{"id":"https://openalex.org/W4385997307","doi":"https://doi.org/10.1002/biot.202300180","title":"Multiomics analysis reveals the biological effects of live Roseburia intestinalis as a high\u2010butyrate\u2010producing bacterium in human intestinal epithelial cells","display_name":"Multiomics analysis reveals the biological effects of live Roseburia intestinalis as a high\u2010butyrate\u2010producing bacterium in human intestinal epithelial cells","publication_year":2023,"publication_date":"2023-08-19","ids":{"openalex":"https://openalex.org/W4385997307","doi":"https://doi.org/10.1002/biot.202300180","pmid":"https://pubmed.ncbi.nlm.nih.gov/37596881"},"language":"en","primary_location":{"id":"doi:10.1002/biot.202300180","doi":"https://doi.org/10.1002/biot.202300180","is_oa":true,"landing_page_url":"https://doi.org/10.1002/biot.202300180","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/biot.202300180","source":{"id":"https://openalex.org/S31411064","display_name":"Biotechnology Journal","issn_l":"1860-6768","issn":["1860-6768","1860-7314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/biot.202300180","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005093901","display_name":"Won\u2010Suk Song","orcid":"https://orcid.org/0000-0003-1590-5649","observed_orcids":["https://orcid.org/0000-0003-1590-5649"]},"institutions":[{"id":"https://openalex.org/I141371507","display_name":"Soongsil University","ror":"https://ror.org/017xnm587","country_code":"KR","type":"education","lineage":["https://openalex.org/I141371507"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Won\u2010Suk Song","raw_affiliation_strings":["Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I141371507"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sung\u2010Hyun Jo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141371507","display_name":"Soongsil University","ror":"https://ror.org/017xnm587","country_code":"KR","type":"education","lineage":["https://openalex.org/I141371507"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung\u2010Hyun Jo","raw_affiliation_strings":["Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I141371507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100694896","display_name":"Jae\u2010Seung Lee","orcid":"https://orcid.org/0000-0002-8571-0663","observed_orcids":["https://orcid.org/0000-0002-8571-0663"]},"institutions":[{"id":"https://openalex.org/I141371507","display_name":"Soongsil University","ror":"https://ror.org/017xnm587","country_code":"KR","type":"education","lineage":["https://openalex.org/I141371507"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae\u2010Seung Lee","raw_affiliation_strings":["Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I141371507"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ji\u2010Eun Kwon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141371507","display_name":"Soongsil University","ror":"https://ror.org/017xnm587","country_code":"KR","type":"education","lineage":["https://openalex.org/I141371507"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji\u2010Eun Kwon","raw_affiliation_strings":["Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I141371507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035504752","display_name":"Ji\u2010Hyeon Park","orcid":"https://orcid.org/0000-0002-6811-8895","observed_orcids":["https://orcid.org/0000-0002-6811-8895"]},"institutions":[{"id":"https://openalex.org/I141371507","display_name":"Soongsil University","ror":"https://ror.org/017xnm587","country_code":"KR","type":"education","lineage":["https://openalex.org/I141371507"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji\u2010Hyeon Park","raw_affiliation_strings":["Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I141371507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113984001","display_name":"Ye\u2010Rim Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141371507","display_name":"Soongsil University","ror":"https://ror.org/017xnm587","country_code":"KR","type":"education","lineage":["https://openalex.org/I141371507"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ye\u2010Rim Kim","raw_affiliation_strings":["Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I141371507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056870193","display_name":"Ji\u2010Hyun Baek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141371507","display_name":"Soongsil University","ror":"https://ror.org/017xnm587","country_code":"KR","type":"education","lineage":["https://openalex.org/I141371507"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji\u2010Hyun Baek","raw_affiliation_strings":["Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I141371507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100383151","display_name":"Min Kim","orcid":"https://orcid.org/0000-0001-8938-700X","observed_orcids":["https://orcid.org/0000-0001-8938-700X"]},"institutions":[{"id":"https://openalex.org/I141371507","display_name":"Soongsil University","ror":"https://ror.org/017xnm587","country_code":"KR","type":"education","lineage":["https://openalex.org/I141371507"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min\u2010Gyu Kim","raw_affiliation_strings":["Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I141371507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055381228","display_name":"Seo\u2010Young