{"id":"https://openalex.org/W4385686246","doi":"https://doi.org/10.4049/jimmunol.210.supp.228.11","title":"ILC3s restrict intestinal inflammation via IL-10 production","display_name":"ILC3s restrict intestinal inflammation via IL-10 production","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4385686246","doi":"https://doi.org/10.4049/jimmunol.210.supp.228.11"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.210.supp.228.11","doi":"https://doi.org/10.4049/jimmunol.210.supp.228.11","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.228.11","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/228.11/1633926/228_11.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/228.11/1633926/228_11.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jing Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":["Vanderbilt University","1Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"1Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024633266","display_name":"Justin Jacobse","orcid":"https://orcid.org/0000-0002-1899-0319","observed_orcids":["https://orcid.org/0000-0002-1899-0319"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["NL","US"],"is_corresponding":false,"raw_author_name":"Justin Jacobse","raw_affiliation_strings":["Leiden University Medical Center","Vanderbilt University","Vanderbilt University Medical Center","2Vanderbilt University Medical Center","3Leiden University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leiden University Medical Center","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt University Medical Center","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"2Vanderbilt University Medical Center","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"3Leiden University Medical Center","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036202498","display_name":"Jeremy A. Goettel","orcid":"https://orcid.org/0000-0002-0749-2357","observed_orcids":["https://orcid.org/0000-0002-0749-2357"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Allen Goettel","raw_affiliation_strings":["Vanderbilt University","Vanderbilt University Medical Center","1Vanderbilt University","2Vanderbilt University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt University Medical Center","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"1Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"2Vanderbilt University Medical Center","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087826096","display_name":"Mary Kay Washington","orcid":"https://orcid.org/0000-0002-9589-7695","observed_orcids":["https://orcid.org/0000-0002-9589-7695"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Kay Washington","raw_affiliation_strings":["Vanderbilt University","1Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"1Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"210","issue":"Supplement_1","first_page":"228.11","last_page":"228.11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12528","display_name":"IL-33, ST2, and ILC Pathways","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ilc3","display_name":"ILC3","score":0.9860000014305115},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9879999756813049},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/intestinal-immune-homeostasis","display_name":"intestinal immune homeostasis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/colitis","display_name":"colitis","score":0.671999990940094},{"id":"https://openalex.org/keywords/intestinal-macrophages","display_name":"intestinal macrophages","score":0.9319999814033508},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.7269999980926514},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.871999979019165},{"id":"https://openalex.org/keywords/rorc","display_name":"RORC","score":0.37400001287460327},{"id":"https://openalex.org/keywords/rag1-deficient-mice","display_name":"Rag1-deficient mice","score":0.6579999923706055},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C47742525","wikidata":"https://www.wikidata.org/wiki/Q13418826","display_name":"Innate lymphoid cell","level":4,"score":0.7034961581230164},{"id":"https://openalex.org/C187316574","wikidata":"https://www.wikidata.org/wiki/Q423698","display_name":"Interleukin 10","level":3,"score":0.6830217242240906},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.609586775302887},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5829699039459229},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5499345064163208},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.5136427283287048},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4715832769870758},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4689089059829712}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.210.supp.228.11","doi":"https://doi.org/10.4049/jimmunol.210.supp.228.11","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.228.11","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/228.11/1633926/228_11.