{"id":"https://openalex.org/W4385872185","doi":"https://doi.org/10.1007/s12032-023-02149-9","title":"Mechanism of anticancer effect of gambogic acid on gastric signet ring cell carcinoma","display_name":"Mechanism of anticancer effect of gambogic acid on gastric signet ring cell carcinoma","publication_year":2023,"publication_date":"2023-08-16","ids":{"openalex":"https://openalex.org/W4385872185","doi":"https://doi.org/10.1007/s12032-023-02149-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/37587317"},"language":"en","primary_location":{"id":"doi:10.1007/s12032-023-02149-9","doi":"https://doi.org/10.1007/s12032-023-02149-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12032-023-02149-9","pdf_url":null,"source":{"id":"https://openalex.org/S204953464","display_name":"Medical Oncology","issn_l":"1357-0560","issn":["1357-0560","1559-131X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-3139250/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081470526","display_name":"Z\u0131ad Joha","orcid":"https://orcid.org/0000-0001-8520-3760","observed_orcids":["https://orcid.org/0000-0001-8520-3760"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ziad Joha","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, Turkey. zead-geha@hotmail.com","Department of Pharmacology, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-8520-3760","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, Turkey. zead-geha@hotmail.com","institution_ids":["https://openalex.org/I12700597"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, Turkey","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075987641","display_name":"Ay\u015feg\u00fcl \u00d6zt\u00fcrk","orcid":"https://orcid.org/0000-0001-8130-7968","observed_orcids":["https://orcid.org/0000-0001-8130-7968"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ay\u015feg\u00fcl \u00d6zt\u00fcrk","raw_affiliation_strings":["Departments of Medical Services and Techniques, Vocational School of Health Services, Sivas Cumhuriyet University, Sivas, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medical Services and Techniques, Vocational School of Health Services, Sivas Cumhuriyet University, Sivas, Turkey","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027608415","display_name":"Fatih Yulak","orcid":"https://orcid.org/0000-0003-3708-6752","observed_orcids":["https://orcid.org/0000-0003-3708-6752"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Fatih Yulak","raw_affiliation_strings":["Department of Physiology, School of Medicine, Cumhuriyet University, Sivas, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Medicine, Cumhuriyet University, Sivas, Turkey","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007491320","display_name":"\u00d6zhan Karata\u015f","orcid":"https://orcid.org/0000-0002-2778-8059","observed_orcids":["https://orcid.org/0000-0002-2778-8059"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u00d6zhan Karata\u015f","raw_affiliation_strings":["Department of Veterinary Pathology, School of Veterinary Medicine, Sivas Cumhuriyet University, Sivas, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Pathology, School of Veterinary Medicine, Sivas Cumhuriyet University, Sivas, Turkey","institution_ids":["https://openalex.org/I12700597"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004654863","display_name":"Hilmi Ataseven","orcid":"https://orcid.org/0000-0001-5458-509X","observed_orcids":["https://orcid.org/0000-0001-5458-509X"]},"institutions":[{"id":"https://openalex.org/I12700597","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77","country_code":"TR","type":"education","lineage":["https://openalex.org/I12700597"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hilmi Ataseven","raw_affiliation_strings":["Departments of Pharmacology, School of Medicine, Sivas Cumhuriyet University, Sivas, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, School of Medicine, Sivas Cumhuriyet University, Sivas, Turkey","institution_ids":["https://openalex.org/I12700597"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081470526"],"corresponding_institution_ids":["https://openalex.org/I12700597"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":2.6688,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.89389117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"40","issue":"9","first_page":"269","last_page":"269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.6729000210762024,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.6729000210762024,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.23100000619888306,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gambogic-acid","display_name":"gambogic acid","score":1.0},{"id":"https://openalex.org/keywords/gastric-signet-ring-cell-carcinoma","display_name":"gastric signet ring cell carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7059999704360962},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.5130000114440918},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.996999979019165},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9440000057220459},{"id":"https://openalex.org/keywords/poly-adp-ribose-polymerase","display_name":"poly(ADP-ribose) polymerase","score":0.7350000143051147},{"id":"https://openalex.org/keywords/8-hydroxy-2-deoxyguanosine","display_name":"8-hydroxy-2'-deoxyguanosine","score":0.8629999756813049},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.7770000100135803},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8880000114440918},{"id":"https://openalex.org/keywords/anticancer-mechanism","display_name":"anticancer mechanism","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C2781360439","wikidata":"https://www.wikidata.org/wiki/Q5519727","display_name":"Gambogic acid","level":3,"score":0.9971113204956055},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.6852772235870361},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.679795503616333},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6504386067390442},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5495504140853882},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5197398662567139},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.488698273897171},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46545010805130005},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4523131251335144},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43663424253463745},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38449928164482117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27264007925987244},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2437039613723755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23375707864761353},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21136721968650818},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1449715495109558},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000067856","descriptor_name":"Poly(ADP-ribose) Polymerase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000080242","descriptor_name":"8-Hydroxy-2'-Deoxyguanosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018279","descriptor_name":"Carcinoma, Signet