{"id":"https://openalex.org/W4385686273","doi":"https://doi.org/10.4049/jimmunol.210.supp.77.12","title":"Tlr5 deficiency exacerbates lupus-like disease in the MRL/lpr mouse model","display_name":"Tlr5 deficiency exacerbates lupus-like disease in the MRL/lpr mouse model","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4385686273","doi":"https://doi.org/10.4049/jimmunol.210.supp.77.12"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.210.supp.77.12","doi":"https://doi.org/10.4049/jimmunol.210.supp.77.12","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.77.12","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/77.12/1631562/77_12.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/77.12/1631562/77_12.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071302433","display_name":"Razan M. Alajoleen","orcid":"https://orcid.org/0000-0003-4623-9167","observed_orcids":["https://orcid.org/0000-0003-4623-9167"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Razan M Alajoleen","raw_affiliation_strings":["Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech","1Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"1Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077380178","display_name":"David Noah Oakland","orcid":"https://orcid.org/0000-0002-7256-912X","observed_orcids":["https://orcid.org/0000-0002-7256-912X"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David N Oakland","raw_affiliation_strings":["Graduate Program of Translational Biology, Medicine, and Health, Virginia Polytechnic Institute and State University , Blacksburg, VA,","2Graduate Program of Translational Biology, Medicine, and Health, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program of Translational Biology, Medicine, and Health, Virginia Polytechnic Institute and State University , Blacksburg, VA,","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"2Graduate Program of Translational Biology, Medicine, and Health, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092793618","display_name":"Rana Estaleen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rana Estaleen","raw_affiliation_strings":["Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech","1Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"1Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108897481","display_name":"Aida Shakeri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aida Shakeri","raw_affiliation_strings":["Department of Biology, College of Science, Virginia Polytechnic Institute and State University , Blacksburg, VA,","3Department of Biology, College of Science, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Science, Virginia Polytechnic Institute and State University , Blacksburg, VA,","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"3Department of Biology, College of Science, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039677416","display_name":"Ran Lu","orcid":"https://orcid.org/0000-0001-5015-8170","observed_orcids":["https://orcid.org/0000-0001-5015-8170"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ran Lu","raw_affiliation_strings":["Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech","1Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"1Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063951434","display_name":"Michael Gyasi Appiah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Appiah","raw_affiliation_strings":["Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech","1Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"1Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086505023","display_name":"Sha Sun","orcid":"https://orcid.org/0000-0002-0044-6403","observed_orcids":["https://orcid.org/0000-0002-0044-6403"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sha Sun","raw_affiliation_strings":["Department of Developmental and Cell Biology, University of California , Irvine, CA,","4Department of Developmental and Cell Biology, University of California, Irvine, CA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology, University of California , Irvine, CA,","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"4Department of Developmental and Cell Biology, University of California, Irvine, CA, United States","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102862582","display_name":"Christopher M. Reilly","orcid":"https://orcid.org/0000-0003-4787-7750","observed_orcids":["https://orcid.org/0000-0003-4787-7750"]},"institutions":[{"id":"https://openalex.org/I896114043","display_name":"Edward Via College of Osteopathic Medicine","ror":"https://ror.org/00sda2672","country_code":"US","type":"education","lineage":["https://openalex.org/I896114043"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M Reilly","raw_affiliation_strings":["Edward Via College of Osteopathic Medicine , Blacksburg, VA,","5Edward Via College of Osteopathic Medicine, Blacksburg, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Edward Via College of Osteopathic Medicine , Blacksburg, VA,","institution_ids":["https://openalex.org/I896114043"]},{"raw_affiliation_string":"5Edward Via College of Osteopathic Medicine, Blacksburg, VA, United States","institution_ids":["https://openalex.org/I896114043"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009329226","display_name":"Xin Luo","orcid":"https://orcid.org/0000-0002-2809-5836","observed_orcids":["https://orcid.org/0000-0002-2809-5836"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin M Luo","raw_affiliation_strings":["Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech","1Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"1Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech","institution_ids":["https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"210","issue":"Supplement_1","first_page":"77.12","last_page":"77.12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9779999852180481},{"id":"https://openalex.org/keywords/mrl-lpr-mice","display_name":"MRL/lpr