{"id":"https://openalex.org/W4385989296","doi":"https://doi.org/10.1093/noajnl/vdad070.028","title":"CLRM-05 ADAPTATION OF NEW CLASSIFICATION OF ASTROCYTOMA IN LOW AND MIDDLE INCOME COUNTRY- HOW SMOOTH IS THE ROAD AHEAD?","display_name":"CLRM-05 ADAPTATION OF NEW CLASSIFICATION OF ASTROCYTOMA IN LOW AND MIDDLE INCOME COUNTRY- HOW SMOOTH IS THE ROAD AHEAD?","publication_year":2023,"publication_date":"2023-08-01","ids":{"openalex":"https://openalex.org/W4385989296","doi":"https://doi.org/10.1093/noajnl/vdad070.028","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10402444"},"language":"en","primary_location":{"id":"doi:10.1093/noajnl/vdad070.028","doi":"https://doi.org/10.1093/noajnl/vdad070.028","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdad070.028","pdf_url":"https://academic.oup.com/noa/article-pdf/5/Supplement_3/iii8/51037888/vdad070.028.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/noa/article-pdf/5/Supplement_3/iii8/51037888/vdad070.028.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104071701","display_name":"Roshani Shrestha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153195","display_name":"Kathmandu Cancer Center","ror":"https://ror.org/04shkzd26","country_code":"NP","type":"healthcare","lineage":["https://openalex.org/I4387153195"]}],"countries":["NP"],"is_corresponding":false,"raw_author_name":"Roshani Shrestha","raw_affiliation_strings":["Kathmandu Cancer Center , Bhaktapur , Nepal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kathmandu Cancer Center , Bhaktapur , Nepal","institution_ids":["https://openalex.org/I4387153195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018244210","display_name":"Simit Sapkota","orcid":"https://orcid.org/0000-0002-6290-4318","observed_orcids":["https://orcid.org/0000-0002-6290-4318","https://orcid.org/0009-0003-0370-2104"]},"institutions":[{"id":"https://openalex.org/I4387153195","display_name":"Kathmandu Cancer Center","ror":"https://ror.org/04shkzd26","country_code":"NP","type":"healthcare","lineage":["https://openalex.org/I4387153195"]}],"countries":["NP"],"is_corresponding":false,"raw_author_name":"Simit Sapkota","raw_affiliation_strings":["Kathmandu Cancer Center , Bhaktapur , Nepal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kathmandu Cancer Center , Bhaktapur , Nepal","institution_ids":["https://openalex.org/I4387153195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085277589","display_name":"Abish Adhikari","orcid":"https://orcid.org/0009-0001-0985-0197","observed_orcids":["https://orcid.org/0009-0001-0985-0197"]},"institutions":[{"id":"https://openalex.org/I4387153195","display_name":"Kathmandu Cancer Center","ror":"https://ror.org/04shkzd26","country_code":"NP","type":"healthcare","lineage":["https://openalex.org/I4387153195"]}],"countries":["NP"],"is_corresponding":false,"raw_author_name":"Abish Adhikari","raw_affiliation_strings":["Kathmandu Cancer Center , Bhaktapur , Nepal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kathmandu Cancer Center , Bhaktapur , Nepal","institution_ids":["https://openalex.org/I4387153195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080720474","display_name":"Subhas Pandit","orcid":"https://orcid.org/0000-0002-8992-5194","observed_orcids":["https://orcid.org/0000-0002-8992-5194"]},"institutions":[{"id":"https://openalex.org/I4387153195","display_name":"Kathmandu Cancer Center","ror":"https://ror.org/04shkzd26","country_code":"NP","type":"healthcare","lineage":["https://openalex.org/I4387153195"]}],"countries":["NP"],"is_corresponding":false,"raw_author_name":"Subhas Pandit","raw_affiliation_strings":["Kathmandu Cancer Center , Bhaktapur , Nepal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kathmandu Cancer Center , Bhaktapur , Nepal","institution_ids":["https://openalex.org/I4387153195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106823522","display_name":"Anjani Kumar Jha","orcid":"https://orcid.org/0009-0002-7134-4540","observed_orcids":["https://orcid.org/0009-0002-7134-4540","https://orcid.org/0000-0002-9579-7176"]},"institutions":[{"id":"https://openalex.org/I4387153195","display_name":"Kathmandu Cancer Center","ror":"https://ror.org/04shkzd26","country_code":"NP","type":"healthcare","lineage":["https://openalex.org/I4387153195"]}],"countries":["NP"],"is_corresponding":false,"raw_author_name":"Anjani