{"id":"https://openalex.org/W4385799334","doi":"https://doi.org/10.1158/1055-9965.epi-23-0174","title":"Assessing a Polygenic Risk Score for Lung Cancer Susceptibility in Non-Hispanic White and Black Populations","display_name":"Assessing a Polygenic Risk Score for Lung Cancer Susceptibility in Non-Hispanic White and Black Populations","publication_year":2023,"publication_date":"2023-08-14","ids":{"openalex":"https://openalex.org/W4385799334","doi":"https://doi.org/10.1158/1055-9965.epi-23-0174","pmid":"https://pubmed.ncbi.nlm.nih.gov/37578347","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10841320"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.epi-23-0174","doi":"https://doi.org/10.1158/1055-9965.epi-23-0174","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-23-0174","pdf_url":null,"source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers &amp; Prevention","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10841320/pdf/nihms-1926107.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047512348","display_name":"Matthew R. Trendowski","orcid":"https://orcid.org/0000-0001-7006-7065","observed_orcids":["https://orcid.org/0000-0001-7006-7065"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew R. Trendowski","raw_affiliation_strings":["1Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan","2Karmanos Cancer Institute, Detroit, Michigan"],"raw_orcid":"https://orcid.org/0000-0001-7006-7065","affiliations":[{"raw_affiliation_string":"1Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"2Karmanos Cancer Institute, Detroit, Michigan","institution_ids":["https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056040799","display_name":"Christine M. Lusk","orcid":"https://orcid.org/0000-0001-8915-4628","observed_orcids":["https://orcid.org/0000-0001-8915-4628"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine M. Lusk","raw_affiliation_strings":["1Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan","2Karmanos Cancer Institute, Detroit, Michigan"],"raw_orcid":"https://orcid.org/0000-0001-8915-4628","affiliations":[{"raw_affiliation_string":"1Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"2Karmanos Cancer Institute, Detroit, Michigan","institution_ids":["https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083317367","display_name":"Angela S. Wenzlaff","orcid":"https://orcid.org/0000-0001-8669-8240","observed_orcids":["https://orcid.org/0000-0001-8669-8240"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela S. Wenzlaff","raw_affiliation_strings":["1Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan","2Karmanos Cancer Institute, Detroit, Michigan"],"raw_orcid":"https://orcid.org/0000-0001-8669-8240","affiliations":[{"raw_affiliation_string":"1Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"2Karmanos Cancer Institute, Detroit, Michigan","institution_ids":["https://openalex.org/I4210090317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005342981","display_name":"Christine M Neslund-Dudas","orcid":"https://orcid.org/0000-0002-2506-1964","observed_orcids":["https://orcid.org/0000-0002-2506-1964"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Neslund-Dudas","raw_affiliation_strings":["3Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan","4Henry Ford Cancer Institute, Henry Ford Health, Detroit, Michigan"],"raw_orcid":"https://orcid.org/0000-0002-2506-1964","affiliations":[{"raw_affiliation_string":"3Department of Public Health Sciences, Henry Ford Health, Detroit, Michigan","institution_ids":["https://openalex.org/I154057602"]},{"raw_affiliation_string":"4Henry Ford Cancer Institute, Henry Ford Health, Detroit, Michigan","institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025836672","display_name":"Shirish M. Gadgeel","orcid":"https://orcid.org/0000-0001-5240-3811","observed_orcids":["https://orcid.org/0000-0001-5240-3811"]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]},{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shirish M. Gadgeel","raw_affiliation_strings":["4Henry Ford Cancer Institute, Henry Ford Health, Detroit, Michigan"],"raw_orcid":"https://orcid.org/0000-0001-5240-3811","affiliations":[{"raw_affiliation_string":"4Henry Ford Cancer Institute, Henry Ford Health, Detroit, Michigan","institution_ids":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057816689","display_name":"Ayman O. Soubani","orcid":"https://orcid.org/0000-0002-0262-4365","observed_orcids":["https://orcid.org/0000-0002-0262-4365"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayman O. Soubani","raw_affiliation_strings":["2Karmanos Cancer Institute, Detroit, Michigan","5Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, Michigan"],"raw_orcid":"https://orcid.org/0000-0002-0262-4365","affiliations":[{"raw_affiliation_string":"2Karmanos Cancer