mice","score":0.9750000238418579},{"id":"https://openalex.org/keywords/lupus-nephritis","display_name":"lupus nephritis","score":0.8029999732971191},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.7829999923706055},{"id":"https://openalex.org/keywords/glomerulonephritis","display_name":"glomerulonephritis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/flagellin","display_name":"flagellin","score":0.8130000233650208},{"id":"https://openalex.org/keywords/leaky-gut","display_name":"leaky gut","score":0.8899999856948853},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8830000162124634},{"id":"https://openalex.org/keywords/lymphoproliferation","display_name":"lymphoproliferation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/autoimmune-disease-exacerbation","display_name":"autoimmune disease exacerbation","score":0.6520000100135803},{"id":"https://openalex.org/keywords/crispr-cas9-deletion","display_name":"CRISPR/Cas9 gene deletion","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C2777338127","wikidata":"https://www.wikidata.org/wiki/Q14914085","display_name":"TLR5","level":5,"score":0.9763525724411011},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.6914603114128113},{"id":"https://openalex.org/C2779912601","wikidata":"https://www.wikidata.org/wiki/Q1621830","display_name":"Lupus nephritis","level":3,"score":0.6694344282150269},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5823882818222046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46245360374450684},{"id":"https://openalex.org/C38117629","wikidata":"https://www.wikidata.org/wiki/Q24788421","display_name":"Flagellin","level":3,"score":0.42029401659965515},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3795090913772583},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33295994997024536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32304465770721436},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.235645592212677},{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.21961084008216858},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.19106075167655945},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.16316789388656616},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.13687732815742493}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.210.supp.77.12","doi":"https://doi.org/10.4049/jimmunol.210.supp.77.12","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.77.12","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/77.12/1631562/77_12.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.210.supp.77.12","doi":"https://doi.org/10.4049/jimmunol.210.supp.77.12","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.77.12","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/77.12/1631562/77_12.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9958000183105469,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385686273.pdf","grobid_xml":"https://content.openalex.org/works/W4385686273.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4383341346","https://openalex.org/W4313408082","https://openalex.org/W2003681375","https://openalex.org/W2040859817","https://openalex.org/W2593376712","https://openalex.org/W1893091919","https://openalex.org/W7100681346","https://openalex.org/W7098370047","https://openalex.org/W6989891082","https://openalex.org/W1625238363"],"abstract_inverted_index":{"Abstract":[0],"A":[1,100],"leaky":[2,42,209],"gut":[3,43,210],"has":[4],"been":[5],"linked":[6],"to":[7,37,76,114,150,163,186,196,234],"numerous":[8],"autoimmune":[9],"disorders,":[10],"including":[11],"systemic":[12],"lupus":[13,187],"erythematosus":[14],"(SLE).":[15],"We":[16,189],"had":[17],"previously":[18],"reported":[19],"significant":[20],"upregulation":[21],"of":[22,28,50,62,82,91,104,131,137,180,229],"anti-flagellin":[23],"antibodies":[24],"in":[25,65,97,108,158,173,184,211],"the":[26,58,80,127,129,169,178,193,207,222,227],"blood":[27],"SLE":[29,45],"patients":[30],"and":[31,60,116,140,146,165],"lupus-prone":[32],"MRL/lpr":[33,66,98,111,160,216],"mice,":[34,175],"which":[35,226],"led":[36],"our":[38,77,87],"hypothesis":[39,78],"that":[40,79,177],"a":[41],"drove":[44],"through":[46],"bacterial":[47],"flagellin-mediated":[48],"activation":[49],"toll-like":[51],"receptor":[52],"5":[53],"(TLR5).":[54],"Here,":[55],"we":[56],"investigated":[57],"initiation":[59],"progression":[61],"lupus-like":[63,92],"disease":[64,93],"mice":[67,112,161],"with":[68,94,123,168],"global":[69],"Tlr5":[70,83,95,124,132,181,202,230],"deletion":[71,81,130,179,228],"generated":[72],"by":[73,225],"CRISPR-Cas9.":[74],"Contrary":[75],"would":[84],"attenuate":[85],"lupus,":[86],"results":[88],"showed":[89],"exacerbation":[90],"deficiency":[96,203],"mice.":[99,217],"significantly":[101,133,156],"higher":[102],"level":[103],"proteinuria":[105],"was":[106],"observed":[107],"Tlr5\u2212/\u2212":[109,159],"female":[110,118,174,213],"compared":[113,162],"Tlr5+/\u2212":[115,164],"Tlr5+/+":[117,166],"littermates,":[119,167],"suggesting":[120,176],"aggravated":[121],"glomerulonephritis":[122],"deficiency.":[125],"In":[126],"kidney,":[128],"increased":[134,157],"renal":[135],"infiltration":[136],"activated":[138],"conventional":[139],"monocyte-derived":[141],"dendritic":[142],"cells.":[143],"Spleen,":[144],"mesenteric":[145],"axillary/cervical":[147],"lymph":[148],"node":[149],"body":[151],"weight":[152],"ratio":[153],"were":[154],"also":[155],"effects":[170],"more":[171],"pronounced":[172],"impacted":[182],"lymphoproliferation":[183],"addition":[185],"nephritis.":[188],"are":[190],"currently":[191],"analyzing":[192],"lymphoid":[194],"tissues":[195],"reveal":[197],"potential":[198],"cellular":[199,232],"mechanisms.":[200],"Notably,":[201],"did":[204],"not":[205],"change":[206],"existing":[208],"either":[212],"or":[214],"male":[215],"Future":[218],"studies":[219],"will":[220],"elucidate":[221],"underlying":[223],"mechanisms":[224],"modulates":[231],"functions":[233],"exacerbate":[235],"lupus.":[236]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-08-10T00:00:00"}