{"id":"https://openalex.org/W4386256201","doi":"https://doi.org/10.1167/iovs.64.11.33","title":"A Method for Real-Time Assessment of Mitochondrial Respiration Using Murine Corneal Biopsy","display_name":"A Method for Real-Time Assessment of Mitochondrial Respiration Using Murine Corneal Biopsy","publication_year":2023,"publication_date":"2023-08-29","ids":{"openalex":"https://openalex.org/W4386256201","doi":"https://doi.org/10.1167/iovs.64.11.33","pmid":"https://pubmed.ncbi.nlm.nih.gov/37642632","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10476441"},"language":"en","primary_location":{"id":"doi:10.1167/iovs.64.11.33","doi":"https://doi.org/10.1167/iovs.64.11.33","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.64.11.33","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/938644/i1552-5783-64-11-33_1693214994.12448.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/938644/i1552-5783-64-11-33_1693214994.12448.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010311212","display_name":"Wentao Liang","orcid":"https://orcid.org/0000-0002-0609-6280","observed_orcids":["https://orcid.org/0000-0002-0609-6280"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]},{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wentao Liang","raw_affiliation_strings":["Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States","Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103279452","display_name":"Li Huang","orcid":"https://orcid.org/0000-0003-3957-0513","observed_orcids":["https://orcid.org/0000-0003-3957-0513"]},"institutions":[{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]},{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Li Huang","raw_affiliation_strings":["Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States","Department of Ophthalmology, Fujian Medical University Union Hospital, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Ophthalmology, Fujian Medical University Union Hospital, Fuzhou, China","institution_ids":["https://openalex.org/I4210163933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009871044","display_name":"Tian Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tian Yuan","raw_affiliation_strings":["Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036949415","display_name":"Rui Cheng","orcid":"https://orcid.org/0000-0002-6634-5699","observed_orcids":["https://orcid.org/0000-0002-6634-5699"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rui Cheng","raw_affiliation_strings":["Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031602557","display_name":"Yusuke Takahashi","orcid":"https://orcid.org/0000-0002-4539-4539","observed_orcids":["https://orcid.org/0000-0002-4539-4539"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yusuke Takahashi","raw_affiliation_strings":["Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080655498","display_name":"Gennadiy P. Moiseyev","orcid":"https://orcid.org/0000-0003-0909-2469","observed_orcids":["https://orcid.org/0000-0003-0909-2469"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gennadiy P. Moiseyev","raw_affiliation_strings":["Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058802938","display_name":"Dimitrios Karamichos","orcid":"https://orcid.org/0000-0002-8761-3824","observed_orcids":["https://orcid.org/0000-0002-8761-3824"]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dimitrios Karamichos","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, Texas, United States","Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, United States","North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, Texas, United States","institution_ids":["https://openalex.org/I165139151"]},{"raw_affiliation_string":"Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, United States","institution_ids":["https://openalex.org/I165139151"]},{"raw_affiliation_string":"North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas, United States","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055841837","display_name":"Jian\u2010xing Ma","orcid":"https://orcid.org/0000-0001-8815-1716","observed_orcids":["https://orcid.org/0000-0001-8815-1716"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jian-Xing Ma","raw_affiliation_strings":["Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5055841837"],"corresponding_institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":{"value":1850,"currency":"USD","value_usd":1850},"fwci":0.6179,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.59424686,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"64","issue":"11","first_page":"33","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6381999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6381999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.18029999732971191,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.984000027179718},{"id":"https://openalex.org/keywords/oxygen-consumption-rate","display_name":"oxygen consumption