{"id":"https://openalex.org/W4386255378","doi":"https://doi.org/10.3390/ijms241713382","title":"S100A8 and S100A9 in Hematologic Malignancies: From Development to Therapy","display_name":"S100A8 and S100A9 in Hematologic Malignancies: From Development to Therapy","publication_year":2023,"publication_date":"2023-08-29","ids":{"openalex":"https://openalex.org/W4386255378","doi":"https://doi.org/10.3390/ijms241713382","pmid":"https://pubmed.ncbi.nlm.nih.gov/37686186","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10488294"},"language":"en","primary_location":{"id":"doi:10.3390/ijms241713382","doi":"https://doi.org/10.3390/ijms241713382","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms241713382","pdf_url":"https://www.mdpi.com/1422-0067/24/17/13382/pdf?version=1693295806","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/24/17/13382/pdf?version=1693295806","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033324167","display_name":"Farnaz Razmkhah","orcid":"https://orcid.org/0000-0003-3321-7938","observed_orcids":["https://orcid.org/0000-0003-3321-7938"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farnaz Razmkhah","raw_affiliation_strings":["Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075200035","display_name":"Sena Kim","orcid":"https://orcid.org/0000-0002-6930-2416","observed_orcids":["https://orcid.org/0000-0002-6930-2416"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sena Kim","raw_affiliation_strings":["Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA"],"raw_orcid":"https://orcid.org/0000-0002-6930-2416","affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059323462","display_name":"Sora Lim","orcid":"https://orcid.org/0000-0002-5746-264X","observed_orcids":["https://orcid.org/0000-0002-5746-264X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sora Lim","raw_affiliation_strings":["Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092711730","display_name":"Abdul-Jalil Dania","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdul-Jalil Dania","raw_affiliation_strings":["Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048630838","display_name":"Jaebok Choi","orcid":"https://orcid.org/0000-0002-5590-087X","observed_orcids":["https://orcid.org/0000-0002-5590-087X"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jaebok Choi","raw_affiliation_strings":["Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA"],"raw_orcid":"https://orcid.org/0000-0002-5590-087X","affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048630838"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":2500,"currency":"CHF","value_usd":2780},"apc_paid":{"value":2500,"currency":"CHF","value_usd":2780},"fwci":0.7383,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.62295193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"24","issue":"17","first_page":"13382","last_page":"13382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13637","display_name":"Calpain Protease Function and Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s100a8","display_name":"S100A8","score":1.0},{"id":"https://openalex.org/keywords/s100a9","display_name":"S100A9","score":1.0},{"id":"https://openalex.org/keywords/calprotectin","display_name":"calprotectin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.9599999785423279},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7080000042915344},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.7110000252723694},{"id":"https://openalex.org/keywords/cell-trafficking","display_name":"cell trafficking","score":0.5180000066757202},{"id":"https://openalex.org/keywords/oncogenic-signaling","display_name":"oncogenic signaling","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C2776307749","wikidata":"https://www.wikidata.org/wiki/Q18031354","display_name":"S100A9","level":3,"score":0.8286679983139038},{"id":"https://openalex.org/C2778557267","wikidata":"https://www.wikidata.org/wiki/Q20969990","display_name":"S100A8","level":3,"score":0.7176138758659363},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5323665142059326},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5114256739616394},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4788670241832733},{"id":"https://openalex.org/C2778292693","wikidata":"https://www.wikidata.org/wiki/Q22328664","display_name":"Calprotectin","level":4,"score":0.44915100932121277},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.44557052850723267},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4378495514392853},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.43133974075317383},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41479307413101196},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4039323627948761},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20533978939056396},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.18405133485794067},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14854389429092407},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07376882433891296},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D039841","descriptor_name":"Leukocyte L1 Antigen Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040501","descriptor_name":"Calgranulin A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040502","descriptor_name":"Calgranulin B","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms241713382","doi":"https://doi.org/10.3390/ijms241713382","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms241713382","pdf_url":"https://www.mdpi.com/1422-0067/24/17/13382/pdf?version=1693295806","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10488294","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10488294","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10488294/pdf/ijms-24-13382.