{"id":"https://openalex.org/W4386208809","doi":"https://doi.org/10.1097/lvt.0000000000000249","title":"Cost-effectiveness analysis of interventional liver-directed therapies for downstaging of HCC before liver transplant","display_name":"Cost-effectiveness analysis of interventional liver-directed therapies for downstaging of HCC before liver transplant","publication_year":2023,"publication_date":"2023-08-28","ids":{"openalex":"https://openalex.org/W4386208809","doi":"https://doi.org/10.1097/lvt.0000000000000249","pmid":"https://pubmed.ncbi.nlm.nih.gov/37639286"},"language":"en","primary_location":{"id":"doi:10.1097/lvt.0000000000000249","doi":"https://doi.org/10.1097/lvt.0000000000000249","is_oa":false,"landing_page_url":"https://doi.org/10.1097/lvt.0000000000000249","pdf_url":null,"source":{"id":"https://openalex.org/S205547219","display_name":"Liver Transplantation","issn_l":"1527-6465","issn":["1527-6465","1527-6473"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015265202","display_name":"Xiao Juan Wu","orcid":"https://orcid.org/0000-0002-2679-7447","observed_orcids":["https://orcid.org/0000-0002-2679-7447"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao Wu","raw_affiliation_strings":["Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA"],"raw_orcid":"https://orcid.org/0000-0002-2679-7447","affiliations":[{"raw_affiliation_string":"Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036536034","display_name":"Allison J. Kwong","orcid":"https://orcid.org/0000-0002-3874-6612","observed_orcids":["https://orcid.org/0000-0002-3874-6612"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison Kwong","raw_affiliation_strings":["Department of Gastroenterology & Hepatology, Stanford University, Stanford, California, USA"],"raw_orcid":"https://orcid.org/0000-0002-3874-6612","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology & Hepatology, Stanford University, Stanford, California, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Heller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Heller","raw_affiliation_strings":["Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070473056","display_name":"Ryan Peter Lokken","orcid":"https://orcid.org/0000-0003-1669-5188","observed_orcids":["https://orcid.org/0000-0003-1669-5188"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Peter Lokken","raw_affiliation_strings":["Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA"],"raw_orcid":"https://orcid.org/0000-0003-1669-5188","affiliations":[{"raw_affiliation_string":"Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060172013","display_name":"Nicholas A. Fidelman","orcid":"https://orcid.org/0000-0002-6040-4184","observed_orcids":["https://orcid.org/0000-0002-6040-4184"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Fidelman","raw_affiliation_strings":["Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071639584","display_name":"Neil J. Mehta","orcid":"https://orcid.org/0000-0002-9476-468X","observed_orcids":["https://orcid.org/0000-0002-9476-468X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Neil Mehta","raw_affiliation_strings":["Department of General Hepatology and Liver Transplantation, University of California, San Francisco, California, USA"],"raw_orcid":"https://orcid.org/0000-0002-9476-468X","affiliations":[{"raw_affiliation_string":"Department of General Hepatology and Liver Transplantation, University of California, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071639584"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":2150,"currency":"USD","value_usd":2150},"apc_paid":null,"fwci":1.6729,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.84265164,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"30","issue":"2","first_page":"151","last_page":"159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.8452000021934509,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.15230000019073486,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12708","display_name":"Economic and Financial Impacts of Cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/liver-directed-therapy","display_name":"liver-directed therapy","score":0.6470000147819519},{"id":"https://openalex.org/keywords/transarterial-chemoembolization","display_name":"transarterial chemoembolization","score":0.9190000295639038},{"id":"https://openalex.org/keywords/radioembolization","display_name":"radioembolization","score":0.9950000047683716},{"id":"https://openalex.org/keywords/downstaging","display_name":"downstaging","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.9549999833106995},{"id":"https://openalex.org/keywords/quality-adjusted-life-years","display_name":"quality-adjusted life years","score":0.9359999895095825},{"id":"https://openalex.org/keywords/milan-criteria","display_name":"Milan criteria","score":0.878000020980835},{"id":"https://openalex.org/keywords/locoregional-therapy","display_name":"locoregional therapy","score":0.8019999861717224},{"id":"https://openalex.org/keywords/compensated-cirrhosis","display_name":"compensated cirrhosis","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9164884090423584},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.6547242403030396},{"id":"https://openalex.org/C2776282453","wikidata":"https://www.wikidata.org/wiki/Q1352293","display_name":"Milan criteria","level":4,"score":0.5497421026229858},{"id":"https://openalex.org/C3019080777","wikidata":"https://www.wikidata.org/wiki/Q1754768","display_name":"Cost