{"id":"https://openalex.org/W4386212643","doi":"https://doi.org/10.1523/jneurosci.0144-23.2023","title":"Notch Signaling Plays a Dual Role in Regulating the Neuron-to-Oligodendrocyte Switch in the Developing Dorsal Forebrain","display_name":"Notch Signaling Plays a Dual Role in Regulating the Neuron-to-Oligodendrocyte Switch in the Developing Dorsal Forebrain","publication_year":2023,"publication_date":"2023-08-28","ids":{"openalex":"https://openalex.org/W4386212643","doi":"https://doi.org/10.1523/jneurosci.0144-23.2023","pmid":"https://pubmed.ncbi.nlm.nih.gov/37640551","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10573779"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.0144-23.2023","doi":"https://doi.org/10.1523/jneurosci.0144-23.2023","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0144-23.2023","pdf_url":null,"source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1523/jneurosci.0144-23.2023","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026859691","display_name":"Luuli N. Tran","orcid":"https://orcid.org/0000-0001-5546-9023","observed_orcids":["https://orcid.org/0000-0001-5546-9023"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luuli N. Tran","raw_affiliation_strings":["Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","Molecular Biology Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","1Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","2Molecular Biology Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Molecular Biology Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"1Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"2Molecular Biology Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032123172","display_name":"Sarah K. Loew","orcid":"https://orcid.org/0000-0002-6690-9474","observed_orcids":["https://orcid.org/0000-0002-6690-9474"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah K. Loew","raw_affiliation_strings":["Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","Gates Summer Internship Program, Gates Institute, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","1Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","3Gates Summer Internship Program, Gates Institute, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045"],"raw_orcid":"https://orcid.org/0000-0002-6690-9474","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Gates Summer Internship Program, Gates Institute, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"1Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"3Gates Summer Internship Program, Gates Institute, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001928112","display_name":"Santos J. Franco","orcid":"https://orcid.org/0000-0002-4478-5634","observed_orcids":["https://orcid.org/0000-0002-4478-5634"]},"institutions":[{"id":"https://openalex.org/I4210096275","display_name":"Children's Hospital Colorado","ror":"https://ror.org/00mj9k629","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210096275"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Santos J. Franco","raw_affiliation_strings":["Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045 Santos.Franco@CUAnschutz.edu","Gates Summer Internship Program, Gates Institute, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","Molecular Biology Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","Program in Pediatric Stem Cell Biology, Children's Hospital Colorado, Aurora, Colorado 80045","1Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","2Molecular Biology Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","3Gates Summer Internship Program, Gates Institute, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","4Program in Pediatric Stem Cell Biology, Children's Hospital Colorado, Aurora, Colorado 80045"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045 Santos.Franco@CUAnschutz.edu","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Gates Summer Internship Program, Gates Institute, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Molecular Biology Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"Program in Pediatric Stem Cell Biology, Children's Hospital Colorado, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I4210096275"]},{"raw_affiliation_string":"1Department of Pediatrics, Section of Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"2Molecular Biology Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"3Gates Summer Internship Program, Gates Institute, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I51713134"]},{"raw_affiliation_string":"4Program in Pediatric Stem Cell Biology, Children's Hospital Colorado, Aurora, Colorado 80045","institution_ids":["https://openalex.org/I4210096275"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6514,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.95131965,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"43","issue":"41","first_page":"6854","last_page":"6871"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9959999918937683},{"id":"https://openalex.org/keywords/oligodendrogenesis","display_name":"oligodendrogenesis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/dorsal-forebrain","display_name":"dorsal forebrain","score":0.800000011920929},{"id":"https://openalex.org/keywords/neural-progenitor-cells","display_name":"neural progenitor