{"id":"https://openalex.org/W4385802421","doi":"https://doi.org/10.1073/pnas.2302603120","title":"RABL2 promotes the outward transition zone passage of signaling proteins in cilia via ARL3","display_name":"RABL2 promotes the outward transition zone passage of signaling proteins in cilia via ARL3","publication_year":2023,"publication_date":"2023-08-14","ids":{"openalex":"https://openalex.org/W4385802421","doi":"https://doi.org/10.1073/pnas.2302603120","pmid":"https://pubmed.ncbi.nlm.nih.gov/37579161","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10450674"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2302603120","doi":"https://doi.org/10.1073/pnas.2302603120","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2302603120","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1073/pnas.2302603120","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071569462","display_name":"Rui\u2010Kai Zhang","orcid":"https://orcid.org/0000-0003-2696-7781","observed_orcids":["https://orcid.org/0000-0003-2696-7781"]},"institutions":[{"id":"https://openalex.org/I132369690","display_name":"Tianjin University of Science and Technology","ror":"https://ror.org/018rbtf37","country_code":"CN","type":"education","lineage":["https://openalex.org/I132369690"]},{"id":"https://openalex.org/I4387152708","display_name":"State Key Laboratory of Food Nutrition and Safety","ror":"https://ror.org/00y9yvy68","country_code":"CN","type":"facility","lineage":["https://openalex.org/I132369690","https://openalex.org/I4387152708"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui-Kai Zhang","raw_affiliation_strings":["State Key Laboratory of Food Nutrition and Safety, Institute of Health Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China"],"raw_orcid":"https://orcid.org/0000-0003-2696-7781","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Food Nutrition and Safety, Institute of Health Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China","institution_ids":["https://openalex.org/I132369690","https://openalex.org/I4387152708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062620840","display_name":"Wei-Yue Sun","orcid":"https://orcid.org/0000-0002-1953-7698","observed_orcids":["https://orcid.org/0000-0002-1953-7698"]},"institutions":[{"id":"https://openalex.org/I132369690","display_name":"Tianjin University of Science and Technology","ror":"https://ror.org/018rbtf37","country_code":"CN","type":"education","lineage":["https://openalex.org/I132369690"]},{"id":"https://openalex.org/I4387152708","display_name":"State Key Laboratory of Food Nutrition and Safety","ror":"https://ror.org/00y9yvy68","country_code":"CN","type":"facility","lineage":["https://openalex.org/I132369690","https://openalex.org/I4387152708"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei-Yue Sun","raw_affiliation_strings":["State Key Laboratory of Food Nutrition and Safety, Institute of Health Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China"],"raw_orcid":"https://orcid.org/0000-0002-1953-7698","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Food Nutrition and Safety, Institute of Health Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China","institution_ids":["https://openalex.org/I132369690","https://openalex.org/I4387152708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100720193","display_name":"Yan\u2010Xia Liu","orcid":"https://orcid.org/0000-0003-4127-7148","observed_orcids":["https://orcid.org/0000-0003-4127-7148"]},"institutions":[{"id":"https://openalex.org/I132369690","display_name":"Tianjin University of Science and Technology","ror":"https://ror.org/018rbtf37","country_code":"CN","type":"education","lineage":["https://openalex.org/I132369690"]},{"id":"https://openalex.org/I4387152708","display_name":"State Key Laboratory of Food Nutrition and Safety","ror":"https://ror.org/00y9yvy68","country_code":"CN","type":"facility","lineage":["https://openalex.org/I132369690","https://openalex.org/I4387152708"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-Xia Liu","raw_affiliation_strings":["State Key Laboratory of Food Nutrition and Safety, Institute of Health Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China"],"raw_orcid":"https://orcid.org/0000-0003-4127-7148","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Food Nutrition and Safety, Institute of Health Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China","institution_ids":["https://openalex.org/I132369690","https://openalex.org/I4387152708"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Emma Y. Zhang","orcid":"https://orcid.org/0009-0000-2203-1885","observed_orcids":["https://orcid.org/0009-0000-2203-1885"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emma Y. Zhang","raw_affiliation_strings":["Hamilton High School, Chandler, AZ 85248"],"raw_orcid":"https://orcid.org/0009-0000-2203-1885","affiliations":[{"raw_affiliation_string":"Hamilton High School, Chandler, AZ 85248","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032451240","display_name":"Zhen\u2010Chuan Fan","orcid":"https://orcid.org/0000-0003-1712-3413","observed_orcids":["https://orcid.org/0000-0003-1712-3413"]},"institutions":[{"id":"https://openalex.org/I132369690","display_name":"Tianjin