effectiveness","level":2,"score":0.4656660556793213},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.4636145234107971},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.46299606561660767},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.45232093334198},{"id":"https://openalex.org/C184834754","wikidata":"https://www.wikidata.org/wiki/Q358564","display_name":"Cost\u2013utility analysis","level":3,"score":0.44950568675994873},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4359981417655945},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4057120084762573},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.281491219997406},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000094703","descriptor_name":"Cost-Effectiveness Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016461","descriptor_name":"Chemoembolization, Therapeutic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/lvt.0000000000000249","doi":"https://doi.org/10.1097/lvt.0000000000000249","is_oa":false,"landing_page_url":"https://doi.org/10.1097/lvt.0000000000000249","pdf_url":null,"source":{"id":"https://openalex.org/S205547219","display_name":"Liver Transplantation","issn_l":"1527-6465","issn":["1527-6465","1527-6473"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver Transplantation","raw_type":"journal-article"},{"id":"pmid:37639286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37639286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1530007295","https://openalex.org/W1574346845","https://openalex.org/W1881850874","https://openalex.org/W1991227640","https://openalex.org/W1996875246","https://openalex.org/W2026525583","https://openalex.org/W2036304264","https://openalex.org/W2077014377","https://openalex.org/W2136034194","https://openalex.org/W2155059637","https://openalex.org/W2277004004","https://openalex.org/W2315027248","https://openalex.org/W2509930573","https://openalex.org/W2582878252","https://openalex.org/W2616591810","https://openalex.org/W2770041126","https://openalex.org/W2770965937","https://openalex.org/W2772445760","https://openalex.org/W2944717688","https://openalex.org/W2964249613","https://openalex.org/W3085961191","https://openalex.org/W3096906134","https://openalex.org/W3137696361","https://openalex.org/W3180541820","https://openalex.org/W3184850586","https://openalex.org/W3189376770","https://openalex.org/W3213277274","https://openalex.org/W4212873698","https://openalex.org/W4221122116","https://openalex.org/W7025699292"],"related_works":["https://openalex.org/W4321781821","https://openalex.org/W4386191885","https://openalex.org/W7130369036","https://openalex.org/W4415045028","https://openalex.org/W2330155213","https://openalex.org/W3010977941","https://openalex.org/W2077014377","https://openalex.org/W4402859302","https://openalex.org/W2546747096","https://openalex.org/W4307349898"],"abstract_inverted_index":{"Transarterial":[0],"chemoembolization":[1],"(TACE)":[2],"and":[3,34,49,76,95,102,108],"transarterial":[4],"radioembolization":[5],"(TARE)":[6],"are":[7],"the":[8,88,134,142,200,212,223,240,245,254,259],"2":[9],"most":[10],"used":[11],"modalities":[12],"for":[13,36,91,264],"patients":[14,39,187,265],"with":[15,40,81,133,266],"HCC":[16,53,267],"while":[17],"awaiting":[18],"liver":[19,74],"transplant.":[20],"The":[21,63,146],"purpose":[22],"of":[23,119,129,138,173,186,203,214,225],"this":[24],"study":[25],"is":[26,258],"to":[27,73,152,238,272],"perform":[28],"a":[29,55,60,116,126],"cost-effectiveness":[30,43,136],"analysis":[31,44,202],"comparing":[32,47],"TACE":[33,48,190,215,255],"TARE":[35,50,114,141,167,178,192,207,226,237,246,257],"downstaging":[37],"(DS)":[38],"HCC.":[41],"A":[42],"was":[45,85,150,168,179,227],"performed":[46],"in":[51,99,148,158,171],"DS":[52,71,80,262],"over":[54],"5-year":[56],"time":[57],"horizon":[58],"from":[59,87,199],"payer's":[61],"perspective.":[62],"clinical":[64],"course,":[65],"including":[66],"those":[67,77],"who":[68,78,188],"achieved":[69,115],"successful":[70],"leading":[72],"transplant":[75],"failed":[79],"possible":[82],"disease":[83],"progression,":[84],"obtained":[86],"United":[89],"Network":[90],"Organ":[92],"Sharing.":[93],"Costs":[94],"effectiveness":[96,118],"were":[97,112,193],"measured":[98],"US":[100],"dollars":[101],"quality-adjusted":[103],"life":[104],"years":[105],"(QALYs).":[106],"Probabilistic":[107,162],"deterministic":[109],"sensitivity":[110,163],"analyses":[111,164,235],"performed.":[113],"higher":[117,127],"2.51":[120],"QALY":[121],"(TACE:":[122,131],"2.29":[123],"QALY)":[124],"at":[125],"cost":[128,213,224],"$172,162":[130],"$159,706),":[132],"incremental":[135],"ratio":[137],"$55,964/QALY,":[139],"making":[140],"more":[143,169,180,209,241,260],"cost-effective":[144,170,210,242,261],"strategy.":[145],"difference":[147],"outcome":[149],"equivalent":[151],"104":[153],"days":[154],"(nearly":[155],"3.5":[156],"months)":[157],"compensated":[159],"cirrhosis":[160],"state.":[161],"showed":[165],"that":[166],"91.69%":[172],"10,000":[174],"Monte":[175],"Carlo":[176],"simulations.":[177],"effective":[181],"if":[182,244],"greater":[183],"than":[184,229,253],"48.2%":[185],"received":[189],"or":[191,221],"successfully":[194],"downstaged":[195],"(base":[196,218,231],"case:":[197,219,232],"74.6%":[198],"pooled":[201],"multiple":[204],"published":[205],"cohorts).":[206],"became":[208],"when":[211,222],"exceeded":[216],"$4,831":[217],"$12,722)":[220],"lower":[228],"$43,542":[230],"$30,609).":[233],"Subgroup":[234],"identified":[236],"be":[239],"strategy":[243,263],"cohort":[247],"required":[248],"1":[249],"fewer":[250],"locoregional":[251],"therapy":[252],"cohort.":[256],"exceeding":[268],"Milan":[269],"criteria":[270],"compared":[271],"TACE.":[273]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-08-29T00:00:00"}
