{"id":"https://openalex.org/W4386098024","doi":"https://doi.org/10.1038/s41580-023-00641-8","title":"The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease","display_name":"The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease","publication_year":2023,"publication_date":"2023-08-23","ids":{"openalex":"https://openalex.org/W4386098024","doi":"https://doi.org/10.1038/s41580-023-00641-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/37612414"},"language":"en","primary_location":{"id":"doi:10.1038/s41580-023-00641-8","doi":"https://doi.org/10.1038/s41580-023-00641-8","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41580-023-00641-8","pdf_url":null,"source":{"id":"https://openalex.org/S196724125","display_name":"Nature Reviews Molecular Cell Biology","issn_l":"1471-0072","issn":["1471-0072","1471-0080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Molecular Cell Biology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4386098024"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027989037","display_name":"Claire Goul","orcid":"https://orcid.org/0000-0002-6556-9631","observed_orcids":["https://orcid.org/0000-0002-6556-9631"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire Goul","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091352143","display_name":"Roberta Peruzzo","orcid":"https://orcid.org/0000-0001-9209-9068","observed_orcids":["https://orcid.org/0000-0001-9209-9068"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberta Peruzzo","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA"],"raw_orcid":"https://orcid.org/0000-0001-9209-9068","affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031840294","display_name":"Roberto Zoncu","orcid":"https://orcid.org/0000-0003-1611-1891","observed_orcids":["https://orcid.org/0000-0003-1611-1891"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roberto Zoncu","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA. rzoncu@berkeley.edu","Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-1611-1891","affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA. rzoncu@berkeley.edu","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031840294"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":null,"apc_paid":null,"fwci":7.2638,"has_fulltext":false,"cited_by_count":310,"citation_normalized_percentile":{"value":0.98749269,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":100},"biblio":{"volume":"24","issue":"12","first_page":"857","last_page":"875"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nutrient-sensing","display_name":"nutrient sensing","score":0.8980000019073486},{"id":"https://openalex.org/keywords/nutrient-signaling","display_name":"nutrient signaling","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"cellular metabolism","score":0.7689999938011169},{"id":"https://openalex.org/keywords/anabolism-and-catabolism","display_name":"anabolism and catabolism","score":0.8069999814033508},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.8999999761581421},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":1.0},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9860000014305115},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.8988615870475769},{"id":"https://openalex.org/C2776030549","wikidata":"https://www.wikidata.org/wiki/Q7829395","display_name":"Nutrient sensing","level":3,"score":0.6358166933059692},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.6277276873588562},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5231524705886841},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4876753091812134},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4626615345478058},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4349100887775421},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4334403872489929},{"id":"https://openalex.org/C142796444","wikidata":"https://www.wikidata.org/wiki/Q181394","display_name":"Nutrient","level":2,"score":0.4120529890060425},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33328938484191895},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3124105930328369},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2621352970600128},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.23113781213760376},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.1600925624370575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14167442917823792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08458450436592102}],"mesh":[{"descriptor_ui":"D000076222","descriptor_name":"Mechanistic Target of Rapamycin Complex 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000078622","descriptor_name":"Nutrients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/s41580-023-00641-8","doi":"https://doi.org/10.1038/s41580-023-00641-8","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41580-023-00641-8","pdf_url":null,"source":{"id":"https://openalex.org/S196724125","display_name":"Nature