University of Science and Technology","ror":"https://ror.org/018rbtf37","country_code":"CN","type":"education","lineage":["https://openalex.org/I132369690"]},{"id":"https://openalex.org/I4387152708","display_name":"State Key Laboratory of Food Nutrition and Safety","ror":"https://ror.org/00y9yvy68","country_code":"CN","type":"facility","lineage":["https://openalex.org/I132369690","https://openalex.org/I4387152708"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhen-Chuan Fan","raw_affiliation_strings":["State Key Laboratory of Food Nutrition and Safety, Institute of Health Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China"],"raw_orcid":"https://orcid.org/0000-0003-1712-3413","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Food Nutrition and Safety, Institute of Health Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China","institution_ids":["https://openalex.org/I132369690","https://openalex.org/I4387152708"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032451240"],"corresponding_institution_ids":["https://openalex.org/I132369690","https://openalex.org/I4387152708"],"apc_list":null,"apc_paid":null,"fwci":1.16,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.77144249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"120","issue":"34","first_page":"e2302603120","last_page":"e2302603120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arl3","display_name":"ARL3","score":0.9620000123977661},{"id":"https://openalex.org/keywords/bbsome","display_name":"BBSome","score":0.8790000081062317},{"id":"https://openalex.org/keywords/ciliary-transition-zone","display_name":"ciliary transition zone","score":0.8050000071525574},{"id":"https://openalex.org/keywords/guanine-nucleotide-exchange-factor","display_name":"guanine nucleotide exchange factor","score":0.8080000281333923},{"id":"https://openalex.org/keywords/phospholipase-d","display_name":"phospholipase D","score":0.8429999947547913},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.8899999856948853},{"id":"https://openalex.org/keywords/bardet-biedl-syndrome","display_name":"Bardet-Biedl syndrome","score":0.9850000143051147},{"id":"https://openalex.org/keywords/chlamydomonas","display_name":"Chlamydomonas","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.8280565142631531},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7355982661247253},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.5954840183258057},{"id":"https://openalex.org/C126619667","wikidata":"https://www.wikidata.org/wiki/Q901088","display_name":"Guanine nucleotide exchange factor","level":3,"score":0.5334591865539551},{"id":"https://openalex.org/C2780298669","wikidata":"https://www.wikidata.org/wiki/Q415071","display_name":"Small GTPase","level":3,"score":0.5332134962081909},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5150279998779297},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.4458346366882324},{"id":"https://openalex.org/C156728348","wikidata":"https://www.wikidata.org/wiki/Q416778","display_name":"Rab","level":3,"score":0.43941372632980347},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3466920852661133},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3249167799949646},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1527235209941864},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002696","descriptor_name":"Chlamydomonas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002923","descriptor_name":"Cilia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020691","descriptor_name":"rab GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020727","descriptor_name":"ADP-Ribosylation Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020727","descriptor_name":"ADP-Ribosylation Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053823","descriptor_name":"Hedgehog Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.2302603120","doi":"https://doi.org/10.1073/pnas.2302603120","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2302603120","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10450674","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10450674","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10450674/pdf/pnas.202302603.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:37579161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37579161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.2302603120","doi":"https://doi.org/10.1073/pnas.2302603120","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2302603120","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2909125164","display_name":null,"funder_award_id":"32070698","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3915059714","display_name":null,"funder_award_id":"32200558","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7372069349","display_name":null,"funder_award_id":"2021M702457","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1894401889","https://openalex.org/W1954666599","https://openalex.org/W1963797735","https://openalex.org/W1968686595","https://openalex.org/W1976421227","