Kwon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141371507","display_name":"Soongsil University","ror":"https://ror.org/017xnm587","country_code":"KR","type":"education","lineage":["https://openalex.org/I141371507"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seo\u2010Young Kwon","raw_affiliation_strings":["Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I141371507"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011272746","display_name":"Yun\u2010Gon Kim","orcid":"https://orcid.org/0000-0001-7388-2989","observed_orcids":["https://orcid.org/0000-0001-7388-2989"]},"institutions":[{"id":"https://openalex.org/I141371507","display_name":"Soongsil University","ror":"https://ror.org/017xnm587","country_code":"KR","type":"education","lineage":["https://openalex.org/I141371507"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yun\u2010Gon Kim","raw_affiliation_strings":["Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Soongsil University, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I141371507"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011272746"],"corresponding_institution_ids":["https://openalex.org/I141371507"],"apc_list":{"value":4330,"currency":"USD","value_usd":4330},"apc_paid":null,"fwci":1.9511,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.87247628,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"18","issue":"12","first_page":"e2300180","last_page":"e2300180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.8076000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.1881999969482422,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/roseburia-intestinalis","display_name":"Roseburia intestinalis","score":1.0},{"id":"https://openalex.org/keywords/butyrate-producing-bacteria","display_name":"butyrate-producing bacteria","score":0.8920000195503235},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.8339999914169312},{"id":"https://openalex.org/keywords/tight-junction-proteins","display_name":"tight junction proteins","score":0.7120000123977661},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.9049999713897705},{"id":"https://openalex.org/keywords/host-microbe-interactions","display_name":"host-microbe interactions","score":0.9340000152587891},{"id":"https://openalex.org/keywords/purine-metabolism","display_name":"purine metabolism","score":0.9739999771118164},{"id":"https://openalex.org/keywords/atp-content","display_name":"ATP levels","score":0.6430000066757202},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.628000020980835},{"id":"https://openalex.org/keywords/heat-killed-bacteria","display_name":"heat-killed bacteria","score":0.8230000138282776},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.5659999847412109},{"id":"https://openalex.org/keywords/gut-health","display_name":"gut health","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C2776706654","wikidata":"https://www.wikidata.org/wiki/Q3941444","display_name":"Roseburia","level":4,"score":0.8255188465118408},{"id":"https://openalex.org/C2776979534","wikidata":"https://www.wikidata.org/wiki/Q193213","display_name":"Butyrate","level":3,"score":0.820143461227417},{"id":"https://openalex.org/C2775980262","wikidata":"https://www.wikidata.org/wiki/Q218870","display_name":"Prebiotic","level":2,"score":0.7089382410049438},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.698058545589447},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6251730918884277},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.5339573621749878},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5105432271957397},{"id":"https://openalex.org/C2780675110","wikidata":"https://www.wikidata.org/wiki/Q3738294","display_name":"Faecalibacterium prausnitzii","level":3,"score":0.42947983741760254},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23530858755111694},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.16295263171195984},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.15311041474342346},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068016","descriptor_name":"Eubacteriales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002087","descriptor_name":"Butyrates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056692","descriptor_name":"Prebiotics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/biot.202300180","doi":"https://doi.org/10.1002/biot.202300180","is_oa":true,"landing_page_url":"https://doi.org/10.1002/biot.202300180","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/biot.202300180","source":{"id":"https://openalex.org/S31411064","display_name":"Biotechnology Journal","issn_l":"1860-6768","issn":["1860-6768","1860-7314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Journal","raw_type":"journal-article"},{"id":"pmid:37596881","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37596881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/biot.202300180","doi":"https://doi.org/10.1002/biot.202300180","is_oa":true,"landing_page_url":"https://doi.org/10.1002/biot.202300180","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/biot.202300180","source":{"id":"https://openalex.org/S31411064","display_name":"Biotechnology Journal","issn_l":"1860-6768","issn":["1860-6768","1860-7314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G106703884","display_name":null,"funder_award_id":"NRF-2019M2C8A2058418","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G1166832996","display_name":null,"funder_award_id":"NRF\u20102020R1A6A1A03044977","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G3664472441","display_name":null,"funder_award_id":"NRF-2022R1F1A1073595","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G3849781155","display_name":null,"funder_award_id":"2020R1A6A1A03044977","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4489634976","display_name":null,"funder_award_id":"NRF-2017M3A9E4077235","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385997307.pdf","grobid_xml":"https://content.openalex.org/works/W4385997307.