{"id":"https://openalex.org/W4386326417","doi":"https://doi.org/10.1038/s42003-023-05277-0","title":"Structural insights into MIC2 recognition by MIC2-associated protein in Toxoplasma gondii","display_name":"Structural insights into MIC2 recognition by MIC2-associated protein in Toxoplasma gondii","publication_year":2023,"publication_date":"2023-08-31","ids":{"openalex":"https://openalex.org/W4386326417","doi":"https://doi.org/10.1038/s42003-023-05277-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/37652989","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10471735"},"language":"en","primary_location":{"id":"doi:10.1038/s42003-023-05277-0","doi":"https://doi.org/10.1038/s42003-023-05277-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-023-05277-0","pdf_url":"https://www.nature.com/articles/s42003-023-05277-0.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s42003-023-05277-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101592092","display_name":"Su Zhang","orcid":"https://orcid.org/0000-0002-3776-5993","observed_orcids":["https://orcid.org/0000-0002-3776-5993"]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Su Zhang","raw_affiliation_strings":["Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 200241, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 200241, Shanghai, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fangfang Wang","orcid":"https://orcid.org/0000-0001-6095-5237","observed_orcids":["https://orcid.org/0000-0001-6095-5237"]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangfang Wang","raw_affiliation_strings":["Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 200241, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0001-6095-5237","affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 200241, Shanghai, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078983894","display_name":"Dujuan Zhang","orcid":"https://orcid.org/0000-0001-7720-4800","observed_orcids":["https://orcid.org/0000-0001-7720-4800"]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dujuan Zhang","raw_affiliation_strings":["Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 200241, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 200241, Shanghai, China","institution_ids":["https://openalex.org/I66867065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100440909","display_name":"Dongsheng Liu","orcid":"https://orcid.org/0000-0002-2053-1752","observed_orcids":["https://orcid.org/0000-0002-2053-1752"]},"institutions":[{"id":"https://openalex.org/I30809798","display_name":"ShanghaiTech University","ror":"https://ror.org/030bhh786","country_code":"CN","type":"education","lineage":["https://openalex.org/I30809798"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongsheng Liu","raw_affiliation_strings":["iHuman Institute, ShanghaiTech University, 201210, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"iHuman Institute, ShanghaiTech University, 201210, Shanghai, China","institution_ids":["https://openalex.org/I30809798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100608631","display_name":"Wei Ding","orcid":"https://orcid.org/0000-0003-4368-8215","observed_orcids":["https://orcid.org/0000-0003-4368-8215","https://orcid.org/0009-0000-8568-5042","https://orcid.org/0009-0008-7483-5584"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210159876","display_name":"Institute of Physics","ror":"https://ror.org/05cvf7v30","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210159876"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Ding","raw_affiliation_strings":["Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, 100190, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-4368-8215","affiliations":[{"raw_affiliation_string":"Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, 100190, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210159876"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003615852","display_name":"Timothy A. Springer","orcid":"https://orcid.org/0000-0001-6627-2904","observed_orcids":["https://orcid.org/0000-0001-6627-2904"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy A. Springer","raw_affiliation_strings":["Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, MA, 02115, USA"],"raw_orcid":"https://orcid.org/0000-0001-6627-2904","affiliations":[{"raw_affiliation_string":"Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Departments of Biological Chemistry and Molecular Pharmacology and of Medicine, Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037732408","display_name":"Gaojie