{"id":"https://openalex.org/W4386154270","doi":"https://doi.org/10.2967/jnumed.123.265546","title":"Clinical Experience with [225Ac]Ac-PSMA Treatment in Patients with [177Lu]Lu-PSMA\u2013Refractory Metastatic Castration-Resistant Prostate Cancer","display_name":"Clinical Experience with [225Ac]Ac-PSMA Treatment in Patients with [177Lu]Lu-PSMA\u2013Refractory Metastatic Castration-Resistant Prostate Cancer","publication_year":2023,"publication_date":"2023-08-24","ids":{"openalex":"https://openalex.org/W4386154270","doi":"https://doi.org/10.2967/jnumed.123.265546","pmid":"https://pubmed.ncbi.nlm.nih.gov/37620050"},"language":"en","primary_location":{"id":"doi:10.2967/jnumed.123.265546","doi":"https://doi.org/10.2967/jnumed.123.265546","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.123.265546","pdf_url":"https://jnm.snmjournals.org/content/jnumed/64/10/1574.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jnm.snmjournals.org/content/jnumed/64/10/1574.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014124223","display_name":"Nalan Alan Sel\u00e7uk","orcid":"https://orcid.org/0000-0002-3738-6491","observed_orcids":["https://orcid.org/0000-0002-3738-6491","https://orcid.org/0000-0002-1688-7924"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Nalan Alan-Selcuk","raw_affiliation_strings":["Department of Nuclear Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040665524","display_name":"Gamze Beyda\u011f\u0131","orcid":"https://orcid.org/0000-0001-7187-7203","observed_orcids":["https://orcid.org/0000-0001-7187-7203"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Gamze Beydagi","raw_affiliation_strings":["Department of Nuclear Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000928557","display_name":"Emre Demirci","orcid":"https://orcid.org/0000-0002-6387-9089","observed_orcids":["https://orcid.org/0000-0002-6387-9089"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]},{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["TR","US"],"is_corresponding":false,"raw_author_name":"Emre Demirci","raw_affiliation_strings":["Department of Nuclear Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey","Department of Radiology, University of Missouri, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey","institution_ids":["https://openalex.org/I100072489"]},{"raw_affiliation_string":"Department of Radiology, University of Missouri, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038339628","display_name":"Meltem Ocak","orcid":"https://orcid.org/0000-0001-9214-3938","observed_orcids":["https://orcid.org/0000-0001-9214-3938"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meltem Ocak","raw_affiliation_strings":["Molecular Imaging and Theranostics Center, University of Missouri, Columbia, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging and Theranostics Center, University of Missouri, Columbia, Missouri","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081991533","display_name":"Serkan \u00c7elik","orcid":"https://orcid.org/0000-0002-5124-6823","observed_orcids":["https://orcid.org/0000-0002-5124-6823"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Serkan Celik","raw_affiliation_strings":["Department of Medical Oncology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112795879","display_name":"Bala Ba\u015fak \u00d6ven","orcid":"https://orcid.org/0000-0002-9921-4089","observed_orcids":["https://orcid.org/0000-0002-9921-4089"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Bala B. Oven","raw_affiliation_strings":["Department of Medical Oncology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Faculty of Medicine, Yeditepe University, Istanbul, Turkey","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038567386","display_name":"T\u00fcrkay Toklu","orcid":"https://orcid.org/0000-0002-5399-9394","observed_orcids":["https://orcid.org/0000-0002-5399-9394"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Turkay Toklu","raw_affiliation_strings":["Department of Nuclear Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075335117","display_name":"\u0130pek \u015e. Karaaslan","orcid":"https://orcid.org/0000-0002-5295-5613","observed_orcids":["https://orcid.org/0000-0002-5295-5613"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ipek Karaaslan","raw_affiliation_strings":["Department of Physics, Yeditepe University, Istanbul, Turkey; and","Department of Physics, Yeditepe University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Yeditepe University, Istanbul, Turkey; and","institution_ids":["https://openalex.org/I100072489"]},{"raw_affiliation_string":"Department of Physics, Yeditepe University, Istanbul, Turkey","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026523491","display_name":"Kaan Ak\u00e7ay","orcid":"https://orcid.org/0000-0002-7706-6388","observed_orcids":["https://orcid.org/0000-0002-7706-6388"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Kaan Akcay","raw_affiliation_strings":["Department of Nuclear Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034015963","display_name":"\u00d6mer