Institute, Detroit, Michigan","institution_ids":["https://openalex.org/I4210090317"]},{"raw_affiliation_string":"5Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, Michigan","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000445673","display_name":"Ann G. Schwartz","orcid":"https://orcid.org/0000-0002-9525-1157","observed_orcids":["https://orcid.org/0000-0002-9525-1157"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]},{"id":"https://openalex.org/I4210090317","display_name":"The Barbara Ann Karmanos Cancer Institute","ror":"https://ror.org/00ee40h97","country_code":"US","type":"facility","lineage":["https://openalex.org/I2800590384","https://openalex.org/I4210090317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann G. Schwartz","raw_affiliation_strings":["1Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan","2Karmanos Cancer Institute, Detroit, Michigan"],"raw_orcid":"https://orcid.org/0000-0002-9525-1157","affiliations":[{"raw_affiliation_string":"1Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"2Karmanos Cancer Institute, Detroit, Michigan","institution_ids":["https://openalex.org/I4210090317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5047512348"],"corresponding_institution_ids":["https://openalex.org/I185443292","https://openalex.org/I4210090317"],"apc_list":null,"apc_paid":null,"fwci":1.4307,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.81117851,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"32","issue":"11","first_page":"1558","last_page":"1563"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.972000002861023},{"id":"https://openalex.org/keywords/lung-cancer-susceptibility","display_name":"lung cancer susceptibility","score":0.9279999732971191},{"id":"https://openalex.org/keywords/genetic-ancestry","display_name":"genetic ancestry","score":0.7170000076293945},{"id":"https://openalex.org/keywords/black-population","display_name":"Black population","score":0.7639999985694885},{"id":"https://openalex.org/keywords/non-hispanic-whites","display_name":"non-Hispanic whites","score":0.7480000257492065},{"id":"https://openalex.org/keywords/genetic-risk-prediction","display_name":"genetic risk prediction","score":0.5299999713897705},{"id":"https://openalex.org/keywords/lung-cancer-screening-eligibility","display_name":"lung cancer screening eligibility","score":0.671999990940094},{"id":"https://openalex.org/keywords/genetic-ancestry-adjustment","display_name":"genetic ancestry adjustment","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.8636798858642578},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7834382057189941},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5944721698760986},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5840533971786499},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5102574825286865},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5044349431991577},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.488498330116272},{"id":"https://openalex.org/C2779372377","wikidata":"https://www.wikidata.org/wiki/Q17147792","display_name":"Lung cancer susceptibility","level":5,"score":0.47431397438049316},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.42309999465942383},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.4101962149143219},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.35904520750045776},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3262282609939575},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.15716338157653809},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09439432621002197},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05928429961204529},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000095223","descriptor_name":"White","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1055-9965.epi-23-0174","doi":"https://doi.org/10.1158/1055-9965.epi-23-0174","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-23-0174","pdf_url":null,"source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers &amp; Prevention","raw_type":"journal-article"},{"id":"pmid:37578347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37578347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10841320","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10841320","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10841320/pdf/nihms-1926107.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Epidemiol Biomarkers Prev","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10841320","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10841320","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10841320/pdf/nihms-1926107.