{"id":"https://openalex.org/W4385882346","doi":"https://doi.org/10.3889/oamjms.2023.11617","title":"The Hematology Profiles of Adults Affiliated with Epilepsy after Receiving Valproic Acid Therapy","display_name":"The Hematology Profiles of Adults Affiliated with Epilepsy after Receiving Valproic Acid Therapy","publication_year":2023,"publication_date":"2023-05-23","ids":{"openalex":"https://openalex.org/W4385882346","doi":"https://doi.org/10.3889/oamjms.2023.11617"},"language":"en","primary_location":{"id":"doi:10.3889/oamjms.2023.11617","doi":"https://doi.org/10.3889/oamjms.2023.11617","is_oa":true,"landing_page_url":"https://doi.org/10.3889/oamjms.2023.11617","pdf_url":"https://oamjms.eu/index.php/mjms/article/download/11617/8542","source":{"id":"https://openalex.org/S2738387300","display_name":"Open Access Macedonian Journal of Medical Sciences","issn_l":"1857-9655","issn":["1857-9655"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310322218","host_organization_name":"ID Design 2012/DOOEL Skopje","host_organization_lineage":["https://openalex.org/P4310322218"],"host_organization_lineage_names":["ID Design 2012/DOOEL Skopje"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Access Macedonian Journal of Medical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://oamjms.eu/index.php/mjms/article/download/11617/8542","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034330906","display_name":"Christiyan Kirilov Naydenov","orcid":"https://orcid.org/0000-0001-6082-4376","observed_orcids":["https://orcid.org/0000-0001-6082-4376"]},"institutions":[{"id":"https://openalex.org/I173112312","display_name":"Trakia University","ror":"https://ror.org/04p2cym91","country_code":"BG","type":"education","lineage":["https://openalex.org/I173112312"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Christiyan Naydenov","raw_affiliation_strings":["Department of Neurology and Psychiatry, Trakia University, Stara Zagora City, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0001-6082-4376","affiliations":[{"raw_affiliation_string":"Department of Neurology and Psychiatry, Trakia University, Stara Zagora City, Bulgaria","institution_ids":["https://openalex.org/I173112312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006984518","display_name":"Ivan Mindov","orcid":"https://orcid.org/0000-0001-9048-7614","observed_orcids":["https://orcid.org/0000-0001-9048-7614"]},"institutions":[{"id":"https://openalex.org/I173112312","display_name":"Trakia University","ror":"https://ror.org/04p2cym91","country_code":"BG","type":"education","lineage":["https://openalex.org/I173112312"]}],"countries":["BG"],"is_corresponding":false,"raw_author_name":"Ivan Mindov","raw_affiliation_strings":["Department of Neurology and Psychiatry, Trakia University, Stara Zagora City, Bulgaria"],"raw_orcid":"https://orcid.org/0000-0001-9048-7614","affiliations":[{"raw_affiliation_string":"Department of Neurology and Psychiatry, Trakia University, Stara Zagora City, Bulgaria","institution_ids":["https://openalex.org/I173112312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I173112312"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"B","first_page":"562","last_page":"564"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.7113999724388123,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.7113999724388123,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.2815000116825104,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9940000176429749},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.9829999804496765},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.847000002861023},{"id":"https://openalex.org/keywords/hematology","display_name":"hematology","score":0.5},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9869999885559082},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.9440000057220459},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8899999856948853},{"id":"https://openalex.org/keywords/generalized-tonic-clonic-seizures","display_name":"generalized tonic-clonic seizures","score":0.9319999814033508},{"id":"https://openalex.org/keywords/adults","display_name":"adults","score":0.4129999876022339}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9186323285102844},{"id":"https://openalex.org/C2777172819","wikidata":"https://www.wikidata.org/wiki/Q240642","display_name":"Valproic