{"id":"https://openalex.org/W4385809472","doi":"https://doi.org/10.1186/s12958-023-01115-4","title":"The impact of non-caloric artificial sweetener aspartame on female reproductive system in mice model","display_name":"The impact of non-caloric artificial sweetener aspartame on female reproductive system in mice model","publication_year":2023,"publication_date":"2023-08-14","ids":{"openalex":"https://openalex.org/W4385809472","doi":"https://doi.org/10.1186/s12958-023-01115-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/37580716","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10424399"},"language":"en","primary_location":{"id":"doi:10.1186/s12958-023-01115-4","doi":"https://doi.org/10.1186/s12958-023-01115-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12958-023-01115-4","pdf_url":"https://rbej.biomedcentral.com/counter/pdf/10.1186/s12958-023-01115-4","source":{"id":"https://openalex.org/S140121985","display_name":"Reproductive Biology and Endocrinology","issn_l":"1477-7827","issn":["1477-7827"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Biology and Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://rbej.biomedcentral.com/counter/pdf/10.1186/s12958-023-01115-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053751317","display_name":"Ab Qayoom Naik","orcid":"https://orcid.org/0000-0003-4593-5152","observed_orcids":["https://orcid.org/0000-0003-4593-5152"]},"institutions":[{"id":"https://openalex.org/I464993","display_name":"Barkatullah University","ror":"https://ror.org/02ax13658","country_code":"IN","type":"education","lineage":["https://openalex.org/I464993"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Ab Qayoom Naik","raw_affiliation_strings":["Department of Zoology, Govt. Degree College, Paloura Mishriwala, Jammu, J & K, 180018, India. scholarnaikqayoom25@gmail.com","Laboratory of Endocrinology, Department of Biosciences, Barkatullah University, Bhopal, M. P, 462026, India. scholarnaikqayoom25@gmail.com","Department of Zoology, Govt. Degree College, Paloura Mishriwala, Jammu, J & K, 180018, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Govt. Degree College, Paloura Mishriwala, Jammu, J & K, 180018, India. scholarnaikqayoom25@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Endocrinology, Department of Biosciences, Barkatullah University, Bhopal, M. P, 462026, India. scholarnaikqayoom25@gmail.com","institution_ids":["https://openalex.org/I464993"]},{"raw_affiliation_string":"Department of Zoology, Govt. Degree College, Paloura Mishriwala, Jammu, J & K, 180018, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024473723","display_name":"Tabassum Zafar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I464993","display_name":"Barkatullah University","ror":"https://ror.org/02ax13658","country_code":"IN","type":"education","lineage":["https://openalex.org/I464993"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tabassum Zafar","raw_affiliation_strings":["Laboratory of Endocrinology, Department of Biosciences, Barkatullah University, Bhopal, M. P, 462026, India. tztabassumzafar@gmail.com","Laboratory of Endocrinology, Department of Biosciences, Barkatullah University, Bhopal, M. P, 462026, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Endocrinology, Department of Biosciences, Barkatullah University, Bhopal, M. P, 462026, India. tztabassumzafar@gmail.com","institution_ids":["https://openalex.org/I464993"]},{"raw_affiliation_string":"Laboratory of Endocrinology, Department of Biosciences, Barkatullah University, Bhopal, M. P, 462026, India","institution_ids":["https://openalex.org/I464993"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038512692","display_name":"Vinoy K. Shrivastava","orcid":"https://orcid.org/0000-0002-4838-8281","observed_orcids":["https://orcid.org/0000-0002-4838-8281"]},"institutions":[{"id":"https://openalex.org/I464993","display_name":"Barkatullah University","ror":"https://ror.org/02ax13658","country_code":"IN","type":"education","lineage":["https://openalex.org/I464993"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vinoy K Shrivastava","raw_affiliation_strings":["Laboratory of Endocrinology, Department of Biosciences, Barkatullah University, Bhopal, M. P, 462026, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Endocrinology, Department of Biosciences, Barkatullah University, Bhopal, M. P, 462026, India","institution_ids":["https://openalex.org/I464993"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053751317"],"corresponding_institution_ids":["https://openalex.org/I464993"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":2.3324,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.86531065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"21","issue":"1","first_page":"73","last_page":"73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.29350000619888306,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.03440000116825104,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspartame","display_name":"aspartame","score":1.0},{"id":"https://openalex.org/keywords/female-reproductive-toxicity","display_name":"female reproductive toxicity","score":0.9430000185966492},{"id":"https://openalex.org/keywords/ovarian-follicle-degeneration","display_name":"ovarian follicle degeneration","score":0.7839999794960022},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-gonadal-axis","display_name":"hypothalamic-pituitary-gonadal