S\u00f6nmez","orcid":"https://orcid.org/0000-0002-7708-4092","observed_orcids":["https://orcid.org/0000-0002-7708-4092"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Omer Sonmez","raw_affiliation_strings":["Department of Nuclear Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008398811","display_name":"Levent Kabasakal","orcid":"https://orcid.org/0000-0002-4050-1972","observed_orcids":["https://orcid.org/0000-0002-4050-1972","https://orcid.org/0000-0002-5474-6436"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]},{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Levent Kabasakal","raw_affiliation_strings":["Department of Nuclear Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey","Department of Nuclear Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey; lkabasakal@tsnm.org","Department of Nuclear Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]},{"raw_affiliation_string":"Department of Nuclear Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey; lkabasakal@tsnm.org","institution_ids":["https://openalex.org/I100072489"]},{"raw_affiliation_string":"Department of Nuclear Medicine, Faculty of Medicine, Yeditepe University, Istanbul, Turkey","institution_ids":["https://openalex.org/I100072489"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.1228,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.96912122,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"64","issue":"10","first_page":"1574","last_page":"1580"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.8047000169754028,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.8047000169754028,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.1509999930858612,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/177lu-lu-psma","display_name":"[177Lu]Lu-PSMA","score":0.8489999771118164},{"id":"https://openalex.org/keywords/metastatic-castration-resistant-prostate-cancer","display_name":"metastatic castration-resistant prostate cancer","score":0.9539999961853027},{"id":"https://openalex.org/keywords/radionuclide-therapy","display_name":"radionuclide therapy","score":0.7429999709129333},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.6179999709129333},{"id":"https://openalex.org/keywords/antiandrogen-therapy","display_name":"antiandrogen therapy","score":0.7059999704360962},{"id":"https://openalex.org/keywords/psma-pet","display_name":"PSMA PET","score":0.574999988079071},{"id":"https://openalex.org/keywords/psa-response","display_name":"PSA response","score":0.7620000243186951},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8050000071525574},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.6150000095367432},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.42500001192092896},{"id":"https://openalex.org/keywords/disease-control-rate","display_name":"disease control rate","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8223577737808228},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.7569482326507568},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6259106993675232},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3709530234336853},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.34864407777786255},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34112685918807983},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3401128947734833},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3255096673965454},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.09324637055397034},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000726","descriptor_name":"Androgen Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006573","descriptor_name":"Heterocyclic Compounds, 1-Ring","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008187","descriptor_name":"Lutetium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.2967/jnumed.123.265546","doi":"https://doi.org/10.2967/jnumed.123.265546","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.123.265546","pdf_url":"https://jnm.snmjournals.org/content/jnumed/64/10/1574.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},{"id":"pmid:37620050","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37620050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:openaccess.yeditepe.edu.tr:20.500.11831/9752","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.11831/9752","pdf_url":null,"source":{"id":"https://openalex.org/S7407055288","display_name":"Yeditepe University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus, PubMed","raw_type":"Journal"}],"best_oa_location":{"id":"doi:10.2967/jnumed.123.265546","doi":"https://doi.org/10.2967/jnumed.123.265546","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.123.265546","pdf_url":"https://jnm.snmjournals.org/content/jnumed/64/10/1574.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386154270.pdf","grobid_xml":"https://content.openalex.org/works/W4386154270.