Song","orcid":"https://orcid.org/0000-0002-7787-6452","observed_orcids":["https://orcid.org/0000-0002-7787-6452"]},"institutions":[{"id":"https://openalex.org/I66867065","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67","country_code":"CN","type":"education","lineage":["https://openalex.org/I66867065"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Gaojie Song","raw_affiliation_strings":["Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 200241, Shanghai, China. gjsong@bio.ecnu.edu.cn","Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 200241, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-7787-6452","affiliations":[{"raw_affiliation_string":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 200241, Shanghai, China. gjsong@bio.ecnu.edu.cn","institution_ids":["https://openalex.org/I66867065"]},{"raw_affiliation_string":"Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 200241, Shanghai, China","institution_ids":["https://openalex.org/I66867065"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5037732408"],"corresponding_institution_ids":["https://openalex.org/I66867065"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":1.4017,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.76545644,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"6","issue":"1","first_page":"895","last_page":"895"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toxoplasma-gondii","display_name":"Toxoplasma gondii","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cd99","display_name":"CD99","score":0.906000018119812},{"id":"https://openalex.org/keywords/microneme-proteins","display_name":"microneme proteins","score":0.7689999938011169},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8209999799728394},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.8059999942779541},{"id":"https://openalex.org/keywords/residue-dynamics","display_name":"residue dynamics","score":0.414000004529953},{"id":"https://openalex.org/keywords/gliding-motility","display_name":"gliding motility","score":0.8730000257492065},{"id":"https://openalex.org/keywords/host-cell-invasion","display_name":"host cell invasion","score":0.9860000014305115}],"concepts":[{"id":"https://openalex.org/C2779934537","wikidata":"https://www.wikidata.org/wiki/Q2655487","display_name":"Microneme","level":5,"score":0.9628820419311523},{"id":"https://openalex.org/C2778128430","wikidata":"https://www.wikidata.org/wiki/Q131003","display_name":"Toxoplasma gondii","level":3,"score":0.6080434918403625},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48913151025772095},{"id":"https://openalex.org/C64745115","wikidata":"https://www.wikidata.org/wiki/Q618561","display_name":"Gliding motility","level":3,"score":0.4796484112739563},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.37520578503608704},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3076964020729065},{"id":"https://openalex.org/C2781023229","wikidata":"https://www.wikidata.org/wiki/Q193030","display_name":"Apicomplexa","level":4,"score":0.21309685707092285},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1794539988040924},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.10661095380783081},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.0},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012108","descriptor_name":"Research Personnel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014122","descriptor_name":"Toxoplasma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021641","descriptor_name":"Recognition, Psychology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s42003-023-05277-0","doi":"https://doi.org/10.1038/s42003-023-05277-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-023-05277-0","pdf_url":"https://www.nature.com/articles/s42003-023-05277-0.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-2880493/v1","doi":"https://doi.org/10.21203/rs.3.rs-2880493/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2880493/v1","pdf_url":"https://www.researchsquare.com/article/rs-2880493/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10471735","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10471735","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10471735/pdf/42003_2023_Article_5277.