{"id":"https://openalex.org/W4386225906","doi":"https://doi.org/10.2147/ijn.s416046","title":"Combined Dextran-Graft-Polyacrylamide/Zinc Oxide Nanocarrier for Effective Anticancer Therapy in vitro","display_name":"Combined Dextran-Graft-Polyacrylamide/Zinc Oxide Nanocarrier for Effective Anticancer Therapy in vitro","publication_year":2023,"publication_date":"2023-08-01","ids":{"openalex":"https://openalex.org/W4386225906","doi":"https://doi.org/10.2147/ijn.s416046","pmid":"https://pubmed.ncbi.nlm.nih.gov/37662686","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10473965"},"language":"en","primary_location":{"id":"doi:10.2147/ijn.s416046","doi":"https://doi.org/10.2147/ijn.s416046","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s416046","pdf_url":"https://www.dovepress.com/getfile.php?fileID=92306","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=92306","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090361741","display_name":"Vasyl A. Chumachenko","orcid":"https://orcid.org/0000-0002-7229-1922","observed_orcids":["https://orcid.org/0000-0002-7229-1922"]},"institutions":[{"id":"https://openalex.org/I189238007","display_name":"Taras Shevchenko National University of Kyiv","ror":"https://ror.org/02aaqv166","country_code":"UA","type":"education","lineage":["https://openalex.org/I189238007"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Vasyl Chumachenko","raw_affiliation_strings":["Chemistry Department, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine","institution_ids":["https://openalex.org/I189238007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062112519","display_name":"Pavlo Virych","orcid":"https://orcid.org/0000-0002-1463-1992","observed_orcids":["https://orcid.org/0000-0002-1463-1992"]},"institutions":[{"id":"https://openalex.org/I189238007","display_name":"Taras Shevchenko National University of Kyiv","ror":"https://ror.org/02aaqv166","country_code":"UA","type":"education","lineage":["https://openalex.org/I189238007"]},{"id":"https://openalex.org/I4210113428","display_name":"R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology","ror":"https://ror.org/02ff7k505","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210113428"]}],"countries":["UA"],"is_corresponding":true,"raw_author_name":"Pavlo Virych","raw_affiliation_strings":["Chemistry Department, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine","Laboratory of Mechanisms of Drug Resistance, R.E. Kavetsky Institute for Experimental Pathology, Oncology and Radiobiology, Kyiv, Ukraine"],"raw_orcid":"https://orcid.org/0000-0002-1463-1992","affiliations":[{"raw_affiliation_string":"Chemistry Department, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine","institution_ids":["https://openalex.org/I189238007"]},{"raw_affiliation_string":"Laboratory of Mechanisms of Drug Resistance, R.E. Kavetsky Institute for Experimental Pathology, Oncology and Radiobiology, Kyiv, Ukraine","institution_ids":["https://openalex.org/I4210113428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076279089","display_name":"Guochao Nie","orcid":"https://orcid.org/0000-0001-8563-0607","observed_orcids":["https://orcid.org/0000-0001-8563-0607"]},"institutions":[{"id":"https://openalex.org/I27462735","display_name":"Yulin Normal University","ror":"https://ror.org/00445hv47","country_code":"CN","type":"education","lineage":["https://openalex.org/I27462735"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guochao Nie","raw_affiliation_strings":["Guangxi Universities Key Laboratory of Complex System Optimization and Big Data Processing, Yulin Normal University, Yulin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Universities Key Laboratory of Complex System Optimization and Big Data Processing, Yulin Normal University, Yulin, People's Republic of China","institution_ids":["https://openalex.org/I27462735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026610110","display_name":"Petro Virych","orcid":"https://orcid.org/0000-0001-6201-3892","observed_orcids":["https://orcid.org/0000-0001-6201-3892"]},"institutions":[{"id":"https://openalex.org/I189238007","display_name":"Taras Shevchenko National University of Kyiv","ror":"https://ror.org/02aaqv166","country_code":"UA","type":"education","lineage":["https://openalex.org/I189238007"]},{"id":"https://openalex.org/I4210113428","display_name":"R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology","ror":"https://ror.org/02ff7k505","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210113428"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Petro Virych","raw_affiliation_strings":["Chemistry Department, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine","Laboratory of Mechanisms of Drug Resistance, R.E. Kavetsky Institute for Experimental Pathology, Oncology and Radiobiology, Kyiv, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine","institution_ids":["https://openalex.org/I189238007"]},{"raw_affiliation_string":"Laboratory of Mechanisms of Drug Resistance, R.E. Kavetsky Institute for Experimental Pathology, Oncology and Radiobiology, Kyiv, Ukraine","institution_ids":["https://openalex.org/I4210113428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032394950","display_name":"Oleg