{"id":"https://openalex.org/W4385877125","doi":"https://doi.org/10.7554/elife.89292.4","title":"Nucleotide binding to the ATP-cone in anaerobic ribonucleotide reductases allosterically regulates activity by modulating substrate binding","display_name":"Nucleotide binding to the ATP-cone in anaerobic ribonucleotide reductases allosterically regulates activity by modulating substrate binding","publication_year":2023,"publication_date":"2023-08-16","ids":{"openalex":"https://openalex.org/W4385877125","doi":"https://doi.org/10.7554/elife.89292.4","pmid":"https://pubmed.ncbi.nlm.nih.gov/38968292","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11226230"},"language":"en","primary_location":{"id":"doi:10.7554/elife.89292.4","doi":"https://doi.org/10.7554/elife.89292.4","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.89292.4","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.89292.4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049608746","display_name":"Ornella Bima\u00ef","orcid":"https://orcid.org/0000-0003-0562-7251","observed_orcids":["https://orcid.org/0000-0003-0562-7251"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ornella Bima\u00ef","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm","Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden;"],"raw_orcid":"https://orcid.org/0000-0003-0562-7251","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm","institution_ids":["https://openalex.org/I161593684"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden;","institution_ids":["https://openalex.org/I161593684"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ipsita Banerjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ipsita Banerjee","raw_affiliation_strings":["Section for Biochemistry and Structural Biology, Centre for Molecular Protein Science, Dept. of Chemistry, Lund University, SE-22100 Lund","Section for Biochemistry and Structural Biology, Centre for Molecular Protein Science, Department of Chemistry, Lund University, Lund, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section for Biochemistry and Structural Biology, Centre for Molecular Protein Science, Dept. of Chemistry, Lund University, SE-22100 Lund","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Section for Biochemistry and Structural Biology, Centre for Molecular Protein Science, Department of Chemistry, Lund University, Lund, Sweden;","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083327859","display_name":"Inna Rozman Grinberg","orcid":"https://orcid.org/0000-0003-3094-1998","observed_orcids":["https://orcid.org/0000-0003-3094-1998"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Inna Rozman Grinberg","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm","Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden;"],"raw_orcid":"https://orcid.org/0000-0003-3094-1998","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm","institution_ids":["https://openalex.org/I161593684"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden;","institution_ids":["https://openalex.org/I161593684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004125015","display_name":"Ping Jie Huang","orcid":"https://orcid.org/0000-0002-7676-6905","observed_orcids":["https://orcid.org/0000-0002-7676-6905"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ping Huang","raw_affiliation_strings":["Department of Chemistry - \u00c5ngstr\u00f6m Laboratory, Uppsala University, SE-75120 Uppsala, Sweden","Department of Chemistry - \u00c5ngstr\u00f6m Laboratory, Uppsala University"],"raw_orcid":"https://orcid.org/0000-0002-7676-6905","affiliations":[{"raw_affiliation_string":"Department of Chemistry - \u00c5ngstr\u00f6m Laboratory, Uppsala University, SE-75120 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Department of Chemistry - \u00c5ngstr\u00f6m Laboratory, Uppsala University","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094029018","display_name":"Lucas Hultgren","orcid":"https://orcid.org/0009-0005-4903-4708","observed_orcids":["https://orcid.org/0009-0005-4903-4708"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lucas Hultgren","raw_affiliation_strings":["Structural Proteomics, SciLifeLab, Lund University, Lund, Sweden;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Proteomics, SciLifeLab, Lund University, Lund, Sweden;","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016902862","display_name":"Simon Ekstr\u00f6m","orcid":"https://orcid.org/0000-0002-7694-285X","observed_orcids":["https://orcid.org/0000-0002-7694-285X"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Simon Ekstr\u00f6m","raw_affiliation_strings":["Structural Proteomics, SciLifeLab, Lund University, Lund, Sweden;"],"raw_orcid":"https://orcid.org/0000-0002-7694-285X","affiliations":[{"raw_affiliation_string":"Structural Proteomics, SciLifeLab, Lund University, Lund, Sweden;","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047734861","display_name":"Daniel