{"id":"https://openalex.org/W4385697351","doi":"https://doi.org/10.3390/molecules28165961","title":"Selenium Protects ARPE-19 and ACBRI 181 Cells against High Glucose-Induced Oxidative Stress","display_name":"Selenium Protects ARPE-19 and ACBRI 181 Cells against High Glucose-Induced Oxidative Stress","publication_year":2023,"publication_date":"2023-08-09","ids":{"openalex":"https://openalex.org/W4385697351","doi":"https://doi.org/10.3390/molecules28165961","pmid":"https://pubmed.ncbi.nlm.nih.gov/37630213","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10459791"},"language":"en","primary_location":{"id":"doi:10.3390/molecules28165961","doi":"https://doi.org/10.3390/molecules28165961","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules28165961","pdf_url":"https://www.mdpi.com/1420-3049/28/16/5961/pdf?version=1691560236","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/28/16/5961/pdf?version=1691560236","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113800160","display_name":"Handan Bardak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Handan Bardak","raw_affiliation_strings":["Department of Ophthalmology, Asya Hospital, 34100 Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Asya Hospital, 34100 Istanbul, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028541442","display_name":"Abd\u00fclhadi Cihangir U\u011fuz","orcid":"https://orcid.org/0000-0002-5778-581X","observed_orcids":["https://orcid.org/0000-0002-5778-581X"]},"institutions":[{"id":"https://openalex.org/I46464968","display_name":"Karamano\u011flu Mehmetbey University","ror":"https://ror.org/037vvf096","country_code":"TR","type":"education","lineage":["https://openalex.org/I46464968"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Abd\u00fclhadi Cihangir U\u011fuz","raw_affiliation_strings":["Department of Biophysics, Faculty of Medicine, Karamano\u011flu Mehmetbey University, 70100 Karaman, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-5778-581X","affiliations":[{"raw_affiliation_string":"Department of Biophysics, Faculty of Medicine, Karamano\u011flu Mehmetbey University, 70100 Karaman, Turkey","institution_ids":["https://openalex.org/I46464968"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073838775","display_name":"Yavuz Bardak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yavuz Bardak","raw_affiliation_strings":["Worldeye Hospital, 34337 Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Worldeye Hospital, 34337 Istanbul, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011527636","display_name":"Javier Rocha-Pimienta","orcid":"https://orcid.org/0000-0003-1206-862X","observed_orcids":["https://orcid.org/0000-0003-1206-862X"]},"institutions":[{"id":"https://openalex.org/I2801884048","display_name":"Government of Extremadura","ror":"https://ror.org/01df4mv68","country_code":"ES","type":"government","lineage":["https://openalex.org/I2801884048"]},{"id":"https://openalex.org/I4405261456","display_name":"Centro de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas de Extremadura","ror":"https://ror.org/05b017y73","country_code":"ES","type":"government","lineage":["https://openalex.org/I4405261456"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Rocha-Pimienta","raw_affiliation_strings":["Technological Agri-Food Institute (CICYTEX-INTAEX), Junta of Extremadura, Avda. Adolfo Su\u00e1rez s/n, 06007 Badajoz, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technological Agri-Food Institute (CICYTEX-INTAEX), Junta of Extremadura, Avda. Adolfo Su\u00e1rez s/n, 06007 Badajoz, Spain","institution_ids":["https://openalex.org/I2801884048","https://openalex.org/I4405261456"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075712316","display_name":"Jonathan Delgado","orcid":"https://orcid.org/0000-0003-3481-9623","observed_orcids":["https://orcid.org/0000-0003-3481-9623"]},"institutions":[{"id":"https://openalex.org/I2801884048","display_name":"Government of Extremadura","ror":"https://ror.org/01df4mv68","country_code":"ES","type":"government","lineage":["https://openalex.org/I2801884048"]},{"id":"https://openalex.org/I4405261456","display_name":"Centro de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas de Extremadura","ror":"https://ror.org/05b017y73","country_code":"ES","type":"government","lineage":["https://openalex.org/I4405261456"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jonathan Delgado-Ad\u00e1mez","raw_affiliation_strings":["Technological Agri-Food Institute (CICYTEX-INTAEX), Junta of Extremadura, Avda. Adolfo Su\u00e1rez s/n, 06007 Badajoz, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technological Agri-Food Institute (CICYTEX-INTAEX), Junta of Extremadura, Avda. Adolfo Su\u00e1rez s/n, 06007 Badajoz, Spain","institution_ids":["https://openalex.org/I2801884048","https://openalex.org/I4405261456"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071156901","display_name":"Javier Espino","orcid":"https://orcid.org/0000-0002-8549-9343","observed_orcids":["https://orcid.org/0000-0002-8549-9343"]},"institutions":[{"id":"https://openalex.org/I80606768","display_name":"Universidad de Extremadura","ror":"https://ror.org/0174shg90","country_code":"ES","type":"education","lineage":["https://openalex.org/I80606768"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Javier Espino","raw_affiliation_strings":["Department of Physiology, Faculty of Science, University of