{"id":"https://openalex.org/W4386100748","doi":"https://doi.org/10.1038/s41586-023-06462-1","title":"OPA1 helical structures give perspective to mitochondrial dysfunction","display_name":"OPA1 helical structures give perspective to mitochondrial dysfunction","publication_year":2023,"publication_date":"2023-08-23","ids":{"openalex":"https://openalex.org/W4386100748","doi":"https://doi.org/10.1038/s41586-023-06462-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/37612506","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12410014"},"language":"en","primary_location":{"id":"doi:10.1038/s41586-023-06462-1","doi":"https://doi.org/10.1038/s41586-023-06462-1","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41586-023-06462-1","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-2039298/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068617038","display_name":"Sarah B. Nyenhuis","orcid":"https://orcid.org/0000-0002-3139-4423","observed_orcids":["https://orcid.org/0000-0002-3139-4423"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah B. Nyenhuis","raw_affiliation_strings":["Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA"],"raw_orcid":"https://orcid.org/0000-0002-3139-4423","affiliations":[{"raw_affiliation_string":"Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025885614","display_name":"Xufeng Wu","orcid":"https://orcid.org/0000-0002-9723-7965","observed_orcids":["https://orcid.org/0000-0002-9723-7965"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xufeng Wu","raw_affiliation_strings":["Light Microscopy Facility, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Light Microscopy Facility, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106499620","display_name":"Marie\u2010Paule Strub","orcid":"https://orcid.org/0000-0003-4840-1893","observed_orcids":["https://orcid.org/0000-0003-4840-1893"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie-Paule Strub","raw_affiliation_strings":["Protein Expression Facility, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Expression Facility, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113631736","display_name":"Yang-In Yim","orcid":"https://orcid.org/0000-0001-5651-4850","observed_orcids":["https://orcid.org/0000-0001-5651-4850"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang-In Yim","raw_affiliation_strings":["Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023449093","display_name":"Abigail E. Stanton","orcid":"https://orcid.org/0000-0002-0602-0745","observed_orcids":["https://orcid.org/0000-0002-0602-0745"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abigail E. Stanton","raw_affiliation_strings":["Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA","Molecular Biology Department, Princeton University, Princeton, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"raw_affiliation_string":"Molecular Biology Department, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003431868","display_name":"Valentina Baena","orcid":"https://orcid.org/0000-0002-6429-439X","observed_orcids":["https://orcid.org/0000-0002-6429-439X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valentina Baena","raw_affiliation_strings":["Electron Microscopy Core, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA"],"raw_orcid":"https://orcid.org/0000-0002-6429-439X","affiliations":[{"raw_affiliation_string":"Electron Microscopy Core, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058752490","display_name":"Zulfeqhar Ali Syed","orcid":"https://orcid.org/0000-0002-5825-9782","observed_orcids":["https://orcid.org/0000-0002-5825-9782"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zulfeqhar A. Syed","raw_affiliation_strings":["Electron Microscopy Core, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA"],"raw_orcid":"https://orcid.org/0000-0002-5825-9782","affiliations":[{"raw_affiliation_string":"Electron Microscopy Core, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075458788","display_name":"Bertram J. Canagarajah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bertram Canagarajah","raw_affiliation_strings":["Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077641368","display_name":"John A. Hammer","orcid":"https://orcid.org/0000-0002-2496-5179","observed_orcids":["https://orcid.org/0000-0002-2496-5179"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Hammer","raw_affiliation_strings":["Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068703722","display_name":"Jenny E. Hinshaw","orcid":"https://orcid.org/0000-0002-5130-5061","observed_orcids":["https://orcid.org/0000-0002-5130-5061"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jenny E. Hinshaw","raw_affiliation_strings":["Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA. jennyh@niddk.nih.gov","Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA"],"raw_orcid":"https://orcid.org/0000-0002-5130-5061","affiliations":[{"raw_affiliation_string":"Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA. jennyh@niddk.