{"id":"https://openalex.org/W4386001920","doi":"https://doi.org/10.1186/s12931-023-02498-z","title":"Polo-like kinase 1 promotes pulmonary hypertension","display_name":"Polo-like kinase 1 promotes pulmonary hypertension","publication_year":2023,"publication_date":"2023-08-19","ids":{"openalex":"https://openalex.org/W4386001920","doi":"https://doi.org/10.1186/s12931-023-02498-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/37598171","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10440037"},"language":"en","primary_location":{"id":"doi:10.1186/s12931-023-02498-z","doi":"https://doi.org/10.1186/s12931-023-02498-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12931-023-02498-z","pdf_url":"https://respiratory-research.biomedcentral.com/counter/pdf/10.1186/s12931-023-02498-z","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://respiratory-research.biomedcentral.com/counter/pdf/10.1186/s12931-023-02498-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Rongrong Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongrong Chen","raw_affiliation_strings":["State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100449116","display_name":"Hongfei Wang","orcid":"https://orcid.org/0000-0002-8162-9243","observed_orcids":["https://orcid.org/0000-0002-8162-9243"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongfei Wang","raw_affiliation_strings":["Department of Cardiac Surgery, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071091196","display_name":"Cuiting Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cuiting Zheng","raw_affiliation_strings":["Department of Pathology, Beijing Lab for Cardiovascular Precision Medicine, Key Laboratory of Medical Engineering for Cardiovascular Disease, Capital Medical University, Beijing, China","State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beijing Lab for Cardiovascular Precision Medicine, Key Laboratory of Medical Engineering for Cardiovascular Disease, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100768337","display_name":"Xiyu Zhang","orcid":"https://orcid.org/0000-0003-3244-3554","observed_orcids":["https://orcid.org/0000-0003-3244-3554"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiyu Zhang","raw_affiliation_strings":["Department of Pathology, Beijing Lab for Cardiovascular Precision Medicine, Key Laboratory of Medical Engineering for Cardiovascular Disease, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beijing Lab for Cardiovascular Precision Medicine, Key Laboratory of Medical Engineering for Cardiovascular Disease, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100361279","display_name":"Li Li","orcid":"https://orcid.org/0000-0002-9496-2280","observed_orcids":["https://orcid.org/0000-0002-9496-2280","https://orcid.org/0000-0001-5622-7333"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Li","raw_affiliation_strings":["State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100439220","display_name":"Shengwei Wang","orcid":"https://orcid.org/0000-0002-3001-4943","observed_orcids":["https://orcid.org/0000-0002-3001-4943"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengwei Wang","raw_affiliation_strings":["Department of Cardiac Surgery, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hongyu Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyu Chen","raw_affiliation_strings":["State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101559120","display_name":"Jing Duan","orcid":"https://orcid.org/0000-0001-5557-6881","observed_orcids":["https://orcid.org/0000-0001-5557-6881"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Duan","raw_affiliation_strings":["State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xian Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xian Zhou","raw_affiliation_strings":["State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088287990","display_name":"Haiyong Peng","orcid":"https://orcid.org/0000-0003-0312-1337","observed_orcids":["https://orcid.org/0000-0003-0312-1337"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyong Peng","raw_affiliation_strings":["State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jing Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Guo","raw_affiliation_strings":["State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048085916","display_name":"Anchen Zhang","orcid":"https://orcid.org/0000-0003-4542-4440","observed_orcids":["https://orcid.org/0000-0003-4542-4440"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anchen Zhang","raw_affiliation_strings":["Department of Cardiac Surgery, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037248070","display_name":"Feifei Li","orcid":"https://orcid.org/0000-0003-1737-3172","observed_orcids":["https://orcid.org/0000-0003-1737-3172"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feifei