{"id":"https://openalex.org/W4386198060","doi":"https://doi.org/10.1016/j.celrep.2023.113045","title":"MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy","display_name":"MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy","publication_year":2023,"publication_date":"2023-08-25","ids":{"openalex":"https://openalex.org/W4386198060","doi":"https://doi.org/10.1016/j.celrep.2023.113045","pmid":"https://pubmed.ncbi.nlm.nih.gov/37632749"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2023.113045","doi":"https://doi.org/10.1016/j.celrep.2023.113045","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2023.113045","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.celrep.2023.113045","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104978209","display_name":"Xue Feng Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2802148028","display_name":"Guangzhou Institutes of Biomedicine and Health","ror":"https://ror.org/02c31t502","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Shi","raw_affiliation_strings":["CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China","CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China","University of Chinese Academy of Sciences, Beijing 100049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038355627","display_name":"Wenfeng Wu","orcid":"https://orcid.org/0000-0002-1994-1877","observed_orcids":["https://orcid.org/0000-0002-1994-1877"]},"institutions":[{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenfeng Wu","raw_affiliation_strings":["Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510530, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510530, China","institution_ids":["https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014939240","display_name":"Zhenhuan Feng","orcid":"https://orcid.org/0000-0002-0056-8451","observed_orcids":["https://orcid.org/0000-0002-0056-8451"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2802148028","display_name":"Guangzhou Institutes of Biomedicine and Health","ror":"https://ror.org/02c31t502","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenhuan Feng","raw_affiliation_strings":["CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China","CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China","University of Chinese Academy of Sciences, Beijing 100049, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peiyang Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80626142","display_name":"Henan Medical University","ror":"https://ror.org/038hzq450","country_code":"CN","type":"education","lineage":["https://openalex.org/I80626142"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peiyang Fan","raw_affiliation_strings":["SanQuan College, Xinxiang Medical University, Xinxiang, Henan 453003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SanQuan College, Xinxiang Medical University, Xinxiang, Henan 453003, China","institution_ids":["https://openalex.org/I80626142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028188819","display_name":"Ruona Shi","orcid":"https://orcid.org/0000-0002-9202-7280","observed_orcids":["https://orcid.org/0000-0002-9202-7280","https://orcid.org/0000-0001-8500-3769"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2802148028","display_name":"Guangzhou Institutes of Biomedicine and Health","ror":"https://ror.org/02c31t502","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruona Shi","raw_affiliation_strings":["CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061287181","display_name":"Xiaofei Zhang","orcid":"https://orcid.org/0000-0002-2564-9258","observed_orcids":["https://orcid.org/0000-0002-2564-9258","https://orcid.org/0000-0002-6539-7366"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2802148028","display_name":"Guangzhou Institutes of Biomedicine and Health","ror":"https://ror.org/02c31t502","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaofei Zhang","raw_affiliation_strings":["CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China; Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510530, China. Electronic address: zhang_xiaofei@gibh.ac.cn","CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China","Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510530, China","University of Chinese Academy of Sciences, Beijing 100049, China"],"raw_orcid":"https://orcid.org/0000-0002-2564-9258","affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China; Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510530, China. Electronic address: zhang_xiaofei@gibh.ac.cn","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028","https://openalex.org/I4210165038","https://openalex.org/I92039509"]},{"raw_affiliation_string":"CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Center for Cell Lineage and