{"id":"https://openalex.org/W4386102437","doi":"https://doi.org/10.1097/01.hs9.0000974220.92611.f9","title":"PB1845: A MULTIOMIC, SINGLE-CELL MEASURABLE RESIDUAL DISEASE (SCMRD) ASSAY FOR PHASING DNA MUTATIONS AND SURFACE IMMUNOPHENOTYPES","display_name":"PB1845: A MULTIOMIC, SINGLE-CELL MEASURABLE RESIDUAL DISEASE (SCMRD) ASSAY FOR PHASING DNA MUTATIONS AND SURFACE IMMUNOPHENOTYPES","publication_year":2023,"publication_date":"2023-08-01","ids":{"openalex":"https://openalex.org/W4386102437","doi":"https://doi.org/10.1097/01.hs9.0000974220.92611.f9","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10429804"},"language":"en","primary_location":{"id":"doi:10.1097/01.hs9.0000974220.92611.f9","doi":"https://doi.org/10.1097/01.hs9.0000974220.92611.f9","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1097/01.hs9.0000974220.92611.f9","pdf_url":null,"source":{"id":"https://openalex.org/S4210211592","display_name":"HemaSphere","issn_l":"2572-9241","issn":["2572-9241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1097/01.hs9.0000974220.92611.f9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Charlie Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105531","display_name":"Mission Bio (United States)","ror":"https://ror.org/01f18s848","country_code":"US","type":"company","lineage":["https://openalex.org/I4210105531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlie Murphy","raw_affiliation_strings":["Mission Bio, South San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mission Bio, South San Francisco, United States","institution_ids":["https://openalex.org/I4210105531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005639381","display_name":"Kathryn L. Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105531","display_name":"Mission Bio (United States)","ror":"https://ror.org/01f18s848","country_code":"US","type":"company","lineage":["https://openalex.org/I4210105531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn Thompson","raw_affiliation_strings":["Mission Bio, South San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mission Bio, South San Francisco, United States","institution_ids":["https://openalex.org/I4210105531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049898881","display_name":"Lubna Nousheen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105531","display_name":"Mission Bio (United States)","ror":"https://ror.org/01f18s848","country_code":"US","type":"company","lineage":["https://openalex.org/I4210105531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lubna Nousheen","raw_affiliation_strings":["Mission Bio, South San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mission Bio, South San Francisco, United States","institution_ids":["https://openalex.org/I4210105531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011876209","display_name":"Aaron Llanso","orcid":"https://orcid.org/0000-0001-9327-6505","observed_orcids":["https://orcid.org/0000-0001-9327-6505"]},"institutions":[{"id":"https://openalex.org/I4210105531","display_name":"Mission Bio (United States)","ror":"https://ror.org/01f18s848","country_code":"US","type":"company","lineage":["https://openalex.org/I4210105531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Llanso","raw_affiliation_strings":["Mission Bio, South San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mission Bio, South San Francisco, United States","institution_ids":["https://openalex.org/I4210105531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057569401","display_name":"Todd E. Druley","orcid":"https://orcid.org/0000-0002-3245-7561","observed_orcids":["https://orcid.org/0000-0002-3245-7561"]},"institutions":[{"id":"https://openalex.org/I4210105531","display_name":"Mission Bio (United States)","ror":"https://ror.org/01f18s848","country_code":"US","type":"company","lineage":["https://openalex.org/I4210105531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Todd Druley","raw_affiliation_strings":["Mission Bio, South San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mission Bio, South San Francisco, United States","institution_ids":["https://openalex.org/I4210105531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058297509","display_name":"Adam