https://openalex.org/W1980100245","https://openalex.org/W1986779023","https://openalex.org/W1995292541","https://openalex.org/W1997628120","https://openalex.org/W2012535690","https://openalex.org/W2027415486","https://openalex.org/W2045907809","https://openalex.org/W2055344766","https://openalex.org/W2065492302","https://openalex.org/W2074458710","https://openalex.org/W2077712321","https://openalex.org/W2078755430","https://openalex.org/W2084234962","https://openalex.org/W2092426118","https://openalex.org/W2103846588","https://openalex.org/W2115163299","https://openalex.org/W2118640963","https://openalex.org/W2122810646","https://openalex.org/W2126210676","https://openalex.org/W2126596063","https://openalex.org/W2133910881","https://openalex.org/W2134685947","https://openalex.org/W2134844061","https://openalex.org/W2145973064","https://openalex.org/W2150269114","https://openalex.org/W2161570516","https://openalex.org/W2340045810","https://openalex.org/W2530648901","https://openalex.org/W2588077932","https://openalex.org/W2590477589","https://openalex.org/W2595488198","https://openalex.org/W2606476542","https://openalex.org/W2625850142","https://openalex.org/W2747901289","https://openalex.org/W2781875842","https://openalex.org/W2784271444","https://openalex.org/W2894129002","https://openalex.org/W2895602084","https://openalex.org/W2912322880","https://openalex.org/W2921263304","https://openalex.org/W2949451105","https://openalex.org/W2989783030","https://openalex.org/W2990291648","https://openalex.org/W3000274870","https://openalex.org/W3108741007","https://openalex.org/W3120558150","https://openalex.org/W3129757680","https://openalex.org/W3134174709","https://openalex.org/W3166468879","https://openalex.org/W3194595305","https://openalex.org/W3196177586","https://openalex.org/W4293567271","https://openalex.org/W4296703624","https://openalex.org/W4322616718","https://openalex.org/W4328048790"],"related_works":["https://openalex.org/W4213157482","https://openalex.org/W4296703624","https://openalex.org/W3108741007","https://openalex.org/W4407842404","https://openalex.org/W4407159843","https://openalex.org/W7204373846","https://openalex.org/W4328048790","https://openalex.org/W3129757680","https://openalex.org/W3205643337","https://openalex.org/W2949451105"],"abstract_inverted_index":{"Certain":[0],"transmembrane":[1],"and":[2,32,67,88,132,158,163],"membrane-tethered":[3],"signaling":[4,57,205,224],"proteins":[5,206],"export":[6],"from":[7,120,154,208],"cilia":[8,112,187,209],"as":[9,74,115,141,197],"BBSome":[10,15,73,199,215,251],"cargoes":[11],"via":[12,113,210],"the":[13,37,56,69,80,130,155,165,178,192,211,249],"outward":[14,52,214,250],"transition":[16],"zone":[17],"(TZ)":[18],"diffusion":[19,217],"pathway,":[20],"indispensable":[21],"for":[22,82,137,161,180,255],"maintaining":[23],"their":[24],"ciliary":[25,83,126,156,181,204,257],"dynamics":[26],"to":[27,30,66,77,134,152,175,191,220],"enable":[28],"cells":[29],"sense":[31],"transduce":[33],"extracellular":[34],"stimuli":[35],"inside":[36],"cell.":[38],"Murine":[39],"Rab-like":[40],"2":[41],"(Rabl2)":[42],"GTPase":[43,49],"resembles":[44],"Chlamydomonas":[45,101],"Arf-like":[46],"3":[47],"(ARL3)":[48],"in":[50,92,103,232,238],"promoting":[51],"TZ":[53,81,179,216,252],"passage":[54,253],"of":[55,171],"protein":[58],"cargo-laden":[59],"BBSome.":[60],"During":[61],"this":[62,93,221],"process,":[63],"ARL3":[64,89,139,143,150,193],"binds":[65],"recruits":[68],"retrograde":[70,121,172],"IFT":[71,114,122,173],"train-dissociated":[72],"its":[75],"effector":[76],"diffuse":[78,176],"through":[79,111,177],"retrieval,":[84],"while":[85],"how":[86],"RABL2":[87,102,135,184,230],"cross":[90],"talk":[91],"event":[94],"remains":[95],"uncertain.":[96],"Here,":[97],"we":[98],"report":[99],"that":[100],"a":[104,125,198,239,245],"GTP-bound":[105],"form":[106],"(RABL2":[107],"GTP":[108,151,194],")":[109],"cycles":[110],"an":[116,142],"IFT-B1":[117],"cargo,":[118],"dissociates":[119],"trains":[123],"at":[124],"region":[127],"right":[128],"above":[129],"TZ,":[131],"converts":[133],"GDP":[136,140,185],"activating":[138],"guanine":[144],"nucleotide":[145],"exchange":[146],"factor.":[147],"This":[148],"confers":[149],"detach":[153],"membrane":[157],"become":[159],"available":[160],"binding":[162],"recruiting":[164],"phospholipase":[166],"D":[167],"(PLD)-laden":[168],"BBSome,":[169],"autonomous":[170],"association,":[174],"retrieval.":[182],"Afterward,":[183],"exits":[186],"by":[188,229],"being":[189],"bound":[190],"/BBSome":[195],"entity":[196],"cargo.":[200],"Our":[201],"data":[202],"identify":[203],"exported":[207],"RABL2-ARL3":[212],"cascade-mediated":[213],"pathway.":[218],"According":[219],"model,":[222],"hedgehog":[223],"defect-induced":[225],"Bardet\u2013Biedl":[226],"syndrome":[227],"caused":[228],"mutations":[231],"humans":[233],"could":[234],"be":[235],"well":[236],"explained":[237],"mutation-specific":[240],"manner,":[241],"providing":[242],"us":[243],"with":[244],"mechanistic":[246],"understanding":[247],"behind":[248],"required":[254],"proper":[256],"signaling.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-08-15T00:00:00"}