{"id":"https://openalex.org/W4385804145","doi":"https://doi.org/10.1055/s-0042-1751479","title":"Multi-step Flow Synthesis of the Anthelmintic Drug Praziquantel","display_name":"Multi-step Flow Synthesis of the Anthelmintic Drug Praziquantel","publication_year":2023,"publication_date":"2023-08-01","ids":{"openalex":"https://openalex.org/W4385804145","doi":"https://doi.org/10.1055/s-0042-1751479"},"language":"en","primary_location":{"id":"doi:10.1055/s-0042-1751479","doi":"https://doi.org/10.1055/s-0042-1751479","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0042-1751479","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0042-1751479.pdf","source":{"id":"https://openalex.org/S4210211857","display_name":"SynOpen","issn_l":"2509-9396","issn":["2509-9396"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SynOpen","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0042-1751479.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070305207","display_name":"Rambabu Gundla","orcid":"https://orcid.org/0000-0003-0390-6505","observed_orcids":["https://orcid.org/0000-0003-0390-6505","https://orcid.org/0000-0002-6469-6022"]},"institutions":[{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rambabu Gundla","raw_affiliation_strings":["Department of Chemistry, School of Science, GITAM (Deemed to Be University)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, School of Science, GITAM (Deemed to Be University)","institution_ids":["https://openalex.org/I885392262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023193536","display_name":"Prathama S. Mainkar","orcid":"https://orcid.org/0000-0002-2696-3759","observed_orcids":["https://orcid.org/0000-0002-2696-3759"]},"institutions":[{"id":"https://openalex.org/I55664587","display_name":"Indian Institute of Chemical Technology","ror":"https://ror.org/040dky007","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I55664587","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Prathama S Mainkar","raw_affiliation_strings":["Academy of Scientific and Innovative Research (AcSIR)","Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Scientific and Innovative Research (AcSIR)","institution_ids":["https://openalex.org/I99364266"]},{"raw_affiliation_string":"Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology","institution_ids":["https://openalex.org/I55664587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071359319","display_name":"Manjinder Singh Phull","orcid":"https://orcid.org/0000-0001-8285-8999","observed_orcids":["https://orcid.org/0000-0001-8285-8999"]},"institutions":[{"id":"https://openalex.org/I4210133301","display_name":"Cipla (India)","ror":"https://ror.org/02w6dqa48","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210133301"]},{"id":"https://openalex.org/I885392262","display_name":"GITAM University","ror":"https://ror.org/0440p1d37","country_code":"IN","type":"education","lineage":["https://openalex.org/I885392262"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manjinder Singh Phull","raw_affiliation_strings":["Cipla Limited Cipla House","Department of Chemistry, School of Science, GITAM (Deemed to Be University)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cipla Limited Cipla House","institution_ids":["https://openalex.org/I4210133301"]},{"raw_affiliation_string":"Department of Chemistry, School of Science, GITAM (Deemed to Be University)","institution_ids":["https://openalex.org/I885392262"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084854319","display_name":"Surender Singh Jadav","orcid":"https://orcid.org/0000-0002-5397-8956","observed_orcids":["https://orcid.org/0000-0002-5397-8956"]},"institutions":[{"id":"https://openalex.org/I55664587","display_name":"Indian Institute of Chemical Technology","ror":"https://ror.org/040dky007","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I55664587","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Surender Singh Jadav","raw_affiliation_strings":["Academy of Scientific and Innovative Research (AcSIR)","Department of Natural Products and Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Scientific and Innovative Research (AcSIR)","institution_ids":["https://openalex.org/I99364266"]},{"raw_affiliation_string":"Department of Natural Products and Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology","institution_ids":["https://openalex.org/I55664587"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014147086","display_name":"Chander