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1982301017","https://openalex.org/W1991497480","https://openalex.org/W2000067794","https://openalex.org/W2004506978","https://openalex.org/W2028905487","https://openalex.org/W2029180586","https://openalex.org/W2085175109","https://openalex.org/W2087156692","https://openalex.org/W2095625773","https://openalex.org/W2098838735","https://openalex.org/W2104423086","https://openalex.org/W2127533496","https://openalex.org/W2135547086","https://openalex.org/W2136759951","https://openalex.org/W2140207977","https://openalex.org/W2140813866","https://openalex.org/W2140937256","https://openalex.org/W2141125135","https://openalex.org/W2141320958","https://openalex.org/W2155770880","https://openalex.org/W2156868373","https://openalex.org/W2168638243","https://openalex.org/W2236332835","https://openalex.org/W2409656339","https://openalex.org/W2463195069","https://openalex.org/W2465534016","https://openalex.org/W2540503396","https://openalex.org/W2544360569","https://openalex.org/W2552041992","https://openalex.org/W2608502548","https://openalex.org/W2730479429","https://openalex.org/W2753989388","https://openalex.org/W2769632036","https://openalex.org/W2789847797","https://openalex.org/W2794931727","https://openalex.org/W2804621837","https://openalex.org/W2806346859","https://openalex.org/W2889977344","https://openalex.org/W2898905022","https://openalex.org/W2900352306","https://openalex.org/W2905800799","https://openalex.org/W2917101543","https://openalex.org/W2933766001","https://openalex.org/W2948160364","https://openalex.org/W2995878355","https://openalex.org/W2996107661","https://openalex.org/W3084294713","https://openalex.org/W3092171925","https://openalex.org/W3120351176","https://openalex.org/W3212258323","https://openalex.org/W4200378328","https://openalex.org/W4213257179","https://openalex.org/W4224739819","https://openalex.org/W4294190738","https://openalex.org/W4296106410"],"related_works":["https://openalex.org/W4296106410","https://openalex.org/W4254127430","https://openalex.org/W4309033875","https://openalex.org/W7165049864","https://openalex.org/W3154776124","https://openalex.org/W2050920580","https://openalex.org/W7096417405","https://openalex.org/W4385232541","https://openalex.org/W4388899438","https://openalex.org/W133889051"],"abstract_inverted_index":{"Butyrate-producing":[0],"bacteria":[1,33,80,167],"play":[2],"a":[3,67,183],"key":[4],"role":[5],"in":[6,15,34,40,104,123,159],"human":[7,36,77,105,119,160],"health,":[8],"and":[9,47,65,85,102,151],"recent":[10],"studies":[11],"have":[12],"triggered":[13],"interest":[14],"their":[16,48],"development":[17],"as":[18,182],"next-generation":[19,184],"probiotics.":[20],"However,":[21],"there":[22],"remains":[23],"limited":[24],"knowledge":[25],"not":[26],"only":[27,147],"on":[28],"the":[29,35,41,51,93,124,133,152],"identification":[30],"of":[31,63,70,96],"high-butyrate-producing":[32],"gut":[37],"but":[38,164],"also":[39],"metabolic":[42],"capacities":[43],"for":[44],"prebiotic":[45,71],"carbohydrates":[46],"interaction":[49,128],"with":[50,75,118],"host.":[52],"Herein,":[53],"it":[54,140],"was":[55,116,141],"discovered":[56,142],"that":[57,143,165,175],"Roseburia":[58,86],"intestinalis":[59,90,115,146,177],"produces":[60],"higher":[61],"levels":[62,158],"butyrate":[64],"digests":[66],"wider":[68],"variety":[69],"polysaccharide":[72],"structures":[73],"compared":[74],"other":[76,111],"major":[78],"butyrate-producing":[79,112],"(Eubacterium":[81],"rectale,":[82],"Faecalibacterium":[83],"prausnitzii,":[84],"hominis).":[87],"Moreover,":[88],"R.":[89,114,145,176],"extracts":[91],"upregulated":[92],"mRNA":[94],"expression":[95],"tight":[97],"junction":[98],"proteins":[99],"(TJP1,":[100],"OCLN,":[101],"CLDN3)":[103],"intestinal":[106,120,126,161,189],"epithelial":[107,121,162],"cells":[108,122],"more":[109],"than":[110],"bacteria.":[113],"cultured":[117],"mimetic":[125],"host-microbe":[127],"coculture":[129],"system":[130],"to":[131,186],"explore":[132],"health-promoting":[134],"effects":[135],"using":[136],"multiomics":[137],"approaches.":[138],"Consequently,":[139],"live":[144],"enhances":[148],"purine":[149],"metabolism":[150],"oxidative":[153],"pathway,":[154],"increasing":[155],"adenosine":[156],"triphosphate":[157],"cells,":[163],"heat-killed":[166],"had":[168],"no":[169],"effect.":[170],"Therefore,":[171],"this":[172],"study":[173],"proposes":[174],"has":[178],"potentially":[179],"high":[180],"value":[181],"probiotic":[185],"promote":[187],"host":[188],"health.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-08-20T00:00:00"}