{"id":"https://openalex.org/W4385973294","doi":"https://doi.org/10.1016/j.onano.2023.100183","title":"Drug delivery systems of gefitinib for improved cancer therapy: A review","display_name":"Drug delivery systems of gefitinib for improved cancer therapy: A review","publication_year":2023,"publication_date":"2023-08-18","ids":{"openalex":"https://openalex.org/W4385973294","doi":"https://doi.org/10.1016/j.onano.2023.100183"},"language":"en","primary_location":{"id":"doi:10.1016/j.onano.2023.100183","doi":"https://doi.org/10.1016/j.onano.2023.100183","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.onano.2023.100183","pdf_url":null,"source":{"id":"https://openalex.org/S2898377343","display_name":"OpenNano","issn_l":"2352-9520","issn":["2352-9520"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OpenNano","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.onano.2023.100183","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092619432","display_name":"Deepak Nagdiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I94616015","display_name":"Punjab Technical University","ror":"https://ror.org/025kz2973","country_code":"IN","type":"education","lineage":["https://openalex.org/I94616015"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Deepak Nagdiya","raw_affiliation_strings":["Department of Quality Assurance, ISF College of Pharmacy, Moga, Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab-142001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quality Assurance, ISF College of Pharmacy, Moga, Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab-142001, India","institution_ids":["https://openalex.org/I94616015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080588119","display_name":"Manish Kumar","orcid":"https://orcid.org/0000-0003-2042-1243","observed_orcids":["https://orcid.org/0000-0003-2042-1243","https://orcid.org/0009-0006-6546-8888"]},"institutions":[{"id":"https://openalex.org/I94616015","display_name":"Punjab Technical University","ror":"https://ror.org/025kz2973","country_code":"IN","type":"education","lineage":["https://openalex.org/I94616015"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manish Kumar","raw_affiliation_strings":["Department of Pharmaceutics, ISF College of Pharmacy, Moga, Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab-142001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, ISF College of Pharmacy, Moga, Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab-142001, India","institution_ids":["https://openalex.org/I94616015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081731218","display_name":"Sanchit Arora","orcid":"https://orcid.org/0000-0002-1766-7974","observed_orcids":["https://orcid.org/0000-0002-1766-7974"]},"institutions":[{"id":"https://openalex.org/I94616015","display_name":"Punjab Technical University","ror":"https://ror.org/025kz2973","country_code":"IN","type":"education","lineage":["https://openalex.org/I94616015"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanchit Arora","raw_affiliation_strings":["Department of Pharmaceutics, ISF College of Pharmacy, Moga, Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab-142001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, ISF College of Pharmacy, Moga, Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab-142001, India","institution_ids":["https://openalex.org/I94616015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067395456","display_name":"Tania Bajaj","orcid":"https://orcid.org/0000-0002-0495-3058","observed_orcids":["https://orcid.org/0000-0002-0495-3058"]},"institutions":[{"id":"https://openalex.org/I94616015","display_name":"Punjab Technical University","ror":"https://ror.org/025kz2973","country_code":"IN","type":"education","lineage":["https://openalex.org/I94616015"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tania Bajaj","raw_affiliation_strings":["Department of Pharmaceutics, ISF College of Pharmacy, Moga, Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab-142001, India","Research Scholar, IK Gujral Punjab Technical University, Kapurthala, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, ISF College of Pharmacy, Moga, Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab-142001, India","institution_ids":["https://openalex.org/I94616015"]},{"raw_affiliation_string":"Research Scholar, IK Gujral Punjab Technical University, Kapurthala, Punjab, India","institution_ids":["https://openalex.org/I94616015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076699088","display_name":"Sima Kujur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I94616015","display_name":"Punjab Technical University","ror":"https://ror.org/025kz2973","country_code":"IN","type":"education","lineage":["https://openalex.org/I94616015"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sima Kujur","raw_affiliation_strings":["Department of Pharmaceutics, ISF