{"id":"https://openalex.org/W4385954597","doi":"https://doi.org/10.7759/cureus.43635","title":"Vitamin E and Pioglitazone: A Comprehensive Systematic Review of Their Efficacy in Non-alcoholic Fatty Liver Disease","display_name":"Vitamin E and Pioglitazone: A Comprehensive Systematic Review of Their Efficacy in Non-alcoholic Fatty Liver Disease","publication_year":2023,"publication_date":"2023-08-17","ids":{"openalex":"https://openalex.org/W4385954597","doi":"https://doi.org/10.7759/cureus.43635","pmid":"https://pubmed.ncbi.nlm.nih.gov/37719477","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10504864"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.43635","doi":"https://doi.org/10.7759/cureus.43635","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.43635","pdf_url":"https://assets.cureus.com/uploads/review_article/pdf/168872/20230817-11583-b5snoe.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://assets.cureus.com/uploads/review_article/pdf/168872/20230817-11583-b5snoe.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112999099","display_name":"Iqra Mazhar","orcid":"https://orcid.org/0009-0001-4435-7517","observed_orcids":["https://orcid.org/0009-0001-4435-7517"]},"institutions":[{"id":"https://openalex.org/I4210111586","display_name":"California Institute of Behavioral Neurosciences and Psychology (United States)","ror":"https://ror.org/01ytd2n62","country_code":"US","type":"company","lineage":["https://openalex.org/I4210111586"]},{"id":"https://openalex.org/I4405273397","display_name":"Quaid-e-Azam Medical College","ror":"https://ror.org/05rxs6b95","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405273397"]},{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["PK","RU","US"],"is_corresponding":true,"raw_author_name":"Iqra J Mazhar","raw_affiliation_strings":["Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK","Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND",". Internal Medicine, Kursk State Medical University, Kursk, RUS",". Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK","institution_ids":["https://openalex.org/I4405273397"]},{"raw_affiliation_string":"Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND","institution_ids":[]},{"raw_affiliation_string":". Internal Medicine, Kursk State Medical University, Kursk, RUS","institution_ids":["https://openalex.org/I44327541"]},{"raw_affiliation_string":". Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077244473","display_name":"Mohamed B. Yasir","orcid":"https://orcid.org/0000-0003-0881-903X","observed_orcids":["https://orcid.org/0000-0003-0881-903X"]},"institutions":[{"id":"https://openalex.org/I4210111586","display_name":"California Institute of Behavioral Neurosciences and Psychology (United States)","ror":"https://ror.org/01ytd2n62","country_code":"US","type":"company","lineage":["https://openalex.org/I4210111586"]},{"id":"https://openalex.org/I4405273397","display_name":"Quaid-e-Azam Medical College","ror":"https://ror.org/05rxs6b95","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405273397"]},{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["PK","RU","US"],"is_corresponding":false,"raw_author_name":"Mohamed Yasir","raw_affiliation_strings":["Internal Medicine, Kursk State Medical University, Kursk, RUS","Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND",". Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK",". Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Kursk State Medical University, Kursk, RUS","institution_ids":["https://openalex.org/I44327541"]},{"raw_affiliation_string":"Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND","institution_ids":[]},{"raw_affiliation_string":". Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK","institution_ids":["https://openalex.org/I4405273397"]},{"raw_affiliation_string":". Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024063411","display_name":"Saba Sarfraz","orcid":"https://orcid.org/0000-0002-2670-3420","observed_orcids":["https://orcid.org/0000-0002-2670-3420"]},"institutions":[{"id":"https://openalex.org/I4210111586","display_name":"California Institute of Behavioral Neurosciences and Psychology (United States)","ror":"https://ror.org/01ytd2n62","country_code":"US","type":"company","lineage":["https://openalex.org/I4210111586"]},{"id":"https://openalex.org/I4405273397","display_name":"Quaid-e-Azam Medical College","ror":"https://ror.org/05rxs6b95","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405273397"]},{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["PK","RU","US"],"is_corresponding":false,"raw_author_name":"Saba Sarfraz","raw_affiliation_strings":["Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND",". Internal Medicine, Kursk State Medical University, Kursk, RUS",". Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK",". Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND","institution_ids":[]},{"raw_affiliation_string":". Internal Medicine, Kursk State Medical University, Kursk, RUS","institution_ids":["https://openalex.org/I44327541"]},{"raw_affiliation_string":". Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK","institution_ids":["https://openalex.org/I4405273397"]},{"raw_affiliation_string":". Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092501298","display_name":"Gandhala Shlaghya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111586","display_name":"California Institute of Behavioral Neurosciences and Psychology (United States)","ror":"https://ror.org/01ytd2n62","country_code":"US","type":"company","lineage":["https://openalex.org/I4210111586"]},{"id":"https://openalex.org/I4405273397","display_name":"Quaid-e-Azam Medical College","ror":"https://ror.org/05rxs6b95","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405273397"]},{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["PK","RU","US"],"is_corresponding":false,"raw_author_name":"Gandhala Shlaghya","raw_affiliation_strings":["Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND",". Internal Medicine, Kursk State Medical University, Kursk, RUS",". Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK",". Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND","institution_ids":[]},{"raw_affiliation_string":". Internal Medicine, Kursk State Medical University, Kursk, RUS","institution_ids":["https://openalex.org/I44327541"]},{"raw_affiliation_string":". Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK","institution_ids":["https://openalex.org/I4405273397"]},{"raw_affiliation_string":". Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002026776","display_name":"Sri Harsha Narayana","orcid":"https://orcid.org/0000-0003-2662-7074","observed_orcids":["https://orcid.org/0000-0003-2662-7074"]},"institutions":[{"id":"https://openalex.org/I4210111586","display_name":"California Institute of Behavioral Neurosciences and Psychology (United States)","ror":"https://ror.org/01ytd2n62","country_code":"US","type":"company","lineage":["https://openalex.org/I4210111586"]},{"id":"https://openalex.org/I4405273397","display_name":"Quaid-e-Azam Medical College","ror":"https://ror.org/05rxs6b95","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405273397"]},{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["PK","RU","US"],"is_corresponding":false,"raw_author_name":"Sri Harsha Narayana","raw_affiliation_strings":["Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND",". Internal Medicine, Kursk State Medical University, Kursk, RUS",". Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK",". Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND","institution_ids":[]},{"raw_affiliation_string":". Internal Medicine, Kursk State Medical University, Kursk, RUS","institution_ids":["https://openalex.org/I44327541"]},{"raw_affiliation_string":". Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK","institution_ids":["https://openalex.org/I4405273397"]},{"raw_affiliation_string":". Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048252292","display_name":"Ujala Mushtaq","orcid":"https://orcid.org/0009-0002-9959-4904","observed_orcids":["https://orcid.org/0009-0002-9959-4904"]},"institutions":[{"id":"https://openalex.org/I4210111586","display_name":"California Institute of Behavioral Neurosciences and Psychology (United States)","ror":"https://ror.org/01ytd2n62","country_code":"US","type":"company","lineage":["https://openalex.org/I4210111586"]},{"id":"https://openalex.org/I4405273397","display_name":"Quaid-e-Azam Medical College","ror":"https://ror.org/05rxs6b95","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405273397"]},{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["PK","RU","US"],"is_corresponding":false,"raw_author_name":"Ujala Mushtaq","raw_affiliation_strings":["Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND",". Internal Medicine, Kursk State Medical University, Kursk, RUS",". Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK",". Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND","institution_ids":[]},{"raw_affiliation_string":". Internal Medicine, Kursk State Medical University, Kursk, RUS","institution_ids":["https://openalex.org/I44327541"]},{"raw_affiliation_string":". Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK","institution_ids":["https://openalex.org/I4405273397"]},{"raw_affiliation_string":". Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034367496","display_name":"Basim Shaman Ameen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111586","display_name":"California Institute of Behavioral Neurosciences and Psychology (United States)","ror":"https://ror.org/01ytd2n62","country_code":"US","type":"company","lineage":["https://openalex.org/I4210111586"]},{"id":"https://openalex.org/I4405273397","display_name":"Quaid-e-Azam Medical College","ror":"https://ror.org/05rxs6b95","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405273397"]},{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["PK","RU","US"],"is_corresponding":false,"raw_author_name":"Basim Shaman Ameen","raw_affiliation_strings":["Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND",". Internal Medicine, Kursk State Medical University, Kursk, RUS",". Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK",". Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND","institution_ids":[]},{"raw_affiliation_string":". Internal Medicine, Kursk State Medical University, Kursk, RUS","institution_ids":["https://openalex.org/I44327541"]},{"raw_affiliation_string":". Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK","institution_ids":["https://openalex.org/I4405273397"]},{"raw_affiliation_string":". Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112962991","display_name":"Chuhao Nie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111586","display_name":"California Institute of Behavioral Neurosciences and Psychology (United States)","ror":"https://ror.org/01ytd2n62","country_code":"US","type":"company","lineage":["https://openalex.org/I4210111586"]},{"id":"https://openalex.org/I4405273397","display_name":"Quaid-e-Azam Medical College","ror":"https://ror.org/05rxs6b95","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405273397"]},{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["PK","RU","US"],"is_corresponding":false,"raw_author_name":"Chuhao Nie","raw_affiliation_strings":["Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND",". Internal Medicine, Kursk State Medical University, Kursk, RUS",". Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK",". Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND","institution_ids":[]},{"raw_affiliation_string":". Internal Medicine, Kursk State Medical University, Kursk, RUS","institution_ids":["https://openalex.org/I44327541"]},{"raw_affiliation_string":". Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK","institution_ids":["https://openalex.org/I4405273397"]},{"raw_affiliation_string":". Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092501297","display_name":"Daniel Nechi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111586","display_name":"California Institute of Behavioral Neurosciences and Psychology (United States)","ror":"https://ror.org/01ytd2n62","country_code":"US","type":"company","lineage":["https://openalex.org/I4210111586"]},{"id":"https://openalex.org/I4405273397","display_name":"Quaid-e-Azam Medical College","ror":"https://ror.org/05rxs6b95","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405273397"]},{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["PK","RU","US"],"is_corresponding":false,"raw_author_name":"Daniel Nechi","raw_affiliation_strings":["Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND",". Internal Medicine, Kursk State Medical University, Kursk, RUS",". Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK",". Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND","institution_ids":[]},{"raw_affiliation_string":". Internal Medicine, Kursk State Medical University, Kursk, RUS","institution_ids":["https://openalex.org/I44327541"]},{"raw_affiliation_string":". Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK","institution_ids":["https://openalex.org/I4405273397"]},{"raw_affiliation_string":". Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084125379","display_name":"Sai Sri Penumetcha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111586","display_name":"California Institute of Behavioral Neurosciences and Psychology (United States)","ror":"https://ror.org/01ytd2n62","country_code":"US","type":"company","lineage":["https://openalex.org/I4210111586"]},{"id":"https://openalex.org/I4405273397","display_name":"Quaid-e-Azam Medical College","ror":"https://ror.org/05rxs6b95","country_code":"PK","type":"education","lineage":["https://openalex.org/I4405273397"]},{"id":"https://openalex.org/I44327541","display_name":"Kursk State Medical University","ror":"https://ror.org/004dwfr15","country_code":"RU","type":"education","lineage":["https://openalex.org/I44327541"]}],"countries":["PK","RU","US"],"is_corresponding":false,"raw_author_name":"Sai Sri Penumetcha","raw_affiliation_strings":["General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND",". Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". Internal Medicine, Kursk State Medical University, Kursk, RUS",". Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK",". Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA",". Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":"General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND","institution_ids":[]},{"raw_affiliation_string":". Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". Internal Medicine, Kursk State Medical University, Kursk, RUS","institution_ids":["https://openalex.org/I44327541"]},{"raw_affiliation_string":". Internal Medicine, Quaid-e-Azam Medical College, Bahawalpur, PAK","institution_ids":["https://openalex.org/I4405273397"]},{"raw_affiliation_string":". Orthopedics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]},{"raw_affiliation_string":". Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA","institution_ids":["https://openalex.org/I4210111586"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5112999099"],"corresponding_institution_ids":["https://openalex.org/I4210111586","https://openalex.org/I4405273397","https://openalex.org/I44327541"],"apc_list":null,"apc_paid":null,"fwci":0.7927,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.71206744,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"15","issue":"8","first_page":"e43635","last_page":"e43635"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9750000238418579},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.8889999985694885},{"id":"https://openalex.org/keywords/pioglitazone","display_name":"pioglitazone","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.7929999828338623},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.7450000047683716},{"id":"https://openalex.org/keywords/steatosis","display_name":"steatosis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.47200000286102295},{"id":"https://openalex.org/keywords/ballooning","display_name":"ballooning","score":0.6439999938011169},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.7089999914169312},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.9200000166893005},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.921999990940094},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.8119999766349792},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8379999995231628},{"id":"https://openalex.org/keywords/drug-efficacy","display_name":"drug efficacy","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C2778384471","wikidata":"https://www.wikidata.org/wiki/Q417765","display_name":"Pioglitazone","level":4,"score":0.9105597734451294},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8882262706756592},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.7398510575294495},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.6475446820259094},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.5290918350219727},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5154064893722534},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.49638086557388306},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4706422686576843},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4576375484466553},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.44523483514785767},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4273778200149536},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.41798335313796997},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.38977721333503723},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34955355525016785},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.30040812492370605},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18924614787101746},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.43635","doi":"https://doi.org/10.7759/cureus.43635","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.43635","pdf_url":"https://assets.cureus.com/uploads/review_article/pdf/168872/20230817-11583-b5snoe.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10504864","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10504864","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10504864/pdf/cureus-0015-00000043635.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"},{"id":"pmid:37719477","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37719477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7759/cureus.43635","doi":"https://doi.org/10.7759/cureus.43635","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.43635","pdf_url":"https://assets.cureus.com/uploads/review_article/pdf/168872/20230817-11583-b5snoe.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385954597.pdf","grobid_xml":"https://content.openalex.org/works/W4385954597.