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Epidemiol Biomarkers Prev","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"},{"id":"https://metadata.un.org/sdg/10","score":0.5676000118255615,"display_name":"Reduced inequalities"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1397749209","display_name":null,"funder_award_id":"R01CA141769","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G3624381649","display_name":null,"funder_award_id":"P30CA022453","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G6047694277","display_name":"Inflammation Pathways and COPD in the Development of Lung Cancer","funder_award_id":"R01CA141769","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000905662","display_name":"CANCER CENTER SUPPORT GRANT","funder_award_id":"P30CA022453","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385799334.pdf","grobid_xml":"https://content.openalex.org/works/W4385799334.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1585613204","https://openalex.org/W2000002112","https://openalex.org/W2140026462","https://openalex.org/W2153883696","https://openalex.org/W2157334646","https://openalex.org/W2169237347","https://openalex.org/W2169838621","https://openalex.org/W2472120540","https://openalex.org/W2510973425","https://openalex.org/W2564667896","https://openalex.org/W2724116530","https://openalex.org/W2762272043","https://openalex.org/W2788346456","https://openalex.org/W2790675687","https://openalex.org/W2806903557","https://openalex.org/W2807800408","https://openalex.org/W2904183131","https://openalex.org/W2947356551","https://openalex.org/W2956442594","https://openalex.org/W3004387588","https://openalex.org/W3033024520","https://openalex.org/W3038459770","https://openalex.org/W3106839128","https://openalex.org/W3121830978","https://openalex.org/W3122107622","https://openalex.org/W3126160703","https://openalex.org/W3128061434","https://openalex.org/W3134447409","https://openalex.org/W3166257787","https://openalex.org/W3187728715","https://openalex.org/W4295358343"],"related_works":["https://openalex.org/W4379280561","https://openalex.org/W4409633910","https://openalex.org/W4220814631","https://openalex.org/W4403213227","https://openalex.org/W7166352575","https://openalex.org/W4412463741","https://openalex.org/W4402749570","https://openalex.org/W4400355399","https://openalex.org/W4410008572","https://openalex.org/W6902209036"],"abstract_inverted_index":{"BACKGROUND:":[0],"Polygenic":[1],"risk":[2,44,63,107,135,162,202,223,263],"scores":[3],"(PRS)":[4],"have":[5,16],"become":[6],"an":[7],"increasingly":[8],"popular":[9],"approach":[10],"to":[11,216,235,256],"evaluate":[12],"cancer":[13,32,43,62,106,161,168,195,222,231,262],"susceptibility,":[14],"but":[15,143],"not":[17,144,208,247],"adequately":[18],"represented":[19],"Black":[20,123,211],"populations":[21],"in":[22,45,51,97,111,136,145,163,196,210,249],"model":[23,245],"development.":[24],"METHODS:":[25],"We":[26],"used":[27],"a":[28,155,183,227],"previously":[29,184,228],"published":[30,229],"lung":[31,42,61,73,105,160,167,194,221,230,261],"PRS":[33,55,94,130,153,232],"on":[34],"the":[35,46,82,92,98,129,214,244,254],"basis":[36],"of":[37,72,76,159,242],"80":[38,93],"SNPs":[39,95,120],"associated":[40,103,133],"with":[41,60,104,134],"OncoArray":[47],"cohort":[48],"and":[49,81,218,258],"validated":[50,185],"UK":[52],"Biobank.":[53],"The":[54,152],"was":[56,131,207,233,246],"evaluated":[57],"for":[58,65,87,127,166,193],"association":[59],"adjusting":[64,126],"age,":[66],"sex,":[67],"total":[68],"pack-years,":[69],"family":[70],"history":[71,75],"cancer,":[74],"chronic":[77],"obstructive":[78],"pulmonary":[79],"disease,":[80],"top":[83],"five":[84],"principal":[85],"components":[86],"genetic":[88],"ancestry.":[89],"RESULTS:":[90],"Among":[91],"included":[96],"score,":[99],"14":[100],"were":[101,117],"significantly":[102,132],"(P":[108,178],"<":[109],"0.05)":[110],"INHALE":[112,122,197],"White":[113,198,237],"participants,":[114,212],"while":[115],"there":[116],"no":[118],"significant":[119,157],"among":[121],"participants.":[124],"After":[125],"covariates,":[128],"Whites":[137,164],"(continuous":[138,147],"score":[139,148],"P":[140,149],"=":[141,150,179],"0.007),":[142],"Blacks":[146],"0.88).":[151],"remained":[154],"statistically":[156],"predictor":[158],"ineligible":[165],"screening":[169],"under":[170],"current":[171],"U.S.":[172],"Preventive":[173],"Services":[174],"Task":[175],"Force":[176],"guidelines":[177],"0.02).":[180],"CONCLUSIONS:":[181],"Using":[182],"PRS,":[186],"we":[187],"did":[188],"find":[189],"some":[190],"predictive":[191,248],"ability":[192],"participants":[199,238],"beyond":[200],"traditional":[201],"factors.":[203],"However,":[204],"this":[205],"effect":[206],"observed":[209],"indicating":[213],"need":[215,255],"develop":[217,257],"validate":[219,259],"ancestry-specific":[220,260],"models.":[224,264],"IMPACT:":[225],"While":[226],"able":[234],"stratify":[236],"into":[239],"different":[240],"levels":[241],"risk,":[243],"Blacks.":[250],"Our":[251],"findings":[252],"highlight":[253]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-08-15T00:00:00"}