{"id":"https://openalex.org/W4386097809","doi":"https://doi.org/10.5530/pj.2023.15.110","title":"Study on the Inhibition of Sinensetin Extract from Cat's Whiskers Plant (Orthosiphon aristatus) on ATP Binding Cassette Sub-Family G Member 2 in Uric Acid","display_name":"Study on the Inhibition of Sinensetin Extract from Cat's Whiskers Plant (Orthosiphon aristatus) on ATP Binding Cassette Sub-Family G Member 2 in Uric Acid","publication_year":2023,"publication_date":"2023-08-15","ids":{"openalex":"https://openalex.org/W4386097809","doi":"https://doi.org/10.5530/pj.2023.15.110"},"language":"en","primary_location":{"id":"doi:10.5530/pj.2023.15.110","doi":"https://doi.org/10.5530/pj.2023.15.110","is_oa":true,"landing_page_url":"https://doi.org/10.5530/pj.2023.15.110","pdf_url":"https://phcogj.com/sites/default/files/PharmacognJ-15-4-506.pdf","source":{"id":"https://openalex.org/S2764874817","display_name":"Pharmacognosy Journal","issn_l":"0975-3575","issn":["0975-3575"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4360969232","host_organization_name":"EManuscript Services","host_organization_lineage":["https://openalex.org/P4360969232"],"host_organization_lineage_names":["EManuscript Services"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacognosy Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://phcogj.com/sites/default/files/PharmacognJ-15-4-506.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103352543","display_name":"Anni Faridah","orcid":"https://orcid.org/0000-0003-4561-6645","observed_orcids":["https://orcid.org/0000-0003-4561-6645"]},"institutions":[{"id":"https://openalex.org/I245308123","display_name":"Universitas Negeri Padang","ror":"https://ror.org/04jrfgq66","country_code":"ID","type":"education","lineage":["https://openalex.org/I245308123"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Anni Faridah","raw_affiliation_strings":["Faculty of Tourism and Hospitality, Universitas Negeri Padang, INDONESIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Tourism and Hospitality, Universitas Negeri Padang, INDONESIA","institution_ids":["https://openalex.org/I245308123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092680315","display_name":"Rismi Verawati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I245308123","display_name":"Universitas Negeri Padang","ror":"https://ror.org/04jrfgq66","country_code":"ID","type":"education","lineage":["https://openalex.org/I245308123"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Rismi Verawati","raw_affiliation_strings":["Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, INDONESIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, INDONESIA","institution_ids":["https://openalex.org/I245308123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013134091","display_name":"Budhi Oktavia","orcid":"https://orcid.org/0000-0003-3376-5053","observed_orcids":["https://orcid.org/0000-0003-3376-5053"]},"institutions":[{"id":"https://openalex.org/I245308123","display_name":"Universitas Negeri Padang","ror":"https://ror.org/04jrfgq66","country_code":"ID","type":"education","lineage":["https://openalex.org/I245308123"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Budhi Oktavia","raw_affiliation_strings":["Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, INDONESIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, INDONESIA","institution_ids":["https://openalex.org/I245308123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070989754","display_name":"Musa Ghufron","orcid":"https://orcid.org/0000-0003-0480-0251","observed_orcids":["https://orcid.org/0000-0003-0480-0251"]},"institutions":[{"id":"https://openalex.org/I4210158925","display_name":"Universitas Muhammadiyah Surabaya","ror":"https://ror.org/05cn2wc35","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210158925"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Musa Ghufron","raw_affiliation_strings":["Department of Public Health and Community Medicine, Faculty of Medicine, Universitas Muhammadiyah Surabaya, INDONESIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health and Community Medicine, Faculty of Medicine, Universitas Muhammadiyah Surabaya, INDONESIA","institution_ids":["https://openalex.org/I4210158925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021237216","display_name":"Devi Purnamasari","orcid":"https://orcid.org/0009-0007-6914-3279","observed_orcids":["https://orcid.org/0009-0007-6914-3279"]},"institutions":[{"id":"https://openalex.org/I4405274702","display_name":"Universitas Awal Bros","ror":"https://ror.org/026zgvd42","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405274702"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Devi Purnamasari","raw_affiliation_strings":["Department