{"id":"https://openalex.org/W4385695706","doi":"https://doi.org/10.4049/jimmunol.210.supp.59.11","title":"Mechanistic insight into immune amnesia and immunity induced by wild-type measles virus compared to live-attenuated measles vaccine","display_name":"Mechanistic insight into immune amnesia and immunity induced by wild-type measles virus compared to live-attenuated measles vaccine","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4385695706","doi":"https://doi.org/10.4049/jimmunol.210.supp.59.11"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.210.supp.59.11","doi":"https://doi.org/10.4049/jimmunol.210.supp.59.11","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.59.11","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/59.11/1631582/59_11.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/59.11/1631582/59_11.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017756978","display_name":"Kwan Pui Chan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kwan Pui Chan","raw_affiliation_strings":["Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","1Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"1Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019722383","display_name":"Maggie L. Bartlett","orcid":"https://orcid.org/0000-0003-1793-1189","observed_orcids":["https://orcid.org/0000-0003-1793-1189"]},"institutions":[{"id":"https://openalex.org/I1312537475","display_name":"Naval Medical Research Command","ror":"https://ror.org/05f421b09","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312537475","https://openalex.org/I1330347796","https://openalex.org/I3130687028","https://openalex.org/I4391768141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maggie Bartlett","raw_affiliation_strings":["Navy Medical Research Center","2Navy Medical Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Navy Medical Research Center","institution_ids":["https://openalex.org/I1312537475"]},{"raw_affiliation_string":"2Navy Medical Research Center","institution_ids":["https://openalex.org/I1312537475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007613574","display_name":"Jessica H. Rubens","orcid":"https://orcid.org/0000-0001-9198-9149","observed_orcids":["https://orcid.org/0000-0001-9198-9149"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Rubens","raw_affiliation_strings":["Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","1Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"1Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010340030","display_name":"Jacqueline Brockhurst","orcid":"https://orcid.org/0000-0001-6946-3132","observed_orcids":["https://orcid.org/0000-0001-6946-3132"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacqueline Brockhurst","raw_affiliation_strings":["Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","1Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"1Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077158328","display_name":"Shristi Ghimire","orcid":"https://orcid.org/0000-0002-8121-9068","observed_orcids":["https://orcid.org/0000-0002-8121-9068"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shristi Ghimire","raw_affiliation_strings":["Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","1Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"1Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083184146","display_name":"Benjamin H. Nguyen","orcid":"https://orcid.org/0000-0002-8603-4046","observed_orcids":["https://orcid.org/0000-0002-8603-4046"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin H Nguyen","raw_affiliation_strings":["Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","1Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"1Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110031337","display_name":"D A Hauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debbie Hauer","raw_affiliation_strings":["Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","1Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"1Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040754947","display_name":"Diane E. Griffin","orcid":"https://orcid.org/0000-0001-6643-2429","observed_orcids":["https://orcid.org/0000-0001-6643-2429"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane E Griffin","raw_affiliation_strings":["Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","1Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"1Molecular Microbiology and Immunology, Johns Hopkins Bloomberg Sch. of Public Hlth","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"210","issue":"Supplement_1","first_page":"59.11","last_page":"59.11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.9014000296592712,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0812000036239624,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/measles-virus","display_name":"measles virus","score":0.8029999732971191},{"id":"https://openalex.org/keywords/live-attenuated-measles-vaccine","display_name":"live attenuated measles vaccine","score":0.9879999756813049},{"id":"https://openalex.org/keywords/b-cell-repertoire","display_name":"B cell receptor