Sciambi","orcid":"https://orcid.org/0000-0002-6899-4449","observed_orcids":["https://orcid.org/0000-0002-6899-4449"]},"institutions":[{"id":"https://openalex.org/I4210105531","display_name":"Mission Bio (United States)","ror":"https://ror.org/01f18s848","country_code":"US","type":"company","lineage":["https://openalex.org/I4210105531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Sciambi","raw_affiliation_strings":["Mission Bio, South San Francisco, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mission Bio, South San Francisco, United States","institution_ids":["https://openalex.org/I4210105531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210105531"],"apc_list":{"value":2480,"currency":"USD","value_usd":2480},"apc_paid":{"value":2480,"currency":"USD","value_usd":2480},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"S3","first_page":"e92611f9","last_page":"e92611f9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.906000018119812},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/clonal-architecture","display_name":"clonal architecture","score":0.6269999742507935},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.8799999952316284},{"id":"https://openalex.org/keywords/recurrence-prediction","display_name":"recurrence prediction","score":0.597000002861023},{"id":"https://openalex.org/keywords/rare-cell-detection","display_name":"rare cell detection","score":0.7269999980926514},{"id":"https://openalex.org/keywords/tapestri","display_name":"Tapestri","score":0.640999972820282},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.7231343984603882},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.6833658218383789},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.611271858215332},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.519568681716919},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.45395180583000183},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4341435730457306},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.43093860149383545},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4210500717163086},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3995809853076935},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3800783157348633},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.37070584297180176},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27984482049942017},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27614063024520874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23482945561408997},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21048879623413086},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1097/01.hs9.0000974220.92611.f9","doi":"https://doi.org/10.1097/01.hs9.0000974220.92611.f9","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1097/01.hs9.0000974220.92611.f9","pdf_url":null,"source":{"id":"https://openalex.org/S4210211592","display_name":"HemaSphere","issn_l":"2572-9241","issn":["2572-9241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10429804","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10429804","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10429804/pdf/hs9-7-e92611f9.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hemasphere","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:847dc98143fe475eb2ef393ecbe85633","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/847dc98143fe475eb2ef393ecbe85633","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HemaSphere, Vol 7, p e92611f9 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1097/01.hs9.0000974220.92611.f9","doi":"https://doi.org/10.1097/01.hs9.0000974220.92611.f9","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1097/01.hs9.0000974220.92611.f9","pdf_url":null,"source":{"id":"https://openalex.org/S4210211592","display_name":"HemaSphere","issn_l":"2572-9241","issn":["2572-9241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386102437.