of Radiology, Universitas Awalbros, Pekanbaru, INDONESIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Universitas Awalbros, Pekanbaru, INDONESIA","institution_ids":["https://openalex.org/I4405274702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070387844","display_name":"Muhammad Raffi Ghifari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Muhammad Raffi Ghifari","raw_affiliation_strings":["Informatics Engineering, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Informatics Engineering, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046031302","display_name":"Linda Rosalina","orcid":"https://orcid.org/0000-0003-2753-403X","observed_orcids":["https://orcid.org/0000-0003-2753-403X"]},"institutions":[{"id":"https://openalex.org/I245308123","display_name":"Universitas Negeri Padang","ror":"https://ror.org/04jrfgq66","country_code":"ID","type":"education","lineage":["https://openalex.org/I245308123"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Linda Rosalina","raw_affiliation_strings":["Department of Makeup and Beauty, Faculty of Tourism and Hospitality, Universitas Negeri Padang, INDONESIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Makeup and Beauty, Faculty of Tourism and Hospitality, Universitas Negeri Padang, INDONESIA","institution_ids":["https://openalex.org/I245308123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067727587","display_name":"Putri Azhari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55892964","display_name":"Andalas University","ror":"https://ror.org/04ded0672","country_code":"ID","type":"education","lineage":["https://openalex.org/I55892964"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Putri Azhari","raw_affiliation_strings":["Department of Agricultural Technology,","Faculty of Agricultural Technology, Universitas Andalas, Padang, West Sumatra, INDONESIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agricultural Technology,","institution_ids":[]},{"raw_affiliation_string":"Faculty of Agricultural Technology, Universitas Andalas, Padang, West Sumatra, INDONESIA","institution_ids":["https://openalex.org/I55892964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004308749","display_name":"Rahadian Zainul","orcid":"https://orcid.org/0000-0002-3740-3597","observed_orcids":["https://orcid.org/0000-0002-3740-3597"]},"institutions":[{"id":"https://openalex.org/I245308123","display_name":"Universitas Negeri Padang","ror":"https://ror.org/04jrfgq66","country_code":"ID","type":"education","lineage":["https://openalex.org/I245308123"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Rahadian Zainul","raw_affiliation_strings":["Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, INDONESIA","Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, INDONESIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, INDONESIA","institution_ids":["https://openalex.org/I245308123"]},{"raw_affiliation_string":"Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, INDONESIA","institution_ids":["https://openalex.org/I245308123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044810587","display_name":"Viol Dhea Kharisma","orcid":"https://orcid.org/0000-0001-9060-0429","observed_orcids":["https://orcid.org/0000-0001-9060-0429"]},"institutions":[{"id":"https://openalex.org/I205133468","display_name":"Universitas Airlangga","ror":"https://ror.org/04ctejd88","country_code":"ID","type":"education","lineage":["https://openalex.org/I205133468"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Viol Dhea Kharisma","raw_affiliation_strings":["Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA","Generasi Biologi Indonesia Foundation, Gresik, INDONESIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA","institution_ids":["https://openalex.org/I205133468"]},{"raw_affiliation_string":"Generasi Biologi Indonesia Foundation, Gresik, INDONESIA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025855311","display_name":"Vikash Jakhmola","orcid":"https://orcid.org/0000-0002-8108-006X","observed_orcids":["https://orcid.org/0000-0002-8108-006X"]},"institutions":[{"id":"https://openalex.org/I3132702812","display_name":"Uttaranchal University","ror":"https://ror.org/00ba6pg24","country_code":"IN","type":"education","lineage":["https://openalex.org/I3132702812"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vikash Jakhmola","raw_affiliation_strings":["Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA","institution_ids":["https://openalex.org/I3132702812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050035322","display_name":"\u041c\u0430\u043a\u0441\u0438\u043c \u0411\u043e\u0440\u0438\u0441\u043e\u0432\u0438\u0447 \u0420\u0435\u0431\u0435\u0437\u043e\u0432","orcid":"https://orcid.org/0000-0003-0857-5143","observed_orcids":["https://orcid.org/0000-0003-0857-5143"]},"institutions":[{"id":"https://openalex.org/I4210104969","display_name":"Ural State Agrarian University","ror":"https://ror.org/01kn8x502","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210104969"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maksim Rebezov","raw_affiliation_strings":["Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, RUSSIAN FEDERATION","Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, RUSSIAN FEDERATION","institution_ids":[]},{"raw_affiliation_string":"Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION","institution_ids":["https://openalex.org/I4210104969"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024496142","display_name":"ANM Ansori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205133468","display_name":"Universitas Airlangga","ror":"https://ror.org/04ctejd88","country_code":"ID","type":"education","lineage":["https://openalex.org/I205133468"]},{"id":"https://openalex.org/I3132702812","display_name":"Uttaranchal University","ror":"https://ror.org/00ba6pg24","country_code":"IN","type":"education","lineage":["https://openalex.org/I3132702812"]}],"countries":["ID","IN"],"is_corresponding":false,"raw_author_name":"ANM Ansori","raw_affiliation_strings":["Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA","Generasi Biologi Indonesia Foundation, Gresik, INDONESIA","Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA","institution_ids":["https://openalex.org/I205133468"]},{"raw_affiliation_string":"Generasi Biologi Indonesia Foundation, Gresik, INDONESIA","institution_ids":[]},{"raw_affiliation_string":"Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA","institution_ids":["https://openalex.org/I3132702812"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5004308749"],"corresponding_institution_ids":["https://openalex.org/I245308123"],"apc_list":null,"apc_paid":null,"fwci":0.174,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.33706887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"15","issue":"4","first_page":"506","last_page":"511"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sinensetin","display_name":"sinensetin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/orthosiphon-aristatus","display_name":"Orthosiphon aristatus","score":0.9950000047683716},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.8619999885559082},{"id":"https://openalex.org/keywords/uric-acid","display_name":"uric acid","score":0.9160000085830688},{"id":"https://openalex.org/keywords/abcg2-inhibitors","display_name":"ABCG2 inhibitors","score":0.5770000219345093},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.890999972820282},{"id":"https://openalex.org/keywords/drug-likeness","display_name":"drug-likeness","score":0.7540000081062317},{"id":"https://openalex.org/keywords/pharmacokinetic-prediction","display_name":"pharmacokinetic prediction","score":0.5839999914169312},{"id":"https://openalex.org/keywords/ginkgo-biloba-extract","display_name":"Ginkgo biloba extract","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7084058523178101},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.6279879808425903},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5260847806930542},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5140860676765442},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3695299029350281},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.27079838514328003},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.198024183511734},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.177412748336792},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.0782330334186554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5530/pj.2023.15.110","doi":"https://doi.org/10.5530/pj.2023.15.110","is_oa":true,"landing_page_url":"https://doi.org/10.5530/pj.2023.15.110","pdf_url":"https://phcogj.com/sites/default/files/PharmacognJ-15-4-506.pdf","source":{"id":"https://openalex.org/S2764874817","display_name":"Pharmacognosy Journal","issn_l":"0975-3575","issn":["0975-3575"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4360969232","host_organization_name":"EManuscript Services","host_organization_lineage":["https://openalex.org/P4360969232"],"host_organization_lineage_names":["EManuscript Services"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacognosy Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.5530/pj.2023.15.110","doi":"https://doi.org/10.5530/pj.2023.15.110","is_oa":true,"landing_page_url":"https://doi.org/10.5530/pj.2023.15.110","pdf_url":"https://phcogj.com/sites/default/files/PharmacognJ-15-4-506.pdf","source":{"id":"https://openalex.org/S2764874817","display_name":"Pharmacognosy Journal","issn_l":"0975-3575","issn":["0975-3575"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4360969232","host_organization_name":"EManuscript Services","host_organization_lineage":["https://openalex.org/P4360969232"],"host_organization_lineage_names":["EManuscript Services"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacognosy Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386097809.pdf","grobid_xml":"https://content.openalex.org/works/W4386097809.