{"id":"https://openalex.org/W4385874485","doi":"https://doi.org/10.3892/or.2023.8615","title":"Neuromedin U contributes to radiation resistance in colorectal cancer via YAP/TAZ signaling activation","display_name":"Neuromedin U contributes to radiation resistance in colorectal cancer via YAP/TAZ signaling activation","publication_year":2023,"publication_date":"2023-08-16","ids":{"openalex":"https://openalex.org/W4385874485","doi":"https://doi.org/10.3892/or.2023.8615","pmid":"https://pubmed.ncbi.nlm.nih.gov/37594135"},"language":"en","primary_location":{"id":"doi:10.3892/or.2023.8615","doi":"https://doi.org/10.3892/or.2023.8615","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2023.8615","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2023.8615/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/10.3892/or.2023.8615/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006189393","display_name":"Myeong-Kyu Sim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088603","display_name":"Korea Institute of Radiological and Medical Sciences","ror":"https://ror.org/00a8tg325","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210088603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Myeong-Kyu Sim","raw_affiliation_strings":["Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea","institution_ids":["https://openalex.org/I4210088603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100335488","display_name":"Ji Eun Park","orcid":"https://orcid.org/0000-0002-3035-6353","observed_orcids":["https://orcid.org/0000-0002-3035-6353"]},"institutions":[{"id":"https://openalex.org/I4210088603","display_name":"Korea Institute of Radiological and Medical Sciences","ror":"https://ror.org/00a8tg325","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210088603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-Eun Park","raw_affiliation_strings":["Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea","institution_ids":["https://openalex.org/I4210088603"]}]},{"author_position":"middle","author":{"id":null,"display_name":"So-Ra Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088603","display_name":"Korea Institute of Radiological and Medical Sciences","ror":"https://ror.org/00a8tg325","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210088603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"So-Ra Kim","raw_affiliation_strings":["Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea","institution_ids":["https://openalex.org/I4210088603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057109520","display_name":"Jeeyong Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088603","display_name":"Korea Institute of Radiological and Medical Sciences","ror":"https://ror.org/00a8tg325","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210088603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jeeyong Lee","raw_affiliation_strings":["Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea","institution_ids":["https://openalex.org/I4210088603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100353126","display_name":"Eun Ju Kim","orcid":"https://orcid.org/0000-0003-2887-0385","observed_orcids":["https://orcid.org/0000-0003-2887-0385"]},"institutions":[{"id":"https://openalex.org/I4210088603","display_name":"Korea Institute of Radiological and Medical Sciences","ror":"https://ror.org/00a8tg325","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210088603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun Kim","raw_affiliation_strings":["Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea","institution_ids":["https://openalex.org/I4210088603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071990813","display_name":"Younjoo Kim","orcid":"https://orcid.org/0000-0001-5182-8260","observed_orcids":["https://orcid.org/0000-0001-5182-8260"]},"institutions":[{"id":"https://openalex.org/I4210088603","display_name":"Korea Institute of Radiological and Medical Sciences","ror":"https://ror.org/00a8tg325","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210088603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Younjoo Kim","raw_affiliation_strings":["Department of Radiological and Clinical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea","Department of Radiological and Clinical Research, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological and Clinical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea","institution_ids":["https://openalex.org/I4210088603"]},{"raw_affiliation_string":"Department of Radiological and Clinical Research, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea","institution_ids":["https://openalex.org/I4210088603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065623926","display_name":"Ui Sup