Development, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028"]},{"raw_affiliation_string":"Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510530, China","institution_ids":["https://openalex.org/I92039509"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5061287181"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2802148028","https://openalex.org/I4210165038","https://openalex.org/I92039509"],"apc_list":{"value":5460,"currency":"USD","value_usd":5460},"apc_paid":{"value":5460,"currency":"USD","value_usd":5460},"fwci":2.6621,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.91288143,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"42","issue":"9","first_page":"113045","last_page":"113045"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atg14","display_name":"ATG14","score":0.9430000185966492},{"id":"https://openalex.org/keywords/autophagy-inhibition","display_name":"autophagy inhibition","score":0.7229999899864197},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.847000002861023},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.902999997138977},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.847000002861023},{"id":"https://openalex.org/keywords/stx17","display_name":"STX17","score":0.75},{"id":"https://openalex.org/keywords/autophagosome-lysosome-fusion","display_name":"autophagosome-lysosome fusion","score":0.9580000042915344},{"id":"https://openalex.org/keywords/autophagic-flux","display_name":"autophagic flux","score":0.8320000171661377},{"id":"https://openalex.org/keywords/post-translational-regulation","display_name":"post-translational regulation","score":0.9010000228881836}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9666942358016968},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7409247159957886},{"id":"https://openalex.org/C168296220","wikidata":"https://www.wikidata.org/wiki/Q14882441","display_name":"Autophagosome","level":4,"score":0.7271270751953125},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6325095891952515},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.6068395376205444},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.5699021816253662},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5222749710083008},{"id":"https://openalex.org/C2780042272","wikidata":"https://www.wikidata.org/wiki/Q27548992","display_name":"ATG8","level":4,"score":0.4252098798751831},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30881810188293457},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28510111570358276},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071182","descriptor_name":"Autophagosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071182","descriptor_name":"Autophagosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071183","descriptor_name":"Autophagy-Related Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000071183","descriptor_name":"Autophagy-Related Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000071183","descriptor_name":"Autophagy-Related Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000071183","descriptor_name":"Autophagy-Related Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033942","descriptor_name":"Adaptor Proteins, Vesicular Transport","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D033942","descriptor_name":"Adaptor Proteins, Vesicular Transport","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D033942","descriptor_name":"Adaptor Proteins, Vesicular Transport","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D033942","descriptor_name":"Adaptor Proteins, Vesicular Transport","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050765","descriptor_name":"Qa-SNARE Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050765","descriptor_name":"Qa-SNARE Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.celrep.2023.113045","doi":"https://doi.org/10.1016/j.celrep.2023.113045","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2023.113045","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmid:37632749","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37632749","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4a61b062921f49649d57343479c3c4a7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4a61b062921f49649d57343479c3c4a7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, Vol 42, Iss 9, Pp 113045- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2023.113045","doi":"https://doi.org/10.1016/j.celrep.2023.113045","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2023.113045","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2454399043","display_name":null,"funder_award_id":"2019QN01Y051","funder_id":"https://openalex.org/F4320324202","funder_display_name":"Guangdong Science and Technology Department"},{"id":"https://openalex.org/G5723663663","display_name":null,"funder_award_id":"2020B1212060052","funder_id":"https://openalex.org/F4320335795","funder_display_name":"Science and Technology Planning Project of Guangdong Province"},{"id":"https://openalex.org/G6035319589","display_name":null,"funder_award_id":"MARCH7-D2","funder_id":"https://openalex.org/F4320321920","funder_display_name":"Innovation and Technology Commission"}],"funders":[{"id":"https://openalex.org/F4320321920","display_name":"Innovation and Technology Commission","ror":"https://ror.org/04vf9tr09"},{"id":"https://openalex.org/F4320324202","display_name":"Guangdong Science