repertoire","score":0.8050000071525574},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.8349999785423279},{"id":"https://openalex.org/keywords/natural-infection-versus-vaccination","display_name":"natural infection versus vaccination","score":0.7179999947547913},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C2776438120","wikidata":"https://www.wikidata.org/wiki/Q79793","display_name":"Measles","level":3,"score":0.8134347200393677},{"id":"https://openalex.org/C2778199166","wikidata":"https://www.wikidata.org/wiki/Q573943","display_name":"Measles virus","level":4,"score":0.7148220539093018},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.7002882361412048},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6485767364501953},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6286149024963379},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6159515380859375},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5846188068389893},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5724616050720215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5630375146865845},{"id":"https://openalex.org/C2780657872","wikidata":"https://www.wikidata.org/wiki/Q6804161","display_name":"Measles vaccine","level":4,"score":0.5548436045646667},{"id":"https://openalex.org/C54602769","wikidata":"https://www.wikidata.org/wiki/Q1810913","display_name":"Attenuated vaccine","level":4,"score":0.5132565498352051},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.44247910380363464},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4209340810775757},{"id":"https://openalex.org/C2776646718","wikidata":"https://www.wikidata.org/wiki/Q908104","display_name":"MMR vaccine","level":5,"score":0.415336936712265},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23532730340957642},{"id":"https://openalex.org/C2778814567","wikidata":"https://www.wikidata.org/wiki/Q155857","display_name":"Rubella","level":4,"score":0.16461321711540222},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.15852782130241394},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09936773777008057},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.210.supp.59.11","doi":"https://doi.org/10.4049/jimmunol.210.supp.59.11","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.59.11","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/59.11/1631582/59_11.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.210.supp.59.11","doi":"https://doi.org/10.4049/jimmunol.210.supp.59.11","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.59.11","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/59.11/1631582/59_11.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385695706.pdf","grobid_xml":"https://content.openalex.org/works/W4385695706.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404173945","https://openalex.org/W4404174453","https://openalex.org/W4385686819","https://openalex.org/W4386154931","https://openalex.org/W7165740366","https://openalex.org/W3015038891","https://openalex.org/W2988996029","https://openalex.org/W2982358031","https://openalex.org/W7027418057","https://openalex.org/W4320061662"],"abstract_inverted_index":{"Abstract":[0],"Despite":[1],"the":[2,45,158],"availability":[3],"of":[4,47,67,109],"a":[5,23],"safe":[6],"and":[7,15,74,85,93,101,118,124,130,157],"effective":[8],"vaccine,":[9],"measles":[10,82,87],"still":[11],"causes":[12],"significant":[13],"mortality":[14],"morbidity":[16],"among":[17],"children":[18],"in":[19,55,126,143],"developing":[20],"countries.":[21],"As":[22],"disease":[24],"that":[25,50],"induces":[26],"immune":[27,127],"amnesia":[28],"with":[29],"increased":[30],"susceptibility":[31],"to":[32,39,148],"other":[33],"infections":[34],"but":[35],"also":[36],"life-long":[37],"immunity":[38],"measles,":[40],"little":[41],"is":[42],"known":[43],"about":[44],"immunogenetics":[46],"B":[48,98,131,139],"cells":[49,72],"elicit":[51],"measles-specific":[52],"antibodies":[53],"(Abs)":[54],"natural":[56,144],"infection":[57,145],"vs":[58],"vaccination.":[59,149],"We":[60],"therefore":[61],"conducted":[62],"single-cell":[63],"RNA":[64],"sequencing":[65],"(scRNA-seq)":[66],"longitudinal":[68],"peripheral":[69],"blood":[70],"mononuclear":[71],"(PBMC)":[73],"lymph":[75],"node":[76],"(LN)":[77],"samples":[78],"from":[79,153],"wild-type":[80],"(WT)":[81],"virus":[83],"(MeV)":[84],"live-attenuated":[86],"vaccine":[88],"(LAMV)-infected":[89],"rhesus":[90],"macaques":[91],"(RMs)":[92],"characterized":[94],"their":[95],"gene":[96],"expression,":[97],"cell":[99,128,132,140],"repertoires":[100],"clonotype":[102],"changes":[103],"via":[104],"bioinformatic":[105],"pipelines.":[106],"Preliminary":[107],"analysis":[108],"two":[110],"RMs":[111],"across":[112],"four":[113],"timepoints":[114],"(one":[115],"WT":[116],"MeV-":[117],"one":[119],"LAMV-infected":[120],"RM)":[121],"revealed":[122],"similarities":[123],"differences":[125],"populations":[129],"repertoires,":[133],"providing":[134],"important":[135],"mechanistic":[136],"insights":[137],"into":[138],"clonal":[141],"development":[142],"as":[146],"compared":[147],"Supported":[150],"by":[151],"grants":[152],"NIH":[154],"R01":[155],"AI153140":[156],"Jeffrey":[159],"Richardson":[160],"Fellowship":[161]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-08-10T00:00:00"}