rate","score":0.9020000100135803},{"id":"https://openalex.org/keywords/corneal-biopsy","display_name":"corneal biopsy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/corneal-metabolism","display_name":"corneal metabolism","score":0.8899999856948853},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.8460000157356262},{"id":"https://openalex.org/keywords/corneal-wound-healing","display_name":"corneal wound healing","score":0.8560000061988831},{"id":"https://openalex.org/keywords/tissue-orientation","display_name":"tissue orientation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/mouse-cornea","display_name":"mouse cornea","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.7852451801300049},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.6757351160049438},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5850462913513184},{"id":"https://openalex.org/C2779564974","wikidata":"https://www.wikidata.org/wiki/Q80863","display_name":"Adenosine triphosphate","level":2,"score":0.5536426901817322},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.529853105545044},{"id":"https://openalex.org/C182215343","wikidata":"https://www.wikidata.org/wiki/Q472287","display_name":"Respiration","level":2,"score":0.5248092412948608},{"id":"https://openalex.org/C2779257441","wikidata":"https://www.wikidata.org/wiki/Q2040445","display_name":"Corneal epithelium","level":3,"score":0.5243085622787476},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5201571583747864},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.46757227182388306},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4303322732448578},{"id":"https://openalex.org/C2775901793","wikidata":"https://www.wikidata.org/wiki/Q1189806","display_name":"Corneal endothelium","level":3,"score":0.42935624718666077},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4010084271430969},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40071043372154236},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3989606499671936},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3281773328781128},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.253389835357666},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.22464776039123535},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20498129725456238},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06907948851585388}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003315","descriptor_name":"Cornea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1167/iovs.64.11.33","doi":"https://doi.org/10.1167/iovs.64.11.33","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.64.11.33","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/938644/i1552-5783-64-11-33_1693214994.12448.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10476441","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10476441","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10476441/pdf/iovs-64-11-33.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Invest Ophthalmol Vis Sci","raw_type":"Text"},{"id":"pmid:37642632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37642632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1167/iovs.64.11.33","doi":"https://doi.org/10.1167/iovs.64.11.33","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.64.11.33","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/938644/i1552-5783-64-11-33_1693214994.12448.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology & Visual Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5179397624","display_name":"Studies of RPE65","funder_award_id":"R01EY012231","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8354973381","display_name":"Choroidal Gamma Delta T Cells as Novel Regulators of RPE Degeneration","funder_award_id":"R01EY028773","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000871770","display_name":"cGAS-STING signaling in diabetic retinopathy","funder_award_id":"R01EY033330","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000877658","display_name":"A Novel Pathogenic Pathway for Diabetic Keratopathy","funder_award_id":"R01EY028949","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000892948","display_name":"Sustained release of fenofibrate for the treatment of diabetic retinopathy","funder_award_id":"R01EY033477","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000920462","display_name":"Studies of retinyl ester hydrolase in the visual cycle","funder_award_id":"R01EY032930","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000920922","display_name":"Dysregulation of Wnt signaling in subretinal fibrosis in AMD","funder_award_id":"R01EY032931","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386256201.pdf","grobid_xml":"https://content.openalex.org/works/W4386256201.