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]},{"raw_affiliation_string":"Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5068703722"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"],"apc_list":{"value":11690,"currency":"USD","value_usd":11690},"apc_paid":null,"fwci":6.0437,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.98090513,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"620","issue":"7976","first_page":"1109","last_page":"1116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opa1","display_name":"OPA1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/autosomal-dominant-optic-atrophy","display_name":"autosomal dominant optic atrophy","score":0.9279999732971191},{"id":"https://openalex.org/keywords/mitochondrial-fusion","display_name":"mitochondrial fusion","score":0.621999979019165},{"id":"https://openalex.org/keywords/gtpase","display_name":"GTPase","score":0.6690000295639038},{"id":"https://openalex.org/keywords/helical-assembly","display_name":"helical assembly","score":0.7110000252723694},{"id":"https://openalex.org/keywords/mitochondrial-cristae-remodeling","display_name":"mitochondrial cristae remodeling","score":0.7329999804496765},{"id":"https://openalex.org/keywords/mitochondrial-fragmentation","display_name":"mitochondrial fragmentation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/childhood-blindness","display_name":"childhood blindness","score":0.5860000252723694},{"id":"https://openalex.org/keywords/pathogenic-variants","display_name":"pathogenic variants","score":0.5839999914169312},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.6039999723434448},{"id":"https://openalex.org/keywords/membrane-binding","display_name":"membrane binding","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.6913459300994873},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.6123368144035339},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6077440977096558},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5914450883865356},{"id":"https://openalex.org/C145488412","wikidata":"https://www.wikidata.org/wiki/Q425007","display_name":"Mitochondrial carrier","level":5,"score":0.48822787404060364},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.48786187171936035},{"id":"https://openalex.org/C65871279","wikidata":"https://www.wikidata.org/wiki/Q42884945","display_name":"Inner membrane","level":3,"score":0.43028199672698975},{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.42976027727127075},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.4192255139350891},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4062844514846802},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32254350185394287},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.29780125617980957},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.2939950227737427},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2419872283935547},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18266132473945618},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.15006273984909058},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008561","descriptor_name":"Membrane Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051336","descriptor_name":"Mitochondrial Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063154","descriptor_name":"Mitochondrial Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41586-023-06462-1","doi":"https://doi.org/10.1038/s41586-023-06462-1","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41586-023-06462-1","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-2039298/v1","doi":"https://doi.org/10.21203/rs.3.rs-2039298/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2039298/v1","pdf_url":"https://www.researchsquare.com/article/rs-2039298/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:37612506","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37612506","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12410014","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12410014/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12410014/pdf/nihms-2101105.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nature","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:nature:v:620:y:2023:i:7976:d:10.1038_s41586-023-06462-1","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41586-023-06462-1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-2039298/v1","doi":"https://doi.org/10.21203/rs.3.rs-2039298/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2039298/v1","pdf_url":"https://www.researchsquare.com/article/rs-2039298/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000876737","display_name":"Structural analysis of dynamins involved in mitochondrial morphology","funder_award_id":"ZIADK060107","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386100748.pdf","grobid_xml":"https://content.openalex.org/works/W4386100748.