Shin","orcid":"https://orcid.org/0000-0002-1714-7469","observed_orcids":["https://orcid.org/0000-0002-1714-7469"]},"institutions":[{"id":"https://openalex.org/I4210088603","display_name":"Korea Institute of Radiological and Medical Sciences","ror":"https://ror.org/00a8tg325","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210088603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ui Shin","raw_affiliation_strings":["Department of Radiological and Clinical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea","Department of Radiological and Clinical Research, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological and Clinical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea","institution_ids":["https://openalex.org/I4210088603"]},{"raw_affiliation_string":"Department of Radiological and Clinical Research, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea","institution_ids":["https://openalex.org/I4210088603"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005999525","display_name":"Hyunggee Kim","orcid":"https://orcid.org/0000-0002-5164-1663","observed_orcids":["https://orcid.org/0000-0002-5164-1663"]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyunggee Kim","raw_affiliation_strings":["Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea","institution_ids":["https://openalex.org/I197347611"]}]},{"author_position":"last","author":{"id":null,"display_name":"Kwang Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088603","display_name":"Korea Institute of Radiological and Medical Sciences","ror":"https://ror.org/00a8tg325","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210088603"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kwang Kim","raw_affiliation_strings":["Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Radiation Biomedical Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea","institution_ids":["https://openalex.org/I4210088603"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7208,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.6279605,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"50","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuromedin-u","display_name":"neuromedin U","score":0.8999999761581421},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9279999732971191},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.9020000100135803},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.6830000281333923},{"id":"https://openalex.org/keywords/yap-taz-signaling","display_name":"YAP/TAZ signaling","score":0.8880000114440918},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.984000027179718},{"id":"https://openalex.org/keywords/yap-nuclear-translocation","display_name":"YAP nuclear translocation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6660000085830688},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9959999918937683},{"id":"https://openalex.org/keywords/axl","display_name":"AXL","score":0.8029999732971191},{"id":"https://openalex.org/keywords/connective-tissue-growth-factor","display_name":"connective tissue growth factor","score":0.9890000224113464},{"id":"https://openalex.org/keywords/creg1","display_name":"CREG1","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.669316291809082},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6222506761550903},{"id":"https://openalex.org/C58962609","wikidata":"https://www.wikidata.org/wiki/Q2353022","display_name":"Radioresistance","level":3,"score":0.5872495770454407},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5247045755386353},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5214040279388428},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.48140764236450195},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4650932848453522},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4055687487125397},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3729081153869629},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.23598504066467285},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07115304470062256}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/or.2023.8615","doi":"https://doi.org/10.3892/or.2023.8615","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2023.8615","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2023.8615/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},{"id":"pmid:37594135","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37594135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/or.2023.8615","doi":"https://doi.org/10.3892/or.2023.8615","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2023.8615","pdf_url":"http://www.spandidos-publications.com/10.3892/or.2023.8615/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1585841373","display_name":null,"funder_award_id":"50531-2022","funder_id":"https://openalex.org/F4320324813","funder_display_name":"Korea Institute of Radiological and Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320324813","display_name":"Korea Institute of Radiological and Medical Sciences","ror":"https://ror.org/00a8tg325"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385874485.pdf","grobid_xml":"https://content.openalex.org/works/W4385874485.