{"id":"https://openalex.org/W4385686408","doi":"https://doi.org/10.4049/jimmunol.210.supp.77.14","title":"Gut microbiome-derived isoflavone metabolites may ameliorate experimental autoimmune encephalomyelitis (EAE) through estrogen receptor signaling in CD8 T-cells","display_name":"Gut microbiome-derived isoflavone metabolites may ameliorate experimental autoimmune encephalomyelitis (EAE) through estrogen receptor signaling in CD8 T-cells","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4385686408","doi":"https://doi.org/10.4049/jimmunol.210.supp.77.14"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.210.supp.77.14","doi":"https://doi.org/10.4049/jimmunol.210.supp.77.14","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.77.14","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/77.14/1630540/77_14.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/77.14/1630540/77_14.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013428846","display_name":"Stephanie R. Peterson","orcid":"https://orcid.org/0000-0002-3160-5702","observed_orcids":["https://orcid.org/0000-0002-3160-5702"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie R Peterson","raw_affiliation_strings":["University of Iowa","1University of Iowa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"1University of Iowa","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028992489","display_name":"Samantha N. Jensen","orcid":"https://orcid.org/0000-0002-3001-5217","observed_orcids":["https://orcid.org/0000-0002-3001-5217"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha Jensen","raw_affiliation_strings":["University of Iowa","Weill Cornell Medical College","1University of Iowa","2Weill Cornell Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Weill Cornell Medical College","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"1University of Iowa","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"2Weill Cornell Medical College","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005548506","display_name":"Ashutosh Kumar Mangalam","orcid":"https://orcid.org/0000-0002-9926-2531","observed_orcids":["https://orcid.org/0000-0002-9926-2531"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashutosh K Mangalam","raw_affiliation_strings":["University of Iowa Carver College of Medicine","3University of Iowa Carver College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Iowa Carver College of Medicine","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"3University of Iowa Carver College of Medicine","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"210","issue":"Supplement_1","first_page":"77.14","last_page":"77.14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.8159000277519226,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.8159000277519226,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.08309999853372574,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.824999988079071},{"id":"https://openalex.org/keywords/isoflavone-metabolites","display_name":"isoflavone metabolites","score":0.9679999947547913},{"id":"https://openalex.org/keywords/phytoestrogens","display_name":"phytoestrogens","score":0.8460000157356262},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.984000027179718},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/estrogen-receptor-signaling","display_name":"estrogen receptor signaling","score":0.7689999938011169},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.7590000033378601},{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":1.0},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9570000171661377},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9240000247955322},{"id":"https://openalex.org/keywords/dietary-isoflavones","display_name":"dietary isoflavones","score":0.6589999794960022},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.6589999794960022},{"id":"https://openalex.org/keywords/perforin","display_name":"perforin","score":0.847000002861023},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6218365430831909},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5780046582221985},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5516635775566101},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5475777387619019},{"id":"https://openalex.org/C2778486448","wikidata":"https://www.wikidata.org/wiki/Q494066","display_name":"Experimental autoimmune encephalomyelitis","level":3,"score":0.49818968772888184},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.46180739998817444},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4583404064178467},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.44587352871894836},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3854178190231323},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.34323811531066895},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3324519991874695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12956908345222473},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0904545783996582},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.210.supp.77.14","doi":"https://doi.org/10.4049/jimmunol.210.supp.77.14","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.77.14","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/77.14/1630540/77_14.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.210.supp.77.14","doi":"https://doi.org/10.4049/jimmunol.210.supp.77.14","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.77.14","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/77.14/1630540/77_14.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385686408.pdf","grobid_xml":"https://content.openalex.org/works/W4385686408.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4313404819","https://openalex.org/W4313368414","https://openalex.org/W4226270323","https://openalex.org/W4298126233","https://openalex.org/W4313358955","https://openalex.org/W3180928764","https://openalex.org/W4307320964","https://openalex.org/W2014490824","https://openalex.org/W1981485245","https://openalex.org/W2627775282"],"abstract_inverted_index":{"Abstract":[0],"Multiple":[1],"sclerosis":[2],"(MS)":[3],"is":[4,84],"an":[5,46,98,111,124],"autoimmune":[6],"demyelinating":[7],"disease":[8,70,121,229],"of":[9,39,49,53,57,64,88,101,127,156,163,174,183,206,211,223,233],"the":[10,60,73,89,105,135,204,209],"CNS":[11],"which":[12,79],"may":[13,149,225],"be":[14],"influenced":[15],"by":[16,241],"diet-":[17],"and":[18,75,91,141,177,179,186,246],"gut":[19,90],"bacteria-produced":[20],"metabolites.":[21],"We":[22,188],"have":[23,97],"shown":[24],"that":[25,94,146,168,220],"phytoestrogen-metabolizing":[26,40,65],"bacteria":[27,41,66],"are":[28,189],"reduced":[29],"in":[30,44,59,104,130,199,208],"MS":[31],"patients":[32],"compared":[33,107],"to":[34,68,108,134,202,227],"healthy":[35],"individuals.":[36],"The":[37],"importance":[38,205],"was":[42],"validated":[43],"EAE,":[45],"animal":[47],"model":[48],"MS,":[50],"where":[51],"lack":[52,63],"isoflavones":[54,224],"(a":[55],"type":[56],"phytoestrogen)":[58],"diet":[61],"and/or":[62],"lead":[67,226],"increased":[69,99],"severity.":[71],"However,":[72],"cellular":[74],"molecular":[76],"pathways":[77],"through":[78,231],"isoflavones/gut":[80],"microbiota":[81],"modulate":[82],"EAE":[83,228],"unknown.":[85],"Cellular":[86],"analysis":[87,162],"periphery":[92],"showed":[93,167],"isoflavone-fed":[95,169],"mice":[96,109,118,170,193],"number":[100],"CD8":[102,115,128,152,165,200,213,234],"T-cell":[103,116],"colon":[106],"on":[110],"isoflavone-free":[112],"diet.":[113],"Moreover,":[114],"knockout":[117],"lose":[119],"isoflavone-mediated":[120],"protection,":[122],"suggesting":[123],"important":[125],"role":[126],"T-cells":[129,153,166,235],"this":[131],"process.":[132],"Due":[133],"structural":[136],"similarity":[137],"between":[138],"isoflavone":[139,147],"metabolites":[140,148],"endogenous":[142],"estrogen,":[143],"we":[144],"hypothesize":[145],"induce":[150],"regulatory":[151],"via":[154,236],"engagement":[155],"estrogen":[157,237],"receptors":[158],"(ERs).":[159],"Flow":[160],"cytometric":[161],"colonic":[164],"had":[171],"higher":[172],"expression":[173],"both":[175],"ER\u03b1":[176,195],"ER\u03b2":[178,197],"produced":[180],"lower":[181],"levels":[182],"IFN\u03b3,":[184],"perforin,":[185],"IL10.":[187],"utilizing":[190],"conditional":[191],"KO":[192],"lacking":[194],"or":[196],"exclusively":[198],"cells":[201],"determine":[203],"ERs":[207],"generation":[210],"diet-induced":[212],"T-cells.":[214],"In":[215],"summary,":[216],"our":[217],"data":[218],"suggest":[219],"bacterial":[221],"metabolism":[222],"suppression":[230],"immunomodulation":[232],"receptor":[238],"signaling.":[239],"Supported":[240],"grants":[242],"from":[243],"NIH":[244],"(1R01AI137075-01)":[245],"VA":[247],"(1I01CX002212)":[248]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-08-10T00:00:00"}