Reviews Molecular Cell Biology","issn_l":"1471-0072","issn":["1471-0072","1471-0080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Molecular Cell Biology","raw_type":"journal-article"},{"id":"pmid:37612414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37612414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Molecular cell biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000869457","display_name":"Dissecting and targeting lysosomal signaling in kidney tumorigenesis","funder_award_id":"R01CA260205","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":237,"referenced_works":["https://openalex.org/W1493142940","https://openalex.org/W1510881494","https://openalex.org/W1511428271","https://openalex.org/W1519230612","https://openalex.org/W1528321953","https://openalex.org/W1570508765","https://openalex.org/W1596556260","https://openalex.org/W1918384196","https://openalex.org/W1966617373","https://openalex.org/W1970195561","https://openalex.org/W1972618720","https://openalex.org/W1975200363","https://openalex.org/W1976896999","https://openalex.org/W1978625554","https://openalex.org/W1978879981","https://openalex.org/W1980396381","https://openalex.org/W1982219839","https://openalex.org/W1984000730","https://openalex.org/W1984754431","https://openalex.org/W1986301677","https://openalex.org/W1987005832","https://openalex.org/W1990960113","https://openalex.org/W1992257057","https://openalex.org/W1995455069","https://openalex.org/W1997241169","https://openalex.org/W1997836389","https://openalex.org/W2001568034","https://openalex.org/W2002583936","https://openalex.org/W2004582874","https://openalex.org/W2005911243","https://openalex.org/W2006559495","https://openalex.org/W2007110714","https://openalex.org/W2008239768","https://openalex.org/W2011282245","https://openalex.org/W2012142261","https://openalex.org/W2014086521","https://openalex.org/W2018302034","https://openalex.org/W2018373960","https://openalex.org/W2018553282","https://openalex.org/W2023012828","https://openalex.org/W2025176940","https://openalex.org/W2027785297","https://openalex.org/W2029589437","https://openalex.org/W2033497590","https://openalex.org/W2035016947","https://openalex.org/W2038874082","https://openalex.org/W2041811289","https://openalex.org/W2044502296","https://openalex.org/W2044874695","https://openalex.org/W2046447620","https://openalex.org/W2047174875","https://openalex.org/W2048059265","https://openalex.org/W2052501713","https://openalex.org/W2054683873","https://openalex.org/W2056664023","https://openalex.org/W2057106513","https://openalex.org/W2060607801","https://openalex.org/W2063013559","https://openalex.org/W2063920469","https://openalex.org/W2065887259","https://openalex.org/W2066659565","https://openalex.org/W2067311782","https://openalex.org/W2070910260","https://openalex.org/W2077499130","https://openalex.org/W2078184757","https://openalex.org/W2080100938","https://openalex.org/W2081920342","https://openalex.org/W2084712051","https://openalex.org/W2086589626","https://openalex.org/W2093154482","https://openalex.org/W2098236219","https://openalex.org/W2100902550","https://openalex.org/W2101083009","https://openalex.org/W2101428185","https://openalex.org/W2104316079","https://openalex.org/W2105738527","https://openalex.org/W2111607026","https://openalex.org/W2111704539","https://openalex.org/W2114859236","https://openalex.org/W2115820946","https://openalex.org/W2116056961","https://openalex.org/W2116505693","https://openalex.org/W2119194577","https://openalex.org/W2121211842","https://openalex.org/W2130396048","https://openalex.org/W2132463881","https://openalex.org/W2134757689","https://openalex.org/W2134892089","https://openalex.org/W2136272779","https://openalex.org/W2136676465","https://openalex.org/W2137372494","https://openalex.org/W2139856846","https://openalex.org/W2139948451","https://openalex.org/W2141133346","https://openalex.org/W2142505357","https://openalex.org/W2143251315","https://openalex.org/W2144059623","https://openalex.org/W2145411470","https://openalex.org/W2146127477","https://openalex.org/W2148208138","https://openalex.org/W2150575159","https://openalex.org/W2152600551","https://openalex.org/W2152855010","https://openalex.org/W2153188271","https://openalex.org/W2156144699","https://openalex.org/W2157760261","https://openalex.org/W2160347316","https://openalex.org/W2160444874","https://openalex.org/W2164895949","https://openalex.org/W2168180694","https://openalex.org/W2206269655","https://openalex.org/W2207318443","https://openalex.org/W2215436807","https://openalex.org/W2231368253","https://openalex.org/W2257158960","https://openalex.org/W2257572427","https://openalex.org