Singh Bohara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133301","display_name":"Cipla (India)","ror":"https://ror.org/02w6dqa48","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210133301"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chander Singh Bohara","raw_affiliation_strings":["Cipla Limited Cipla House"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cipla Limited Cipla House","institution_ids":["https://openalex.org/I4210133301"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":300,"currency":"EUR","value_usd":340},"apc_paid":{"value":300,"currency":"EUR","value_usd":340},"fwci":0.1564,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.25816888,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"07","issue":"03","first_page":"362","last_page":"370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/praziquantel","display_name":"praziquantel","score":0.996999979019165},{"id":"https://openalex.org/keywords/flow-synthesis","display_name":"flow synthesis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/flow-chemistry","display_name":"flow chemistry","score":0.652999997138977},{"id":"https://openalex.org/keywords/anthelmintics","display_name":"anthelmintics","score":0.8090000152587891},{"id":"https://openalex.org/keywords/phenylethylamine","display_name":"phenylethylamine","score":0.9319999814033508},{"id":"https://openalex.org/keywords/schistosomiasis-treatment","display_name":"schistosomiasis treatment","score":0.8220000267028809},{"id":"https://openalex.org/keywords/drug-synthesis","display_name":"drug synthesis","score":0.527999997138977},{"id":"https://openalex.org/keywords/process-intensification","display_name":"process intensification","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C2779744950","wikidata":"https://www.wikidata.org/wiki/Q424145","display_name":"Praziquantel","level":4,"score":0.9646871089935303},{"id":"https://openalex.org/C2776908094","wikidata":"https://www.wikidata.org/wiki/Q572294","display_name":"Anthelmintic","level":2,"score":0.6791695356369019},{"id":"https://openalex.org/C206139338","wikidata":"https://www.wikidata.org/wiki/Q192355","display_name":"Raw material","level":2,"score":0.6626887917518616},{"id":"https://openalex.org/C2776225656","wikidata":"https://www.wikidata.org/wiki/Q221159","display_name":"Schistosomiasis","level":3,"score":0.45026731491088867},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4273243546485901},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.4003259837627411},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3910595774650574},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37499988079071045},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3420184850692749},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.33896446228027344},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.32863444089889526},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30479714274406433},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1567574143409729},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.1165199875831604},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11260131001472473},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09781566262245178},{"id":"https://openalex.org/C42972112","wikidata":"https://www.wikidata.org/wiki/Q170201","display_name":"Veterinary medicine","level":1,"score":0.09689787030220032},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1055/s-0042-1751479","doi":"https://doi.org/10.1055/s-0042-1751479","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0042-1751479","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0042-1751479.pdf","source":{"id":"https://openalex.org/S4210211857","display_name":"SynOpen","issn_l":"2509-9396","issn":["2509-9396"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SynOpen","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:f18eff5c4eef40cfaa5388c073d19867","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f18eff5c4eef40cfaa5388c073d19867","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"SynOpen, Vol 07, Iss 03, Pp 362-370 (2023)","raw_type":"article"},{"id":"doi:10.60692/fw4m9-rrk64","doi":"https://doi.org/10.60692/fw4m9-rrk64","is_oa":true,"landing_page_url":"https://doi.org/10.60692/fw4m9-rrk64","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/zrpwh-3r672","doi":"https://doi.org/10.60692/zrpwh-3r672","is_oa":true,"landing_page_url":"https://doi.org/10.60692/zrpwh-3r672","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1055/s-0042-1751479","doi":"https://doi.org/10.1055/s-0042-1751479","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0042-1751479","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0042-1751479.pdf","source":{"id":"https://openalex.org/S4210211857","display_name":"SynOpen","issn_l":"2509-9396","issn":["2509-9396"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321135","host_organization_name":"Georg Thieme Verlag","host_organization_lineage":["https://openalex.org/P4310321135","https://openalex.org/P4310320000"],"host_organization_lineage_names":["Georg Thieme Verlag","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SynOpen","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385804145.pdf","grobid_xml":"https://content.openalex.org/works/W4385804145.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1970058635","https://openalex.org/W1971649849","https://openalex.org/W1973320156","https://openalex.org/W1979322807","https://openalex.org/W1991555453","https://openalex.org/W2000332199","https://openalex.org/W2008535026","https://openalex.org/W2021008950","https://openalex.org/W2050391458","https://openalex.org/W2107113064","https://openalex.org/W2166047939","https://openalex.org/W2167245774","https://openalex.org/W2170657871","https://openalex.org/W2307072057","https://openalex.org/W2582840251","https://openalex.org/W2618884428","https://openalex.org/W2621108245","https://openalex.org/W2950340690","https://openalex.org/W3005847557","https://openalex.org/W3017205600","https://openalex.org/W3020282496","https://openalex.org/W3046855463","https://openalex.org/W3106896018","https://openalex.org/W3141339282","https://openalex.org/W3158612833","https://openalex.org/W3188805634","https://openalex.org/W3205317899"],"related_works":["https://openalex.org/W2392301469","https://openalex.org/W2537371154","https://openalex.org/W2389866276","https://openalex.org/W2338658656","https://openalex.org/W1991555453","https://openalex.org/W1975108108","https://openalex.org/W2167245774","https://openalex.org/W2368751802","https://openalex.org/W2363920111","https://openalex.org/W2354063594"],"abstract_inverted_index":{"Abstract":[0],"Praziquantel":[1],"(PZQ;":[2],"Brand":[3],"name:":[4],"Biltricide)":[5],"is":[6,14,78,96,182],"categorized":[7],"as":[8,33,85,135],"an":[9],"anthelminthic":[10],"drug,":[11],"and":[12,21,38,66,119],"it":[13,32],"used":[15],"for":[16,69,103],"the":[17,36,43,53,70,86,93,104,111,126,129,156,175],"treatment":[18],"of":[19,35,47,56,61,72,92,106,128,153,178],"Schistosomiasis":[20],"other":[22],"parasitic":[23],"infections.":[24],"The":[25,45,89,149],"World":[26],"Health":[27],"Organization":[28],"(WHO)":[29],"has":[30],"classified":[31],"one":[34],"essential":[37,133],"emergency":[39],"medicines":[40],"needed":[41],"across":[42],"globe.":[44],"price":[46],"PZQ":[48,73,107,154],"formulated":[49],"product":[50],"depends":[51],"on":[52],"associated":[54],"method":[55,68],"preparation,":[57],"along":[58],"with":[59],"cost":[60],"raw":[62],"materials.":[63],"A":[64],"precise":[65],"reliable":[67],"preparation":[71,151],"using":[74,83,168],"a":[75,99],"flow-chemistry":[76],"approach":[77],"described":[79],"in":[80,132,155,161,186],"this":[81],"study":[82,95,158],"phenylethylamine":[84],"starting":[87],"material.":[88],"main":[90],"objective":[91],"present":[94],"to":[97,117,122],"identify":[98],"new":[100],"economical":[101],"route":[102],"synthesis":[105],"that":[108],"could":[109],"decrease":[110],"production":[112],"time":[113,163],"drastically":[114],"from":[115],"days":[116],"minutes":[118],"be":[120],"transferred":[121],"large-scale":[123],"production.":[124],"Simultaneously,":[125],"purity":[127],"obtained":[130],"intermediates":[131],"steps,":[134],"single":[136],"or":[137],"continuous":[138,150],"process,":[139],"determined":[140],"by":[141],"HPLC":[142],"analysis":[143],"were":[144],"more":[145],"than":[146,167,185],"90%":[147],"pure.":[148],"process":[152],"current":[157],"was":[159],"achieved":[160],"less":[162,184],"(ca.":[164,171],"3\u20134":[165,172],"h)":[166],"conventional":[169],"methods":[170],"days).":[173],"Moreover,":[174],"required":[176],"quantity":[177],"key":[179],"intermediate":[180],"dimethoxyethanamine":[181],"40\u201350%":[183],"existing":[187],"methods.":[188]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2023-08-15T00:00:00"}