College of Pharmacy, Moga, Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab-142001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, ISF College of Pharmacy, Moga, Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab-142001, India","institution_ids":["https://openalex.org/I94616015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109664945","display_name":"Prinsy Rana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155284866","display_name":"Maharishi Markandeshwar University, Mullana","ror":"https://ror.org/013qfkw58","country_code":"IN","type":"education","lineage":["https://openalex.org/I155284866"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prinsy Rana","raw_affiliation_strings":["M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala-133207, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala-133207, Haryana, India","institution_ids":["https://openalex.org/I155284866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068712584","display_name":"Arun Kumar","orcid":"https://orcid.org/0000-0002-7874-0469","observed_orcids":["https://orcid.org/0000-0002-7874-0469","https://orcid.org/0000-0002-5497-9678"]},"institutions":[{"id":"https://openalex.org/I343503978","display_name":"Central University of South Bihar","ror":"https://ror.org/01t1agx36","country_code":"IN","type":"education","lineage":["https://openalex.org/I343503978"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arun Kumar","raw_affiliation_strings":["Department of Pharmacy, School of Health Sciences, Central University of South Bihar, Gaya-824209, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, School of Health Sciences, Central University of South Bihar, Gaya-824209, India","institution_ids":["https://openalex.org/I343503978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043413263","display_name":"Arti Singh","orcid":"https://orcid.org/0000-0001-5168-4930","observed_orcids":["https://orcid.org/0000-0001-5168-4930"]},"institutions":[{"id":"https://openalex.org/I94616015","display_name":"Punjab Technical University","ror":"https://ror.org/025kz2973","country_code":"IN","type":"education","lineage":["https://openalex.org/I94616015"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arti Singh","raw_affiliation_strings":["Department of Pharmacology, ISF College of Pharmacy, Moga, Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab-142001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, ISF College of Pharmacy, Moga, Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab-142001, India","institution_ids":["https://openalex.org/I94616015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081211064","display_name":"Charan Singh","orcid":"https://orcid.org/0000-0002-1630-3183","observed_orcids":["https://orcid.org/0000-0002-1630-3183"]},"institutions":[{"id":"https://openalex.org/I185052938","display_name":"Hemwati Nandan Bahuguna Garhwal University","ror":"https://ror.org/00mvp1q86","country_code":"IN","type":"education","lineage":["https://openalex.org/I185052938"]},{"id":"https://openalex.org/I94616015","display_name":"Punjab Technical University","ror":"https://ror.org/025kz2973","country_code":"IN","type":"education","lineage":["https://openalex.org/I94616015"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Charan Singh","raw_affiliation_strings":["Department of Pharmaceutical Sciences, School of Sciences, Hemvati Nandan Bahuguna Garhwal University (A Central University), Srinagar, Uttarakhand-246174, India","Department of Pharmaceutics, ISF College of Pharmacy, Moga, Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab-142001, India"],"raw_orcid":"https://orcid.org/0000-0002-1630-3183","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, School of Sciences, Hemvati Nandan Bahuguna Garhwal University (A Central University), Srinagar, Uttarakhand-246174, India","institution_ids":["https://openalex.org/I185052938"]},{"raw_affiliation_string":"Department of Pharmaceutics, ISF College of Pharmacy, Moga, Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab-142001, India","institution_ids":["https://openalex.org/I94616015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5081211064"],"corresponding_institution_ids":["https://openalex.org/I185052938","https://openalex.org/I94616015"],"apc_list":{"value":2160,"currency":"USD","value_usd":2160},"apc_paid":{"value":2160,"currency":"USD","value_usd":2160},"fwci":1.2499,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.73804128,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"14","issue":null,"first_page":"100183","last_page":"100183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":1.0},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.8700000047683716},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9800000190734863},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor-tyrosine-kinase-inhibitors","display_name":"epidermal