{"id":"https://openalex.org/W4386023124","doi":"https://doi.org/10.1021/acs.jmedchem.3c00406","title":"Structure\u2013Activity Relationships of the Antimicrobial Peptide Natural Product Apidaecin","display_name":"Structure\u2013Activity Relationships of the Antimicrobial Peptide Natural Product Apidaecin","publication_year":2023,"publication_date":"2023-08-21","ids":{"openalex":"https://openalex.org/W4386023124","doi":"https://doi.org/10.1021/acs.jmedchem.3c00406","pmid":"https://pubmed.ncbi.nlm.nih.gov/37603874","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10768847"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jmedchem.3c00406","doi":"https://doi.org/10.1021/acs.jmedchem.3c00406","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.3c00406","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10768847/pdf/nihms-1952439.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050103864","display_name":"Kornelia J. Skowron","orcid":"https://orcid.org/0000-0002-0846-6134","observed_orcids":["https://orcid.org/0000-0002-0846-6134"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kornelia J. Skowron","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States"],"raw_orcid":"https://orcid.org/0000-0002-0846-6134","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085546570","display_name":"Chetana Baliga","orcid":"https://orcid.org/0000-0001-9876-6810","observed_orcids":["https://orcid.org/0000-0001-9876-6810"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chetana Baliga","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tatum Johnson","orcid":"https://orcid.org/0000-0002-1291-004X","observed_orcids":["https://orcid.org/0000-0002-1291-004X"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatum Johnson","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States"],"raw_orcid":"https://orcid.org/0000-0002-1291-004X","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060004079","display_name":"Kyle M. Kremiller","orcid":"https://orcid.org/0000-0002-7715-6535","observed_orcids":["https://orcid.org/0000-0002-7715-6535"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle M. Kremiller","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117351892","display_name":"Alexandra Castroverde","orcid":"https://orcid.org/0009-0000-0472-9016","observed_orcids":["https://orcid.org/0009-0000-0472-9016"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Castroverde","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058732907","display_name":"Trevor T. Dean","orcid":"https://orcid.org/0000-0002-3912-2828","observed_orcids":["https://orcid.org/0000-0002-3912-2828"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trevor T. Dean","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065689655","display_name":"A\u2019Lester C. Allen","orcid":"https://orcid.org/0000-0002-7199-8838","observed_orcids":["https://orcid.org/0000-0002-7199-8838"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A\u2019Lester C. Allen","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111044134","display_name":"Ana M. Lopez-Hernandez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana M. Lopez-Hernandez","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059787350","display_name":"Elena V. Aleksandrova","orcid":"https://orcid.org/0000-0002-1808-5319","observed_orcids":["https://orcid.org/0000-0002-1808-5319"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena V. Aleksandrova","raw_affiliation_strings":["Department of Biological Sciences, College of Liberal Arts and Sciences, University of Illinois Chicago, Chicago, Illinois 60607, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, College of Liberal Arts and Sciences, University of Illinois Chicago, Chicago, Illinois 60607, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030287279","display_name":"Dorota Klepacki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorota Klepacki","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022417892","display_name":"Alexander S. Mankin","orcid":"https://orcid.org/0000-0002-3301-827X","observed_orcids":["https://orcid.org/0000-0002-3301-827X"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander S. Mankin","raw_affiliation_strings":["Center for Biomolecular Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United States","Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States"],"raw_orcid":"https://orcid.org/0000-0002-3301-827X","affiliations":[{"raw_affiliation_string":"Center for Biomolecular Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037721703","display_name":"Yury S. Polikanov","orcid":"https://orcid.org/0000-0002-5064-0327","observed_orcids":["https://orcid.org/0000-0002-5064-0327"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yury S. Polikanov","raw_affiliation_strings":["Center for Biomolecular Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United States","Department of Biological Sciences, College of Liberal Arts and Sciences, University of Illinois Chicago, Chicago, Illinois 60607, United States","Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States"],"raw_orcid":"https://orcid.org/0000-0002-5064-0327","affiliations":[{"raw_affiliation_string":"Center for Biomolecular Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Biological Sciences, College of Liberal Arts and Sciences, University of Illinois Chicago, Chicago, Illinois 60607, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048635691","display_name":"Terry W. Moore","orcid":"https://orcid.org/0000-0002-5410-306X","observed_orcids":["https://orcid.org/0000-0002-5410-306X"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Terry W. Moore","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States","University of Illinois Cancer Center, University of Illinois Chicago, Chicago, Illinois 60612, United States"],"raw_orcid":"https://orcid.org/0000-0002-5410-306X","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"University of Illinois Cancer Center, University of Illinois Chicago, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048635691"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":5.3307,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.97073326,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"66","issue":"17","first_page":"11831","last_page":"11842"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apidaecin","display_name":"apidaecin","score":1.0},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.8809999823570251},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9570000171661377},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.7540000081062317},{"id":"https://openalex.org/keywords/peptide-analogs","display_name":"peptide