Jha","raw_affiliation_strings":["Kathmandu Cancer Center , Bhaktapur , Nepal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kathmandu Cancer Center , Bhaktapur , Nepal","institution_ids":["https://openalex.org/I4387153195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043306348","display_name":"Prakriti Karki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153195","display_name":"Kathmandu Cancer Center","ror":"https://ror.org/04shkzd26","country_code":"NP","type":"healthcare","lineage":["https://openalex.org/I4387153195"]}],"countries":["NP"],"is_corresponding":false,"raw_author_name":"Prakriti Karki","raw_affiliation_strings":["Kathmandu Cancer Center , Bhaktapur , Nepal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kathmandu Cancer Center , Bhaktapur , Nepal","institution_ids":["https://openalex.org/I4387153195"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4387153195"],"apc_list":{"value":2371,"currency":"USD","value_usd":2371},"apc_paid":{"value":2371,"currency":"USD","value_usd":2371},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"Supplement_3","first_page":"iii8","last_page":"iii8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astrocytoma","display_name":"astrocytoma","score":0.9760000109672546},{"id":"https://openalex.org/keywords/who-2021-cns-tumor-classification","display_name":"WHO 2021 CNS tumor classification","score":0.8299999833106995},{"id":"https://openalex.org/keywords/idh-mutation","display_name":"IDH mutation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/atrx-loss","display_name":"ATRX loss","score":0.8650000095367432},{"id":"https://openalex.org/keywords/1p-19q-codeletion","display_name":"1p/19q codeletion","score":0.9729999899864197},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9290000200271606},{"id":"https://openalex.org/keywords/low-grade-glioma","display_name":"low-grade glioma","score":0.7360000014305115},{"id":"https://openalex.org/keywords/molecular-profiling","display_name":"molecular profiling","score":0.6290000081062317},{"id":"https://openalex.org/keywords/resource-limited-settings","display_name":"resource-limited settings","score":0.7260000109672546},{"id":"https://openalex.org/keywords/nepal","display_name":"Nepal","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C2776689207","wikidata":"https://www.wikidata.org/wiki/Q17835753","display_name":"ATRX","level":4,"score":0.9913074970245361},{"id":"https://openalex.org/C2777931997","wikidata":"https://www.wikidata.org/wiki/Q1318384","display_name":"Oligodendroglioma","level":4,"score":0.7565336227416992},{"id":"https://openalex.org/C2778880634","wikidata":"https://www.wikidata.org/wiki/Q177755","display_name":"Astrocytoma","level":3,"score":0.5930187702178955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5410363674163818},{"id":"https://openalex.org/C127848430","wikidata":"https://www.wikidata.org/wiki/Q18027543","display_name":"IDH1","level":4,"score":0.5184709429740906},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5071930885314941},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5020020008087158},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.4916113018989563},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4894072115421295},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.4802406430244446},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.31422293186187744},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.3015928268432617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2400917112827301},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2301473319530487},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.20397421717643738},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15263181924819946},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10777989029884338}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/noajnl/vdad070.028","doi":"https://doi.org/10.1093/noajnl/vdad070.028","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdad070.028","pdf_url":"https://academic.oup.com/noa/article-pdf/5/Supplement_3/iii8/51037888/vdad070.028.