A. Yeshchenko","orcid":"https://orcid.org/0000-0001-8927-5673","observed_orcids":["https://orcid.org/0000-0001-8927-5673"]},"institutions":[{"id":"https://openalex.org/I189238007","display_name":"Taras Shevchenko National University of Kyiv","ror":"https://ror.org/02aaqv166","country_code":"UA","type":"education","lineage":["https://openalex.org/I189238007"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Oleg Yeshchenko","raw_affiliation_strings":["Physics Department, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physics Department, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine","institution_ids":["https://openalex.org/I189238007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027879258","display_name":"Pavlo S. Khort","orcid":"https://orcid.org/0000-0002-1169-2431","observed_orcids":["https://orcid.org/0000-0002-1169-2431"]},"institutions":[{"id":"https://openalex.org/I189238007","display_name":"Taras Shevchenko National University of Kyiv","ror":"https://ror.org/02aaqv166","country_code":"UA","type":"education","lineage":["https://openalex.org/I189238007"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Pavlo Khort","raw_affiliation_strings":["Physics Department, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine"],"raw_orcid":"https://orcid.org/0000-0002-1169-2431","affiliations":[{"raw_affiliation_string":"Physics Department, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine","institution_ids":["https://openalex.org/I189238007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075527617","display_name":"Anton S. Tkachenko","orcid":"https://orcid.org/0000-0002-1029-1636","observed_orcids":["https://orcid.org/0000-0002-1029-1636"]},"institutions":[{"id":"https://openalex.org/I76407603","display_name":"Kharkiv National Medical University","ror":"https://ror.org/01sks0025","country_code":"UA","type":"education","lineage":["https://openalex.org/I76407603"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Anton Tkachenko","raw_affiliation_strings":["Research Institute of Experimental and Clinical Medicine, Kharkiv National Medical University, Kharkiv, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Experimental and Clinical Medicine, Kharkiv National Medical University, Kharkiv, Ukraine","institution_ids":["https://openalex.org/I76407603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057540400","display_name":"Volodymyr Prokop\u0456uk","orcid":"https://orcid.org/0000-0003-4379-4130","observed_orcids":["https://orcid.org/0000-0003-4379-4130"]},"institutions":[{"id":"https://openalex.org/I149851306","display_name":"National Academy of Sciences of Ukraine","ror":"https://ror.org/00je4t102","country_code":"UA","type":"government","lineage":["https://openalex.org/I149851306"]},{"id":"https://openalex.org/I4210166931","display_name":"Institute for Problems of Cryobiology and Cryomedicine","ror":"https://ror.org/05sczh171","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210166931"]},{"id":"https://openalex.org/I76407603","display_name":"Kharkiv National Medical University","ror":"https://ror.org/01sks0025","country_code":"UA","type":"education","lineage":["https://openalex.org/I76407603"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Volodymyr Prokopiuk","raw_affiliation_strings":["Department of Cryobiochemistry, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv, Ukraine","Research Institute of Experimental and Clinical Medicine, Kharkiv National Medical University, Kharkiv, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cryobiochemistry, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv, Ukraine","institution_ids":["https://openalex.org/I149851306","https://openalex.org/I4210166931"]},{"raw_affiliation_string":"Research Institute of Experimental and Clinical Medicine, Kharkiv National Medical University, Kharkiv, Ukraine","institution_ids":["https://openalex.org/I76407603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085291205","display_name":"N Yu Lukianova","orcid":"https://orcid.org/0000-0002-3698-3868","observed_orcids":["https://orcid.org/0000-0002-3698-3868"]},"institutions":[{"id":"https://openalex.org/I4210113428","display_name":"R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology","ror":"https://ror.org/02ff7k505","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210113428"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Nataliia Lukianova","raw_affiliation_strings":["Laboratory of Mechanisms of Drug Resistance, R.E. Kavetsky Institute for Experimental Pathology, Oncology and Radiobiology, Kyiv, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Mechanisms of Drug Resistance, R.E. Kavetsky Institute for Experimental Pathology, Oncology and Radiobiology, Kyiv, Ukraine","institution_ids":["https://openalex.org/I4210113428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037718994","display_name":"Taras