":[42],"populations.":[43],"Pathway-specific":[44],"(pPGS),":[46],"which":[47,219],"restrict":[48],"to":[50,59,67,148,191,217],"genomic":[51],"locations":[52],"within":[53,115],"distinct":[54],"biological":[55],"units,":[56],"could":[57],"lead":[58,66],"increased":[60,213],"mechanistic":[61],"understanding":[62],"pathways":[64,125],"that":[65],"risk":[68,113,129,244,255],"and":[69,88,101,120,163,208,247],"improve":[70,253],"cross-ancestry":[71,254],"prediction":[72,256],"by":[73],"reducing":[74],"noise":[75],"genetic":[77,243],"predictors.":[78],"This":[79],"study":[80],"examined":[81],"the":[82,109,135,153,169,172,178,187,198,201,214,223],"predictive":[83,224],"power":[84,225],"genome-wide":[86,180],"nine":[89],"pathway-specific":[90],"pPGS":[91,203,236],"unique":[94],"Chinese-ancestry":[95],"sample":[96],"deeply-phenotyped":[98],"patients":[100],"non-psychiatric":[102],"controls.":[103],"We":[104,132],"found":[105,134],"strong":[106],"evidence":[107],"involvement":[110],"schizophrenia-associated":[112],"variants":[114],"\"nervous":[116,205],"system":[117,206],"development\"":[118,207],"(p=2.5e-4)":[119],"\"regulation":[121,209],"neuron":[123,211],"differentiation\"":[124,212],"(p=3.0e-4)":[126],"predicting":[128],"psychosis.":[131],"also":[133,252],"\"ion":[136],"channel":[137],"complex\"":[138],"pPGS,":[139],"weights":[141],"derived":[142],"from":[143],"GWAS":[144],"bipolar":[146,174],"disorder,":[147],"be":[149],"strongly":[150],"associated":[151],"number":[154],"inpatient":[156],"psychiatry":[157],"admissions":[158],"patient":[160],"experiences":[161],"(p=1.5e-3)":[162],"majority":[167],"signal":[170],"overall":[173],"PGS.":[175],"Importantly,":[176],"although":[177],"schizophrenia":[179],"alone":[182],"explained":[183,216],"3.7%":[185],"liability":[190],"this":[194],"Chinese":[195],"ancestry":[196,230],"sample,":[197],"addition":[199],"schizophrenia-weighted":[202],"6.9%,":[218],"is":[220],"on-par":[221],"European":[229],"samples.":[231],"Thus,":[232],"not":[233],"can":[235],"provide":[237],"greater":[238],"insight":[239],"into":[240],"mechanisms":[241],"underlying":[242],"disease":[246],"clinical":[248],"outcomes,":[249],"may":[251],"accuracy.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-09-04T00:00:00"}