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:37686186","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37686186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.wustl.edu:oa_4-5240","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/oa_4/4242","pdf_url":null,"source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2020-Current year OA Pubs","raw_type":"text"}],"best_oa_location":{"id":"doi:10.3390/ijms241713382","doi":"https://doi.org/10.3390/ijms241713382","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms241713382","pdf_url":"https://www.mdpi.com/1422-0067/24/17/13382/pdf?version=1693295806","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6120206497","display_name":null,"funder_award_id":"CA091842","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000902713","display_name":"Specialized Program of Research Excellence (SPORE) in Leukemia","funder_award_id":"P50CA171963","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000907135","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA091842","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306761","display_name":"Be The Match Foundation","ror":"https://ror.org/016cke005"},{"id":"https://openalex.org/F4320311601","display_name":"Gabrielle's Angel Foundation for Cancer Research","ror":"https://ror.org/04aj0cy60"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386255378.pdf","grobid_xml":"https://content.openalex.org/works/W4386255378.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W1589237240","https://openalex.org/W1867383795","https://openalex.org/W1927464939","https://openalex.org/W2004150448","https://openalex.org/W2008794259","https://openalex.org/W2010075352","https://openalex.org/W2017656054","https://openalex.org/W2020543365","https://openalex.org/W2023019884","https://openalex.org/W2026359714","https://openalex.org/W2031062135","https://openalex.org/W2035603682","https://openalex.org/W2041278117","https://openalex.org/W2044702943","https://openalex.org/W2046443345","https://openalex.org/W2061123122","https://openalex.org/W2064200041","https://openalex.org/W2081438440","https://openalex.org/W2092800030","https://openalex.org/W2097599737","https://openalex.org/W2101254765","https://openalex.org/W2110459971","https://openalex.org/W2111063688","https://openalex.org/W2121775952","https://openalex.org/W2124020845","https://openalex.org/W2126503106","https://openalex.org/W2129049052","https://openalex.org/W2144578507","https://openalex.org/W2161888715","https://openalex.org/W2297779503","https://openalex.org/W2324431009","https://openalex.org/W2517883814","https://openalex.org/W2521273475","https://openalex.org/W2559237318","https://openalex.org/W2560367415","https://openalex.org/W2568946517","https://openalex.org/W2569641803","https://openalex.org/W2582670998","https://openalex.org/W2584081828","https://openalex.org/W2622196654","https://openalex.org/W2754423591","https://openalex.org/W2760225611","https://openalex.org/W2761473139","https://openalex.org/W2780126758","https://openalex.org/W2781615683","https://openalex.org/W2806434239","https://openalex.org/W2809916290","https://openalex.org/W2836167102","https://openalex.org/W2914866647","https://openalex.org/W2921502464","https://openalex.org/W2953490300","https://openalex.org/W2959497269","https://openalex.org/W2963400443","https://openalex.org/W2968972266","https://openalex.org/W2987326625","https://openalex.org/W3009625308","https://openalex.org/W3012961980","https://openalex.org/W3046176877","https://openalex.org/W3049095668","https://openalex.org/W3112914139","https://openalex.org/W3120074395","https://openalex.org/W3142753891","https://openalex.org/W3158013729","https://openalex.org/W3160902759","https://openalex.org/W3167457623","https://openalex.org/W3173062350","https://openalex.org/W3194298692","https://openalex.org/W4205996427","https://openalex.org/W4225506103","https://openalex.org/W4252225072","https://openalex.org/W4280520403","https://openalex.org/W4301159569","https://openalex.org/W4312123975","https://openalex.org/W4316371798","https://openalex.org/W4318240230","https://openalex.org/W6733322735","https://openalex.org/W6738886364","https://openalex.org/W6770042236","https://openalex.org/W6774875115","https://openalex.org/W6799801611"],"related_works":["https://openalex.org/W4361290181","https://openalex.org/W3135333594","https://openalex.org/W2582670998","https://openalex.org/W2586281078","https://openalex.org/W2987326598","https://openalex.org/W2922158965","https://openalex.org/W4412663643","https://openalex.org/W2943451868","https://openalex.org/W2896134157","https://openalex.org/W4225506103"],"abstract_inverted_index":{"S100A8":[0,57,116],"and":[1,12,18,27,37,58,84,109,117,121,137],"S100A9":[2,59],"are":[3],"multifunctional":[4],"proteins":[5,38],"that":[6],"can":[7,88],"initiate":[8],"various":[9,141],"signaling":[10],"pathways":[11],"modulate":[13],"cell":[14,77],"function":[15],"both":[16],"inside":[17],"outside":[19],"immune":[20],"cells,":[21],"depending":[22],"on":[23,131],"their":[24,67,132],"receptors,":[25],"mediators,":[26],"molecular":[28],"environment.":[29],"They":[30],"have":[31],"been":[32],"reported":[33],"as":[34,73,135],"dysregulated":[35],"genes":[36],"in":[39,60,119,140],"a":[40],"wide":[41],"range":[42],"of":[43,56,106,115,143],"cancers,":[44],"including":[45,79],"hematologic":[46,61,144],"malignancies,":[47],"from":[48,146],"diagnosis":[49,147],"to":[50,52,66,69,75,90,148],"response":[51],"therapy.":[53],"The":[54],"role":[55],"malignancies":[62,145],"is":[63],"highlighted":[64],"due":[65],"ability":[68],"work":[70],"together":[71],"or":[72,94,112],"antagonists":[74],"modify":[76],"phenotype,":[78],"viability,":[80],"differentiation,":[81],"chemosensitivity,":[82],"trafficking,":[83],"transcription":[85],"strategies,":[86],"which":[87],"lead":[89],"an":[91],"oncogenic":[92],"phase":[93],"reduced":[95],"symptoms.":[96],"In":[97],"this":[98],"review":[99],"article,":[100],"we":[101],"discuss":[102],"the":[103,123],"critical":[104],"roles":[105,134],"S100A8,":[107],"S100A9,":[108],"calprotectin":[110],"(heterodimer":[111],"heterotetramer":[113],"forms":[114],"S100A9)":[118],"forming":[120],"promoting":[122],"malignant":[124],"bone":[125],"marrow":[126],"microenvironment.":[127],"We":[128],"also":[129],"focus":[130],"potential":[133],"biomarkers":[136],"therapeutic":[138],"targets":[139],"stages":[142],"treatment.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-08-30T00:00:00"}