Lundin","orcid":"https://orcid.org/0000-0002-8779-6464","observed_orcids":["https://orcid.org/0000-0002-8779-6464"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Daniel Lundin","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm","Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden;"],"raw_orcid":"https://orcid.org/0000-0002-8779-6464","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm","institution_ids":["https://openalex.org/I161593684"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden;","institution_ids":["https://openalex.org/I161593684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016136510","display_name":"Britt\u2010Marie Sj\u00f6berg","orcid":"https://orcid.org/0000-0001-5953-3360","observed_orcids":["https://orcid.org/0000-0001-5953-3360"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Britt-Marie Sj\u00f6berg","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm","Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden;"],"raw_orcid":"https://orcid.org/0000-0001-5953-3360","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm","institution_ids":["https://openalex.org/I161593684"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden;","institution_ids":["https://openalex.org/I161593684"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023580049","display_name":"Derek T. Logan","orcid":"https://orcid.org/0000-0002-0098-8560","observed_orcids":["https://orcid.org/0000-0002-0098-8560"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Derek T. Logan","raw_affiliation_strings":["Section for Biochemistry and Structural Biology, Centre for Molecular Protein Science, Dept. of Chemistry, Lund University, SE-22100 Lund","Cryo-EM for Life Science, SciLifeLab, Lund University, Lund, Sweden","Section for Biochemistry and Structural Biology, Centre for Molecular Protein Science, Department of Chemistry, Lund University, Lund, Sweden;"],"raw_orcid":"https://orcid.org/0000-0002-0098-8560","affiliations":[{"raw_affiliation_string":"Section for Biochemistry and Structural Biology, Centre for Molecular Protein Science, Dept. of Chemistry, Lund University, SE-22100 Lund","institution_ids":["https://openalex.org/I187531555"]},{"raw_affiliation_string":"Cryo-EM for Life Science, SciLifeLab, Lund University, Lund, Sweden","institution_ids":["https://openalex.org/I187531555","https://openalex.org/I2800139495"]},{"raw_affiliation_string":"Section for Biochemistry and Structural Biology, Centre for Molecular Protein Science, Department of Chemistry, Lund University, Lund, Sweden;","institution_ids":["https://openalex.org/I187531555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5023580049"],"corresponding_institution_ids":["https://openalex.org/I187531555","https://openalex.org/I2800139495"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":0.5272,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.6655348,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.4961000084877014,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.4961000084877014,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.3513000011444092,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.12610000371932983,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribonucleotide-reductase","display_name":"ribonucleotide reductase","score":0.9200000166893005},{"id":"https://openalex.org/keywords/anaerobic-ribonucleotide-reductase","display_name":"anaerobic ribonucleotide reductase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/prevotella-copri","display_name":"Prevotella copri","score":0.8270000219345093},{"id":"https://openalex.org/keywords/glycyl-radical","display_name":"glycyl radical","score":0.7879999876022339},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.847000002861023},{"id":"https://openalex.org/keywords/atp-binding","display_name":"ATP binding","score":0.9259999990463257},{"id":"https://openalex.org/keywords/oligomerization","display_name":"oligomerization","score":0.7070000171661377},{"id":"https://openalex.org/keywords/dimer-tetramer-equilibrium","display_name":"dimer-tetramer equilibrium","score":0.8019999861717224},{"id":"https://openalex.org/keywords/substrate-binding","display_name":"substrate binding","score":0.5789999961853027},{"id":"https://openalex.org/keywords/radical-transfer","display_name":"radical transfer","score":0.5989999771118164},{"id":"https://openalex.org/keywords/cryo-em-structure","display_name":"cryo-EM structure","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C98892162","wikidata":"https://www.wikidata.org/wiki/Q422484","display_name":"Ribonucleotide","level":4,"score":0.7223761081695557},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.6715871095657349},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.5751802325248718},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.525821328163147},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5247876048088074},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5193387269973755},{"id":"https://openalex.org/C2779564974","wikidata":"https://www.wikidata.org/wiki/Q80863","display_name":"Adenosine