axis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/gonadotropins","display_name":"gonadotropins","score":0.9340000152587891},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9169999957084656},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/endometrium","display_name":"endometrium","score":0.8299999833106995},{"id":"https://openalex.org/keywords/gonadosomatic-index","display_name":"gonadosomatic index","score":0.7960000038146973},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.6060000061988831},{"id":"https://openalex.org/keywords/swiss-albino-mice","display_name":"Swiss mice","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C2778278337","wikidata":"https://www.wikidata.org/wiki/Q182040","display_name":"Aspartame","level":2,"score":0.9327771663665771},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5988209247589111},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5746404528617859},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4970450699329376},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4837246239185333},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4117748439311981},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35152190923690796},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.09560593962669373}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001218","descriptor_name":"Aspartame","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013549","descriptor_name":"Sweetening Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12958-023-01115-4","doi":"https://doi.org/10.1186/s12958-023-01115-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12958-023-01115-4","pdf_url":"https://rbej.biomedcentral.com/counter/pdf/10.1186/s12958-023-01115-4","source":{"id":"https://openalex.org/S140121985","display_name":"Reproductive Biology and Endocrinology","issn_l":"1477-7827","issn":["1477-7827"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Biology and Endocrinology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10424399","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10424399","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10424399/pdf/12958_2023_Article_1115.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reprod Biol Endocrinol","raw_type":"Text"},{"id":"pmid:37580716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37580716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive biology and endocrinology : RB&E","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:980f40a0762442e18d0f0e4896ab6a67","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/980f40a0762442e18d0f0e4896ab6a67","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Reproductive Biology and Endocrinology, Vol 21, Iss 1, Pp 1-12 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12958-023-01115-4","doi":"https://doi.org/10.1186/s12958-023-01115-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12958-023-01115-4","pdf_url":"https://rbej.biomedcentral.com/counter/pdf/10.1186/s12958-023-01115-4","source":{"id":"https://openalex.org/S140121985","display_name":"Reproductive Biology and Endocrinology","issn_l":"1477-7827","issn":["1477-7827"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive Biology and Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4045358724","display_name":null,"funder_award_id":"BT/PR4479/INF/22/175/2012","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"}],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385809472.pdf","grobid_xml":"https://content.openalex.org/works/W4385809472.grobid-xml"},"referenced_works_count":111,"referenced_works":["https://openalex.org/W1148896616","https://openalex.org/W1534330292","https://openalex.org/W1708429683","https://openalex.org/W1915513917","https://openalex.org/W1949298326","https://openalex.org/W1963564461","https://openalex.org/W1971280724","https://openalex.org/W1972696281","https://openalex.org/W1974485684","https://openalex.org/W1979371844","https://openalex.org/W2005614483","https://openalex.org/W2011667745","https://openalex.org/W2016092552","https://openalex.org/W2026377171","https://openalex.org/W2028744644","https://openalex.org/W2029755975","https://openalex.org/W2030645331","https://openalex.org/W2037647835","https://openalex.org/W2040092435","https://openalex.org/W2040577031","https://openalex.org/W2043351054","https://openalex.org/W2045158080","https://openalex.org/W2059454385","https://openalex.org/W2061120524","https://openalex.org/W2061504188","https://openalex.org/W2064525704","https://openalex.org/W2069351419","https://openalex.org/W2070296690","https://openalex.org/W2082543799","https://openalex.org/W2086341250","https://openalex.org/W2093088433","https://openalex.org/W2094433610","https://openalex.org/W2096170202","https://openalex.org/W2096429037","https://openalex.org/W2097480836","https://openalex.org/W2097558914","https://openalex.org/W2100831124","https://openalex.org/W2101301224","https://openalex.org/W2105244954","https://openalex.org/W2107558401","https://openalex.org/W2110470209","https://openalex.org/W2112491880","https://openalex.org/W2113433435","https://openalex.org/W2114872570","https://openalex.org/W2119511015","https://openalex.org/W2123880692","https://openalex.org/W2124072109","https://openalex.org/W2124551859","https://openalex.org/W2130284699","https://openalex.org/W2132154473","https://openalex.org/W2136949042","https://openalex.org/W2138094299","https://openalex.org/W2151442620","https://openalex.org/W2159187409","https://openalex.org/W2160182726","https://openalex.org/W2161960007","https://openalex.org/W2161969524","https://openalex.org/W2167139179","https://openalex.org/W2168056522