Li","raw_affiliation_strings":["Department of Cardiac Surgery, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100785737","display_name":"Wang Wang","orcid":"https://orcid.org/0000-0001-9093-412X","observed_orcids":["https://orcid.org/0000-0001-9093-412X"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wang Wang","raw_affiliation_strings":["Department of Physiology, Capital Medical University, Beijing, China","Department of Cardiac Surgery, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"Department of Cardiac Surgery, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063077523","display_name":"Yu Zhang","orcid":"https://orcid.org/0000-0002-2614-5975","observed_orcids":["https://orcid.org/0000-0002-2614-5975"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767655","display_name":"State Key Laboratory of Molecular Oncology","ror":"https://ror.org/014gmtw23","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210141458","https://openalex.org/I4391767655"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Zhang","raw_affiliation_strings":["State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","Department of Pathology, Beijing Lab for Cardiovascular Precision Medicine, Key Laboratory of Medical Engineering for Cardiovascular Disease, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767655"]},{"raw_affiliation_string":"Department of Pathology, Beijing Lab for Cardiovascular Precision Medicine, Key Laboratory of Medical Engineering for Cardiovascular Disease, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100384761","display_name":"Jun Wang","orcid":"https://orcid.org/0000-0002-5470-4631","observed_orcids":["https://orcid.org/0000-0002-5470-4631"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Wang","raw_affiliation_strings":["Department of Physiology, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092178027","display_name":"Chen Wang","orcid":"https://orcid.org/0009-0001-7218-318X","observed_orcids":["https://orcid.org/0009-0001-7218-318X"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Wang","raw_affiliation_strings":["State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102737885","display_name":"Yan Meng","orcid":"https://orcid.org/0000-0002-0002-6038","observed_orcids":["https://orcid.org/0000-0002-0002-6038"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Meng","raw_affiliation_strings":["Department of Pathology, Beijing Lab for Cardiovascular Precision Medicine, Key Laboratory of Medical Engineering for Cardiovascular Disease, Capital Medical University, Beijing, China. yanmeng_my@ccmu.edu.cn","Department of Pathology, Beijing Lab for Cardiovascular Precision Medicine, Key Laboratory of Medical Engineering for Cardiovascular Disease, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beijing Lab for Cardiovascular Precision Medicine, Key Laboratory of Medical Engineering for Cardiovascular Disease, Capital Medical University, Beijing, China. yanmeng_my@ccmu.edu.cn","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"Department of Pathology, Beijing Lab for Cardiovascular Precision Medicine, Key Laboratory of Medical Engineering for Cardiovascular Disease, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102224615","display_name":"Xinling Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xinling Du","raw_affiliation_strings":["Department of Cardiac Surgery, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. xinlingdu@hust.edu.cn","Department of Cardiac Surgery, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. xinlingdu@hust.edu.cn","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]},{"raw_affiliation_string":"Department of Cardiac Surgery, Institute of Cardiovascular Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100656977","display_name":"Hongbing Zhang","orcid":"https://orcid.org/0000-0001-6291-1027","observed_orcids":["https://orcid.org/0000-0001-6291-1027","https://orcid.org/0000-0001-6644-9255"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4391767653","display_name":"Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences","ror":"https://ror.org/055qbch41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongbing Zhang","raw_affiliation_strings":["State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. hbzhang@ibms.pumc.edu.cn","State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. hbzhang@ibms.pumc.edu.cn","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]},{"raw_affiliation_string":"State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Department of Physiology, Institute of Basic