analogues","score":0.3700000047683716}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.7922959327697754},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7682574391365051},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.7071525454521179},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6852651238441467},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5869159698486328},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5377089977264404},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.4411258399486542},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.41715043783187866},{"id":"https://openalex.org/C7927669","wikidata":"https://www.wikidata.org/wiki/Q898529","display_name":"Protein quaternary structure","level":4,"score":0.41004806756973267},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34160932898521423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1374657154083252},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.12684524059295654},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.124962717294693},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jmedchem.3c00406","doi":"https://doi.org/10.1021/acs.jmedchem.3c00406","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.3c00406","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:37603874","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37603874","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10768847","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10768847","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10768847/pdf/nihms-1952439.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Med Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10768847","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10768847","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10768847/pdf/nihms-1952439.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Med Chem","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3706093669","display_name":"IRACDA at University of Illinois at Chicago","funder_award_id":"K12GM139186","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4894371729","display_name":"Advancing ribosome-targeting antibacterial peptides with a unique mechanism of action","funder_award_id":"R56AI162961","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000876069","display_name":"Advancing ribosome-targeting antibacterial peptides with a unique mechanism of action","funder_award_id":"R01AI162961","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332222","display_name":"University of Illinois at Urbana-Champaign","ror":"https://ror.org/047426m28"},{"id":"https://openalex.org/F4320332697","display_name":"University of Illinois at Chicago","ror":"https://ror.org/02mpq6x41"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386023124.pdf","grobid_xml":"https://content.openalex.org/works/W4386023124.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W144997804","https://openalex.org/W1514431151","https://openalex.org/W1960043122","https://openalex.org/W1966599354","https://openalex.org/W1971332950","https://openalex.org/W1978600513","https://openalex.org/W1981510650","https://openalex.org/W1991830829","https://openalex.org/W1993456678","https://openalex.org/W1996359284","https://openalex.org/W1997828001","https://openalex.org/W2009359258","https://openalex.org/W2012115019","https://openalex.org/W2013278992","https://openalex.org/W2016264452","https://openalex.org/W2037492976","https://openalex.org/W2065903733","https://openalex.org/W2070692558","https://openalex.org/W2071451650","https://openalex.org/W2091516391","https://openalex.org/W2091821114","https://openalex.org/W2103847950","https://openalex.org/W2104623056","https://openalex.org/W2135533782","https://openalex.org/W2135964866","https://openalex.org/W2146157756","https://openalex.org/W2169957497","https://openalex.org/W2239738725","https://openalex.org/W2263465463","https://openalex.org/W2280314624","https://openalex.org/W2330322271","https://openalex.org/W2347118269","https://openalex.org/W2409814849","https://openalex.org/W2465031613","https://openalex.org/W2522501918","https://openalex.org/W2556869241","https://openalex.org/W2562261325","https://openalex.org/W2587135659","https://openalex.org/W2596981174","https://openalex.org/W2619787325","https://openalex.org/W2735523552","https://openalex.org/W2738678411","https://openalex.org/W2756935148","https://openalex.org/W2767246150","https://openalex.org/W2794251447","https://openalex.org/W2794817296","https://openalex.org/W2811225767","https://openalex.org/W2886462433","https://openalex.org/W2889474824","https://openalex.org/W2952812009","https://openalex.org/W2964426765","https://openalex.org/W2970052317","https://openalex.org/W2999569426","https://openalex.org/W3025708624","https://openalex.org/W3047157985","https://openalex.org/W3092909579","https://openalex.org/W3101923829","https://openalex.org/W3111531342","https://openalex.org/W3131431845","https://openalex.org/W3134196835","https://openalex.org/W3140198700","https://openalex.org/W3194188670","https://openalex.org/W3214904139","https://openalex.org/W4362459568"],"related_works":["https://openalex.org/W6889121147","https://openalex.org/W4400242339","https://openalex.org/W3134196835","https://openalex.org/W4396801984","https://openalex.org/W4224315121","https://openalex.org/W1482443219","https://openalex.org/W4313277434","https://openalex.org/W1960043122","https://openalex.org/W3044519894","https://openalex.org/W2053534461"],"abstract_inverted_index":{"With":[0],"the":[1,60,64,93,100,104,111,128],"growing":[2],"crisis":[3],"of":[4,17,45,59,63,69,110,114,141],"antimicrobial":[5,32,35,123],"resistance,":[6],"it":[7],"is":[8,50],"critical":[9],"to":[10,12,24,41,79],"continue":[11],"seek":[13],"out":[14],"new":[15],"sources":[16],"novel":[18],"antibiotics.":[19],"This":[20],"need":[21],"has":[22],"led":[23],"renewed":[25],"interest":[26],"in":[27,92],"natural":[28],"product":[29],"antimicrobials,":[30],"specifically":[31],"peptides.":[33,143],"Nonlytic":[34],"peptides":[36],"are":[37,97],"highly":[38,116],"promising":[39],"due":[40],"their":[42],"unique":[43],"mechanisms":[44],"action.":[46],"One":[47],"such":[48],"peptide":[49,119],"apidaecin":[51,70],"(Api),":[52],"which":[53],"inhibits":[54],"translation":[55,129],"termination":[56],"through":[57],"stabilization":[58],"quaternary":[61,105],"complex":[62],"ribosome-apidaecin-tRNA-release":[65],"factor.":[66],"Synthetic":[67],"derivatives":[68],"have":[71,77,86],"been":[72],"developed,":[73],"but":[74],"structure-guided":[75,139],"modifications":[76],"yet":[78],"be":[80],"considered.":[81],"In":[82],"this":[83],"work,":[84],"we":[85],"focused":[87],"on":[88],"modifying":[89],"key":[90],"residues":[91],"Api":[94,118,142],"sequence":[95],"that":[96,102,120],"responsible":[98],"for":[99,137],"interactions":[101],"stabilize":[103],"complex.":[106,130],"We":[107],"present":[108],"one":[109],"first":[112],"examples":[113],"a":[115,134],"modified":[117],"maintains":[121],"its":[122],"activity":[124],"and":[125],"interaction":[126],"with":[127],"These":[131],"findings":[132],"establish":[133],"starting":[135],"point":[136],"further":[138],"optimization":[140]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":14}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-08-22T00:00:00"}