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389248510","https://openalex.org/W4405054885","https://openalex.org/W4386282264","https://openalex.org/W4402022489","https://openalex.org/W4310112971","https://openalex.org/W4405039615","https://openalex.org/W4405096092","https://openalex.org/W7148629258","https://openalex.org/W4417006707","https://openalex.org/W7132840959"],"abstract_inverted_index":{"Topic:":[0],"4.":[1],"Acute":[2,344],"myeloid":[3,32,345],"leukemia":[4,33,122],"-":[5],"Clinical":[6],"Background:":[7],"The":[8,136],"small":[9],"population":[10],"of":[11,28,84,106,199,224,276],"cancerous":[12],"cells":[13,38,309,314],"that":[14,51,257],"remain":[15],"following":[16],"treatment,":[17],"known":[18],"as":[19],"measurable":[20],"residual":[21,121,348],"disease":[22],"(MRD),":[23],"is":[24],"a":[25,72,80,96,103,142,161,184,331],"strong":[26],"predictor":[27],"relapse":[29,85],"in":[30,49,174,206,232],"acute":[31],"(AML).":[34],"Often,":[35],"these":[36,293],"refractory":[37],"have":[39],"gained":[40],"additional":[41],"resistance":[42],"mutations":[43],"or":[44,54,65,129],"changed":[45],"their":[46,282],"surface":[47,283],"immunophenotypes":[48],"ways":[50],"preclude":[52],"detection":[53,140,339],"discrimination":[55],"from":[56,303],"preleukemic":[57],"clones":[58],"by":[59,148,267,306],"current":[60],"gold":[61],"standard":[62,143],"flow":[63,268],"cytometry":[64],"bulk":[66],"NGS":[67],"assays.":[68],"For":[69],"this":[70,234,328],"reason,":[71],"multi-omic":[73],"single":[74,111,191],"cell":[75,112,192],"MRD":[76,99,170,279,296,338],"assay":[77,101,137,329],"could":[78],"offer":[79],"more":[81],"comprehensive":[82,336],"indicator":[83],"and":[86,115,163,172,179,182,217,240,259,286,340],"the":[87,197,222,261,273,277,319],"potential":[88,332],"for":[89,132,157,168,228,265,335],"faster":[90],"response.":[91],"Aims:":[92],"Here,":[93],"we":[94,300],"present":[95,301],"new":[97,185],"single-cell":[98,241],"(scMRD)":[100],"with":[102,176,318,326],"0.01%":[104],"limit":[105],"detection,":[107],"while":[108],"also":[109,125],"giving":[110],"clonal":[113],"architecture":[114],"immunophenotyping":[116],"to":[117,155,189,201,243,253,298],"not":[118],"only":[119],"identify":[120,126],"cells,":[123,159,280],"but":[124],"putative":[127],"DNA":[128,162,230],"protein":[130,164,284],"targets":[131],"salvage":[133],"therapy.":[134],"Methods:":[135],"enables":[138],"rare-cell":[139],"on":[141,295],"Mission":[144,225],"Bio":[145],"Tapestri":[146],"run":[147,208],"adding:":[149],"(i)":[150],"an":[151,255],"upfront":[152],"bead-based":[153],"protocol":[154],"enrich":[156],"blast":[158],"(ii)":[160],"panel":[165],"specifically":[166],"designed":[167],"AML":[169,337],"diagnosis":[171],"treatment":[173],"alignment":[175],"both":[177],"ICC":[178],"ELN":[180],"guidelines,":[181],"(iii)":[183],"automated":[186],"analysis":[187],"pipeline":[188,235],"evaluate":[190],"multiomics":[193],"output.":[194],"In":[195],"addition,":[196],"multiplexing":[198],"up":[200],"three":[202],"patient":[203],"samples":[204,304],"combined":[205],"one":[207],"via":[209],"germline":[210],"identification":[211],"further":[212],"reduces":[213],"per":[214],"sample":[215],"costs":[216],"increases":[218],"throughput.":[219],"Results:":[220],"Through":[221],"use":[223],"Bio\u2019s":[226],"technology":[227],"detecting":[229],"variants":[231],"single-cells,":[233],"leverages":[236],"variant-specific":[237],"error":[238],"modeling":[239],"co-occurrence":[242],"sensitively":[244],"detect":[245],"de":[246],"novo":[247],"variants,":[248],"reducing":[249],"false":[250],"positive":[251],"rates":[252],"achieve":[254],"LOD":[256],"meets":[258],"exceeds":[260],"recommended":[262],"0.1%":[263],"cutoff":[264],"MRD-positivity":[266],"cytometry.":[269],"It":[270],"furthermore":[271],"reconstructs":[272],"phylogenetic":[274],"tree":[275],"detected":[278],"presents":[281],"signature":[285],"arm-level":[287],"copy":[288],"number":[289],"changes.":[290],"To":[291],"demonstrate":[292],"features":[294],"down":[297],"0.01%,":[299],"data":[302],"constructed":[305],"titrating":[307],"diseased":[308],"into":[310],"healthy":[311],"bone":[312],"marrow":[313],"before":[315],"processing":[316],"them":[317],"scMRD":[320],"assay.":[321],"Summary/Conclusion:":[322],"Combining":[323],"high":[324],"sensitivity":[325],"multi-omics,":[327],"offers":[330],"scalable":[333],"solution":[334],"guiding":[341],"therapeutic":[342],"decision-making.Keywords:":[343],"leukemia,":[346],"Measurable":[347],"disease,":[349],"Immunophenotype,":[350],"Somatic":[351],"mutation":[352]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2023-08-24T00:00:00"}