Zadvornyi","orcid":"https://orcid.org/0000-0003-3033-3976","observed_orcids":["https://orcid.org/0000-0003-3033-3976"]},"institutions":[{"id":"https://openalex.org/I4210113428","display_name":"R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology","ror":"https://ror.org/02ff7k505","country_code":"UA","type":"facility","lineage":["https://openalex.org/I149851306","https://openalex.org/I4210113428"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Taras Zadvornyi","raw_affiliation_strings":["Laboratory of Mechanisms of Drug Resistance, R.E. Kavetsky Institute for Experimental Pathology, Oncology and Radiobiology, Kyiv, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Mechanisms of Drug Resistance, R.E. Kavetsky Institute for Experimental Pathology, Oncology and Radiobiology, Kyiv, Ukraine","institution_ids":["https://openalex.org/I4210113428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035278804","display_name":"Michel Rawiso","orcid":"https://orcid.org/0000-0002-5245-3795","observed_orcids":["https://orcid.org/0000-0002-5245-3795"]},"institutions":[{"id":"https://openalex.org/I183225218","display_name":"Institut Charles Sadron","ror":"https://ror.org/05whrjc31","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I183225218","https://openalex.org/I2801509770","https://openalex.org/I4210128300","https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel Rawiso","raw_affiliation_strings":["Institut Charles Sadron, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Charles Sadron, Strasbourg, France","institution_ids":["https://openalex.org/I183225218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112989043","display_name":"Liyao Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27462735","display_name":"Yulin Normal University","ror":"https://ror.org/00445hv47","country_code":"CN","type":"education","lineage":["https://openalex.org/I27462735"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyao Ding","raw_affiliation_strings":["Guangxi Universities Key Laboratory of Complex System Optimization and Big Data Processing, Yulin Normal University, Yulin, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Universities Key Laboratory of Complex System Optimization and Big Data Processing, Yulin Normal University, Yulin, People's Republic of China","institution_ids":["https://openalex.org/I27462735"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074631085","display_name":"Nataliya V. Kutsevol","orcid":"https://orcid.org/0000-0002-1468-4111","observed_orcids":["https://orcid.org/0000-0002-1468-4111"]},"institutions":[{"id":"https://openalex.org/I183225218","display_name":"Institut Charles Sadron","ror":"https://ror.org/05whrjc31","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I183225218","https://openalex.org/I2801509770","https://openalex.org/I4210128300","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I189238007","display_name":"Taras Shevchenko National University of Kyiv","ror":"https://ror.org/02aaqv166","country_code":"UA","type":"education","lineage":["https://openalex.org/I189238007"]}],"countries":["FR","UA"],"is_corresponding":false,"raw_author_name":"Nataliya Kutsevol","raw_affiliation_strings":["Chemistry Department, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine","Institut Charles Sadron, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine","institution_ids":["https://openalex.org/I189238007"]},{"raw_affiliation_string":"Institut Charles Sadron, Strasbourg, France","institution_ids":["https://openalex.org/I183225218"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5062112519","https://openalex.org/A5076279089"],"corresponding_institution_ids":["https://openalex.org/I189238007","https://openalex.org/I27462735","https://openalex.org/I4210113428"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.802,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.59400016,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"Volume 18","issue":null,"first_page":"4821","last_page":"4838"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.02419999986886978,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.016300000250339508,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zinc-oxide-nanoparticles","display_name":"zinc oxide nanoparticles","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hybrid-nanocarriers","display_name":"hybrid nanocarriers","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cancer-nanomedicine","display_name":"cancer nanomedicine","score":0.7419999837875366},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4740000069141388},{"id":"https://openalex.org/keywords/selective-cytotoxicity","display_name":"selective cytotoxicity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/prostate-cancer-cells","display_name":"prostate cancer cells","score":0.6460000276565552},{"id":"https://openalex.org/keywords/breast-cancer-cells","display_name":"breast cancer cells","score":1.0},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.8299999833106995},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.625},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.6169999837875366},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8579999804496765},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.8550000190734863},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.7705897092819214},{"id":"https://openalex.org/C2779102032","wikidata":"https://www.wikidata.org/wiki/Q342717","display_name":"Acridine