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W2111951337","https://openalex.org/W2907399017","https://openalex.org/W2922577842","https://openalex.org/W2923741290","https://openalex.org/W2931372771","https://openalex.org/W2945700549","https://openalex.org/W2970684805","https://openalex.org/W2987164845","https://openalex.org/W2989927463","https://openalex.org/W3019568499","https://openalex.org/W3047056909","https://openalex.org/W3049394606","https://openalex.org/W3094135301","https://openalex.org/W3112815584","https://openalex.org/W3116533914","https://openalex.org/W3123893780","https://openalex.org/W3127981559","https://openalex.org/W3129584656","https://openalex.org/W3134320092","https://openalex.org/W3134547301","https://openalex.org/W3137822935","https://openalex.org/W3158749710","https://openalex.org/W3163776584","https://openalex.org/W3193811807","https://openalex.org/W3196055218","https://openalex.org/W4200200509","https://openalex.org/W4220832833","https://openalex.org/W4221005344","https://openalex.org/W4241721607","https://openalex.org/W4280513462","https://openalex.org/W4284705169","https://openalex.org/W4285037598","https://openalex.org/W4309655159","https://openalex.org/W4379386464"],"related_works":["https://openalex.org/W4404917080","https://openalex.org/W4214696772","https://openalex.org/W7219926535","https://openalex.org/W4317779432","https://openalex.org/W2763586398","https://openalex.org/W6908667178","https://openalex.org/W4361297693","https://openalex.org/W2743199257","https://openalex.org/W3201880865","https://openalex.org/W2038929426"],"abstract_inverted_index":{"Non-alcoholic":[0],"fatty":[1],"liver":[2,102,104,246],"disease":[3],"(NAFLD)":[4],"is":[5,37],"becoming":[6],"increasingly":[7],"prevalent":[8],"worldwide,":[9],"especially":[10],"in":[11,100,114,144,239,277],"people":[12],"with":[13,116,154,310,319],"obesity,":[14],"dyslipidemia,":[15],"type":[16],"2":[17],"diabetes":[18],"mellitus":[19],"(T2DM),":[20],"and":[21,26,45,64,83,95,106,132,153,165,169,194,209,234,243,261,280,303,316],"metabolic":[22],"syndrome.":[23],"Weight":[24],"loss":[25],"dietary":[27],"modifications":[28],"are":[29,237],"established":[30],"first-line":[31],"treatments":[32],"for":[33,41,75,191,198,207,212,219,291],"NAFLD.":[34],"Currently,":[35],"there":[36,249],"no":[38],"approved":[39],"drug":[40],"NAFLD;":[42],"however,":[43],"pioglitazone":[44,99,233,270,284,289],"vitamin":[46,61,65,93,96,235,275,281,324],"E":[47,66,97,236,276,282],"have":[48],"shown":[49],"some":[50],"beneficial":[51],"effects.":[52],"This":[53],"systematic":[54,129,199],"review":[55,78],"covers":[56],"the":[57,73,89,140,145,160,187,201,210,213],"comparative":[58],"efficacies":[59],"of":[60,70,91,182,204,215,224],"E,":[62,94],"pioglitazone,":[63,92,315],"plus":[67,98,283],"pioglitazone.":[68],"As":[69],"December":[71],"2022,":[72],"sources":[74],"prior":[76],"literature":[77],"included":[79,86],"PubMed,":[80],"PubMed":[81],"Central,":[82],"Medline.":[84],"We":[85],"studies":[87,134],"assessing":[88],"efficacy":[90,273,287],"improving":[101],"histology,":[103],"markers,":[105,247],"lipid":[107],"profile":[108],"when":[109],"compared":[110],"to":[111,251,274],"other":[112],"interventions":[113],"patients":[115,309,318],"NAFLD/non-alcoholic":[117],"steatohepatitis":[118],"(NASH).":[119],"Review":[120,217],"materials":[121],"include":[122],"randomized":[123],"control":[124],"trials":[125],"(RCTs),":[126],"traditional":[127],"reviews,":[128,130,200],"meta-analyses,":[131],"observational":[133],"on":[135,149,255],"human":[136],"participants":[137],"published":[138],"within":[139],"last":[141],"five":[142],"years":[143],"English":[146],"language.":[147],"Studies":[148],"animals,":[150],"pediatric":[151],"populations,":[152],"insufficient":[155],"data":[156,254],"were":[157,227],"excluded":[158],"from":[159],"review.":[161],"Two":[162],"authors":[163],"scanned":[164],"filtered":[166],"articles":[167,226],"independently":[168],"later":[170],"performed":[171],"quality":[172],"checks.":[173],"A":[174,222],"third":[175],"reviewer":[176],"resolved":[177],"any":[178],"conflicts.":[179],"The":[180,229],"risk":[181],"bias":[183],"was":[184],"assessed":[185],"using":[186],"Preferred":[188],"Reporting":[189],"Items":[190],"Systematic":[192],"Reviews":[193],"Meta-Analyses":[195],"2020":[196],"guidelines":[197],"Cochrane":[202],"Risk":[203],"Bias":[205],"Tool":[206],"RCTs,":[208],"Scale":[211],"Assessment":[214],"Narrative":[216],"Articles":[218],"Traditional":[220],"Reviews.":[221],"total":[223],"21":[225],"shortlisted.":[228],"results":[230],"showed":[231],"that":[232,269],"effective":[238],"reducing":[240,245],"steatosis,":[241],"inflammation,":[242],"ballooning,":[244],"but":[248],"seem":[250],"be":[252,313,322],"conflicting":[253],"fibrosis":[256,278],"resolution.":[257,293],"Pioglitazone":[258],"decreases":[259],"triglycerides":[260],"increases":[262],"high-density":[263],"lipoproteins.":[264],"One":[265],"study":[266],"has":[267,271,285],"suggested":[268],"superior":[272,286],"reduction":[279],"than":[288],"alone":[290],"NASH":[292],"However,":[294],"these":[295],"conclusions":[296],"require":[297],"further":[298],"validation":[299],"through":[300],"extensive":[301],"analysis":[302],"additional":[304],"research.":[305],"In":[306],"conclusion,":[307],"diabetic":[308],"NAFLD":[311,320],"can":[312,321],"given":[314,323],"non-diabetic":[317],"E.":[325]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-08-18T00:00:00"}