{"id":"https://openalex.org/W4385855865","doi":"https://doi.org/10.1056/nejme2305639","title":"Headway against Brain Tumors with Molecular Targeting of IDH-Mutant Gliomas","display_name":"Headway against Brain Tumors with Molecular Targeting of IDH-Mutant Gliomas","publication_year":2023,"publication_date":"2023-08-16","ids":{"openalex":"https://openalex.org/W4385855865","doi":"https://doi.org/10.1056/nejme2305639","pmid":"https://pubmed.ncbi.nlm.nih.gov/37585632"},"language":"en","primary_location":{"id":"doi:10.1056/nejme2305639","doi":"https://doi.org/10.1056/nejme2305639","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejme2305639","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023905352","display_name":"David Schiff","orcid":"https://orcid.org/0000-0002-1896-2502","observed_orcids":["https://orcid.org/0000-0002-1896-2502","https://orcid.org/0000-0003-1561-9220"]},"institutions":[{"id":"https://openalex.org/I4210134211","display_name":"University of Virginia Medical Center","ror":"https://ror.org/046kb4y45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794","https://openalex.org/I4210134211"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Schiff","raw_affiliation_strings":["From the Division of Neuro-Oncology, Department of Neurology, University of Virginia School of Medicine, Charlottesville","Division of Neuro-Oncology, Department of Neurology, University of Virginia School of Medicine, Charlottesville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Neuro-Oncology, Department of Neurology, University of Virginia School of Medicine, Charlottesville","institution_ids":["https://openalex.org/I4210134211","https://openalex.org/I51556381"]},{"raw_affiliation_string":"Division of Neuro-Oncology, Department of Neurology, University of Virginia School of Medicine, Charlottesville","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5023905352"],"corresponding_institution_ids":["https://openalex.org/I4210134211","https://openalex.org/I51556381"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"389","issue":"7","first_page":"653","last_page":"654"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idh-mutant-glioma","display_name":"IDH-mutant glioma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/idh-mutation","display_name":"IDH mutation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7350000143051147},{"id":"https://openalex.org/keywords/low-grade-glioma","display_name":"low-grade glioma","score":0.8830000162124634},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.6100000143051147},{"id":"https://openalex.org/keywords/radiation-necrosis","display_name":"radiation necrosis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8510000109672546},{"id":"https://openalex.org/keywords/fractionated-radiotherapy","display_name":"fractionated radiotherapy","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.837701678276062},{"id":"https://openalex.org/C2777150147","wikidata":"https://www.wikidata.org/wiki/Q261968","display_name":"Isocitrate dehydrogenase","level":3,"score":0.7849241495132446},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6251185536384583},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5726791620254517},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5571740865707397},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5320509672164917},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.48933571577072144},{"id":"https://openalex.org/C127848430","wikidata":"https://www.wikidata.org/wiki/Q18027543","display_name":"IDH1","level":4,"score":0.4382704794406891},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.43514424562454224},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42157718539237976},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.28887659311294556},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2013087272644043},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.18499571084976196},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0776415765285492},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07490795850753784},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007521","descriptor_name":"Isocitrate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejme2305639","doi":"https://doi.org/10.1056/nejme2305639","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejme2305639","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:37585632","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37585632","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Editorial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W2505666614","https://openalex.org/W2939093001","https://openalex.org/W2980663762","https://openalex.org/W3021794778","https://openalex.org/W3144267543","https://openalex.org/W3164133956","https://openalex.org/W4210555554","https://openalex.org/W4306247069","https://openalex.org/W4321611101","https://openalex.org/W4379284101","https://openalex.org/W4385855855"],"related_works":["https://openalex.org/W7140708436","https://openalex.org/W7122730146","https://openalex.org/W7126233435","https://openalex.org/W3205069009","https://openalex.org/W4385781587","https://openalex.org/W4402543180","https://openalex.org/W4399973103","https://openalex.org/W4308917777","https://openalex.org/W7139963205","https://openalex.org/W4399042708"],"abstract_inverted_index":{"Approximately":[0],"2500":[1],"persons":[2],"in":[3],"the":[4],"United":[5],"States":[6],"receive":[7],"a":[8,37,78],"diagnosis":[9],"of":[10,47,81],"isocitrate":[11],"dehydrogenase":[12],"(IDH)\u2013mutated":[13],"grade":[14],"2":[15],"glioma":[16],"each":[17],"year.1":[18],"These":[19,49],"patients":[20],"tend":[21],"to":[22,54],"be":[23],"young":[24],"(median":[25],"age,":[26],"40":[27],"years),":[28],"and":[29,34,44,56,69,95],"most":[30],"have":[31],"tumor-related":[32],"epilepsy":[33],"grapple":[35],"with":[36],"tumor":[38],"that":[39],"may":[40],"affect":[41],"cognition,":[42],"employment,":[43],"other":[45],"aspects":[46],"life.":[48],"tumors":[50,75],"typically":[51],"become":[52],"refractory":[53],"treatment":[55],"are":[57],"eventually":[58],"fatal,":[59],"belying":[60],"their":[61],"designation":[62],"as":[63],"\u201clow-grade\u201d":[64],"gliomas.":[65],"Both":[66],"fractionated":[67],"radiotherapy":[68],"alkylator-based":[70],"chemotherapy":[71,99],"help":[72],"control":[73],"these":[74],"but":[76],"convey":[77],"substantial":[79],"risk":[80],"permanent":[82],"toxic":[83],"effects.":[84],"With":[85],"radiation":[86,93],"therapy,":[87],"such":[88],"effects":[89],"include":[90],"fatigue,":[91],"alopecia,":[92],"necrosis,":[94],"particularly,":[96],"cognitive":[97],"dysfunction;":[98],".":[100,101,102]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-08-17T00:00:00"}