{"id":"https://openalex.org/W4386215836","doi":"https://doi.org/10.1038/s41467-023-40949-9","title":"Surface frustration re-patterning underlies the structural landscape and evolvability of fungal orphan candidate effectors","display_name":"Surface frustration re-patterning underlies the structural landscape and evolvability of fungal orphan candidate effectors","publication_year":2023,"publication_date":"2023-08-28","ids":{"openalex":"https://openalex.org/W4386215836","doi":"https://doi.org/10.1038/s41467-023-40949-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/37640704","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10462633"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-023-40949-9","doi":"https://doi.org/10.1038/s41467-023-40949-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-40949-9","pdf_url":"https://www.nature.com/articles/s41467-023-40949-9.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-023-40949-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074393350","display_name":"Mark C. Derbyshire","orcid":"https://orcid.org/0000-0001-5302-9868","observed_orcids":["https://orcid.org/0000-0001-5302-9868"]},"institutions":[{"id":"https://openalex.org/I205640436","display_name":"Curtin University","ror":"https://ror.org/02n415q13","country_code":"AU","type":"education","lineage":["https://openalex.org/I205640436"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mark C. Derbyshire","raw_affiliation_strings":["Centre for Crop and Disease Management, School of Molecular and Life Sciences, Curtin University, Perth, Australia","Curtin University (Address: Kent Street, Bentley Western Australia, 6102 / Postal address: GPO Box U1987, Perth Western Australia, 6845 - Australia)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Crop and Disease Management, School of Molecular and Life Sciences, Curtin University, Perth, Australia","institution_ids":["https://openalex.org/I205640436"]},{"raw_affiliation_string":"Curtin University (Address: Kent Street, Bentley Western Australia, 6102 / Postal address: GPO Box U1987, Perth Western Australia, 6845 - Australia)","institution_ids":["https://openalex.org/I205640436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073950892","display_name":"Sylvain Raffaele","orcid":"https://orcid.org/0000-0002-2442-9632","observed_orcids":["https://orcid.org/0000-0002-2442-9632"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668"]},{"id":"https://openalex.org/I4210115873","display_name":"Laboratoire des Interactions Plantes Microbes Environnement","ror":"https://ror.org/02gwt2810","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210088668","https://openalex.org/I4210115873","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Sylvain Raffaele","raw_affiliation_strings":["Laboratoire des Interactions Plantes Micro-organismes Environnement (LIPME), INRAE, CNRS, Universit\u00e9 de Toulouse, 31326, Castanet-Tolosan, France. sylvain.raffaele@inrae.fr","LIPME - Laboratoire des Interactions Plantes Microbes Environnement (Chemin de Borde-Rouge - BP 27 31326 CASTANET TOLOSAN CEDEX - Changement de libell\u00e9 et de sigle le 1er janvier 2021 - Ancien libell\u00e9 : Laboratoire des interactions plantes micro-organismes - Ancien sigle : LIPM - France)"],"raw_orcid":"https://orcid.org/0000-0002-2442-9632","affiliations":[{"raw_affiliation_string":"Laboratoire des Interactions Plantes Micro-organismes Environnement (LIPME), INRAE, CNRS, Universit\u00e9 de Toulouse, 31326, Castanet-Tolosan, France. sylvain.raffaele@inrae.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210088668","https://openalex.org/I4210115873","https://openalex.org/I4405258862"]},{"raw_affiliation_string":"LIPME - Laboratoire des Interactions Plantes Microbes Environnement (Chemin de Borde-Rouge - BP 27 31326 CASTANET TOLOSAN CEDEX - Changement de libell\u00e9 et de sigle le 1er janvier 2021 - Ancien libell\u00e9 : Laboratoire des interactions plantes micro-organismes - Ancien sigle : LIPM - France)","institution_ids":["https://openalex.org/I4210115873"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5073950892"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210088668","https://openalex.org/I4210115873","https://openalex.org/I4405258862"],"apc_list":{"value":6290,"currency":"USD","value_usd":6290},"apc_paid":{"value":6290,"currency":"USD","value_usd":6290},"fwci":4.9105,"has_fulltext":true,"cited_by_count":65,"citation_normalized_percentile":{"value":0.97239479,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"14","issue":"1","first_page":"5244","last_page":"5244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.2184000015258789,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.2184000015258789,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10825","display_name":"Plant Pathogens and Fungal Diseases","score":0.1500999927520752,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.13210000097751617,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fungal-effectors","display_name":"fungal effectors","score":0.828000009059906},{"id":"https://openalex.org/keywords/pezizomycotina","display_name":"Pezizomycotina","score":0.9120000004768372},{"id":"https://openalex.org/keywords/structural-frustration","display_name":"structural frustration","score":0.5},{"id":"https://openalex.org/keywords/surface-residues","display_name":"surface residues","score":0.6819999814033508},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.7440000176429749},{"id":"https://openalex.org/keywords/effector-families","display_name":"effector