Ring Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D044004","descriptor_name":"Xanthones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s12032-023-02149-9","doi":"https://doi.org/10.1007/s12032-023-02149-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12032-023-02149-9","pdf_url":null,"source":{"id":"https://openalex.org/S204953464","display_name":"Medical Oncology","issn_l":"1357-0560","issn":["1357-0560","1559-131X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Oncology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-3139250/v1","doi":"https://doi.org/10.21203/rs.3.rs-3139250/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3139250/v1","pdf_url":"https://www.researchsquare.com/article/rs-3139250/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:37587317","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37587317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical oncology (Northwood, London, England)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-3139250/v1","doi":"https://doi.org/10.21203/rs.3.rs-3139250/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3139250/v1","pdf_url":"https://www.researchsquare.com/article/rs-3139250/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321621","display_name":"Sivas Cumhuriyet \u00dcniversitesi","ror":"https://ror.org/04f81fm77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385872185.pdf","grobid_xml":"https://content.openalex.org/works/W4385872185.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1907485278","https://openalex.org/W1971257733","https://openalex.org/W2026383979","https://openalex.org/W2047098332","https://openalex.org/W2056793355","https://openalex.org/W2064617995","https://openalex.org/W2066991013","https://openalex.org/W2084946596","https://openalex.org/W2094500834","https://openalex.org/W2131456594","https://openalex.org/W2132998852","https://openalex.org/W2133190342","https://openalex.org/W2162863528","https://openalex.org/W2167599925","https://openalex.org/W2187779086","https://openalex.org/W2205505436","https://openalex.org/W2233407520","https://openalex.org/W2360734399","https://openalex.org/W2484603232","https://openalex.org/W2509538052","https://openalex.org/W2605617080","https://openalex.org/W2619327001","https://openalex.org/W2737989983","https://openalex.org/W2770133273","https://openalex.org/W2810560130","https://openalex.org/W2915339266","https://openalex.org/W2948680670","https://openalex.org/W2981233955","https://openalex.org/W3049157545","https://openalex.org/W3115239638","https://openalex.org/W3154916867","https://openalex.org/W3175403223","https://openalex.org/W4226048638","https://openalex.org/W4285983714","https://openalex.org/W4293089477","https://openalex.org/W4310205552","https://openalex.org/W4361250605"],"related_works":["https://openalex.org/W2015085089","https://openalex.org/W1549989429","https://openalex.org/W2350125527","https://openalex.org/W4283795627","https://openalex.org/W2376463133","https://openalex.org/W2390577498","https://openalex.org/W1967586988","https://openalex.org/W2359175740","https://openalex.org/W2059091687","https://openalex.org/W2064639547"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Gambogic":[2,37],"acid":[3,38,62,122,139,235,260],"has":[4],"demonstrated":[5],"inhibitory":[6],"effects":[7],"on":[8,39,131],"the":[9,33,51,75,78,156,190,255],"growth":[10],"of":[11,36,60,74,137,163,181,192,199,233,258],"various":[12],"cancer":[13],"cell":[14,47,80,87,240,269],"types,":[15],"such":[16],"as":[17,213,215,261],"breast":[18],"cancer,":[19,21,23,25],"pancreatic":[20],"prostate":[22],"lung":[24],"and":[26,49,55,77,99,110,126,171,250],"osteosarcoma.":[27],"This":[28,252],"study":[29],"aims":[30],"to":[31,85,92,107,145,196,244,247],"investigate":[32],"antiproliferative":[34,129,231],"activity":[35],"SNU-16":[40,66,114,132,141],"cells":[41,67,142],"derived":[42],"from":[43],"gastric":[44,237,266],"signet":[45,238,267],"ring":[46,239,268],"carcinoma":[48,241],"elucidate":[50],"underlying":[52],"mechanisms.":[53],"Material":[54],"Methods":[56],"The":[57,134,230],"cytotoxic":[58],"effect":[59,130,232],"gambogic":[61,121,138,234,259],"was":[63,83,90,105,118,143],"evaluated":[64],"in":[65,113,140,211,218],"by":[68],"treating":[69],"them":[70],"with":[71,178,227],"different":[72],"concentrations":[73],"compound,":[76],"XTT":[79],"viability":[81],"assay":[82],"employed":[84],"assess":[86,108],"viability.":[88],"ELISA":[89],"used":[91],"measure":[93],"bax,":[94],"BCL-2,":[95],"caspase":[96,168],"3,":[97,169],"PARP,":[98],"8-oxo-dG":[100,109,200],"levels.":[101],"Additionally,":[102],"immunofluorescence":[103],"staining":[104],"applied":[106],"LC3\u03b2":[111,219],"levels":[112,220],"cells.":[115,133],"Results":[116],"It":[117],"observed":[119],"that":[120],"exerted":[123],"a":[124,160,179,204,224,262],"dose-dependent":[125],"statistically":[127],"significant":[128,161],"IC50":[135,157],"value":[136],"found":[144],"be":[146],"655.1":[147],"nM":[148],"for":[149,265],"24":[150],"hours.":[151],"Subsequent":[152],"investigations":[153],"conducted":[154],"using":[155],"dose":[158],"revealed":[159],"upregulation":[162,198],"apoptotic":[164],"proteins":[165],"including":[166],"cleaved":[167,172],"Bax,":[170],"PARP":[173],"(p":[174,183,201,221],"<":[175,184,202,222],"0.001),":[176,185,203],"along":[177],"downregulation":[180],"BCL-2":[182],"an":[186,197,216],"anti-apoptotic":[187],"protein.":[188],"Moreover,":[189],"administration":[191],"this":[193],"drug":[194],"led":[195],"widely":[205],"acknowledged":[206],"biomarker":[207],"indicating":[208],"oxidative":[209],"damage":[210],"DNA,":[212],"well":[214],"increase":[217],"0.05),":[223],"marker":[225],"associated":[226],"autophagy.":[228,251],"Conclusion":[229],"against":[236],"is":[242],"attributed":[243],"its":[245],"ability":[246],"induce":[248],"apoptosis":[249],"discovery":[253],"highlights":[254],"promising":[256],"potential":[257],"treatment":[263],"option":[264],"carcinoma.":[270]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-08-17T00:00:00"}