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.210.supp.228.11","doi":"https://doi.org/10.4049/jimmunol.210.supp.228.11","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.228.11","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/228.11/1633926/228_11.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6100000143051147}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385686246.pdf","grobid_xml":"https://content.openalex.org/works/W4385686246.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4407821165","https://openalex.org/W2336334025","https://openalex.org/W2940340554","https://openalex.org/W6902702764","https://openalex.org/W2935362216","https://openalex.org/W2948911456","https://openalex.org/W2965829044","https://openalex.org/W1971692163","https://openalex.org/W2913678715","https://openalex.org/W2271015490"],"abstract_inverted_index":{"Abstract":[0],"In":[1],"this":[2],"study,":[3],"we":[4,127,172],"investigated":[5],"the":[6,26,39,42,164,167,192],"role":[7,234],"of":[8,28,44,121,169,194,255],"IL-10":[9,29,45,103,122,129,236],"production":[10,120,237],"by":[11,133,148,238],"group":[12],"3":[13],"innate":[14],"lymphoid":[15],"cells":[16,179],"(ILC3s)":[17],"in":[18,34,38,46,58,131,156,166],"regulating":[19],"intestinal":[20,94,158,170,242],"immunity.":[21],"Prior":[22],"work":[23],"has":[24],"established":[25],"importance":[27],"as":[30,32,221],"well":[31],"ILC3s":[33,47,74,100,132,239],"promoting":[35],"immune":[36,243],"homeostasis":[37,49],"gut.":[40],"However,":[41],"requirement":[43],"for":[48,202,208,235],"remains":[50],"unknown.":[51],"We":[52,77],"examined":[53,173],"an":[54,154,232],"ILC3":[55,119],"focused":[56],"cluster":[57],"a":[59,124],"publicly":[60],"available":[61],"single-cell":[62],"RNA":[63],"sequencing":[64],"dataset":[65],"from":[66],"patients":[67],"with":[68,88,109],"ileal":[69],"Crohn\u2019s":[70],"disease":[71,114],"and":[72,85,96,205,257,259],"detected":[73],"expressing":[75],"IL10.":[76],"then":[78],"developed":[79,225],"Rag1\u2212/\u2212;":[80,135],"Il10GFP;":[81],"Rosa26lsltdTomato;":[82],"RorcCre":[83,138],"mice":[84,142,190,224],"injected":[86],"them":[87],"PBS":[89],"or":[90],"anti-CD40":[91,110,149],"to":[92,153,183,188,240],"induce":[93],"inflammation":[95,220],"determine":[97],"if":[98],"putative":[99],"expressed":[101],"IL-10.":[102],"was":[104,151],"significantly":[105,144],"upregulated":[106],"following":[107,113],"treatment":[108],"7":[111],"days":[112],"initiation.":[115],"To":[116],"assess":[117],"whether":[118,174],"played":[123],"functional":[125],"role,":[126],"targeted":[128],"specifically":[130],"generating":[134],"Il10flox/flox;":[136],"Rosa26lsl\u2212tdTomato;":[137],"(Il10\u0394ILC3)":[139],"mice.":[140],"Il10\u0394ILC3":[141,189,223],"displayed":[143],"worse":[145],"colitis":[146,185],"induced":[147],"that":[150],"attributed":[152],"increase":[155],"Ly6ChiMHCIIhi":[157],"macrophages":[159],"(M\u03d5)":[160],"at":[161,210],"baseline.":[162],"Given":[163],"alterations":[165],"phenotype":[168],"M\u03d5,":[171],"unfractionated":[175],"wild-type":[176],"CD4+":[177],"T":[178,196],"would":[180],"be":[181],"sufficient":[182],"cause":[184],"when":[186],"transferred":[187],"despite":[191],"presence":[193],"regulatory":[195],"cells.":[197],"Mice":[198],"were":[199],"monitored":[200],"weekly":[201],"weight":[203],"loss":[204],"colons":[206],"harvested":[207],"histology":[209],"8":[211],"weeks.":[212],"While":[213],"IL-10-sufficient":[214],"littermate":[215],"controls":[216],"did":[217],"not":[218],"develop":[219],"expected,":[222],"severe":[226],"colitis.":[227],"Collectively,":[228],"our":[229],"findings":[230],"identify":[231],"essential":[233],"maintain":[241],"homeostasis.":[244],"Vanderbilt":[245],"Digestive":[246,258],"Disease":[247],"Research":[248],"Center":[249],"Grant":[250],"(P30DK058404)":[251],"The":[252],"National":[253],"Institute":[254],"Diabetes":[256],"Kidney":[260],"Diseases":[261],"R03DK123489":[262]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-08-10T00:00:00"}