orange","level":3,"score":0.7220818996429443},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6093084812164307},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.548888623714447},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.539726734161377},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5162200927734375},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4225960969924927},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.40782272815704346},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4012686610221863},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3953993022441864},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36143893003463745},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3610454797744751},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.30764883756637573},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.27943623065948486},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24363559484481812},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2376880645751953},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2273743450641632},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2176820933818817},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000099166","descriptor_name":"Polyacrylamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000180","descriptor_name":"Acrylic Resins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015034","descriptor_name":"Zinc Oxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019287","descriptor_name":"Zinc Sulfate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2147/ijn.s416046","doi":"https://doi.org/10.2147/ijn.s416046","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s416046","pdf_url":"https://www.dovepress.com/getfile.php?fileID=92306","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10473965","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10473965","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10473965/pdf/ijn-18-4821.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Nanomedicine","raw_type":"Text"},{"id":"pmid:37662686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37662686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nanomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:dovepress.com/86234","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/combined-dextran-graft-polyacrylamidezinc-oxide-nanocarrier-for-effect-peer-reviewed-fulltext-article-IJN","pdf_url":"https://www.dovepress.com/article/download/86234","source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:8c342b3a65f24071998864437f2e4112","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8c342b3a65f24071998864437f2e4112","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol Volume 18, Pp 4821-4838 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2147/ijn.s416046","doi":"https://doi.org/10.2147/ijn.s416046","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s416046","pdf_url":"https://www.dovepress.com/getfile.php?fileID=92306","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4467384148","display_name":null,"funder_award_id":"2020.02/0022","funder_id":"https://openalex.org/F4320318013","funder_display_name":"National Research Foundation of Ukraine"},{"id":"https://openalex.org/G7622482614","display_name":null,"funder_award_id":"Project 2020.02/0022","funder_id":"https://openalex.org/F4320318013","funder_display_name":"National Research Foundation of Ukraine"}],"funders":[{"id":"https://openalex.org/F4320318013","display_name":"National Research Foundation of Ukraine","ror":"https://ror.org/02gmp5156"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322147","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386225906.pdf","grobid_xml":"https://content.openalex.org/works/W4386225906.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1968953482","https://openalex.org/W1983570934","https://openalex.org/W1986026336","https://openalex.org/W1994526311","https://openalex.org/W2005053806","https://openalex.org/W2005101507","https://openalex.org/W2025725394","https://openalex.org/W2038503712","https://openalex.org/W2046178638","https://openalex.org/W2052668636","https://openalex.org/W2055404249","https://openalex.org/W2082546994","https://openalex.org/W2093221448","https://openalex.org/W2096569841","https://openalex.org/W2100404577","https://openalex.org/W2112066669","https://openalex.org/W2129489356","https://openalex.org/W2149078229","https://openalex.org/W2158685498","https://openalex.org/W2163702095","https://openalex.org/W2164844252","https://openalex.org/W2168561406","https://openalex.org/W2179717856","https://openalex.org/W2259322982","https://openalex.org/W2314102813","https://openalex.org/W2348094781","https://openalex.org/W2410631057","https://openalex.org/W2439807060","https://openalex.org/W2472710818","https://openalex.org/W2478782740","https://openalex.org/W2527692788","https://openalex.org/W2555588985","https://openalex.org/W2773063173","https://openalex.org/W2785351870","https://openalex.org/W2803328077","https://openalex.org/W2807410