cells","score":0.7979999780654907},{"id":"https://openalex.org/keywords/hes1","display_name":"Hes1","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hes5","display_name":"Hes5","score":1.0},{"id":"https://openalex.org/keywords/ascl1","display_name":"ASCL1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dorsal-pallium","display_name":"dorsal pallium","score":0.6489999890327454},{"id":"https://openalex.org/keywords/oligodendrocyte-lineage","display_name":"oligodendrocyte lineage","score":0.7089999914169312},{"id":"https://openalex.org/keywords/glial-specification","display_name":"glial specification","score":0.4359999895095825},{"id":"https://openalex.org/keywords/neurogenesis-timing","display_name":"neurogenesis timing","score":0.43700000643730164},{"id":"https://openalex.org/keywords/crispr-cas9-knockdown","display_name":"CRISPR/Cas9 knockdown","score":0.75},{"id":"https://openalex.org/keywords/mouse-embryonic-development","display_name":"mouse embryo development","score":0.6010000109672546},{"id":"https://openalex.org/keywords/sex-differences-in-brain-development","display_name":"sex differences in brain development","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.8076192140579224},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.7779567241668701},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7286670207977295},{"id":"https://openalex.org/C2780283210","wikidata":"https://www.wikidata.org/wiki/Q18027301","display_name":"HES1","level":4,"score":0.6812106370925903},{"id":"https://openalex.org/C2779715522","wikidata":"https://www.wikidata.org/wiki/Q507027","display_name":"Forebrain","level":3,"score":0.648179292678833},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5878351926803589},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5427743196487427},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5424228310585022},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.517957329750061},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.48629721999168396},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46880462765693665},{"id":"https://openalex.org/C2779055221","wikidata":"https://www.wikidata.org/wiki/Q18035130","display_name":"OLIG2","level":5,"score":0.46449923515319824},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.439314603805542},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.25244396924972534},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.25218239426612854},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.179274320602417},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.15136781334877014},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09222128987312317},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.0144-23.2023","doi":"https://doi.org/10.1523/jneurosci.0144-23.2023","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0144-23.2023","pdf_url":null,"source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10573779","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10573779","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:37640551","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37640551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.0144-23.2023","doi":"https://doi.org/10.1523/jneurosci.0144-23.2023","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0144-23.2023","pdf_url":null,"source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2322084113","display_name":"Mechanisms of Oligodendrocyte Fate Specification in the Developing Neocortex","funder_award_id":"R56NS109239","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2692470610","display_name":"The Role of Notch Signaling in Shh-mediated Oligodendrocyte Fate Specification","funder_award_id":"F31NS129289","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3064205516","display_name":"Mechanisms of Oligodendrocyte Fate Specification in the Developing Neocortex","funder_award_id":"R01NS109239","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000869722","display_name":"Temporal and Spatial Control of Oligodendrocyte Fate Specification","funder_award_id":"R01NS124166","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000877063","display_name":"University of Colorado Anschutz Medical Campus DRC","funder_award_id":"P30DK116073","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000885198","display_name":"Predoctoral Training in Molecular and Cellular Biology","funder_award_id":"T32GM136444","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000891461","display_name":"University of Colorado Cancer Center Support Grant","funder_award_id":"P30CA046934","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1492377354","https://openalex.org/W1551331657","https://openalex.org/W1890846155","https://openalex.org/W1899815911","https://openalex.org/W1970756199","https://openalex.org/W1971571526","https://openalex.org/W1971954495","https://openalex.org/W1977709885","https://openalex.org/W1979755285","https://openalex.org/W1985086027","https://openalex.org/W1987582818","https://openalex.org/W1988976106","https://openalex.org/W1995960135","https://openalex.org/W1998766660","https://openalex.org/W2011341845","https://openalex.org/W2018738048","https://openalex.org/W2019433791","https://openalex.org/W2043655216","https://openalex.org/W2045044865","https://openalex.org/W2046760762","https://openalex.org/W2048389644","https://openalex.org/W2050583613","https://openalex.org/W2051877370","https://openalex.org/W2056273367","https://openalex.org/W2056577696","https://openalex.