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1545743138","https://openalex.org/W1563461009","https://openalex.org/W1973063620","https://openalex.org/W1981914236","https://openalex.org/W1990944630","https://openalex.org/W1994771936","https://openalex.org/W2007079916","https://openalex.org/W2014256858","https://openalex.org/W2021676032","https://openalex.org/W2028711466","https://openalex.org/W2040660199","https://openalex.org/W2047818504","https://openalex.org/W2054114650","https://openalex.org/W2057628250","https://openalex.org/W2060827364","https://openalex.org/W2071281071","https://openalex.org/W2099709490","https://openalex.org/W2101848273","https://openalex.org/W2102786125","https://openalex.org/W2107255006","https://openalex.org/W2107277218","https://openalex.org/W2109838283","https://openalex.org/W2118761613","https://openalex.org/W2132603015","https://openalex.org/W2159392554","https://openalex.org/W2291767161","https://openalex.org/W2291973388","https://openalex.org/W2302412397","https://openalex.org/W2397676097","https://openalex.org/W2493781925","https://openalex.org/W2553504547","https://openalex.org/W2599520572","https://openalex.org/W2600881934","https://openalex.org/W2757783981","https://openalex.org/W2971548352","https://openalex.org/W3012832784","https://openalex.org/W3169271492","https://openalex.org/W3169601793","https://openalex.org/W3172646654","https://openalex.org/W3197284009","https://openalex.org/W3198019397","https://openalex.org/W4200369963","https://openalex.org/W6712650276"],"related_works":["https://openalex.org/W4311580231","https://openalex.org/W3197284009","https://openalex.org/W2037173214","https://openalex.org/W4409636199","https://openalex.org/W7135049465","https://openalex.org/W7099534397","https://openalex.org/W6927413291","https://openalex.org/W4246219943","https://openalex.org/W1545743138","https://openalex.org/W4225247795"],"abstract_inverted_index":{"Resistance":[0],"to":[1,27,53,97,204],"radiation":[2,28,103],"therapy":[3,29],"remains":[4,49],"a":[5,21],"treatment":[6],"obstacle":[7],"for":[8],"patients":[9],"with":[10,133],"high\u2011risk":[11],"colorectal":[12,35,47,59,87,109,159,210],"cancer.":[13],"Neuromedin":[14],"U":[15],"(NMU)":[16],"has":[17],"been":[18],"identified":[19],"as":[20],"potential":[22],"predictor":[23],"of":[24,34,44,56,108,126,141,149,172,207],"the":[25,42,95,123,139,146,170,173,205,214],"response":[26],"by":[30,113,212],"RNA":[31,68],"sequencing":[32],"analysis":[33],"cancer":[36,48,88,110,160,211],"tissues":[37],"obtained":[38],"from":[39,138],"patients.":[40],"However,":[41],"role":[43,55],"NMU":[45,57,61,84,100,120,156,163,192,201],"in":[46,58,158,190,209],"unknown.":[50],"In":[51],"order":[52],"investigate":[54],"cancer,":[60],"expression":[62,171],"was":[63,153],"regulated":[64,164],"using":[65],"small":[66],"interfering":[67],"or":[69],"an":[70,191],"NMU\u2011expression":[71],"pCMV3":[72],"vector,":[73],"and":[74,78,91,93,106,116,130,151,166,169,175,185,220],"cell":[75,89],"counting,":[76],"wound\u2011healing":[77],"clonogenic":[79],"assays":[80],"were":[81],"subsequently":[82],"performed.":[83],"knockdown":[85,121],"decreased":[86],"proliferation":[90,105],"migration,":[92],"sensitized":[94],"cells":[96],"radiation.":[98],"Conversely,":[99],"overexpression":[101,157],"increased":[102,154],"resistance,":[104],"migration":[107],"cells.":[111,161],"Furthermore,":[112],"western":[114],"blotting":[115],"nuclear":[117,124,147],"fractionation":[118],"experiments,":[119],"inhibited":[122],"translocation":[125,148],"yes\u2011associated":[127],"protein":[128],"(YAP)":[129],"transcriptional":[131,177],"co\u2011activator":[132],"PDZ\u2011binding":[134],"motif":[135],"(TAZ),":[136],"resulting":[137],"phosphorylation":[140],"these":[142],"proteins.":[143],"By":[144],"contrast,":[145],"YAP":[150,165,174,219],"TAZ":[152,167,176,221],"following":[155],"Recombinant":[162],"activity,":[168],"target":[178],"genes":[179],"AXL,":[180],"connective":[181],"tissue":[182],"growth":[183],"factor":[184],"cysteine\u2011rich":[186],"angiogenic":[187],"inducer":[188],"61":[189],"receptor":[193],"1":[194],"activity\u2011dependent":[195],"manner.":[196],"These":[197],"results":[198],"suggested":[199],"that":[200],"may":[202],"contribute":[203],"acquisition":[206],"radioresistance":[208],"enhancing":[213],"Hippo":[215],"signaling":[216],"pathway":[217],"via":[218],"activation.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-08-17T00:00:00"}