{"id":"https://openalex.org/W4385687339","doi":"https://doi.org/10.4049/jimmunol.210.supp.218.26","title":"Vaccination prior to SARS-CoV-2 infection reduces autoreactive antibody induction","display_name":"Vaccination prior to SARS-CoV-2 infection reduces autoreactive antibody induction","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4385687339","doi":"https://doi.org/10.4049/jimmunol.210.supp.218.26"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.210.supp.218.26","doi":"https://doi.org/10.4049/jimmunol.210.supp.218.26","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.218.26","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/218.26/1630824/218_26.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/218.26/1630824/218_26.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026857344","display_name":"Chun-Yang Lin","orcid":"https://orcid.org/0000-0002-3064-0178","observed_orcids":["https://orcid.org/0000-0002-3064-0178"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chun-Yang Lin","raw_affiliation_strings":["St Jude Children\u2019s Research Hospital","University of Tennessee Health Science Center","1St Jude Children's Research Hospital","2University of Tennessee Health Science Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"University of Tennessee Health Science Center","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"1St Jude Children's Research Hospital","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"2University of Tennessee Health Science Center","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052088262","display_name":"Ashley H. Castellaw","orcid":"https://orcid.org/0000-0002-4149-4209","observed_orcids":["https://orcid.org/0000-0002-4149-4209"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley Castellaw","raw_affiliation_strings":["St Jude Children\u2019s Research Hospital","1St Jude Children's Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"1St Jude Children's Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049170289","display_name":"David C. Brice","orcid":"https://orcid.org/0000-0002-0294-9987","observed_orcids":["https://orcid.org/0000-0002-0294-9987"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Brice","raw_affiliation_strings":["St Jude Children\u2019s Research Hospital","1St Jude Children's Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"1St Jude Children's Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":null,"display_name":"SJTRC Study Team","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SJTRC Study Team","raw_affiliation_strings":["1St Jude Children's Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1St Jude Children's Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088615597","display_name":"Stacey Schultz\u2010Cherry","orcid":"https://orcid.org/0000-0002-2021-727X","observed_orcids":["https://orcid.org/0000-0002-2021-727X"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacey Schultz-Cherry","raw_affiliation_strings":["St Jude Children\u2019s Research Hospital","1St Jude Children's Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"1St Jude Children's Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005724506","display_name":"Paul Glyndwr Thomas","orcid":"https://orcid.org/0000-0001-7955-0256","observed_orcids":["https://orcid.org/0000-0001-7955-0256"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Thomas","raw_affiliation_strings":["St Jude Children\u2019s Research Hospital","1St Jude Children's Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"1St Jude Children's Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107220267","display_name":"Joshua Wolf","orcid":"https://orcid.org/0000-0002-9912-3646","observed_orcids":["https://orcid.org/0000-0002-9912-3646"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josh Wolf","raw_affiliation_strings":["St Jude Children\u2019s Research Hospital","1St Jude Children's Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"1St Jude Children's Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089320652","display_name":"Maureen Ann McGargill","orcid":"https://orcid.org/0000-0002-0916-0372","observed_orcids":["https://orcid.org/0000-0002-0916-0372"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maureen McGargill","raw_affiliation_strings":["St Jude Children\u2019s Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St Jude Children\u2019s Research Hospital","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"210","issue":"Supplement_1","first_page":"218.26","last_page":"218.26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.045899998396635056,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9390000104904175},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9120000004768372},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.8859999775886536},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.9290000200271606},{"id":"https://openalex.org/keywords/covid-19-vaccination","display_name":"COVID-19 vaccination","score":0.9259999990463257},{"id":"https://openalex.org/keywords/prior-infection","display_name":"prior