families","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.9213839173316956},{"id":"https://openalex.org/C176147130","wikidata":"https://www.wikidata.org/wiki/Q909622","display_name":"Evolvability","level":2,"score":0.6991382837295532},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6538172960281372},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38560667634010315},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3757232427597046},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3509962260723114},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2877711355686188}],"mesh":[{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41467-023-40949-9","doi":"https://doi.org/10.1038/s41467-023-40949-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-40949-9","pdf_url":"https://www.nature.com/articles/s41467-023-40949-9.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2023.01.06.522876","doi":"https://doi.org/10.1101/2023.01.06.522876","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.01.06.522876","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/01/07/2023.01.06.522876.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10462633","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10462633","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10462633/pdf/41467_2023_Article_40949.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:37640704","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37640704","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-04222363v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.inrae.fr/hal-04222363","pdf_url":"https://hal.inrae.fr/hal-04222363v1/document","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, 2023, 14 (1), pp.5244. &#x27E8;10.1038/s41467-023-40949-9&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40949-9","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-023-40949-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:906f45af7b6a47169bcd31e0f4f07d7f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/906f45af7b6a47169bcd31e0f4f07d7f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-023-40949-9","doi":"https://doi.org/10.1038/s41467-023-40949-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-40949-9","pdf_url":"https://www.nature.com/articles/s41467-023-40949-9.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1715931817","display_name":null,"funder_award_id":"grant CUR00023","funder_id":"https://openalex.org/F4320320420","funder_display_name":"Grains Research and Development Corporation"},{"id":"https://openalex.org/G2233882941","display_name":"Evolution of eudicots quantitative disease resistance to necrotrophic fungal pathogens","funder_award_id":"ANR-21-CE20-0030","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2254089396","display_name":"Leveraging genetic diversity in the model liverwort Marchantia to discover novel immunity mechanisms in plants.","funder_award_id":"ANR-21-CE20-0010","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3010527862","display_name":null,"funder_award_id":"ANR\u201019","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3922085928","display_name":null,"funder_award_id":"ANR\u201021\u2010CE20\u201030","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G39567056","display_name":null,"funder_award_id":"ANR-10-LABX- 41","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4015558518","display_name":null,"funder_award_id":"ANR-21-CE20-10","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G4866930200","display_name":null,"funder_award_id":"ANR-11-IDEX","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G52474758","display_name":"Universit\u00e9 F\u00e9d\u00e9rale de Toulouse","funder_award_id":"ANR-11-IDEX-0002","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5261993341","display_name":null,"funder_award_id":"ANR-11IDEX-0002-02","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G6436362748","display_name":null,"funder_award_id":"CUR00023","funder_id":"https://openalex.org/F4320320420","funder_display_name":"Grains Research and Development Corporation"},{"id":"https://openalex.org/G7240651115","display_name":null,"funder_award_id":"ANR-10","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G7395235486","display_name":null,"funder_award_id":"CUR00023","funder_id":"https://openalex.org/F4320320987","funder_display_name":"Curtin University of Technology"},{"id":"https://openalex.org/G7658697405","display_name":null,"funder_award_id":"10-LABX-41","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G819176831","display_name":null,"funder_award_id":"ANR\u201019\u2010CE20\u201015","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320320420","display_name":"Grains Research and Development Corporation","ror":"https://ror.org/02xwr1996"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320987","display_name":"Curtin University of Technology","ror":"https://ror.org/02n415q13"},{"id":"https://openalex.org/F4320326768","display_name":"Government of Western