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W2588473297","https://openalex.org/W2598962082","https://openalex.org/W2604353006","https://openalex.org/W2610550630","https://openalex.org/W2779118329","https://openalex.org/W2800312947","https://openalex.org/W2804878284","https://openalex.org/W2884813674","https://openalex.org/W2907746977","https://openalex.org/W2923269054","https://openalex.org/W2943185278","https://openalex.org/W3000419847","https://openalex.org/W3004663246","https://openalex.org/W3010761615","https://openalex.org/W3016296419","https://openalex.org/W3048084948","https://openalex.org/W3091850792","https://openalex.org/W3109991752","https://openalex.org/W3116221844","https://openalex.org/W3154969514","https://openalex.org/W3195782228","https://openalex.org/W3199174445","https://openalex.org/W4212792347","https://openalex.org/W4283731438","https://openalex.org/W4294754729","https://openalex.org/W4294754976","https://openalex.org/W4296280672","https://openalex.org/W4307862495","https://openalex.org/W4308867916","https://openalex.org/W4311798436","https://openalex.org/W4312281957","https://openalex.org/W4312618092","https://openalex.org/W4312777434","https://openalex.org/W4312983812","https://openalex.org/W4312999342","https://openalex.org/W4313909135","https://openalex.org/W4315498676","https://openalex.org/W4317626589","https://openalex.org/W4321446183","https://openalex.org/W4362587488","https://openalex.org/W4365454991","https://openalex.org/W4382678173","https://openalex.org/W4382678195","https://openalex.org/W4382678223","https://openalex.org/W4382678311","https://openalex.org/W4382706037","https://openalex.org/W4396727803","https://openalex.org/W4396755375","https://openalex.org/W6903819778"],"related_works":["https://openalex.org/W2944839745","https://openalex.org/W7015921608","https://openalex.org/W4408001408","https://openalex.org/W6911820001","https://openalex.org/W2557656881","https://openalex.org/W4414845203","https://openalex.org/W4401880837","https://openalex.org/W6940085491","https://openalex.org/W4205635839","https://openalex.org/W2327013603"],"abstract_inverted_index":{"This":[0],"study":[1],"aims":[2],"to":[3],"investigate":[4],"the":[5,13,90,97,101,107,116,154],"potential":[6,120],"of":[7,55,72,80,103,110,127,141,147,156],"sinensetin,":[8],"a":[9,119,124,137,144,170],"compound":[10],"found":[11],"in":[12,22,176,179],"Cat's":[14],"Whiskers":[15],"plant":[16],"(Orthosiphon":[17],"aristatus),":[18],"as":[19,46,118,169],"an":[20,161],"inhibitor":[21],"inhibiting":[23],"uric":[24,157],"acid":[25,158],"through":[26,160],"its":[27],"interaction":[28,91],"with":[29,68,123],"ATP":[30],"Binding":[31,69],"Cassette":[32],"Sub-Family":[33],"G":[34],"Member":[35],"2":[36],"(ABCG2).The":[37],"in-silico":[38,162],"approach":[39],"was":[40],"employed":[41],"using":[42,59,86,106],"software":[43],"tools":[44],"such":[45],"Pymol,":[47],"PyRx,":[48],"Protein":[49,87],"Plus,":[50],"and":[51,66,75,77,83,94,143,164,178],"Lepinski":[52,108],"Rule.The":[53],"results":[54],"molecular":[56,125],"docking":[57,99],"analysis":[58,85],"PyRx":[60],"demonstrated":[61],"significant":[62],"interactions":[63],"between":[64,92],"sinensetin":[65,93,114],"ABCG2,":[67,95],"Affinity":[70],"values":[71,79],"-6.8,":[73],"-6.6,":[74,76],"RMSD":[78],"0,":[81],"0.785,":[82],"1.379.The":[84],"Plus":[88],"confirmed":[89],"supporting":[96],"previous":[98],"findings.Furthermore,":[100],"evaluation":[102],"pharmacokinetic":[104],"parameters":[105],"Rule":[109],"Five":[111],"revealed":[112],"that":[113],"meets":[115],"criteria":[117],"drug":[121],"compound,":[122],"weight":[126],"372,":[128],"no":[129],"hydrogen":[130,134],"bond":[131,135],"donors,":[132],"seven":[133],"acceptors,":[136],"log":[138],"P":[139],"value":[140],"3.345,":[142],"molar":[145],"reactivity":[146],"98.5.This":[148],"research":[149,174],"provides":[150],"new":[151],"insights":[152],"into":[153],"development":[155],"therapy":[159],"approach,":[163],"these":[165],"findings":[166],"can":[167],"serve":[168],"basis":[171],"for":[172],"further":[173],"involving":[175],"vitro":[177],"vivo":[180],"validation.":[181]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-08-24T00:00:00"}