growth factor receptor tyrosine kinase inhibitors","score":0.8700000047683716},{"id":"https://openalex.org/keywords/nanoparticles","display_name":"nanoparticles","score":0.7699999809265137},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.9269999861717224},{"id":"https://openalex.org/keywords/solid-lipid-nanoparticles","display_name":"solid lipid nanoparticles","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nanostructured-lipid-carriers","display_name":"nanostructured lipid carriers","score":0.9959999918937683},{"id":"https://openalex.org/keywords/albumin-nanoparticles","display_name":"albumin nanoparticles","score":0.8889999985694885},{"id":"https://openalex.org/keywords/silica-nanoparticles","display_name":"silica nanoparticles","score":0.9990000128746033},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.859000027179718},{"id":"https://openalex.org/keywords/stimuli-responsive-drug-delivery","display_name":"stimuli-responsive drug delivery","score":0.7900000214576721},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8579999804496765},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.5730000138282776},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.9625735282897949},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7517268657684326},{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.7284063696861267},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6562674641609192},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.6074624061584473},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5124545693397522},{"id":"https://openalex.org/C2781047461","wikidata":"https://www.wikidata.org/wiki/Q679692","display_name":"Biopharmaceutical","level":2,"score":0.5109183192253113},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4962776303291321},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.48672011494636536},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4796050786972046},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4303252696990967},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.42759302258491516},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4237959086894989},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.31456810235977173},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2594853937625885},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.17101073265075684},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1251012682914734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.106077641248703},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.onano.2023.100183","doi":"https://doi.org/10.1016/j.onano.2023.100183","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.onano.2023.100183","pdf_url":null,"source":{"id":"https://openalex.org/S2898377343","display_name":"OpenNano","issn_l":"2352-9520","issn":["2352-9520"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OpenNano","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:d0a379df2ac04305bcc8f215289786a7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d0a379df2ac04305bcc8f215289786a7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"OpenNano, Vol 14, Iss , Pp 100183- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.onano.2023.100183","doi":"https://doi.org/10.1016/j.onano.2023.100183","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.onano.2023.100183","pdf_url":null,"source":{"id":"https://openalex.org/S2898377343","display_name":"OpenNano","issn_l":"2352-9520","issn":["2352-9520"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OpenNano","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W1514264189","https://openalex.org/W1804398254","https://openalex.org/W1896281489","https://openalex.org/W1909975518","https://openalex.org/W1949393443","https://openalex.org/W1975227912","https://openalex.org/W1978106396","https://openalex.org/W2020030503","https://openalex.org/W2021330831","https://openalex.org/W2028009636","https://openalex.org/W2054841768","https://openalex.org/W2060345044","https://openalex.org/W2061932411","https://openalex.org/W2063851889","https://openalex.org/W2069649187","https://openalex.org/W2102206827","https://openalex.org/W2103225497","https://openalex.org/W2105832080","https://openalex.org/W2114953089","https://openalex.org/W2116798922","https://openalex.org/W2117051942","https://openalex.org/W2119760603","https://openalex.org/W2126044896","https://openalex.org/W2130777678","https://openalex.org/W2143573503","https://openalex.org/W2146418087","https://openalex.org/W2146729192","https://openalex.org/W2152779325","https://openalex.org/W2168151031","https://openalex.org/W2172096113","https://openalex.org/W2175544846","https://openalex.org/W2184779060","https://openalex.org/W2190088367","https://openalex.org/W2275565293","https://openalex.org/W2302518824","https://openalex.org/W2341429116","https://openalex.org/