{"id":"https://openalex.org/W4386385482","doi":"https://doi.org/10.1177/1721727x231197498","title":"A review of Janus kinase/signal transducer and activator of transcription signaling and cytokines in the pain mechanism of rheumatoid arthritis","display_name":"A review of Janus kinase/signal transducer and activator of transcription signaling and cytokines in the pain mechanism of rheumatoid arthritis","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4386385482","doi":"https://doi.org/10.1177/1721727x231197498"},"language":"en","primary_location":{"id":"doi:10.1177/1721727x231197498","doi":"https://doi.org/10.1177/1721727x231197498","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1721727x231197498","pdf_url":null,"source":{"id":"https://openalex.org/S177651330","display_name":"European Journal of Inflammation","issn_l":"1721-727X","issn":["1721-727X","2058-7392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Inflammation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/1721727x231197498","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055763186","display_name":"Yue Xiong","orcid":"https://orcid.org/0000-0002-7238-9153","observed_orcids":["https://orcid.org/0000-0002-7238-9153"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Xiong","raw_affiliation_strings":["Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-7238-9153","affiliations":[{"raw_affiliation_string":"Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101849861","display_name":"Xiaohui Song","orcid":"https://orcid.org/0009-0008-3484-2843","observed_orcids":["https://orcid.org/0009-0008-3484-2843"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohui Song","raw_affiliation_strings":["Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046658971","display_name":"Xiangrui Sheng","orcid":"https://orcid.org/0000-0002-6168-7198","observed_orcids":["https://orcid.org/0000-0002-6168-7198"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangrui Sheng","raw_affiliation_strings":["Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066108947","display_name":"Jian Hui Wu","orcid":"https://orcid.org/0000-0002-2793-4810","observed_orcids":["https://orcid.org/0000-0002-2793-4810"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Wu","raw_affiliation_strings":["Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006947330","display_name":"Xin Chang","orcid":"https://orcid.org/0009-0003-2863-6019","observed_orcids":["https://orcid.org/0009-0003-2863-6019"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Chang","raw_affiliation_strings":["Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109300336","display_name":"Tian Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian Ren","raw_affiliation_strings":["Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112173854","display_name":"Jin Cao","orcid":"https://orcid.org/0000-0002-1247-4129","observed_orcids":["https://orcid.org/0000-0002-1247-4129"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Cao","raw_affiliation_strings":["Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039111637","display_name":"Tao Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Cheng","raw_affiliation_strings":["Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210153519"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100734755","display_name":"Mingjun Wang","orcid":"https://orcid.org/0009-0001-1656-9555","observed_orcids":["https://orcid.org/0009-0001-1656-9555","https://orcid.org/0000-0002-5848-0444"]},"institutions":[{"id":"https://openalex.org/I4210153519","display_name":"First Affiliated Hospital of Soochow University","ror":"https://ror.org/051jg5p78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153519"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingjun Wang","raw_affiliation_strings":["Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210153519"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100734755"],"corresponding_institution_ids":["https://openalex.org/I4210153519"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":1.2187,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.73009591,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.8276000022888184,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0917000025510788,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.06260000169277191,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pain-mechanisms","display_name":"pain mechanisms","score":0.6200000047683716},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9950000047683716},{"id":"https://openalex.org/keywords/central-sensitization","display_name":"central sensitization","score":0.968999981880188},{"id":"https://openalex.org/keywords/peripheral-sensitization","display_name":"peripheral sensitization","score":1.0},{"id":"https://openalex.org/keywords/nociceptors","display_name":"nociceptors","score":0.8180000185966492},{"id":"https://openalex.org/keywords/jak-inhibitors","display_name":"JAK inhibitors","score":0.902999997138977},{"id":"https://openalex.org/keywords/pain-modulation","display_name":"pain modulation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C112392421","wikidata":"https://www.wikidata.org/wiki/Q903451","display_name":"Janus kinase","level":3,"score":0.8492032885551453},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7918837070465088},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.7813713550567627},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.6268764138221741},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.5973700284957886},{"id":"https://openalex.org/C157333092","wikidata":"https://www.wikidata.org/wiki/Q902835","display_name":"JAK-STAT signaling