org/W2059114536","https://openalex.org/W2060941026","https://openalex.org/W2066972166","https://openalex.org/W2067935676","https://openalex.org/W2068795982","https://openalex.org/W2080417264","https://openalex.org/W2082631547","https://openalex.org/W2083425643","https://openalex.org/W2085945159","https://openalex.org/W2088969512","https://openalex.org/W2089485070","https://openalex.org/W2092433467","https://openalex.org/W2098272219","https://openalex.org/W2099540110","https://openalex.org/W2110388838","https://openalex.org/W2117719082","https://openalex.org/W2118159405","https://openalex.org/W2119497156","https://openalex.org/W2127136880","https://openalex.org/W2127208829","https://openalex.org/W2129605816","https://openalex.org/W2136051820","https://openalex.org/W2138800935","https://openalex.org/W2154861644","https://openalex.org/W2347142312","https://openalex.org/W2752775019","https://openalex.org/W2799466292","https://openalex.org/W2801000730","https://openalex.org/W2911258795","https://openalex.org/W3093042877","https://openalex.org/W3128800788","https://openalex.org/W3130038695","https://openalex.org/W3163152898","https://openalex.org/W3194376748","https://openalex.org/W4224926149"],"related_works":["https://openalex.org/W4393224869","https://openalex.org/W7214122229","https://openalex.org/W2110388838","https://openalex.org/W2044269722","https://openalex.org/W1964521451","https://openalex.org/W7097208549","https://openalex.org/W2063639010","https://openalex.org/W6980789466","https://openalex.org/W2092051900","https://openalex.org/W3093042877"],"abstract_inverted_index":{"Neural":[0],"progenitor":[1,94,217,280,301],"cells":[2,80,120],"in":[3,45,63,81,106,126,144,198,351],"the":[4,18,23,39,75,82,122,127,133,159,210,233,237,252,256,277,289,316,336,343,353],"developing":[5],"dorsal":[6,46,83],"forebrain":[7,47],"generate":[8,52,117],"excitatory":[9],"neurons":[10],"followed":[11],"by":[12,312],"oligodendrocytes":[13,53,224,244],"(OLs)":[14],"and":[15,91,109,125,139,163,282,298,347,355],"astrocytes.":[16],"However,":[17,85],"specific":[19],"mechanisms":[20,253],"that":[21,38,71,184,223,254,275,306],"regulate":[22],"timing":[24,235,257,354],"of":[25,42,57,66,77,158,182,236,258,345,357],"this":[26,34,145,259,265],"neuron\u2013glia":[27,238],"switch":[28,260],"are":[29,225,261,310],"not":[30,226],"fully":[31],"understood.":[32,263],"In":[33,264],"study,":[35,266],"we":[36,69,267],"show":[37],"proper":[40],"balance":[41,278],"Notch":[43,72,86,104,135,170,183,200,269,284,294,318,326,346],"signaling":[44,105,201,270,285,295,319,327],"progenitors":[48,208,242],"is":[49,286],"required":[50,287],"to":[51,116,165,189,206,232,248],"during":[54],"late":[55],"stages":[56],"embryonic":[58],"development.":[59],"Usingex":[60],"vivoandin":[61],"uteroapproaches":[62],"mouse":[64],"embryos":[65],"both":[67,107],"sexes,":[68],"found":[70],"inhibition":[73],"reduced":[74],"number":[76],"oligodendrocyte":[78,118,192,211,290,358],"lineage":[79,119,212],"pallium.":[84],"overactivation":[87,171],"also":[88,214],"prevented":[89],"oligodendrogenesis":[90,297,333],"maintained":[92],"a":[93,100,179,196,216,272,300],"state.":[95,302],"These":[96],"results":[97],"point":[98],"toward":[99,209],"dual":[101],"role":[102],"for":[103,288],"promoting":[108],"inhibiting":[110],"oligodendrogenesis,":[111,177],"which":[112,199],"must":[113],"be":[114],"fine-tuned":[115],"at":[121],"right":[123,128],"time":[124],"numbers.":[129],"We":[130,194,303],"further":[131],"identified":[132],"canonical":[134],"downstream":[136],"factors":[137,322],"HES1":[138],"HES5":[140],"as":[141,271],"negative":[142],"regulators":[143],"process.":[146],"CRISPR":[147],"(clustered":[148],"regularly":[149],"interspaced":[150],"short":[151],"palindromic":[152],"repeat)/Cas9-mediated":[153],"knockdown":[154],"ofHes1andHes5caused":[155],"increased":[156],"expression":[157],"pro-oligodendrocyte":[160],"factor":[161,338],"ASCL1":[162,173,188,205],"led":[164],"precocious":[166],"oligodendrogenesis.":[167,283,324],"Conversely,":[168],"combining":[169],"with":[172,187,204,335],"overexpression":[174],"robustly":[175],"promoted":[176],"indicating":[178],"separate":[180],"mechanism":[181,331],"operates":[185],"synergistically":[186,334],"specify":[190,207],"an":[191,329],"fate.":[193],"propose":[195],"model":[197],"works":[202],"together":[203],"but":[213,251,292],"maintains":[215,299],"state":[218],"through":[219,320,328],"Hes-dependent":[220],"repression":[221],"ofAscl1so":[222],"made":[227],"too":[228],"early,":[229],"thus":[230],"contributing":[231],"precise":[234],"switch.":[239],"SIGNIFICANCE":[240],"STATEMENTNeural":[241],"make":[243],"after":[245],"neurogenesis":[246],"starts":[247],"wind":[249],"down,":[250],"control":[255],"poorly":[262],"identify":[268],"critical":[273],"pathway":[274],"regulates":[276],"between":[279],"maintenance":[281],"fate,":[291],"elevated":[293],"prevents":[296],"provide":[304],"evidence":[305],"these":[307],"opposing":[308],"functions":[309],"controlled":[311],"different":[313],"mechanisms.":[314],"Before":[315],"switch,":[317],"Hes":[321],"represses":[323],"Later,":[325],"unknown":[330],"promotes":[332],"transcription":[337],"ASCL1.":[339],"Our":[340],"study":[341],"underscores":[342],"complexity":[344],"reveals":[348],"its":[349],"importance":[350],"regulating":[352],"numbers":[356],"production.":[359]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-08-29T00:00:00"}
