{"id":"https://openalex.org/W4385686240","doi":"https://doi.org/10.4049/jimmunol.210.supp.150.12","title":"Reduced \u03b3\u03b4 intraepithelial lymphocyte number and motility precede the onset of Crohn\u2019s disease-like ileitis","display_name":"Reduced \u03b3\u03b4 intraepithelial lymphocyte number and motility precede the onset of Crohn\u2019s disease-like ileitis","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4385686240","doi":"https://doi.org/10.4049/jimmunol.210.supp.150.12"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.210.supp.150.12","doi":"https://doi.org/10.4049/jimmunol.210.supp.150.12","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.150.12","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/150.12/1631838/150_12.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/150.12/1631838/150_12.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057463337","display_name":"Natasha B. Golovchenko","orcid":"https://orcid.org/0000-0001-8323-4643","observed_orcids":["https://orcid.org/0000-0001-8323-4643"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natasha B Golovchenko","raw_affiliation_strings":["Rutgers New Jersey Med. Sch","1Rutgers New Jersey Med. Sch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers New Jersey Med. Sch","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]},{"raw_affiliation_string":"1Rutgers New Jersey Med. Sch","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065010488","display_name":"Weili Xu","orcid":"https://orcid.org/0000-0002-6040-2883","observed_orcids":["https://orcid.org/0000-0002-6040-2883","https://orcid.org/0009-0006-9243-0332"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weili Xu","raw_affiliation_strings":["Rutgers New Jersey Med. Sch","1Rutgers New Jersey Med. Sch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers New Jersey Med. Sch","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]},{"raw_affiliation_string":"1Rutgers New Jersey Med. Sch","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew Fong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Fong","raw_affiliation_strings":["Rutgers New Jersey Med. Sch","1Rutgers New Jersey Med. Sch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers New Jersey Med. Sch","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]},{"raw_affiliation_string":"1Rutgers New Jersey Med. Sch","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046441324","display_name":"Lanjing Zhang","orcid":"https://orcid.org/0000-0001-5436-887X","observed_orcids":["https://orcid.org/0000-0001-5436-887X"]},"institutions":[{"id":"https://openalex.org/I4210143392","display_name":"University of Pennsylvania Health System","ror":"https://ror.org/04h81rw26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lanjing Zhang","raw_affiliation_strings":["Penn Medicine Princeton Medical Center","2Penn Medicine Princeton Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Penn Medicine Princeton Medical Center","institution_ids":["https://openalex.org/I4210143392"]},{"raw_affiliation_string":"2Penn Medicine Princeton Medical Center","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028529598","display_name":"Karen L. Edelblum","orcid":"https://orcid.org/0000-0001-8288-4898","observed_orcids":["https://orcid.org/0000-0001-8288-4898"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Edelblum","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai","Rutgers New Jersey Med. Sch","1Rutgers New Jersey Med. Sch","3Icahn School of Medicine at Mount Sinai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Rutgers New Jersey Med. Sch","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]},{"raw_affiliation_string":"1Rutgers New Jersey Med. Sch","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]},{"raw_affiliation_string":"3Icahn School of Medicine at Mount Sinai","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"210","issue":"Supplement_1","first_page":"150.12","last_page":"150.12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9070000052452087},{"id":"https://openalex.org/keywords/paneth-cells","display_name":"Paneth cells","score":0.5600000023841858},{"id":"https://openalex.org/keywords/intravital-microscopy","display_name":"intravital microscopy","score":0.722000002861023},{"id":"https://openalex.org/keywords/lymphocyte-motility","display_name":"lymphocyte motility","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C2780941987","wikidata":"https://www.wikidata.org/wiki/Q3796380","display_name":"Ileitis","level":4,"score":0.9279232025146484},{"id":"https://openalex.org/C152605822","wikidata":"https://www.wikidata.org/wiki/Q17100626","display_name":"Intraepithelial