triphosphate","level":2,"score":0.5072009563446045},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46452105045318604},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39057594537734985},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3892388343811035},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3881787657737732},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1709812879562378},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000693","descriptor_name":"Anaerobiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003838","descriptor_name":"Deoxyadenine Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012264","descriptor_name":"Ribonucleotide Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012264","descriptor_name":"Ribonucleotide Reductases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.7554/elife.89292.4","doi":"https://doi.org/10.7554/elife.89292.4","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.89292.4","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"doi:10.7554/elife.89292","doi":"https://doi.org/10.7554/elife.89292","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.89292","pdf_url":"https://elifesciences.org/reviewed-preprints/89292.pdf","source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"doi:10.1101/2023.06.20.545753","doi":"https://doi.org/10.1101/2023.06.20.545753","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.06.20.545753","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/06/20/2023.06.20.545753.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11226230","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11226230","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11226230/pdf/elife-89292.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmid:38968292","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38968292","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:DiVA.org:uu-535490","doi":null,"is_oa":true,"landing_page_url":"https://uu.diva-portal.org/smash/get/diva2:1886449/FULLTEXT01","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:58c8ed64ca754d1ea6c8072d269703e7","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/58c8ed64ca754d1ea6c8072d269703e7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 12 (2024)","raw_type":"article"},{"id":"pmh:oai:lup.lub.lu.se:bee7ab88-2e7a-4920-bf3f-f931cfa795f3","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/bee7ab88-2e7a-4920-bf3f-f931cfa795f3","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 2050-084X","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.7554/elife.89292.4","doi":"https://doi.org/10.7554/elife.89292.4","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.89292.4","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5299156840","display_name":null,"funder_award_id":"20 1210 PjF","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G5706605303","display_name":"Structure-function studies on proteins important for cellular survival and proliferation: ribonucleotide reductases and glypicans","funder_award_id":"2016-04855","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G6265702644","display_name":null,"funder_award_id":"2019-","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"},{"id":"https://openalex.org/G6553387601","display_name":"Exploring ribonucleotide reductase as a target to combat bacterial infections","funder_award_id":"2019-01400","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G722103358","display_name":null,"funder_award_id":"CAN 20 1210 PjF","funder_id":"https://openalex.org/F4320321491","funder_display_name":"Cancerfonden"}],"funders":[{"id":"https://openalex.org/F4320315060","display_name":"Wenner-Gren Stiftelserna","ror":"https://ror.org/033b0v780"},{"id":"https://openalex.org/F4320316838","display_name":"Kempe Foundation","ror":"https://ror.org/05vbwqf43"},{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320322971","display_name":"Ume\u00e5 Universitet","ror":"https://ror.org/05kb8h459"},{"id":"https://openalex.org/F4320324119","display_name":"Uppsala Universitet","ror":"https://ror.org/048a87296"},{"id":"https://openalex.org/F4320324135","display_name":"Kempestiftelserna","ror":"https://ror.org/05cszw148"},{"id":"https://openalex.org/F4320325669","display_name":"Stockholms Universitet","ror":"https://ror.org/05f0yaq80"},{"id":"https://openalex.org/F4320325677","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385877125.pdf","grobid_xml":"https://content.openalex.org/works/W4385877125.