Medical Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4391767653"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100656977","https://openalex.org/A5102224615","https://openalex.org/A5102737885"],"corresponding_institution_ids":["https://openalex.org/I183519381","https://openalex.org/I200296433","https://openalex.org/I4210129222","https://openalex.org/I4391767653","https://openalex.org/I47720641"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":1.9634,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.86311987,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"24","issue":"1","first_page":"204","last_page":"204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plk1","display_name":"PLK1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.9610000252723694},{"id":"https://openalex.org/keywords/alveolar-hypoxia","display_name":"alveolar hypoxia","score":0.9319999814033508},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.8479999899864197},{"id":"https://openalex.org/keywords/rela","display_name":"RelA","score":0.972000002861023},{"id":"https://openalex.org/keywords/plk1-inhibitors","display_name":"PLK1 inhibitors","score":0.8820000290870667},{"id":"https://openalex.org/keywords/bi-2536","display_name":"BI2536","score":0.9520000219345093},{"id":"https://openalex.org/keywords/pulmonary-artery-smooth-muscle-cells","display_name":"pulmonary artery smooth muscle cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/mitotic-regulators","display_name":"mitotic regulators","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C146276462","wikidata":"https://www.wikidata.org/wiki/Q21131841","display_name":"PLK1","level":4,"score":0.8005831241607666},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7443479299545288},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.6814146637916565},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5483291149139404},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42626258730888367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3912528455257416},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3673560619354248},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30339550971984863},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2798815369606018},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2546774744987488},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1882680058479309},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.1742294728755951},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.12482950091362},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.06933361291885376},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000097869","descriptor_name":"Polo-Like Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12931-023-02498-z","doi":"https://doi.org/10.1186/s12931-023-02498-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12931-023-02498-z","pdf_url":"https://respiratory-research.biomedcentral.com/counter/pdf/10.1186/s12931-023-02498-z","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10440037","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10440037","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10440037/pdf/12931_2023_Article_2498.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respir Res","raw_type":"Text"},{"id":"pmid:37598171","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37598171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b48611da284a49b3adfca50cf5e3ebbe","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b48611da284a49b3adfca50cf5e3ebbe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Respiratory Research, Vol 24, Iss 1, Pp 1-16 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12931-023-02498-z","doi":"https://doi.org/10.1186/s12931-023-02498-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12931-023-02498-z","pdf_url":"https://respiratory-research.biomedcentral.com/counter/pdf/10.1186/s12931-023-02498-z","source":{"id":"https://openalex.org/S186153782","display_name":"Respiratory Research","issn_l":"1465-9921","issn":["1465-9921","1465-993X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1890183734","display_name":null,"funder_award_id":"2021-I2M-1-049","funder_id":"https://openalex.org/F4320323137","funder_display_name":"Chinese Academy of Medical Sciences"},{"id":"https://openalex.org/G2137745768","display_name":"Rho GDI\u901a\u8fc7T\u6dcb\u5df4\u7ec6\u80de\u8c03\u8282\u9ad8\u8840\u538b\u53d1\u751f\u7684\u75c5\u7406\u751f\u7406\u673a\u5236","funder_award_id":"81670380","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4888196815","display_name":null,"funder_award_id":"2021YFC2500700","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323137","display_name":"Chinese Academy of Medical Sciences","ror":"https://ror.org/03cve4549"},{"id":"https://openalex.org/F4320326853","display_name":"Peking Union Medical College","ror":"https://ror.org/02drdmm93"},{"id":"https://openalex.org/F4320335783","display_name":"China-Japan Friendship Hospital","ror":"https://ror.org/037cjxp13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4386001920.pdf","grobid_xml":"https://content.openalex.org/works/W4386001920.