Extremadura, Avda. de Elvas, s/n, 06006 Badajoz, Spain"],"raw_orcid":"https://orcid.org/0000-0002-8549-9343","affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Science, University of Extremadura, Avda. de Elvas, s/n, 06006 Badajoz, Spain","institution_ids":["https://openalex.org/I80606768"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5028541442","https://openalex.org/A5071156901"],"corresponding_institution_ids":["https://openalex.org/I46464968","https://openalex.org/I80606768"],"apc_list":{"value":2300,"currency":"CHF","value_usd":2558},"apc_paid":{"value":2300,"currency":"CHF","value_usd":2558},"fwci":3.8924,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.94600305,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"28","issue":"16","first_page":"5961","last_page":"5961"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selenium","display_name":"selenium","score":0.9990000128746033},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.7919999957084656},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9779999852180481},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9409999847412109},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.996999979019165},{"id":"https://openalex.org/keywords/retinal-microvascular-endothelial-cells","display_name":"retinal microvascular endothelial cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9010000228881836},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8669999837875366},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.949999988079071},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.777999997138977},{"id":"https://openalex.org/keywords/mitochondrial-membrane-depolarization","display_name":"mitochondrial depolarization","score":0.8740000128746033},{"id":"https://openalex.org/keywords/intracellular-calcium-release","display_name":"intracellular calcium release","score":0.7570000290870667},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9330000281333923},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9079999923706055},{"id":"https://openalex.org/keywords/calcium-overload","display_name":"calcium overload","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8219635486602783},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6084681749343872},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5893713235855103},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.5827943682670593},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5624454617500305},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4896910488605499},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4761528968811035},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.4575369358062744},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.440236359834671},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4088844656944275},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39745253324508667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34837794303894043},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.31863564252853394},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.2028489112854004},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012643","descriptor_name":"Selenium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.3390/molecules28165961","doi":"https://doi.org/10.3390/molecules28165961","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules28165961","pdf_url":"https://www.mdpi.com/1420-3049/28/16/5961/pdf?version=1691560236","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10459791","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10459791","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10459791/pdf/molecules-28-05961.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmid:37630213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37630213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:dehesa.unex.es:10662/25729","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10662/25729","pdf_url":null,"source":{"id":"https://openalex.org/S4306401011","display_name":"Institutional Repository University of Extremadura (University of Extremadura)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I80606768","host_organization_name":"Universidad de Extremadura","host_organization_lineage":["https://openalex.org/I80606768"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:5e60b49fd584479599f2cd8010d548f6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5e60b49fd584479599f2cd8010d548f6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 28, Iss 16, p 5961 (2023)","raw_type":"article"},{"id":"pmh:oai:earsiv.kmu.edu.tr:11492/7985","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11492/7985","pdf_url":null,"source":{"id":"https://openalex.org/S4377196479","display_name":"eAr\u015fiv - KM\u00dc (Karamano\u011flu Mehmetbey University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I46464968","host_organization_name":"Karamano\u011flu Mehmetbey University","host_organization_lineage":["https://openalex.org/I46464968"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/molecules28165961","doi":"https://doi.org/10.3390/molecules28165961","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules28165961","pdf_url":"https://www.mdpi.com/1420-3049/28/16/5961/pdf?version=1691560236","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385697351.pdf","grobid_xml":"https://content.openalex.org/works/W4385697351.