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W138576226","https://openalex.org/W178922452","https://openalex.org/W1790599019","https://openalex.org/W1946256555","https://openalex.org/W1965308433","https://openalex.org/W1966985858","https://openalex.org/W1990551485","https://openalex.org/W2009646137","https://openalex.org/W2011272035","https://openalex.org/W2034340811","https://openalex.org/W2040042862","https://openalex.org/W2058151591","https://openalex.org/W2069230662","https://openalex.org/W2075330404","https://openalex.org/W2078642612","https://openalex.org/W2083269101","https://openalex.org/W2084086913","https://openalex.org/W2087039291","https://openalex.org/W2094608725","https://openalex.org/W2097493124","https://openalex.org/W2105199418","https://openalex.org/W2108588173","https://openalex.org/W2124026197","https://openalex.org/W2127322768","https://openalex.org/W2130079299","https://openalex.org/W2131501854","https://openalex.org/W2134952190","https://openalex.org/W2138122982","https://openalex.org/W2152562710","https://openalex.org/W2215194374","https://openalex.org/W2287905726","https://openalex.org/W2343629959","https://openalex.org/W2409474656","https://openalex.org/W2587625522","https://openalex.org/W2620712420","https://openalex.org/W2755131625","https://openalex.org/W2756025658","https://openalex.org/W2788528130","https://openalex.org/W2887067252","https://openalex.org/W2888997683","https://openalex.org/W2944930475","https://openalex.org/W2973457155","https://openalex.org/W2974844924","https://openalex.org/W3013674006","https://openalex.org/W3082258754","https://openalex.org/W3083406432","https://openalex.org/W3093513099","https://openalex.org/W3177828909","https://openalex.org/W3182767159","https://openalex.org/W3197273087","https://openalex.org/W3208691473","https://openalex.org/W4220746198","https://openalex.org/W4237422512","https://openalex.org/W4250520477","https://openalex.org/W4280502066","https://openalex.org/W4282922306","https://openalex.org/W4294025888","https://openalex.org/W4307515216","https://openalex.org/W4315489831"],"related_works":["https://openalex.org/W4393992039","https://openalex.org/W4385876922","https://openalex.org/W4416801221","https://openalex.org/W4225412347","https://openalex.org/W2343629959","https://openalex.org/W1790599019","https://openalex.org/W2951661197","https://openalex.org/W3184953904","https://openalex.org/W2064787048","https://openalex.org/W4401729121"],"abstract_inverted_index":{"A":[0],"small,":[1],"nucleotide-binding":[2],"domain,":[3],"the":[4,9,29,68,72,77,87,91,108,116,140,151,173,179,190,199,209,213,231,239,242,255,260,272,275],"ATP-cone,":[5],"is":[6,97,158,205],"found":[7],"at":[8],"N-terminus":[10],"of":[11,32,35,48,110,153,172,176,184,189,224,274],"most":[12],"ribonucleotide":[13],"reductase":[14],"(RNR)":[15],"catalytic":[16],"subunits.":[17],"By":[18],"binding":[19,114,283],"adenosine":[20],"triphosphate":[21,25],"(ATP)":[22],"or":[23],"deoxyadenosine":[24],"(dATP)":[26],"it":[27,194],"regulates":[28],"enzyme":[30,124],"activity":[31,54,185,227],"all":[33],"classes":[34],"RNR.":[36],"Functional":[37],"and":[38,58,90,104,112,142,160,186,247,277,284],"structural":[39,105],"work":[40],"on":[41,76,107],"aerobic":[42],"RNRs":[43,268],"has":[44,161],"revealed":[45],"a":[46,60,81,127,162,221,248],"plethora":[47],"ways":[49],"in":[50,71,126,169,182,198,208,226,266],"which":[51],"dATP":[52,113,146,177,240,264],"inhibits":[53],"by":[55,270],"inducing":[56],"oligomerisation":[57],"preventing":[59,280],"productive":[61],"radical":[62,84,166,204,285],"transfer":[63],"from":[64,119,238],"one":[65,170],"subunit":[66],"to":[67,86,115,139,178],"active":[69,88,159,256],"site":[70,89,246],"other.":[73],"Anaerobic":[74],"RNRs,":[75],"other":[78],"hand,":[79],"store":[80],"stable":[82],"glycyl":[83,165,203],"next":[85],"basis":[92],"for":[93],"their":[94],"dATP-dependent":[95],"inhibition":[96,265],"completely":[98],"unknown.":[99],"We":[100],"present":[101],"biochemical,":[102],"biophysical,":[103],"information":[106],"effects":[109],"ATP":[111,135],"anaerobic":[117,267],"RNR":[118],"Prevotella":[120],"copri":[121,156],".":[122],"The":[123,202,218],"exists":[125],"dimer\u2013tetramer":[128],"equilibrium":[129],"biased":[130],"towards":[131],"dimers":[132],"when":[133,144],"two":[134,145],"molecules":[136,147],"are":[137,148],"bound":[138],"ATP-cone":[141,180],"tetramers":[143],"bound.":[149],"In":[150],"presence":[152],"ATP,":[154],"P.":[155],"NrdD":[157],"fully":[163],"ordered":[164],"domain":[167],"(GRD)":[168],"monomer":[171],"dimer.":[174],"Binding":[175],"results":[181,261],"loss":[183],"increased":[187],"dynamics":[188],"GRD,":[191,278],"such":[192],"that":[193,229,263],"cannot":[195],"be":[196],"detected":[197],"cryo-EM":[200],"structures.":[201],"formed":[206],"even":[207],"dATP-bound":[210],"form,":[211],"but":[212,250],"substrate":[214,244,282],"does":[215],"not":[216],"bind.":[217],"structures":[219],"implicate":[220],"complex":[222],"network":[223],"interactions":[225],"regulation":[228],"involve":[230],"GRD":[232],"more":[233],"than":[234],"30":[235],"\u00c5":[236],"away":[237],"molecules,":[241],"allosteric":[243],"specificity":[245],"conserved":[249],"previously":[251],"unseen":[252],"flap":[253,276],"over":[254],"site.":[257],"Taken":[258],"together,":[259],"suggest":[262],"acts":[269],"increasing":[271],"flexibility":[273],"thereby":[279],"both":[281],"mobilisation.":[286]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-08-17T00:00:00"}