lymphocyte","level":3,"score":0.9055480360984802},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5230427980422974},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4729554355144501},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47094690799713135},{"id":"https://openalex.org/C66090201","wikidata":"https://www.wikidata.org/wiki/Q15995009","display_name":"Crypt","level":2,"score":0.45844224095344543},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.4358579218387604},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4332835078239441},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42497915029525757},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39453285932540894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3255452811717987},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.22084811329841614},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.19779738783836365}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.210.supp.150.12","doi":"https://doi.org/10.4049/jimmunol.210.supp.150.12","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.150.12","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/150.12/1631838/150_12.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.210.supp.150.12","doi":"https://doi.org/10.4049/jimmunol.210.supp.150.12","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.150.12","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/150.12/1631838/150_12.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385686240.pdf","grobid_xml":"https://content.openalex.org/works/W4385686240.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4225415773","https://openalex.org/W4408695640","https://openalex.org/W4380990448","https://openalex.org/W4383388576","https://openalex.org/W4283008785","https://openalex.org/W1983697895","https://openalex.org/W2039734810","https://openalex.org/W3137742875","https://openalex.org/W4408817233","https://openalex.org/W2596617895"],"abstract_inverted_index":{"Abstract":[0],"Crohn\u2019s":[1],"disease":[2,8],"(CD)":[3],"is":[4,60],"a":[5,24,92,151,226],"relapsing,":[6],"remitting":[7],"resulting":[9],"in":[10,55,70,95,102,130,153,159,162,176,198,210,228,232,270,290],"chronic":[11,75,294],"intestinal":[12],"inflammation.":[13],"Recent":[14],"studies":[15,245],"of":[16,26,52,58,98,140,156,172,206,293],"resected":[17],"ileal":[18,99,142,199,229],"tissue":[19,143],"from":[20,144],"CD":[21,219],"patients":[22],"reported":[23,183],"loss":[25],"intraepithelial":[27],"lymphocytes":[28],"expressing":[29],"the":[30,41,50,56,67,96,154,170,177,258,291],"\u03b3\u03b4":[31,37,53,100,118,157,173,186,248,286],"T":[32],"cell":[33],"receptor":[34],"(\u03b3\u03b4":[35],"IELs).":[36],"IELs":[38,54,101,158,174,187,249],"continuously":[39],"survey":[40],"epithelial":[42],"barrier":[43],"and":[44,84,147,188,254],"protect":[45],"against":[46],"experimental":[47],"colitis;":[48],"however,":[49],"role":[51],"initiation":[57],"ileitis":[59,77,86,240,263,295],"unknown.":[61],"To":[62],"this":[63],"end,":[64],"we":[65,115,192],"profiled":[66],"IEL":[68,119,287],"compartment":[69],"TNF\u0394ARE/+":[71,104,131,148,163,212,233],"mice,":[72,213],"which":[73,265],"develop":[74],"CD-like":[76,271],"at":[78,136],"8":[79],"wks":[80],"old,":[81],"prior":[82,238,261],"to":[83,107,134,166,236,239,262],"during":[85],"onset":[87,241,292],"(4\u201310":[88],"wks).":[89],"We":[90,201],"observed":[91,116],"2.5-fold":[93],"reduction":[94,152,227],"frequency":[97],"5-wk-old":[103],"mice":[105,132,149,164,234],"compared":[106,133,235],"TNF+/+":[108],"(WT)":[109],"littermates":[110],"(p<0.001).":[111],"Using":[112],"intravital":[113],"microscopy,":[114],"reduced":[117],"surveillance":[120,252,288],"behavior":[121,253,289],"(10.6":[122],"vs":[123],"6.4":[124],"mm/min":[125],"track":[126],"speed":[127],"mean,":[128],"p<0.0001)":[129],"WT":[135,146,237],"6":[137],"wks.":[138],"Analysis":[139],"cleared":[141],"6-wk-old":[145,211],"revealed":[150],"number":[155],"villus":[160],"tips":[161],"relative":[165],"WT,":[167],"thereby":[168],"increasing":[169],"proportion":[171,205],"found":[175,202],"crypt":[178],"region.":[179],"Based":[180],"on":[181],"several":[182],"links":[184],"between":[185],"Paneth":[189],"cells":[190],"(PC),":[191],"quantified":[193],"PCs":[194,209],"by":[195,225],"lysozyme":[196],"immunostaining":[197],"tissue.":[200],"an":[203],"increased":[204],"morphologically":[207],"abnormal":[208],"reflecting":[214],"PC":[215,268],"dysfunction":[216,269],"consistent":[217],"with":[218,267],"pathology.":[220],"These":[221],"findings":[222],"are":[223],"supported":[224],"Lyz1":[230],"expression":[231],"(p=0.02).":[242],"Together,":[243],"these":[244],"demonstrate":[246],"that":[247],"exhibit":[250],"impaired":[251],"altered":[255],"distribution":[256],"along":[257],"crypt/villus":[259],"axis":[260],"onset,":[264],"coincides":[266],"ileitis.":[272],"COCR23PRF017":[273],"NJCCR":[274],"Predoctoral":[275],"Fellowship":[276],"Golovchenko":[277],"(PI)":[278],"June":[279],"1,":[280],"2022":[281],"\u2013":[282],"May":[283],"31,":[284],"2024":[285]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-08-10T00:00:00"}