{"id":"https://openalex.org/W4385837109","doi":"https://doi.org/10.1158/1538-7445.kidney23-ia016","title":"Abstract IA016: Remodeling of tumor metabolism by L-2-hydroxyglutarate: Implications for renal cancer growth and progression","display_name":"Abstract IA016: Remodeling of tumor metabolism by L-2-hydroxyglutarate: Implications for renal cancer growth and progression","publication_year":2023,"publication_date":"2023-08-15","ids":{"openalex":"https://openalex.org/W4385837109","doi":"https://doi.org/10.1158/1538-7445.kidney23-ia016"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.kidney23-ia016","doi":"https://doi.org/10.1158/1538-7445.kidney23-ia016","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.kidney23-ia016","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086808449","display_name":"Sunil Sudarshan","orcid":"https://orcid.org/0000-0001-7257-6277","observed_orcids":["https://orcid.org/0000-0001-7257-6277"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sunil Sudarshan","raw_affiliation_strings":["1University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086808449"],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"83","issue":"16_Supplement","first_page":"IA016","last_page":"IA016"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-2-hydroxyglutarate","display_name":"L-2-hydroxyglutarate","score":0.9980000257492065},{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.8059999942779541},{"id":"https://openalex.org/keywords/serine-biosynthesis","display_name":"serine biosynthesis","score":0.7210000157356262},{"id":"https://openalex.org/keywords/serine-deficiency","display_name":"serine deficiency","score":0.5899999737739563},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/rna-n6-methyladenosine","display_name":"RNA N6-methyladenosine","score":0.949999988079071},{"id":"https://openalex.org/keywords/n6-methyladenosine","display_name":"N6-methyladenosine","score":0.6449999809265137},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.8479999899864197},{"id":"https://openalex.org/keywords/metabolic-vulnerability","display_name":"metabolic vulnerability","score":0.6000000238418579},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.5989999771118164},{"id":"https://openalex.org/keywords/tumor-growth-and-progression","display_name":"tumor growth and progression","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.636222243309021},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6228671073913574},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5043619871139526},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4884735643863678},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.47932374477386475},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.45992881059646606},{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.42870819568634033},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4255150258541107},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40218645334243774},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2978888750076294},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2909053564071655},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20763319730758667},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20641887187957764},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12725508213043213},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11315876245498657}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.kidney23-ia016","doi":"https://doi.org/10.1158/1538-7445.kidney23-ia016","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.kidney23-ia016","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4396905187","https://openalex.org/W4385837061","https://openalex.org/W4362544107","https://openalex.org/W2181925745","https://openalex.org/W1984882020","https://openalex.org/W2885264397","https://openalex.org/W4311361639","https://openalex.org/W2075355391","https://openalex.org/W2886264778","https://openalex.org/W3113261641"],"abstract_inverted_index":{"Abstract":[0],"Tumor":[1],"cells":[2,78,103],"remodel":[3],"their":[4,8],"metabolism":[5,74,165],"to":[6,13,42,53,108],"meet":[7],"unique":[9],"demands":[10],"in":[11,34,47,75,96,110,184],"order":[12],"support":[14,109],"tumor":[15,112,164],"growth":[16,113,172],"and":[17,86,114,173],"progression.":[18],"However,":[19],"this":[20,153],"reprogramming":[21],"may":[22],"create":[23],"metabolic":[24],"vulnerabilities.":[25],"The":[26,90],"small":[27,44],"molecule":[28],"L-2-hdroxyglutarate":[29],"(L-2HG)":[30],"is":[31],"commonly":[32],"elevated":[33,46],"clear":[35],"cell":[36,38],"renal":[37,76,170],"carcinoma":[39],"(ccRCC).":[40],"Similar":[41],"other":[43],"molecules":[45],"cancer,":[48],"L-2HG":[49,71,94,123,140],"has":[50],"the":[51,80,150,179],"potential":[52],"regulate":[54],"gene":[55],"expression":[56,128],"by":[57,146,166],"altering":[58],"DNA,":[59],"histone,":[60],"and/or":[61],"RNA":[62,87],"methylation.":[63],"Using":[64],"unbiased":[65],"profiling":[66],"methodologies,":[67],"we":[68],"find":[69],"that":[70,100,138,148],"remodels":[72],"tumoral":[73],"cancer":[77,171],"through":[79],"combined":[81,91],"effects":[82,92],"on":[83,105],"histone":[84],"methylation":[85],"N6-methyladenosine":[88],"(m6A).":[89],"of":[93,129,152,163,178],"result":[95],"a":[97],"serine":[98,107,130],"liability":[99],"renders":[101],"tumors":[102,125,142],"reliant":[104],"exogenous":[106],"vitro/vivo":[111],"redox":[115],"balance.":[116],"In":[117,133],"agreement":[118],"with":[119],"these":[120],"data,":[121],"raised":[122],"kidney":[124,141],"have":[126],"reduced":[127],"biosynthetic":[131],"enzymes.":[132],"summary,":[134],"our":[135],"data":[136],"reveal":[137],"high":[139],"could":[143],"be":[144],"targeted":[145],"strategies":[147],"limit":[149],"availability":[151],"now":[154],"\"essential\"":[155],"amino":[156],"acid.":[157],"Citation":[158],"Format:":[159],"Sunil":[160],"Sudarshan.":[161],"Remodeling":[162],"L-2-hydroxyglutarate:":[167],"Implications":[168],"for":[169],"progression":[174],"[abstract].":[175],"In:":[176],"Proceedings":[177],"AACR":[180],"Special":[181],"Conference:":[182],"Advances":[183],"Kidney":[185],"Cancer":[186,196],"Research;":[187],"2023":[188],"Jun":[189],"24-27;":[190],"Austin,":[191],"Texas.":[192],"Philadelphia":[193],"(PA):":[194],"AACR;":[195],"Res":[197],"2023;83(16":[198],"Suppl):Abstract":[199],"nr":[200],"IA016.":[201]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2023-08-16T00:00:00"}