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W774723499","https://openalex.org/W1775749144","https://openalex.org/W1975980695","https://openalex.org/W1996024251","https://openalex.org/W2008366677","https://openalex.org/W2008746284","https://openalex.org/W2015309205","https://openalex.org/W2020407889","https://openalex.org/W2027756656","https://openalex.org/W2035167975","https://openalex.org/W2039600625","https://openalex.org/W2047393488","https://openalex.org/W2050219286","https://openalex.org/W2051241024","https://openalex.org/W2053270619","https://openalex.org/W2057491414","https://openalex.org/W2060697162","https://openalex.org/W2060768530","https://openalex.org/W2063576996","https://openalex.org/W2081020818","https://openalex.org/W2087378367","https://openalex.org/W2090995263","https://openalex.org/W2092608998","https://openalex.org/W2101169632","https://openalex.org/W2126295203","https://openalex.org/W2127187656","https://openalex.org/W2141260882","https://openalex.org/W2170289210","https://openalex.org/W2205469249","https://openalex.org/W2309550201","https://openalex.org/W2310524135","https://openalex.org/W2313489940","https://openalex.org/W2340867627","https://openalex.org/W2761604622","https://openalex.org/W2767395086","https://openalex.org/W2782168921","https://openalex.org/W2943729509","https://openalex.org/W2949110934","https://openalex.org/W2994945824","https://openalex.org/W3040277109","https://openalex.org/W3102088761","https://openalex.org/W3164533014","https://openalex.org/W4298125761","https://openalex.org/W4317743579"],"related_works":["https://openalex.org/W7014706884","https://openalex.org/W4289776581","https://openalex.org/W2358886528","https://openalex.org/W3122722867","https://openalex.org/W4382068999","https://openalex.org/W3126157787","https://openalex.org/W2095128491","https://openalex.org/W2774233182","https://openalex.org/W3018701222","https://openalex.org/W2774399708"],"abstract_inverted_index":{"Diabetic":[0],"retinopathy":[1],"(DR),":[2],"a":[3,20,162,198,228,240,280],"complication":[4],"of":[5,37,71,142,149,186,213,247,258,266],"diabetes":[6],"mellitus":[7],"(DM),":[8],"can":[9],"cause":[10],"severe":[11],"visual":[12],"loss.":[13],"The":[14,147,270],"retinal":[15,24,41,48],"pigment":[16,42],"epithelium":[17,43],"(RPE)":[18],"plays":[19],"crucial":[21],"role":[22],"in":[23,87,201,227,231,242],"physiology":[25],"but":[26],"is":[27,298],"vulnerable":[28],"to":[29,76,79,137,144,208,255],"oxidative":[30,58,85,202,291],"damage.":[31],"We":[32],"investigated":[33],"the":[34,81,94,139,184,245,302],"protective":[35,281,296],"effects":[36],"selenium":[38],"(Se)":[39],"on":[40,283],"(ARPE-19)":[44],"and":[45,60,89,93,126,154,156,169,178,183,219,244,249,260,268,285,293],"primary":[46],"human":[47],"microvascular":[49],"endothelial":[50,122],"(ACBRI":[51],"181)":[52],"cells":[53,92,288],"against":[54,289],"high":[55],"glucose":[56],"(HG)-induced":[57],"stress":[59,86,203,292],"apoptotic":[61,95],"cascade.":[62],"To":[63,165],"achieve":[64],"this":[65,273],"objective,":[66],"we":[67],"utilized":[68,175],"varying":[69],"concentrations":[70],"D-glucose":[72],"(ranging":[73],"from":[74,188,272],"5":[75],"80":[77],"mM)":[78],"induce":[80],"HG":[82],"model.":[83],"HG-induced":[84,290],"ARPE-19":[88,284],"ACBRI":[90,286],"181":[91,287],"cascade":[96],"were":[97,174,191],"evaluated":[98,192],"by":[99,176,193,205,235],"determining":[100],"Ca2+":[101,187,221,304],"overload,":[102],"mitochondrial":[103,180,214],"membrane":[104,181,215],"depolarization,":[105,182],"caspase-3/-9":[106],"activation,":[107],"intracellular":[108,189,220,303],"reactive":[109],"oxygen":[110],"species":[111],"(ROS),":[112],"lipid":[113],"peroxidation":[114],"(LP),":[115],"glutathione":[116,118],"(GSH),":[117],"peroxidase":[119],"(GSH-Px),":[120],"vascular":[121],"growth":[123],"factor":[124],"(VEGF)":[125],"apoptosis":[127,243],"levels.":[128],"A":[129],"cell":[130],"viability":[131],"assay":[132],"utilizing":[133],"MTT":[134],"was":[135,159],"conducted":[136],"ascertain":[138],"optimal":[140],"concentration":[141],"Se":[143,225,252,278],"be":[145],"employed.":[146],"quantification":[148],"MTT,":[150],"ROS,":[151],"VEGF":[152,259],"levels,":[153,171,218],"caspase-3":[155,248],"-9":[157],"activation":[158,246],"accomplished":[160],"using":[161],"plate":[163],"reader.":[164],"quantitatively":[166],"assess":[167],"LP":[168,261],"GSH":[170,267],"GSH-Px":[172],"activities":[173],"spectrophotometer":[177],"apoptosis,":[179],"release":[185],"stores":[190],"spectrofluorometer.":[194],"Our":[195],"investigation":[196],"revealed":[197],"significant":[199],"augmentation":[200],"induced":[204,234],"HG,":[206,236],"leading":[207],"cellular":[209],"damage":[210],"through":[211,301],"modulation":[212],"potential,":[216],"ROS":[217,232],"release.":[222],"Incubation":[223],"with":[224],"resulted":[226],"notable":[229],"reduction":[230,241],"production":[233],"as":[237,239],"well":[238],"-9.":[250],"Additionally,":[251],"incubation":[253],"led":[254],"decreased":[256],"levels":[257,265],"while":[262],"concurrently":[263],"increasing":[264],"GSH-Px.":[269],"findings":[271],"study":[274],"strongly":[275],"suggest":[276],"that":[277],"exerts":[279],"effect":[282],"apoptosis.":[294],"This":[295],"mechanism":[297],"partially":[299],"mediated":[300],"signaling":[305],"pathway.":[306]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-08-10T00:00:00"}