/W2258753819","https://openalex.org/W2262016342","https://openalex.org/W2293646973","https://openalex.org/W2302804942","https://openalex.org/W2330972395","https://openalex.org/W2336647682","https://openalex.org/W2396636851","https://openalex.org/W2407198816","https://openalex.org/W2469926161","https://openalex.org/W2485649401","https://openalex.org/W2509099384","https://openalex.org/W2542664757","https://openalex.org/W2567875529","https://openalex.org/W2588791993","https://openalex.org/W2588870577","https://openalex.org/W2588948554","https://openalex.org/W2589112207","https://openalex.org/W2589276620","https://openalex.org/W2591793663","https://openalex.org/W2593816418","https://openalex.org/W2603916465","https://openalex.org/W2605743056","https://openalex.org/W2606899102","https://openalex.org/W2626522201","https://openalex.org/W2706229700","https://openalex.org/W2734490934","https://openalex.org/W2744571323","https://openalex.org/W2745669578","https://openalex.org/W2745793992","https://openalex.org/W2757150230","https://openalex.org/W2763844770","https://openalex.org/W2765356256","https://openalex.org/W2765487476","https://openalex.org/W2765934351","https://openalex.org/W2767139423","https://openalex.org/W2767250022","https://openalex.org/W2773300145","https://openalex.org/W2777391038","https://openalex.org/W2781529662","https://openalex.org/W2786931791","https://openalex.org/W2794845581","https://openalex.org/W2803875384","https://openalex.org/W2884223904","https://openalex.org/W2885823448","https://openalex.org/W2886012836","https://openalex.org/W2890480133","https://openalex.org/W2901963762","https://openalex.org/W2902312600","https://openalex.org/W2909096837","https://openalex.org/W2920928376","https://openalex.org/W2936807256","https://openalex.org/W2952521211","https://openalex.org/W2957848130","https://openalex.org/W2964289809","https://openalex.org/W2964341190","https://openalex.org/W2973505555","https://openalex.org/W2976971613","https://openalex.org/W2979459757","https://openalex.org/W2979884643","https://openalex.org/W2981122284","https://openalex.org/W2982601264","https://openalex.org/W2987429137","https://openalex.org/W2989525167","https://openalex.org/W2990526911","https://openalex.org/W2991456852","https://openalex.org/W2999421965","https://openalex.org/W3005216907","https://openalex.org/W3006500278","https://openalex.org/W3007530406","https://openalex.org/W3024366742","https://openalex.org/W3033031597","https://openalex.org/W3034390811","https://openalex.org/W3039449072","https://openalex.org/W3040600898","https://openalex.org/W3044495713","https://openalex.org/W3047598497","https://openalex.org/W3081868833","https://openalex.org/W3095141346","https://openalex.org/W3097716180","https://openalex.org/W3102357733","https://openalex.org/W3111617283","https://openalex.org/W3111971324","https://openalex.org/W3115843226","https://openalex.org/W3156151969","https://openalex.org/W3161971970","https://openalex.org/W3178500894","https://openalex.org/W3185175899","https://openalex.org/W3196608509","https://openalex.org/W4205303769","https://openalex.org/W4220953706","https://openalex.org/W4221037022","https://openalex.org/W4223901740","https://openalex.org/W4238567307","https://openalex.org/W4281681825","https://openalex.org/W4283728447","https://openalex.org/W4283759203","https://openalex.org/W4285087929","https://openalex.org/W4286005654","https://openalex.org/W4293242926","https://openalex.org/W4294992272","https://openalex.org/W4295428427","https://openalex.org/W4295509638","https://openalex.org/W4295706123","https://openalex.org/W4295763173","https://openalex.org/W4307366279","https://openalex.org/W4307659347","https://openalex.org/W4311686836","https://openalex.org/W4313545526","https://openalex.org/W4317952732","https://openalex.org/W4318071652","https://openalex.org/W4318982706","https://openalex.org/W4363677298","https://openalex.org/W4366507114","https://openalex.org/W6680220988","https://openalex.org/W6687988774","https://openalex.org/W6688155079","https://openalex.org/W6692525933","https://openalex.org/W6753617982","https://openalex.org/W6760201578","https://openalex.org/W6839338054","https://openalex.org/W7073932351"],"related_works":["https://openalex.org/W4280646008","https://openalex.org/W2088184211","https://openalex.org/W2920670758","https://openalex.org/W4401610845","https://openalex.org/W2022984399","https://openalex.org/W3132255180","https://openalex.org/W2086528604","https://openalex.org/W2158216631","https://openalex.org/W4404576211","https://openalex.org/W2078821200"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":130},{"year":2025,"cited_by_count":125},{"year":2024,"cited_by_count":45},{"year":2023,"cited_by_count":9},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2023-08-24T00:00:00"}