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Commun Biol","raw_type":"Text"},{"id":"pmid:37652989","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37652989","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4431fa76051345d7807e29556d4d5649","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4431fa76051345d7807e29556d4d5649","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Communications Biology, Vol 6, Iss 1, Pp 1-8 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s42003-023-05277-0","doi":"https://doi.org/10.1038/s42003-023-05277-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42003-023-05277-0","pdf_url":"https://www.nature.com/articles/s42003-023-05277-0.pdf","source":{"id":"https://openalex.org/S4210225776","display_name":"Communications Biology","issn_l":"2399-3642","issn":["2399-3642"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2115317271","display_name":null,"funder_award_id":"2018YFA0507001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5207044721","display_name":null,"funder_award_id":"32171215","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5399062191","display_name":null,"funder_award_id":"2018YFA0507001","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G915091377","display_name":"\u7c98\u9644G\u86cb\u767d\u5076\u8054\u53d7\u4f53\u7684\u914d\u4f53\u53d1\u73b0\u4e0e\u5206\u5b50\u673a\u7406","funder_award_id":"21JC1402400","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320322370","display_name":"East China Normal University","ror":"https://ror.org/02n96ep67"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386326417.pdf","grobid_xml":"https://content.openalex.org/works/W4386326417.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1607578682","https://openalex.org/W1983764955","https://openalex.org/W2014645398","https://openalex.org/W2017312501","https://openalex.org/W2023521131","https://openalex.org/W2026251237","https://openalex.org/W2029208282","https://openalex.org/W2064234671","https://openalex.org/W2074857354","https://openalex.org/W2075731957","https://openalex.org/W2086588775","https://openalex.org/W2105911630","https://openalex.org/W2113301165","https://openalex.org/W2124026197","https://openalex.org/W2127552172","https://openalex.org/W2132895866","https://openalex.org/W2133811920","https://openalex.org/W2133960169","https://openalex.org/W2168974130","https://openalex.org/W2170877356","https://openalex.org/W2180229411","https://openalex.org/W2413529945","https://openalex.org/W2548803249","https://openalex.org/W3160694359","https://openalex.org/W3177828909","https://openalex.org/W3201853407","https://openalex.org/W4211218717","https://openalex.org/W4248872320"],"related_works":["https://openalex.org/W4403651035","https://openalex.org/W6987424758","https://openalex.org/W2064234671","https://openalex.org/W1970054731","https://openalex.org/W2127552172","https://openalex.org/W2105911630","https://openalex.org/W2099095285","https://openalex.org/W2098411740","https://openalex.org/W3173896089","https://openalex.org/W2010284578"],"abstract_inverted_index":{"Abstract":[0],"Microneme":[1],"protein":[2,7],"2":[3],"(MIC2)":[4],"and":[5,16,27,33,72,129,157,162],"MIC2-associated":[6],"(M2AP)":[8],"play":[9],"crucial":[10],"roles":[11],"in":[12,73,130,134],"the":[13,36,39,49,57,104,124,135,147,155],"gliding":[14],"motility":[15],"host":[17],"cell":[18],"invasion":[19],"of":[20,53,69,88,97,123,137,159],"Toxoplasma":[21],"gondii.":[22],"Complex":[23],"formation":[24],"between":[25,120],"MIC2":[26,54],"M2AP":[28,46],"is":[29,116],"required":[30],"for":[31],"maturation":[32],"transport":[34],"from":[35],"microneme":[37],"to":[38,107,142,146,166,170],"parasite":[40],"surface.":[41],"Previous":[42],"studies":[43],"showed":[44],"that":[45,112],"associates":[47],"with":[48,75,85,99],"6th":[50],"TSR":[51,77],"domain":[52],"(TSR6),":[55],"but":[56],"detailed":[58],"interaction":[59],"remains":[60],"unclear.":[61],"In":[62],"this":[63,175],"study,":[64],"we":[65,110],"determined":[66],"crystal":[67],"structures":[68],"MA2P":[70],"alone":[71],"complex":[74],"TSR6.":[76],"domains":[78],"have":[79],"an":[80],"unusually":[81],"thin,":[82],"long":[83],"structure":[84],"a":[86,131],"layer":[87,125],"intercalated":[89],"residues":[90],"on":[91],"one":[92],"side.":[93],"The":[94],"non-layered":[95],"side":[96],"TSR6":[98,113],"hotspot":[100],"residue":[101,114],"His-620":[102],"at":[103],"center":[105],"binds":[106],"M2AP.":[108,138],"Remarkably,":[109],"discovered":[111],"Y602":[115,144],"dynamic;":[117],"it":[118],"equilibrates":[119],"being":[121],"part":[122],"(the":[126],"layered":[127],"state)":[128],"flipped-out":[132,148],"state":[133],"absence":[136],"However,":[139],"when":[140],"bound":[141],"M2AP,":[143],"shifts":[145],"state.":[149],"Our":[150],"findings":[151],"provide":[152],"insights":[153],"into":[154],"association":[156],"stabilization":[158],"MIC2-M2AP":[160],"complex,":[161],"may":[163],"be":[164],"used":[165],"develop":[167],"new":[168],"therapies":[169],"prevent":[171],"infections":[172],"caused":[173],"by":[174],"parasite.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-09-01T00:00:00"}