infection","score":0.48100000619888306},{"id":"https://openalex.org/keywords/autoantibody-induction","display_name":"autoantibody induction","score":0.7490000128746033},{"id":"https://openalex.org/keywords/asymptomatic-infection","display_name":"asymptomatic infection","score":0.6919999718666077},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.44200000166893005},{"id":"https://openalex.org/keywords/plasma-cells","display_name":"plasma cells","score":0.3630000054836273},{"id":"https://openalex.org/keywords/autoimmune-disease-susceptibility","display_name":"autoimmune disease susceptibility","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.8240276575088501},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.7487204670906067},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7041764259338379},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.6305045485496521},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.5455507636070251},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49959683418273926},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.44928598403930664},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.38956648111343384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3827601969242096},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3556925058364868},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09376734495162964}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.210.supp.218.26","doi":"https://doi.org/10.4049/jimmunol.210.supp.218.26","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.218.26","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/218.26/1630824/218_26.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.210.supp.218.26","doi":"https://doi.org/10.4049/jimmunol.210.supp.218.26","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.218.26","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/218.26/1630824/218_26.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8399999737739563}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385687339.pdf","grobid_xml":"https://content.openalex.org/works/W4385687339.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7171551077","https://openalex.org/W4385695721","https://openalex.org/W4313405751","https://openalex.org/W4313596722","https://openalex.org/W4307437110","https://openalex.org/W4407585337","https://openalex.org/W7141182816","https://openalex.org/W7168129577","https://openalex.org/W4281288831","https://openalex.org/W3198977459"],"abstract_inverted_index":{"Abstract":[0],"SARS-CoV-2":[1,27,86,108,130,186,205,224],"infection":[2,10,28,48,87,109,131,178,187,209],"leads":[3],"to":[4,11,23,54,81,96,120,177,180,208],"diverse":[5],"outcomes":[6],"ranging":[7],"from":[8,103,216],"asymptomatic":[9,122],"death.":[12],"Several":[13],"studies":[14],"reported":[15],"elevated":[16,69],"autoreactive":[17,44,64,70,135,154,174,190,202],"antibodies":[18,45,65,71,136,155,175],"in":[19,51,153,173,200],"SARS-CoV-2-infected":[20],"individuals":[21,52,149,160,166],"compared":[22,176],"healthy":[24],"controls,":[25],"suggesting":[26],"promotes":[29],"autoantibodies,":[30],"which":[31],"could":[32],"increase":[33,152,199],"the":[34,57,73,83],"risk":[35],"of":[36,75,85,138,148],"autoimmunity.":[37],"However,":[38],"it":[39,78],"is":[40,79],"not":[41,195],"known":[42],"whether":[43],"observed":[46],"after":[47,128,168],"were":[49,113,126],"present":[50],"prior":[53,179,207],"infection.":[55,123],"Further,":[56],"prevalence,":[58],"duration,":[59],"and":[60,100,132,220,226],"vaccine":[61],"impact":[62,84],"on":[63,88],"are":[66],"unresolved.":[67],"Since":[68],"precede":[72],"onset":[74],"autoimmune":[76,140],"disease,":[77],"important":[80],"investigate":[82],"self-reactive":[89],"antibodies.":[90,203],"We":[91],"established":[92],"a":[93,146,197],"longitudinal":[94],"study":[95],"collect":[97],"baseline":[98],"PBMC":[99],"plasma":[101],"samples":[102,125],"participants":[104],"at":[105],"enrollment,":[106],"before":[107],"or":[110],"vaccination.":[111,181],"Participants":[112],"screened":[114],"weekly":[115],"by":[116,214],"nasal":[117],"swab":[118],"PCR":[119],"detect":[121],"Additional":[124],"collected":[127],"confirmed":[129],"assessed":[133],"for":[134],"predictive":[137],"various":[139],"disorders.":[141],"Preliminary":[142],"analysis":[143],"showed":[144],"that":[145,185],"subset":[147],"exhibited":[150],"an":[151],"following":[156],"infection,":[157],"while":[158],"other":[159],"unexpectedly":[161],"displayed":[162,170],"decreased":[163],"levels.":[164],"Notably,":[165],"infected":[167],"vaccination":[169,206],"fewer":[171],"changes":[172],"Our":[182],"data":[183],"suggest":[184],"increases":[188],"specific":[189],"antibody":[191],"levels":[192],"but":[193],"does":[194],"induce":[196],"widespread":[198],"all":[201],"Moreover,":[204],"reduced":[210],"autoantibody":[211],"induction.":[212],"Supported":[213],"grants":[215],"NIH":[217],"CEIRS":[218],"HHSN272201400006C":[219],"Household":[221],"Respiratory":[222],"Virus":[223],"Transmission":[225],"Immunity":[227],"Sub-Study":[228],"(HRTS)":[229],"3U01AI144616-02S1":[230]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-08-10T00:00:00"}