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W1570552209","https://openalex.org/W1745155715","https://openalex.org/W1926628858","https://openalex.org/W1958746655","https://openalex.org/W1963950126","https://openalex.org/W1964379391","https://openalex.org/W1970851569","https://openalex.org/W1975043141","https://openalex.org/W1986477156","https://openalex.org/W2004939344","https://openalex.org/W2004942398","https://openalex.org/W2008080532","https://openalex.org/W2014253236","https://openalex.org/W2025449918","https://openalex.org/W2033155870","https://openalex.org/W2035503835","https://openalex.org/W2046909156","https://openalex.org/W2052544119","https://openalex.org/W2059320820","https://openalex.org/W2094123735","https://openalex.org/W2109065242","https://openalex.org/W2113729748","https://openalex.org/W2117769560","https://openalex.org/W2124026197","https://openalex.org/W2128131255","https://openalex.org/W2136937485","https://openalex.org/W2161892574","https://openalex.org/W2164886443","https://openalex.org/W2167279371","https://openalex.org/W2168200110","https://openalex.org/W2173732482","https://openalex.org/W2180229411","https://openalex.org/W2342500021","https://openalex.org/W2540686316","https://openalex.org/W2587625522","https://openalex.org/W2593511418","https://openalex.org/W2626238074","https://openalex.org/W2752531558","https://openalex.org/W2765322245","https://openalex.org/W2793821504","https://openalex.org/W2806535099","https://openalex.org/W2887032631","https://openalex.org/W2896957283","https://openalex.org/W2898224116","https://openalex.org/W2899714098","https://openalex.org/W2902800597","https://openalex.org/W2905458255","https://openalex.org/W2950108090","https://openalex.org/W2951384153","https://openalex.org/W2953320394","https://openalex.org/W2957566337","https://openalex.org/W2957646157","https://openalex.org/W2960011603","https://openalex.org/W2972504037","https://openalex.org/W2999878740","https://openalex.org/W3005655837","https://openalex.org/W3006567658","https://openalex.org/W3013603319","https://openalex.org/W3023971742","https://openalex.org/W3083406432","https://openalex.org/W3093699410","https://openalex.org/W3102013022","https://openalex.org/W3107730440","https://openalex.org/W3108495343","https://openalex.org/W3127326657","https://openalex.org/W3138378202","https://openalex.org/W3172887937","https://openalex.org/W3177828909","https://openalex.org/W3178720314","https://openalex.org/W3182767159","https://openalex.org/W3195672811","https://openalex.org/W4206528003","https://openalex.org/W4223552703","https://openalex.org/W4223928799","https://openalex.org/W4226378057","https://openalex.org/W4303431191","https://openalex.org/W4313648969","https://openalex.org/W6661978531"],"related_works":["https://openalex.org/W4319917349","https://openalex.org/W2010338778","https://openalex.org/W3023971742","https://openalex.org/W4385055314","https://openalex.org/W4327566957","https://openalex.org/W4386086719","https://openalex.org/W6939875565","https://openalex.org/W3005296597","https://openalex.org/W2913123367","https://openalex.org/W3013603319"],"abstract_inverted_index":{"Abstract":[0],"Dominant":[1],"Optic":[2,24],"Atrophy":[3,25],"is":[4,43],"the":[5,19,22,31,37,46,52,65,82,110,132,151,183],"leading":[6],"cause":[7,176],"of":[8,13,18,36,51,64,74,86,109,115,153,186],"childhood":[9],"blindness,":[10],"with":[11,101],"60-80%":[12],"cases":[14],"caused":[15],"by":[16,88],"mutation":[17],"gene":[20],"encoding":[21],"protein":[23,99,158],"1,":[26],"OPA1.":[27],"This":[28],"condition":[29],"dysregulates":[30],"GTPase":[32,111],"mediated":[33],"fusion":[34,63],"process":[35],"mitochondrial":[38,67,177],"inner-":[39],"and":[40,49,61,84,105,162,173],"outer-membranes.":[41],"OPA1":[42,75,125,170],"critical":[44],"to":[45,55,122,168],"dynamic":[47],"organization":[48],"regulation":[50],"mitochondria":[53],"due":[54],"its":[56,137],"role":[57],"in":[58,81,131,145,179],"cristae":[59],"remodeling":[60],"GTPase-mediated":[62],"inner":[66],"membrane.":[68],"Here,":[69],"we":[70],"solved":[71],"helical":[72,93],"structures":[73,130],"assembled":[76],"on":[77,150,157],"lipid":[78],"membrane":[79,138,163,174],"tubes,":[80],"presence":[83],"absence":[85],"nucleotide":[87],"cryo-electron":[89],"microscopy":[90],"methods.":[91],"These":[92],"assemblies":[94],"organize":[95],"into":[96],"densely":[97],"packed":[98],"rungs":[100],"minimal":[102],"inter-rung":[103],"connectivity":[104],"exhibit":[106],"nucleotide-dependent":[107],"dimerization":[108],"domains,":[112],"a":[113],"hallmark":[114],"dynamin":[116],"superfamily":[117],"proteins":[118],"(DSPs).":[119],"In":[120],"contrast":[121],"other":[123],"DSPs,":[124],"contains":[126],"several":[127],"unique":[128],"secondary":[129],"paddle":[133],"domain":[134],"that":[135],"strengthen":[136],"association.":[139],"The":[140],"novel":[141],"structural":[142],"features":[143],"identified":[144],"this":[146],"study":[147],"shed":[148],"light":[149],"effects":[152],"pathogenic":[154],"point":[155],"mutations":[156,166],"folding,":[159],"inter-protein":[160],"assembly,":[161],"interactions.":[164,188],"Further,":[165],"chosen":[167],"disrupt":[169],"assembly":[171],"interfaces":[172],"binding":[175],"fragmentation":[178],"cell-based":[180],"assays,":[181],"demonstrating":[182],"biological":[184],"relevance":[185],"these":[187]},"counts_by_year":[{"year":2026,"cited_by_count":28},{"year":2025,"cited_by_count":32},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-08-24T00:00:00"}