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W2045191513","https://openalex.org/W2110534364","https://openalex.org/W2120292596","https://openalex.org/W2123526148","https://openalex.org/W2141454098","https://openalex.org/W2148643283","https://openalex.org/W2167331614","https://openalex.org/W2467018059","https://openalex.org/W2784080506","https://openalex.org/W2809848353","https://openalex.org/W2889014405","https://openalex.org/W2889801464","https://openalex.org/W2945915427","https://openalex.org/W2991821398","https://openalex.org/W3044164917","https://openalex.org/W3048833320","https://openalex.org/W3089634467","https://openalex.org/W3093608677","https://openalex.org/W3112030517","https://openalex.org/W3113494864","https://openalex.org/W3119005666","https://openalex.org/W3130934287","https://openalex.org/W3160757120","https://openalex.org/W3162340133","https://openalex.org/W3176208875","https://openalex.org/W3209889299","https://openalex.org/W4225533139","https://openalex.org/W4225792535","https://openalex.org/W4304630351"],"related_works":["https://openalex.org/W4404474361","https://openalex.org/W7106213517","https://openalex.org/W7128382243","https://openalex.org/W4406379059","https://openalex.org/W2977901723","https://openalex.org/W3203984656","https://openalex.org/W4408042686","https://openalex.org/W4238196928","https://openalex.org/W2789405501","https://openalex.org/W3160757120"],"abstract_inverted_index":{"For":[0],"patients":[1,34,52,118,128,206,224,234,251,313],"with":[2,24,36,59,66,170,334],"advanced-stage":[3,335],"metastatic":[4],"castration-resistant":[5],"prostate":[6],"cancer":[7],"(mCRPC)":[8],"who":[9,61,235],"do":[10],"not":[11],"respond":[12],"to":[13,64,76,102,259,273],"[177Lu]Lu-PSMA":[14,67],"therapy,":[15,121,134],"there":[16,211],"are":[17,26],"limited":[18],"treatment":[19,48,65,245,341],"options.":[20],"Clinical":[21],"results":[22,49],"obtained":[23],"[225Ac]Ac-PSMA":[25,37,114,167,209,324],"promising.":[27],"We":[28,45,321],"retrospectively":[29],"analyzed":[30],"the":[31,47,110,198,241,267],"outcomes":[32],"of":[33,50,113,154,174,189,217,244,250,315],"treated":[35],"between":[38,159],"December":[39],"2018":[40],"and":[41,96,125,131,149,191,266,282,297,328],"October":[42],"2022.":[43],"Methods:":[44],"evaluated":[46],"23":[51],"(mean":[53],"age,":[54],"70.3":[55],"\u00b1":[56],"8.8":[57],"y)":[58],"mCRPC":[60,336],"were":[62,184,343],"refractory":[63],"(2\u20139":[68],"cycles).":[69],"The":[70,156],"safety":[71],"profile":[72],"was":[73,87,161,168,194,202,212,231,271,279,286,301,326],"assessed":[74,88,232],"according":[75,101,258],"Common":[77],"Technology":[78],"Criteria":[79],"for":[80],"Adverse":[81],"Events":[82],"version":[83],"5.0.":[84],"Treatment":[85,229],"efficacy":[86],"using":[89],"prostate-specific":[90,97,260],"membrane":[91,261],"antigen":[92,98,262],"PET":[93,263],"progression":[94,257,264],"criteria":[95,108],"(PSA)":[99],"response":[100,201,230],"Prostate":[103],"Cancer":[104],"Working":[105],"Group":[106],"2":[107,141,147],"after":[109,208],"first":[111,242],"cycle":[112,153,243],"treatment.":[115,319],"Results:":[116],"All":[117],"received":[119,129,138,142,146,151],"androgen-deprivation":[120],"whereas":[122],"22":[123],"(96%)":[124],"19":[126],"(83%)":[127],"chemotherapy":[130],"second-generation":[132],"antiandrogen":[133],"respectively.":[135],"One":[136],"patient":[137],"4":[139],"cycles,":[140,144,148],"3":[143,290,299],"8":[145],"12":[150],"1":[152,295],"[225Ac]Ac-PSMA.":[155],"median":[157,283],"interval":[158],"cycles":[160],"13":[162],"wk":[163],"(range,":[164,177],"8\u201328":[165],"wk).":[166],"administered":[169],"a":[171],"mean":[172],"activity":[173],"7.6":[175],"MBq":[176],"6.2\u201310.0":[178],"MBq)":[179],"in":[180,204,219,222,233,294,303,332,337],"each":[181],"cycle.":[182],"Patients":[183],"at":[185,213],"an":[186],"advanced":[187],"stage":[188],"disease,":[190],"tumor":[192],"burden":[193],"very":[195],"high.":[196],"Although":[197],"best":[199],"PSA":[200,220],"observed":[203,221,302,322],"5":[205],"(26%)":[207],"treatment,":[210],"least":[214],"some":[215],"level":[216],"decline":[218],"11":[223],"(58%;":[225],"n":[226],"=":[227,247,253],"19).":[228],"underwent":[236],"[68Ga]Ga-PSMA":[237],"PET/CT":[238],"imaging.":[239],"After":[240],"(n":[246,252],"18),":[248],"50%":[249],"9)":[254],"showed":[255,329],"disease":[256,268],"criteria,":[265],"control":[269],"rate":[270],"calculated":[272],"be":[274],"50%.":[275],"Median":[276],"progression-free":[277],"survival":[278,285],"3.1":[280],"mo,":[281],"overall":[284],"7.7":[287],"mo.":[288],"Grade":[289],"hematologic":[291],"toxicity":[292],"occurred":[293],"patient,":[296],"grade":[298],"nephrotoxicity":[300],"another":[304],"patient.":[305],"Parotid":[306],"SUVmax":[307],"decreased":[308],"by":[309],"33%,":[310],"although":[311],"all":[312,339],"complained":[314],"dry":[316],"mouth":[317],"before":[318],"Conclusion:":[320],"that":[323],"therapy":[325],"safe":[327],"potential":[330],"even":[331],"cases":[333],"which":[338],"other":[340],"options":[342],"completed.":[344]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-08-26T00:00:00"}