Australia","ror":"https://ror.org/00wqdbc63"},{"id":"https://openalex.org/F4320331560","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386215836.pdf","grobid_xml":"https://content.openalex.org/works/W4386215836.grobid-xml"},"referenced_works_count":106,"referenced_works":["https://openalex.org/W1520784216","https://openalex.org/W1605984840","https://openalex.org/W1911339904","https://openalex.org/W1964529071","https://openalex.org/W1971323492","https://openalex.org/W1978641740","https://openalex.org/W1980521280","https://openalex.org/W1985508535","https://openalex.org/W1987526931","https://openalex.org/W1991194470","https://openalex.org/W1992500937","https://openalex.org/W1993595643","https://openalex.org/W1996423252","https://openalex.org/W2012221569","https://openalex.org/W2016336737","https://openalex.org/W2036378152","https://openalex.org/W2054562396","https://openalex.org/W2072895708","https://openalex.org/W2091898331","https://openalex.org/W2100001046","https://openalex.org/W2102245393","https://openalex.org/W2109441358","https://openalex.org/W2110397834","https://openalex.org/W2111211467","https://openalex.org/W2117026292","https://openalex.org/W2123810848","https://openalex.org/W2127157300","https://openalex.org/W2130479394","https://openalex.org/W2132629607","https://openalex.org/W2134233898","https://openalex.org/W2144877714","https://openalex.org/W2148239117","https://openalex.org/W2148314524","https://openalex.org/W2156125289","https://openalex.org/W2156465034","https://openalex.org/W2160619010","https://openalex.org/W2165215330","https://openalex.org/W2166432938","https://openalex.org/W2168762972","https://openalex.org/W2206302801","https://openalex.org/W2279891355","https://openalex.org/W2303521084","https://openalex.org/W2504726038","https://openalex.org/W2560196098","https://openalex.org/W2588321446","https://openalex.org/W2598527232","https://openalex.org/W2609207099","https://openalex.org/W2612885746","https://openalex.org/W2742822384","https://openalex.org/W2743822700","https://openalex.org/W2752786463","https://openalex.org/W2774012114","https://openalex.org/W2790476189","https://openalex.org/W2807184840","https://openalex.org/W2883251903","https://openalex.org/W2917576966","https://openalex.org/W2921939310","https://openalex.org/W2927639726","https://openalex.org/W2947935250","https://openalex.org/W2951870836","https://openalex.org/W2958743291","https://openalex.org/W2972411752","https://openalex.org/W2972802954","https://openalex.org/W2980170804","https://openalex.org/W2990504175","https://openalex.org/W2999449147","https://openalex.org/W3000377151","https://openalex.org/W3006472695","https://openalex.org/W3014258958","https://openalex.org/W3020059968","https://openalex.org/W3036404410","https://openalex.org/W3082483165","https://openalex.org/W3086638143","https://openalex.org/W3095147562","https://openalex.org/W3119507732","https://openalex.org/W3120108237","https://openalex.org/W3120513454","https://openalex.org/W3133756645","https://openalex.org/W3136442199","https://openalex.org/W3164850750","https://openalex.org/W3173506056","https://openalex.org/W3177828909","https://openalex.org/W3195436488","https://openalex.org/W3195529914","https://openalex.org/W3197607994","https://openalex.org/W3200376337","https://openalex.org/W3207450620","https://openalex.org/W3210015555","https://openalex.org/W3217477316","https://openalex.org/W4214858427","https://openalex.org/W4221099724","https://openalex.org/W4223552703","https://openalex.org/W4225794010","https://openalex.org/W4280641219","https://openalex.org/W4281291892","https://openalex.org/W4284714656","https://openalex.org/W4288097069","https://openalex.org/W4290075586","https://openalex.org/W4304758064","https://openalex.org/W4307171449","https://openalex.org/W4308496352","https://openalex.org/W4311201893","https://openalex.org/W4313557127","https://openalex.org/W4384693301","https://openalex.org/W4393891652","https://openalex.org/W4404486484"],"related_works":["https://openalex.org/W4313557127","https://openalex.org/W4408846257","https://openalex.org/W7140348136","https://openalex.org/W7163737371","https://openalex.org/W4386597898","https://openalex.org/W2598527232","https://openalex.org/W7141511626","https://openalex.org/W4401851705","https://openalex.org/W2134233898","https://openalex.org/W2170323490"],"abstract_inverted_index":{"Pathogens":[0],"secrete":[1],"effector":[2,66,96,110,132],"proteins":[3],"to":[4,27,40,89],"subvert":[5],"host":[6,21,29,121],"physiology":[7],"and":[8,47,123],"cause":[9],"disease.":[10],"Effectors":[11],"are":[12],"engaged":[13],"in":[14,23,68,77,119],"a":[15,125],"molecular":[16,36],"arms":[17],"race":[18],"with":[19,134],"the":[20,43,61,69,91,94,128],"resulting":[22],"conflicting":[24],"evolutionary":[25,117],"constraints":[26],"manipulate":[28],"cells":[30],"without":[31],"triggering":[32],"immune":[33],"responses.":[34],"The":[35,85],"mechanisms":[37],"allowing":[38],"effectors":[39,73],"be":[41],"at":[42,82],"same":[44],"time":[45],"robust":[46],"evolvable":[48],"remain":[49],"largely":[50],"enigmatic.":[51],"Here,":[52],"we":[53],"show":[54],"that":[55],"62":[56],"conserved":[57,109,135],"structure-related":[58],"families":[59,111,133],"encompass":[60],"majority":[62],"of":[63,79,93,130],"fungal":[64],"orphan":[65],"candidates":[67],"Pezizomycotina":[70],"subphylum.":[71],"These":[72],"diversified":[74],"through":[75],"changes":[76],"patterns":[78],"thermodynamic":[80],"frustration":[81],"surface":[83],"residues.":[84],"underlying":[86],"mutations":[87],"tended":[88],"increase":[90],"robustness":[92],"overall":[95],"protein":[97],"structure":[98],"while":[99],"switching":[100],"potential":[101],"binding":[102],"interfaces.":[103],"This":[104],"mechanism":[105],"could":[106],"explain":[107],"how":[108],"maintained":[112],"biological":[113],"activity":[114],"over":[115],"long":[116],"timespans":[118],"different":[120],"environments":[122],"provides":[124],"model":[126],"for":[127],"emergence":[129],"sequence-unrelated":[131],"structures.":[136]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-08-29T00:00:00"}