Acid","level":3,"score":0.8763070106506348},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.8634272813796997},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.7888798713684082},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.7057027816772461},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.5986813902854919},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5680510401725769},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.5220515727996826},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.5075379610061646},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4620373249053955},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.16958001255989075}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3889/oamjms.2023.11617","doi":"https://doi.org/10.3889/oamjms.2023.11617","is_oa":true,"landing_page_url":"https://doi.org/10.3889/oamjms.2023.11617","pdf_url":"https://oamjms.eu/index.php/mjms/article/download/11617/8542","source":{"id":"https://openalex.org/S2738387300","display_name":"Open Access Macedonian Journal of Medical Sciences","issn_l":"1857-9655","issn":["1857-9655"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310322218","host_organization_name":"ID Design 2012/DOOEL Skopje","host_organization_lineage":["https://openalex.org/P4310322218"],"host_organization_lineage_names":["ID Design 2012/DOOEL Skopje"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Access Macedonian Journal of Medical Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3889/oamjms.2023.11617","doi":"https://doi.org/10.3889/oamjms.2023.11617","is_oa":true,"landing_page_url":"https://doi.org/10.3889/oamjms.2023.11617","pdf_url":"https://oamjms.eu/index.php/mjms/article/download/11617/8542","source":{"id":"https://openalex.org/S2738387300","display_name":"Open Access Macedonian Journal of Medical Sciences","issn_l":"1857-9655","issn":["1857-9655"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310322218","host_organization_name":"ID Design 2012/DOOEL Skopje","host_organization_lineage":["https://openalex.org/P4310322218"],"host_organization_lineage_names":["ID Design 2012/DOOEL Skopje"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Access Macedonian Journal of Medical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385882346.pdf","grobid_xml":"https://content.openalex.org/works/W4385882346.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2071934663","https://openalex.org/W2140914231","https://openalex.org/W2975279423","https://openalex.org/W4240368266","https://openalex.org/W4312587185"],"related_works":["https://openalex.org/W2975279423","https://openalex.org/W2972870606","https://openalex.org/W3040386425","https://openalex.org/W3035504261","https://openalex.org/W4232711563","https://openalex.org/W1999589693","https://openalex.org/W7220583135","https://openalex.org/W4408586279","https://openalex.org/W4407168089","https://openalex.org/W3119168904"],"abstract_inverted_index":{"AIM:":[0],"Epilepsy":[1],"is":[2,16,43,48,113],"a":[3,51],"socially":[4],"significant":[5],"neurological":[6],"disease":[7],"spread":[8],"all":[9],"over":[10],"the":[11,19,39,57,79,164],"world.":[12],"Valproic":[13],"acid":[14],"(VPA)":[15],"one":[17],"of":[18,60,78,89,93,145,154,167,169,194],"most":[20],"used":[21],"antiepileptic":[22],"drug":[23,182],"(AED)":[24],"for":[25],"treatment":[26],"which":[27],"has":[28],"some":[29],"side":[30],"effects":[31],"on":[32],"hematology":[33,58,96],"field.":[34],"A":[35],"nowadays":[36],"update":[37],"to":[38,49,55,185],"adult":[40],"safety":[41],"information":[42],"needed.":[44],"The":[45,110,172],"current":[46],"aim":[47],"conduct":[50],"cross-sectional":[52],"study":[53],"and":[54,75,95,119,150,179,189],"describe":[56],"profile":[59],"adults":[61],"with":[62],"epilepsy":[63],"treated":[64,102],"by":[65,103,162],"VPA.":[66,195],"MATERIALS":[67],"AND":[68],"METHODS:":[69],"Data":[70],"collection":[71],"was":[72],"done":[73],"retrospectively":[74],"includes":[76],"characteristics":[77],"subjects":[80,101],"such":[81],"as":[82],"age,":[83],"gender,":[84],"electroencephalography":[85],"(EEG)":[86],"finding,":[87],"duration":[88],"VPA":[90,104,186],"treatment,":[91,94],"type":[92],"profile.":[97],"We":[98,140],"report":[99],"50":[100],"at":[105,147],"least":[106],"1":[107],"year.":[108],"RESULTS:":[109],"mean":[111],"age":[112],"46,":[114],"4":[115,142],"years,":[116],"50%":[117,120],"male":[118],"female.":[121],"About":[122],"92%":[123],"were":[124,130,137,160,175,187],"generalized":[125],"tonic-clonic":[126],"seizure.":[127],"Seven":[128],"percent":[129],"partial":[131],"complex":[132],"epilepsy.":[133],"Twenty-four":[134],"EEG":[135,173],"results":[136],"abnormal":[138],"(48%).":[139],"found":[141],"cases":[143,152],"(7%)":[144],"thrombocytopenia":[146,188],"therapeutic":[148],"dose":[149],"8":[151],"(16%)":[153],"mild":[155],"anemia.":[156,190],"DISCUSSION:":[157],"Gender":[158],"differences":[159],"eliminated":[161],"having":[163],"same":[165],"number":[166],"participants":[168],"each":[170],"gender.":[171],"findings":[174],"almost":[176],"equally":[177],"normal":[178],"abnormal.":[180],"Reported":[181],"reactions":[183],"due":[184],"Thrombocytopenia":[191],"requires":[192],"discontinuation":[193]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-08-17T00:00:00"}