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10402444","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10402444","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10402444/pdf/vdad070.028.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurooncol Adv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/noajnl/vdad070.028","doi":"https://doi.org/10.1093/noajnl/vdad070.028","is_oa":true,"landing_page_url":"https://doi.org/10.1093/noajnl/vdad070.028","pdf_url":"https://academic.oup.com/noa/article-pdf/5/Supplement_3/iii8/51037888/vdad070.028.pdf","source":{"id":"https://openalex.org/S4210237914","display_name":"Neuro-Oncology Advances","issn_l":"2632-2498","issn":["2632-2498"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385989296.pdf","grobid_xml":"https://content.openalex.org/works/W4385989296.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4411118508","https://openalex.org/W4313554837","https://openalex.org/W4281757010","https://openalex.org/W7170358968","https://openalex.org/W4200577642","https://openalex.org/W4399264996","https://openalex.org/W2607969913","https://openalex.org/W2896677271","https://openalex.org/W3206402529","https://openalex.org/W4281996163"],"abstract_inverted_index":{"Abstract":[0],"BACKGROUND":[1],"The":[2,91,106],"2021":[3,85],"WHO":[4],"CNS":[5],"5":[6,244],"classification":[7,167],"made":[8],"major":[9],"changes":[10],"with":[11,82,128,217],"integration":[12],"of":[13,33,58,64,144,153,178,187,203,223,254,289],"immunohistochemistry,":[14],"molecular":[15,77],"profiling":[16],"and":[17,37,56,113,115,118,125,130,139,196,214,225,273],"sequencing":[18],"in":[19,47,79,84,86,181,260,270,283],"addition":[20],"to":[21,23,42,66,74,173],"histopathology":[22],"classify":[24],"brain":[25],"tumors.":[26],"IDH":[27,124,148,157,176,193,206,218,255,266],"mutation":[28,127],"is":[29],"mainstay":[30],"for":[31,165],"diagnosis":[32,57],"low":[34],"grade":[35,137,212],"glioma":[36],"1p/19q":[38,237],"testing":[39,164],"required":[40,162],"only":[41,234],"confirm":[43],"oligodendroglioma":[44],"but":[45,168],"not":[46,246,281],"all":[48],"cases.":[49],"This":[50,121],"integrated":[51],"approach":[52],"has":[53],"favored":[54],"prognosis,":[55],"disease":[59],"as":[60,62,110,198],"well":[61],"prediction":[63],"response":[65],"therapy.":[67],"METHODS":[68],"A":[69],"retrospective":[70],"study":[71,122],"was":[72,184,208,241,258],"conducted":[73],"analyze":[75],"the":[76,97,102,188,204,265],"alterations":[78],"patients":[80,107,152,205,233],"diagnosed":[81],"astrocytoma":[83],"Kathmandu":[87],"Cancer":[88],"Center,":[89],"Nepal.":[90],"demographic":[92],"data":[93],"were":[94,108,147,156,192,245],"collected":[95],"from":[96,101],"patients\u2019":[98],"archived":[99],"files":[100],"medical":[103],"record":[104],"department.":[105],"categorized":[109],"IDH:":[111],"mutant":[112,149,267],"wild,":[114],"ATRX:":[116],"retained":[117],"lost.":[119],"RESULTS":[120],"demonstrated":[123],"ATRX":[126,224,228],"30.3%":[129],"24.23%":[131],"respectively.":[132],"In":[133,201,250],"our":[134],"study,":[135],"among":[136],"2":[138,151,213,220,272],"3":[140,215,274],"patients,":[141],"8":[142,211],"out":[143],"11":[145],"(72.7%)":[146],"types.":[150],"this":[154,182],"group":[155,183],"wild":[158,194,256],"type,":[159],"who":[160],"ideally":[161],"further":[163],"correct":[166],"couldn\u2019t":[169],"be":[170],"done":[171,239],"due":[172],"financial":[174],"constraints.":[175],"status":[177,207],"one":[179,235],"patient":[180],"unknown.":[185,209],"72.7%":[186],"Grade":[189,261,271],"4":[190,262],"gliomas":[191],"type":[195,257,268],"classified":[197],"Glioblastoma":[199],"Multiforme.":[200],"6":[202,226,232],"Among":[210,230],"tumors":[216],"mutant,":[219],"had":[221,227,236],"loss":[222],"retained.":[229],"these":[231],"co-deletion":[238],"which":[240],"positive.":[242],"Rests":[243],"properly":[247],"classified.":[248],"CONCLUSION":[249],"conclusion,":[251],"higher":[252],"percentage":[253],"seen":[259],"gliomas.":[263,275],"Similarly,":[264],"predominated":[269],"More":[276],"pronounced":[277],"investigations":[278],"are":[279],"still":[280],"feasible":[282],"low-":[284],"and-middle":[285],"income":[286],"countries":[287],"because":[288],"limited":[290],"resources.":[291]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2023-08-19T00:00:00"}