and Technology Department","ror":"https://ror.org/00tjzgn92"},{"id":"https://openalex.org/F4320334009","display_name":"Guangdong Provincial Pearl River Talents Program","ror":null},{"id":"https://openalex.org/F4320335795","display_name":"Science and Technology Planning Project of Guangdong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1461242143","https://openalex.org/W1570595295","https://openalex.org/W1776950904","https://openalex.org/W1781673660","https://openalex.org/W1975293376","https://openalex.org/W1987769185","https://openalex.org/W1995740655","https://openalex.org/W2000111822","https://openalex.org/W2007719003","https://openalex.org/W2009490810","https://openalex.org/W2014918593","https://openalex.org/W2023354199","https://openalex.org/W2023445018","https://openalex.org/W2031697171","https://openalex.org/W2032997281","https://openalex.org/W2065301559","https://openalex.org/W2066697766","https://openalex.org/W2073941831","https://openalex.org/W2079469172","https://openalex.org/W2080093026","https://openalex.org/W2080752012","https://openalex.org/W2084158898","https://openalex.org/W2085682466","https://openalex.org/W2088724822","https://openalex.org/W2088980243","https://openalex.org/W2101090646","https://openalex.org/W2126118460","https://openalex.org/W2143238979","https://openalex.org/W2149789119","https://openalex.org/W2163018106","https://openalex.org/W2164778558","https://openalex.org/W2289887068","https://openalex.org/W2560000662","https://openalex.org/W2586326639","https://openalex.org/W2612278559","https://openalex.org/W2618911114","https://openalex.org/W2736820743","https://openalex.org/W2748137738","https://openalex.org/W2771558695","https://openalex.org/W2781926636","https://openalex.org/W2787897791","https://openalex.org/W2896090977","https://openalex.org/W2944740206","https://openalex.org/W2954137892","https://openalex.org/W2962633544","https://openalex.org/W2980168206","https://openalex.org/W2986770082","https://openalex.org/W2988906435","https://openalex.org/W2988977920","https://openalex.org/W2998324388","https://openalex.org/W3000045791","https://openalex.org/W3004193861","https://openalex.org/W3071760388","https://openalex.org/W3081693490","https://openalex.org/W3081702599","https://openalex.org/W3105177816","https://openalex.org/W3121536984","https://openalex.org/W3131260049","https://openalex.org/W3183916544","https://openalex.org/W3192387066","https://openalex.org/W3197947571","https://openalex.org/W3198853168","https://openalex.org/W3214677673","https://openalex.org/W4200126388","https://openalex.org/W4213095954","https://openalex.org/W4214662482","https://openalex.org/W4225083938","https://openalex.org/W4229375713","https://openalex.org/W4281717370","https://openalex.org/W6805327451"],"related_works":["https://openalex.org/W2044889666","https://openalex.org/W2808868012","https://openalex.org/W4407095237","https://openalex.org/W1986290546","https://openalex.org/W1970861248","https://openalex.org/W2100605768","https://openalex.org/W2102368462","https://openalex.org/W2048006439","https://openalex.org/W2054919679","https://openalex.org/W2082865308"],"abstract_inverted_index":{"Autophagy":[0],"is":[1,21,30,47,54],"a":[2,34,134,141],"fundamental":[3],"biological":[4],"process":[5,20],"critical":[6],"to":[7,32,124],"all":[8],"eukaryotic":[9],"cellular":[10],"life.":[11],"Although":[12],"autophagy":[13,72,128,138],"has":[14,118],"been":[15],"increasingly":[16],"studied,":[17],"how":[18,45],"its":[19,94],"precisely":[22],"coordinated":[23],"remains":[24],"an":[25,67],"open":[26],"question.":[27],"ATG14":[28,46,91,117],"(ATG14L/Barkor)":[29],"known":[31],"play":[33],"crucial":[35],"role":[36],"in":[37,96,136],"both":[38],"autophagosome":[39],"formation":[40],"and":[41,81,92,139],"autophagosome-lysosome":[42],"fusion.":[43],"However,":[44],"regulated,":[48],"especially":[49],"at":[50],"the":[51,88,105,125,145],"post-translation":[52],"level,":[53],"still":[55],"not":[56],"clear.":[57],"Here,":[58],"we":[59,99,113],"report":[60],"that":[61,101,115],"MARCH7":[62,76,102],"(membrane-associated":[63],"ring-CH-type":[64],"finger":[65],"7),":[66],"E3":[68],"ubiquitin":[69],"ligase,":[70],"inhibits":[71],"by":[73],"ubiquitinating":[74],"ATG14.":[75],"significantly":[77],"promotes":[78],"K6-,":[79],"K11-,":[80],"K63-linked":[82],"mixed":[83],"polyubiquitination":[84],"on":[85],"ATG14,":[86],"triggering":[87],"aggregation":[89],"of":[90,107,127,147],"reducing":[93],"solubility":[95],"cells.":[97],"Functionally,":[98],"find":[100],"depletion":[103],"decreases":[104],"number":[106],"aggresome-like":[108],"induced":[109],"structures":[110],"(ALISs).":[111],"Mechanistically,":[112],"show":[114],"ubiquitinated":[116],"fewer":[119],"interactions":[120],"with":[121],"STX17,":[122],"leading":[123],"inhibition":[126],"flux.":[129],"Collectively,":[130],"our":[131],"study":[132],"reveals":[133],"mechanism":[135],"regulating":[137],"suggests":[140],"potential":[142],"strategy":[143],"for":[144],"treatment":[146],"autophagy-related":[148],"diseases.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