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1970142469","https://openalex.org/W1976016385","https://openalex.org/W1979991648","https://openalex.org/W1982694306","https://openalex.org/W1982794477","https://openalex.org/W1988744799","https://openalex.org/W1990604299","https://openalex.org/W2013876080","https://openalex.org/W2015886716","https://openalex.org/W2020232519","https://openalex.org/W2024267786","https://openalex.org/W2044848395","https://openalex.org/W2089670732","https://openalex.org/W2108170632","https://openalex.org/W2109830887","https://openalex.org/W2151470490","https://openalex.org/W2157512814","https://openalex.org/W2164530918","https://openalex.org/W2291187754","https://openalex.org/W2413407223","https://openalex.org/W2545846206","https://openalex.org/W2547603597","https://openalex.org/W2599149063","https://openalex.org/W2618770389","https://openalex.org/W2760875867","https://openalex.org/W2767576903","https://openalex.org/W2780539753","https://openalex.org/W2868852369","https://openalex.org/W2884609746","https://openalex.org/W2891618652","https://openalex.org/W2900382967","https://openalex.org/W2903926441","https://openalex.org/W2906577689","https://openalex.org/W2912353511","https://openalex.org/W2949526802","https://openalex.org/W2961273452","https://openalex.org/W2991033511","https://openalex.org/W2995049166","https://openalex.org/W3047459414","https://openalex.org/W3102125270","https://openalex.org/W3148011013","https://openalex.org/W3163674610","https://openalex.org/W3186029911","https://openalex.org/W3206416348","https://openalex.org/W3208694771","https://openalex.org/W4206837213","https://openalex.org/W4239024657","https://openalex.org/W4249402283","https://openalex.org/W4252321190","https://openalex.org/W4286855532","https://openalex.org/W4307561067","https://openalex.org/W4307903675","https://openalex.org/W4328047994"],"related_works":["https://openalex.org/W3163674610","https://openalex.org/W4416279349","https://openalex.org/W837933935","https://openalex.org/W4400613102","https://openalex.org/W4392593238","https://openalex.org/W4210370388","https://openalex.org/W2594152898","https://openalex.org/W2919788018","https://openalex.org/W4283734390","https://openalex.org/W2588516057"],"abstract_inverted_index":{"Purpose:":[0],"To":[1],"develop":[2],"and":[3,55,114,130,180],"optimize":[4],"a":[5,25,37,50,75,205],"method":[6],"to":[7,208,234],"monitor":[8],"real-time":[9,210],"mitochondrial":[10,56,71,198,211],"function":[11,212],"by":[12,148],"measuring":[13],"the":[14,128,149,157,189,194,226],"oxygen":[15],"consumption":[16],"rate":[17,67],"(OCR)":[18],"in":[19,82,109,121,138,145,166,193,213,232,242],"murine":[20,86],"corneal":[21,32,44,87,102,106,167,216,230],"biopsy":[22,38,107,125],"punches":[23,108,126],"with":[24,60],"Seahorse":[26,51],"extracellular":[27],"flux":[28],"analyzer.":[29],"Methods:":[30],"Murine":[31],"biopsies":[33],"were":[34,164],"obtained":[35],"using":[36,49],"punch":[39],"immediately":[40],"after":[41],"euthanasia.":[42],"The":[43,124,201],"metabolic":[45],"profile":[46],"was":[47,58,142],"assessed":[48],"XFe96":[52],"pro":[53],"analyzer,":[54],"respiration":[57],"analyzed":[59],"specific":[61],"settings.":[62],"Results:":[63],"Real-time":[64],"adenosine":[65,79],"triphosphate":[66,80],"assay":[68],"showed":[69,187],"that":[70,188],"oxidative":[72],"phosphorylation":[73],"is":[74],"major":[76],"source":[77],"of":[78,225],"production":[81],"ex":[83,227],"vivo":[84,228],"live":[85,229],"biopsies.":[88],"Euthanasia":[89],"methods":[90],"(carbon":[91],"dioxide":[92],"asphyxiation":[93],"vs.":[94,156,174],"overdosing":[95],"on":[96],"anesthetic":[97],"drugs)":[98],"did":[99,133],"not":[100,134],"affect":[101],"OCR":[103,117,139,146,168],"values.":[104,140],"Mouse":[105],"1.5-mm":[110],"diameter":[111],"generated":[112],"higher":[113],"more":[115],"reproducible":[116],"values":[118],"than":[119],"those":[120],"1.0-mm":[122],"diameter.":[123],"from":[127],"central":[129],"off-central":[131],"cornea":[132,196],"show":[135],"significant":[136,162],"differences":[137,163],"There":[141],"no":[143],"difference":[144],"reading":[147],"tissue":[150],"orientations":[151],"(the":[152],"epithelium":[153],"side":[154,159],"up":[155],"endothelium":[158],"up).":[160],"No":[161],"found":[165],"levels":[169],"between":[170],"sexes,":[171],"strains":[172],"(C57BL/6J":[173],"BALB/cJ),":[175],"or":[176,239],"ages":[177],"(4,":[178],"8,":[179],"32":[181],"weeks).":[182],"Using":[183],"this":[184],"method,":[185],"we":[186],"wound":[190],"healing":[191],"process":[192],"mouse":[195,215,243],"affected":[197],"activity.":[199],"Conclusions:":[200],"present":[202],"study":[203],"validated":[204],"new":[206],"strategy":[207],"measure":[209],"fresh":[214],"tissues.":[217],"This":[218],"procedure":[219],"should":[220],"be":[221],"helpful":[222],"for":[223],"studies":[224],"metabolism":[231],"response":[233],"genetic":[235],"manipulations,":[236],"disease":[237],"conditions,":[238],"pharmacological":[240],"treatments":[241],"models.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-08-30T00:00:00"}