","https://openalex.org/W2169323511","https://openalex.org/W2169795817","https://openalex.org/W2170649441","https://openalex.org/W2171131656","https://openalex.org/W2172742114","https://openalex.org/W2175200887","https://openalex.org/W2297144948","https://openalex.org/W2316084138","https://openalex.org/W2321722657","https://openalex.org/W2402649133","https://openalex.org/W2412192865","https://openalex.org/W2515946872","https://openalex.org/W2547749232","https://openalex.org/W2580003996","https://openalex.org/W2593970154","https://openalex.org/W2606123334","https://openalex.org/W2620554690","https://openalex.org/W2686070502","https://openalex.org/W2734494266","https://openalex.org/W2736805908","https://openalex.org/W2791244870","https://openalex.org/W2803765047","https://openalex.org/W2885168109","https://openalex.org/W2886743861","https://openalex.org/W2889736971","https://openalex.org/W2902900484","https://openalex.org/W2924669252","https://openalex.org/W2948436810","https://openalex.org/W2994672341","https://openalex.org/W3004465995","https://openalex.org/W3034895011","https://openalex.org/W3043745005","https://openalex.org/W3084346878","https://openalex.org/W3087276081","https://openalex.org/W3118800583","https://openalex.org/W3122829241","https://openalex.org/W3127731131","https://openalex.org/W3175914943","https://openalex.org/W3195836314","https://openalex.org/W3198259760","https://openalex.org/W4206735398","https://openalex.org/W4206812126","https://openalex.org/W4220722417","https://openalex.org/W4220836731","https://openalex.org/W4229459993","https://openalex.org/W4233484258","https://openalex.org/W4240596769","https://openalex.org/W4283712860","https://openalex.org/W4296578716","https://openalex.org/W4307273289","https://openalex.org/W4308559981","https://openalex.org/W4377094751"],"related_works":["https://openalex.org/W7217792776","https://openalex.org/W3087276081","https://openalex.org/W4210804752","https://openalex.org/W3043745005","https://openalex.org/W4400148799","https://openalex.org/W4417266941","https://openalex.org/W4391283583","https://openalex.org/W4388613280","https://openalex.org/W7119408826","https://openalex.org/W6893437508"],"abstract_inverted_index":{"BACKGROUND:":[0],"Artificial":[1],"sweeteners,":[2],"used":[3,27],"as":[4],"sugar":[5],"substitutes":[6],"have":[7,92],"found":[8],"their":[9,50],"ways":[10],"into":[11,60],"almost":[12],"all":[13],"the":[14,19,33,67,97,102,105,208,221,225,241,253,261,265,277,281],"food":[15,30],"items":[16],"due":[17],"to":[18,48,100,112,275],"notion":[20],"that":[21,118],"they":[22],"are":[23,273],"non-caloric.":[24],"Aspartame":[25,156],"is":[26],"in":[28,110,132,151,184,191,207],"numerous":[29],"products":[31],"throughout":[32],"world.":[34],"The":[35,75],"primary":[36],"users":[37],"of":[38,69,107,138,186,220,227,243,248,258,268],"aspartame":[39,83,123,238,262],"include":[40],"diabetics":[41],"and":[42,71,89,126,140,142,161,171,174,177,196,224,245,280],"calorie":[43,51],"conscious":[44],"people":[45],"who":[46],"intend":[47],"limit":[49],"intake.":[52],"METHODS:":[53],"Female":[54],"Swiss":[55],"albino":[56],"mice":[57,64,109,120],"were":[58,147,198,204,230],"divided":[59],"three":[61],"groups":[62,77],"(12":[63],"each)":[65],"for":[66,124,159],"duration":[68],"30":[70,125,160],"60":[72,127,152,162],"days":[73,128,153,163],"consecutively.":[74],"treatment":[76,103,154],"received":[78],"40":[79],"mg/kg":[80],"b.":[81],"w.":[82],"orally.":[84],"Hormone":[85],"assays":[86],"using":[87],"ELISA":[88],"tissue":[90],"histopathology":[91],"been":[93],"performed":[94],"along":[95],"with":[96,122],"fertility":[98,106],"assay":[99],"access":[101],"outcomeon":[104],"treated":[108,121,157],"comparison":[111],"controls.":[113],"RESULTS:":[114],"Present":[115],"study":[116],"reports":[117],"female":[119,269],"showed":[129,164],"significant":[130],"reduction":[131,183],"body":[133],"weight,":[134],"relative":[135],"organ":[136],"weight":[137],"(liver":[139],"kidney)":[141],"gonadosomatic":[143],"index.":[144],"These":[145],"changes":[146,190,203],"more":[148],"significantly":[149],"recorded":[150],"group.":[155],"animals":[158],"duration-dependent":[165],"decrease":[166],"gonandotropins":[167],"(follicle":[168],"stimulating":[169],"hormone":[170],"luteinizing":[172],"hormone),":[173],"steroids":[175],"(estradiol":[176],"progesterone).":[178],"Moreover,":[179],"severe":[180],"histopathological":[181],"changes,":[182],"number":[185],"growing":[187],"follicles,":[188],"degenerative":[189],"follicular":[192],"structure,":[193],"corona":[194],"radiata":[195],"zonagranulosa":[197],"also":[199,205,231],"observed.":[200],"Besides,":[201],"histomorphological":[202],"observed":[206],"uterine":[209,213],"structure":[210,223],"including":[211,237],"atrophic":[212],"endometrial":[214,217,222],"glands,":[215],"contracted":[216],"lining,":[218],"disruption":[219],"shapes":[226],"blood":[228],"vessels":[229],"altered.":[232],"CONCLUSION:":[233],"Non-nutritive":[234],"artificial":[235],"sweeteners":[236],"negatively":[239,263],"impact":[240],"function":[242],"ovaries":[244],"feedback":[246],"mechanism":[247,279],"reproductive":[249,266],"hormones":[250],"by":[251],"affecting":[252],"hypothalamic-pituitary-gonadal":[254],"axis.":[255],"In":[256],"light":[257],"present":[259],"findings":[260],"impacted":[264],"system":[267],"mice.":[270],"More":[271],"studies":[272],"required":[274],"identify":[276],"molecular":[278],"pathways":[282],"involved.":[283]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-08-15T00:00:00"}
