{"id":"https://openalex.org/W4386026537","doi":"https://doi.org/10.1016/j.jaapos.2023.06.007","title":"Factors associated with visual acuity improvement with a binocular digital therapeutic for amblyopia","display_name":"Factors associated with visual acuity improvement with a binocular digital therapeutic for amblyopia","publication_year":2023,"publication_date":"2023-08-21","ids":{"openalex":"https://openalex.org/W4386026537","doi":"https://doi.org/10.1016/j.jaapos.2023.06.007","pmid":"https://pubmed.ncbi.nlm.nih.gov/37611818","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11867222"},"language":"en","primary_location":{"id":"doi:10.1016/j.jaapos.2023.06.007","doi":"https://doi.org/10.1016/j.jaapos.2023.06.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jaapos.2023.06.007","pdf_url":null,"source":{"id":"https://openalex.org/S40629775","display_name":"Journal of American Association for Pediatric Ophthalmology and Strabismus","issn_l":"1091-8531","issn":["1091-8531","1528-3933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of American Association for Pediatric Ophthalmology and Strabismus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11867222/pdf/nihms-2053746.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055573377","display_name":"Isdin Oke","orcid":"https://orcid.org/0000-0002-6596-3284","observed_orcids":["https://orcid.org/0000-0002-6596-3284"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Isdin Oke","raw_affiliation_strings":["Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: Isdin.Oke@childrens.harvard.edu"],"raw_orcid":"https://orcid.org/0000-0002-6596-3284","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: Isdin.Oke@childrens.harvard.edu","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024121483","display_name":"Eric D. Gaier","orcid":"https://orcid.org/0000-0002-2923-0024","observed_orcids":["https://orcid.org/0000-0002-2923-0024"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric D. Gaier","raw_affiliation_strings":["Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000643157","display_name":"Michael X. Repka","orcid":"https://orcid.org/0000-0002-0192-6951","observed_orcids":["https://orcid.org/0000-0002-0192-6951"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael X. Repka","raw_affiliation_strings":["Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5055573377"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.3976,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.6139531,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"27","issue":"5","first_page":"300","last_page":"303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10381","display_name":"Ophthalmology and Visual Impairment Studies","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10381","display_name":"Ophthalmology and Visual Impairment Studies","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10427","display_name":"Visual perception and processing mechanisms","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amblyopia","display_name":"amblyopia","score":0.996999979019165},{"id":"https://openalex.org/keywords/visual-acuity-gain","display_name":"visual acuity improvement","score":0.8930000066757202},{"id":"https://openalex.org/keywords/treatment-response-factors","display_name":"treatment response factors","score":0.7620000243186951},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.7360000014305115},{"id":"https://openalex.org/keywords/amblyopia-severity","display_name":"amblyopia severity","score":0.8080000281333923},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.7235401272773743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6993865370750427},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5325576066970825},{"id":"https://openalex.org/C121958486","wikidata":"https://www.wikidata.org/wiki/Q609543","display_name":"Binocular vision","level":2,"score":0.4382862150669098},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.36148011684417725},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.2305959165096283},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15689662098884583},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000550","descriptor_name":"Amblyopia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015348","descriptor_name":"Vision, Binocular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018910","descriptor_name":"Video Games","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jaapos.2023.06.007","doi":"https://doi.org/10.1016/j.jaapos.2023.06.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jaapos.2023.06.007","pdf_url":null,"source":{"id":"https://openalex.org/S40629775","display_name":"Journal of American Association for Pediatric Ophthalmology and Strabismus","issn_l":"1091-8531","issn":["1091-8531","1528-3933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of American Association for Pediatric Ophthalmology and Strabismus","raw_type":"journal-article"},{"id":"pmid:37611818","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37611818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus","raw_type":"Randomized Controlled Trial"},{"id":"pmh:oai:pubmedcentral.nih.gov:11867222","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11867222","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11867222/pdf/nihms-2053746.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J AAPOS","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11867222","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11867222","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11867222/pdf/nihms-2053746.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J AAPOS","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G774738304","display_name":"Exploiting principles of timing-dependent synaptic plasticity to treat amblyopia","funder_award_id":"K08EY030164","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8570405196","display_name":"CHILD HEALTH SERVICES RESEARCH TRAINING PROGRAM","funder_award_id":"T32HS000063","funder_id":"https://openalex.org/F4320332177","funder_display_name":"Agency for Healthcare Research and Quality"}],"funders":[{"id":"https://openalex.org/F4320332177","display_name":"Agency for Healthcare Research and Quality","ror":"https://ror.org/03jmfdf59"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386026537.pdf","grobid_xml":"https://content.openalex.org/works/W4386026537.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2105500446","https://openalex.org/W3026959915","https://openalex.org/W3157919519","https://openalex.org/W3201282100","https://openalex.org/W4220695807"],"related_works":["https://openalex.org/W3201282100","https://openalex.org/W4285806049","https://openalex.org/W4387948598","https://openalex.org/W3200580400","https://openalex.org/W3025825348","https://openalex.org/W3157919519","https://openalex.org/W4406489348","https://openalex.org/W7168302542","https://openalex.org/W3199059384","https://openalex.org/W2978201158"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-08-22T00:00:00"}