W2466033276","https://openalex.org/W2552327471","https://openalex.org/W2578736186","https://openalex.org/W2753716327","https://openalex.org/W2758752166","https://openalex.org/W2762549894","https://openalex.org/W2766199030","https://openalex.org/W2770483363","https://openalex.org/W2771155547","https://openalex.org/W2788317469","https://openalex.org/W2792526880","https://openalex.org/W2796130272","https://openalex.org/W2804086212","https://openalex.org/W2807410315","https://openalex.org/W2809374624","https://openalex.org/W2811244359","https://openalex.org/W2891350031","https://openalex.org/W2893140976","https://openalex.org/W2897463729","https://openalex.org/W2914584422","https://openalex.org/W2918847986","https://openalex.org/W2921007507","https://openalex.org/W2936468984","https://openalex.org/W2946325785","https://openalex.org/W2948112742","https://openalex.org/W2951782016","https://openalex.org/W2970797066","https://openalex.org/W2979321351","https://openalex.org/W2988131634","https://openalex.org/W2992874540","https://openalex.org/W2997516063","https://openalex.org/W3009966202","https://openalex.org/W3037883719","https://openalex.org/W3046010551","https://openalex.org/W3089095477","https://openalex.org/W3089736761","https://openalex.org/W3095502396","https://openalex.org/W3110679581","https://openalex.org/W3121594139","https://openalex.org/W3161472154","https://openalex.org/W3178508134","https://openalex.org/W3181712735","https://openalex.org/W3185001815","https://openalex.org/W3204915054","https://openalex.org/W3207908366","https://openalex.org/W4282921608","https://openalex.org/W4307498150","https://openalex.org/W7074071409"],"related_works":["https://openalex.org/W3185001815","https://openalex.org/W4210455117","https://openalex.org/W7215164596","https://openalex.org/W7221585396","https://openalex.org/W3135135635","https://openalex.org/W4382700684","https://openalex.org/W2951782016","https://openalex.org/W174892843","https://openalex.org/W4313585045","https://openalex.org/W4406877759"],"abstract_inverted_index":{"Lung":[0],"cancer":[1,21,27,57,178,184,208],"is":[2,39],"an":[3,40,189],"uncontrolled":[4],"and":[5,48,90,121,140,155,179,203,215],"abnormal":[6],"mass":[7],"of":[8,52,65,115,133,164,168,176,191,196,218],"growing":[9],"cells":[10,58],"with":[11,36,78,221,247],"the":[12,17,50,66,85,113,130,162,213,243],"highest":[13],"mortality":[14],"rate":[15],"in":[16,76,124],"world.":[18],"Progressive":[19],"lung":[20,80,125,165,177,183,207],"shows":[22],"a":[23,222],"robust":[24],"resistance":[25],"to":[26,84,92,117,128,241],"therapy;":[28],"today":[29],"no":[30],"acceptable":[31],"therapeutic":[32,119,131,227],"results":[33],"are":[34],"achieved":[35],"drugs.":[37],"Gefitinib":[38,82],"epidermal":[41,67],"growth":[42,68],"factor":[43,69],"receptor":[44],"tyrosine":[45,63],"kinase":[46],"inhibitor":[47],"blocks":[49],"proliferation":[51],"downstream":[53],"signals":[54],"that":[55,231],"prevent":[56],"from":[59],"proliferating":[60],"by":[61],"inhibiting":[62],"phosphorylation":[64],"receptor.":[70],"It":[71,210],"also":[72,211],"increases":[73],"survival":[74],"rates":[75],"patients":[77],"progressive":[79],"cancer.":[81,126,166],"belongs":[83],"BCS":[86],"class":[87],"II":[88],"drugs":[89],"due":[91],"its":[93,96],"low":[94],"bioavailability;":[95],"clinical":[97,251],"use":[98,114],"has":[99],"been":[100,110,137,159],"severely":[101],"restricted.":[102],"In":[103],"recent":[104],"years,":[105],"several":[106,141],"research":[107],"papers":[108],"have":[109,136,158,171],"published":[111],"on":[112],"nanoparticles":[116,135,142,157,205],"increase":[118],"efficacy":[120,132],"drug":[122],"targeting":[123],"Furthermore,":[127],"enhance":[129],"gefitinib,":[134],"extensively":[138],"studied":[139],"including":[143],"polymers,":[144],"liposomes,":[145],"solid":[146],"lipid":[147,150],"nanoparticles,":[148],"nanostructured":[149],"carriers,":[151],"nano":[152],"cells,":[153],"albumin,":[154,202],"silica":[156,204],"developed":[160],"for":[161,182,206,225,238,249],"treatment":[163,175],"All":[167],"these":[169],"nanocarriers":[170],"improved":[172,180],"targeted":[173,214],"gefitinib":[174,197,219,248],"nanomedicines":[181],"treatment.":[185],"This":[186],"article":[187],"provides":[188],"overview":[190],"various":[192],"nanotechnology-based":[193],"carrier":[194],"systems":[195],"such":[198],"as":[199],"polymeric,":[200],"lipidic,":[201],"therapy.":[209],"discusses":[212],"responsive":[216],"delivery":[217],"along":[220],"combination":[223],"strategy":[224],"better":[226,250],"efficacy.":[228],"We":[229],"believe":[230],"this":[232],"manuscript":[233],"will":[234],"bring":[235],"important":[236],"information":[237],"formulation":[239],"scientists":[240],"overcome":[242],"biopharmaceutical":[244],"challenges":[245],"associated":[246],"outcomes.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-08-19T00:00:00"}