pathway","level":4,"score":0.5807788968086243},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5066655278205872},{"id":"https://openalex.org/C172659308","wikidata":"https://www.wikidata.org/wiki/Q412542","display_name":"Nociceptor","level":4,"score":0.5006184577941895},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.48160454630851746},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48053795099258423},{"id":"https://openalex.org/C2778277574","wikidata":"https://www.wikidata.org/wiki/Q665327","display_name":"stat","level":4,"score":0.4712764620780945},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4225751459598541},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3561524748802185},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2684534788131714},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.24226880073547363},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21921801567077637},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.20337358117103577},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.12982523441314697},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11072677373886108},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11046966910362244}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1177/1721727x231197498","doi":"https://doi.org/10.1177/1721727x231197498","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1721727x231197498","pdf_url":null,"source":{"id":"https://openalex.org/S177651330","display_name":"European Journal of Inflammation","issn_l":"1721-727X","issn":["1721-727X","2058-7392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Inflammation","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:e11e8b10864449a7ad37dc8777114280","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e11e8b10864449a7ad37dc8777114280","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Inflammation, Vol 21 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/1721727x231197498","doi":"https://doi.org/10.1177/1721727x231197498","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1721727x231197498","pdf_url":null,"source":{"id":"https://openalex.org/S177651330","display_name":"European Journal of Inflammation","issn_l":"1721-727X","issn":["1721-727X","2058-7392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Inflammation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1456802477","display_name":null,"funder_award_id":"82101887","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1531520808","https://openalex.org/W1963774677","https://openalex.org/W1963899026","https://openalex.org/W1970918436","https://openalex.org/W1976833987","https://openalex.org/W1987032872","https://openalex.org/W2018491206","https://openalex.org/W2020526335","https://openalex.org/W2039416520","https://openalex.org/W2040002852","https://openalex.org/W2047718343","https://openalex.org/W2057674925","https://openalex.org/W2066155284","https://openalex.org/W2069302785","https://openalex.org/W2091055562","https://openalex.org/W2094528524","https://openalex.org/W2100478793","https://openalex.org/W2108554603","https://openalex.org/W2110598751","https://openalex.org/W2114432397","https://openalex.org/W2117780076","https://openalex.org/W2124140916","https://openalex.org/W2136697942","https://openalex.org/W2140115878","https://openalex.org/W2148658155","https://openalex.org/W2167670280","https://openalex.org/W2168629054","https://openalex.org/W2336401338","https://openalex.org/W2341474207","https://openalex.org/W2396579854","https://openalex.org/W2399704196","https://openalex.org/W2436723632","https://openalex.org/W2540974094","https://openalex.org/W2552865097","https://openalex.org/W2626892937","https://openalex.org/W2800246801","https://openalex.org/W2803736038","https://openalex.org/W2885562809","https://openalex.org/W2897965012","https://openalex.org/W2899747393","https://openalex.org/W2914209107","https://openalex.org/W2942037985","https://openalex.org/W2950575436","https://openalex.org/W3003321101","https://openalex.org/W3038042679","https://openalex.org/W3043476716","https://openalex.org/W3084960147","https://openalex.org/W3136549884","https://openalex.org/W3206628795","https://openalex.org/W3214034736","https://openalex.org/W3216146155","https://openalex.org/W4254038388","https://openalex.org/W4289176925"],"related_works":["https://openalex.org/W3097462853","https://openalex.org/W4408343372","https://openalex.org/W3098076485","https://openalex.org/W4414862354","https://openalex.org/W3041249443","https://openalex.org/W2788592978","https://openalex.org/W2362199015","https://openalex.org/W4401111923","https://openalex.org/W7167669928","https://openalex.org/W7119145237"],"abstract_inverted_index":{"Rheumatoid":[0],"arthritis":[1],"(RA)":[2],"is":[3,16,64],"a":[4,47,129],"progressive":[5],"autoimmune":[6],"disease":[7],"characterized":[8],"by":[9,66],"chronic":[10],"synovitis":[11],"and":[12,19,39,69,75,111,117,144],"articular":[13],"destruction.":[14],"Pain":[15,60],"the":[17,32,37,51,81,85,100,106,120,133,147],"earliest":[18],"most":[20],"important":[21],"symptom.":[22],"The":[23],"Janus":[24],"kinase/stat":[25],"signaling":[26],"pathway":[27,113],"not":[28],"only":[29],"participates":[30],"in":[31,50,57,61,114,125,137,152],"physiological":[33,101],"processes":[34],"such":[35,54],"as":[36,55],"growth":[38],"differentiation":[40],"of":[41,99,103,109,122,132,135,150],"normal":[42],"cells,":[43],"but":[44],"also":[45],"plays":[46],"significant":[48],"role":[49],"pathological":[52],"mechanisms":[53],"pain":[56,104,115,136,151],"RA":[58,62,138,153],"patients.":[59,154],"patients":[63],"mediated":[65],"both":[67],"inflammatory":[68],"non-inflammatory":[70],"factors,":[71],"including":[72],"central":[73],"sensitization":[74],"peripheral":[76],"sensitization.":[77,91],"Cytokines":[78],"can":[79],"regulate":[80],"nociceptor":[82],"threshold":[83],"through":[84],"JAK":[86,123],"pathway,":[87],"which":[88],"leads":[89],"to":[90],"In":[92],"this":[93],"review,":[94],"we":[95],"provide":[96,140],"an":[97],"overview":[98],"basis":[102],"modulation,":[105,116],"underlying":[107],"importance":[108],"cytokines":[110],"JAK/STAT":[112],"finally":[118],"introduce":[119],"performance":[121],"inhibitors":[124],"clinical":[126,148],"research.":[127],"Having":[128],"better":[130],"understanding":[131],"mechanism":[134],"may":[139],"new":[141],"therapeutic":[142],"ideas":[143],"directions":[145],"for":[146],"improvement":[149]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-09-02T00:00:00"}