315","https://openalex.org/W2816050627","https://openalex.org/W2888807024","https://openalex.org/W2890167612","https://openalex.org/W2892057781","https://openalex.org/W2948489071","https://openalex.org/W2968917632","https://openalex.org/W2973631700","https://openalex.org/W2984395468","https://openalex.org/W2991627211","https://openalex.org/W3013627576","https://openalex.org/W3015797184","https://openalex.org/W3024157048","https://openalex.org/W3035342891","https://openalex.org/W3042209815","https://openalex.org/W3085212187","https://openalex.org/W3094199129","https://openalex.org/W3101974256","https://openalex.org/W3105769573","https://openalex.org/W3133421834","https://openalex.org/W3142110808","https://openalex.org/W3164577482","https://openalex.org/W3198922546","https://openalex.org/W3208985294","https://openalex.org/W4200191473","https://openalex.org/W4214907302","https://openalex.org/W4229056137","https://openalex.org/W4229378530","https://openalex.org/W4291414834","https://openalex.org/W4308143899","https://openalex.org/W4308183723","https://openalex.org/W4309961549","https://openalex.org/W4311283534","https://openalex.org/W4316673223","https://openalex.org/W4317885389","https://openalex.org/W4319460656"],"related_works":["https://openalex.org/W4404222060","https://openalex.org/W4389767687","https://openalex.org/W4308183723","https://openalex.org/W4403992181","https://openalex.org/W4390580398","https://openalex.org/W2616278095","https://openalex.org/W7212278454","https://openalex.org/W2776480240","https://openalex.org/W4408071926","https://openalex.org/W4396932582"],"abstract_inverted_index":{"Introduction:":[0],"Cancer":[1],"chemotherapy":[2],"faces":[3],"two":[4],"major":[5],"challenges":[6],"\u2013":[7],"high":[8,259],"toxicity":[9],"of":[10,31,54,136,159,188,193,216,264,267,285],"active":[11],"substances":[12],"and":[13,47,75,88,101,123,143,169,218,229,272,291],"tumor":[14],"resistance":[15],"to":[16,40,150,180,247,262],"drugs.":[17],"Low":[18],"toxic":[19],"nanocarriers":[20],"in":[21,35,63,113,154,184,207,270],"combination":[22],"with":[23,43,66,190,235],"anticancer":[24],"agents":[25],"can":[26,292],"significantly":[27],"increase":[28],"the":[29,44,185,191,282],"effectiveness":[30],"therapy.":[32],"Modern":[33],"advances":[34],"nanotechnology":[36],"make":[37],"it":[38],"easy":[39],"create":[41],"materials":[42],"necessary":[45],"physical":[46],"chemical":[48],"properties.":[49],"Methods:":[50],"Two":[51],"hybrid":[52],"nanosystems":[53,177,244],"dextran-polyacrylamide/":[55],"zinc":[56,67,76,256,300],"oxide":[57,301],"nanoparticles":[58],"(D-PAA/ZnO":[59,69,78],"NPs)":[60],"were":[61,95,104,132,178,196,245],"synthesized":[62,254],"aqueous":[64],"solution":[65],"sulphate":[68,257],"NPs":[70,79,161,171,237,252,287],"(SO":[71,162,238],"4":[72,163,239],"2-":[73,164,240],"))":[74],"acetate":[77],"(-OAc)).":[80],"The":[81,157,176,243,250],"light":[82,86],"absorption,":[83],"fluorescence,":[84],"dynamic":[85],"scattering":[87],"transmission":[89],"electron":[90],"microscopy":[91],"for":[92,115,134,198,222,296],"nanocomposite":[93],"characterization":[94],"used.":[96],"MTT,":[97],"neutral":[98],"red":[99],"uptake":[100],"scratch":[102],"assays":[103],"selected":[105],"as":[106],"fibroblasts":[107],"cytotoxicity":[108,260,284],"assays.":[109],"Cytotoxicity":[110],"was":[111,148,166,173,220],"tested":[112],"vitro":[114,271],"normal":[116],"fibroblasts,":[117,181,248],"MAEC,":[118],"prostate":[119,308],"(LNCaP,":[120],"PC-3,":[121,227],"DU-145)":[122],"breast":[124,310],"(MDA-MB-231,":[125],"MCF-7)":[126],"cancer":[127,201,208,223,268,289,297,311],"cells":[128,209,224,269,290],"lines.":[129,203],"Immunocytochemical":[130],"methods":[131],"used":[133,149,295],"detection":[135],"Ki-67,":[137],"p53,":[138],"Bcl-2,":[139],"Bax,":[140],"e-cadherin,":[141],"N-cadherin":[142,219],"CD44":[144],"expression.":[145],"Acridine":[146],"orange":[147],"detect":[151],"morphological":[152],"changes":[153],"cells.":[155,277],"Results:":[156],"radius":[158],"ZnO":[160,170],")":[165],"1.5":[167],"nm":[168],"(-OAc)":[172],"2":[174],"nm.":[175],"low-toxic":[179,246],"MAEC.":[182,249],"Cells":[183],"last":[186],"stages":[187],"apoptosis":[189],"formation":[192],"apoptotic":[194,212],"bodies":[195],"detected":[197],"all":[199],"investigated":[200],"cell":[202],"Proapoptotic":[204],"proteins":[205],"expression":[206,215],"indicates":[210],"an":[211],"death.":[213],"Increased":[214],"E-cadherin":[217],"registered":[221],"line":[225],"LNCaP,":[226],"DU-145":[228],"MCF-7":[230],"after":[231],"48":[232],"h":[233],"incubation":[234],"D-PAA/ZnO":[236,251,286],").":[241],"Conclusion:":[242],"nanosystem":[253],"using":[255],"demonstrates":[258],"due":[261],"destruction":[263],"various":[265],"types":[266],"potentially":[273,294],"increases":[274],"adhesion":[275],"between":[276],"Thus,":[278],"our":[279],"findings":[280],"indicate":[281],"selective":[283],"against":[288],"be":[293],"treatment.":[298],"Keywords:":[299],"nanoparticles,":[302],"polymer":[303],"nanocarrier,":[304],"drug":[305],"delivery,":[306],"cytotoxicity,":[307],"cancer,":[309]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-08-29T00:00:00"}