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W293495194","https://openalex.org/W1863597969","https://openalex.org/W1967980682","https://openalex.org/W1972392879","https://openalex.org/W1980111004","https://openalex.org/W2019784830","https://openalex.org/W2029108033","https://openalex.org/W2036238945","https://openalex.org/W2040825881","https://openalex.org/W2079353906","https://openalex.org/W2089137356","https://openalex.org/W2091960020","https://openalex.org/W2098368231","https://openalex.org/W2102419092","https://openalex.org/W2103154710","https://openalex.org/W2116715687","https://openalex.org/W2119979409","https://openalex.org/W2121208012","https://openalex.org/W2128213692","https://openalex.org/W2137542804","https://openalex.org/W2138408725","https://openalex.org/W2140364596","https://openalex.org/W2158094911","https://openalex.org/W2160833360","https://openalex.org/W2162121911","https://openalex.org/W2166825418","https://openalex.org/W2231303906","https://openalex.org/W2347151465","https://openalex.org/W2407059413","https://openalex.org/W2433384223","https://openalex.org/W2511170343","https://openalex.org/W2518911298","https://openalex.org/W2521303659","https://openalex.org/W2522325334","https://openalex.org/W2562390400","https://openalex.org/W2735253422","https://openalex.org/W2767793022","https://openalex.org/W2775830363","https://openalex.org/W2789769541","https://openalex.org/W2791919196","https://openalex.org/W2793282665","https://openalex.org/W2794636105","https://openalex.org/W2808535852","https://openalex.org/W2809566874","https://openalex.org/W2870127380","https://openalex.org/W2884470297","https://openalex.org/W2888085831","https://openalex.org/W2890764600","https://openalex.org/W2905582258","https://openalex.org/W2942931819","https://openalex.org/W2946660965","https://openalex.org/W2964652143","https://openalex.org/W2996734298","https://openalex.org/W2998979631","https://openalex.org/W3030387378","https://openalex.org/W3081354116","https://openalex.org/W3083382503","https://openalex.org/W3089284867","https://openalex.org/W3091312213","https://openalex.org/W3092416032","https://openalex.org/W3107412563","https://openalex.org/W3138163117","https://openalex.org/W3192883323","https://openalex.org/W3197904135","https://openalex.org/W3208137674","https://openalex.org/W4221134463","https://openalex.org/W4287654898","https://openalex.org/W4296468274","https://openalex.org/W4323535268","https://openalex.org/W4362581039","https://openalex.org/W6660802088","https://openalex.org/W6801078203","https://openalex.org/W6925145776"],"related_works":["https://openalex.org/W2983883957","https://openalex.org/W2082363584","https://openalex.org/W2947081378","https://openalex.org/W2054627346","https://openalex.org/W4395042932","https://openalex.org/W38744719","https://openalex.org/W2179762441","https://openalex.org/W6886121218","https://openalex.org/W2164391088","https://openalex.org/W2366689785"],"abstract_inverted_index":{"BACKGROUND:":[0],"Pulmonary":[1],"hypertension":[2],"(PH)":[3],"is":[4,136,144],"a":[5,145],"lethal":[6],"vascular":[7],"disease":[8],"with":[9,49,116],"limited":[10],"therapeutic":[11],"options.":[12],"The":[13,25],"mechanistic":[14],"connections":[15],"between":[16],"alveolar":[17],"hypoxia":[18,66],"and":[19,56,83,88,113,143],"PH":[20,43,76,130,142],"are":[21],"not":[22],"well":[23],"understood.":[24],"aim":[26],"of":[27,35,65,97,102,111,119,141],"this":[28],"study":[29],"was":[30,72],"to":[31,61,74,124],"investigate":[32,62],"the":[33,63,95,100,139],"role":[34],"mitotic":[36],"regulator":[37],"Polo-like":[38],"kinase":[39],"1":[40],"(PLK1)":[41],"in":[42,77,99,131],"development.":[44],"METHODS:":[45],"Mouse":[46],"lungs":[47],"along":[48],"human":[50],"pulmonary":[51],"arterial":[52],"smooth":[53],"muscle":[54],"cells":[55,58],"endothelial":[57],"were":[59,92,121],"used":[60],"effects":[64],"on":[67],"PLK1.":[68],"Hypoxia-":[69],"or":[70],"Sugen5416/hypoxia":[71],"applied":[73],"induce":[75],"mice.":[78,132],"Plk1":[79,120],"heterozygous":[80,117],"knockout":[81],"mice":[82,91],"PLK1":[84,98,107,127,135],"inhibitors":[85,128],"(BI":[86],"2536":[87],"BI":[89],"6727)-treated":[90],"checked":[93],"for":[94,138,148],"significance":[96],"development":[101,140],"PH.":[103,126,149],"RESULTS:":[104],"Hypoxia":[105],"stimulated":[106],"expression":[108],"through":[109],"induction":[110],"HIF1\u03b1":[112],"RELA.":[114],"Mice":[115],"deletion":[118],"partially":[122],"resistant":[123],"hypoxia-induced":[125],"ameliorated":[129],"CONCLUSIONS:":[133],"Augmented":[134],"essential":[137],"druggable":[146],"target":[147]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-08-20T00:00:00"}
