{"id":"https://openalex.org/W4385686199","doi":"https://doi.org/10.4049/jimmunol.210.supp.161.08","title":"Rosiglitazone improves alveolar macrophage mitochondrial derangements induced by chronic alcohol consumption and infection with Klebsiella pneumoniae","display_name":"Rosiglitazone improves alveolar macrophage mitochondrial derangements induced by chronic alcohol consumption and infection with Klebsiella pneumoniae","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4385686199","doi":"https://doi.org/10.4049/jimmunol.210.supp.161.08"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.210.supp.161.08","doi":"https://doi.org/10.4049/jimmunol.210.supp.161.08","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.161.08","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/161.08/1633550/161_08.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/161.08/1633550/161_08.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044627146","display_name":"Samantha M. Yeligar","orcid":"https://orcid.org/0000-0001-9309-0233","observed_orcids":["https://orcid.org/0000-0001-9309-0233"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210152539","display_name":"Atlanta VA Medical Center","ror":"https://ror.org/04z89xx32","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210149289","https://openalex.org/I4210152539"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Samantha M Yeligar","raw_affiliation_strings":["Atlanta Veterans Affairs Medical Center","Emory University","1Emory University","2Atlanta Veterans Affairs Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Atlanta Veterans Affairs Medical Center","institution_ids":["https://openalex.org/I2799886695"]},{"raw_affiliation_string":"Emory University","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"1Emory University","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"2Atlanta Veterans Affairs Medical Center","institution_ids":["https://openalex.org/I4210152539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5044627146"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I2799886695","https://openalex.org/I4210152539"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"210","issue":"Supplement_1","first_page":"161.08","last_page":"161.08"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.27469998598098755,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.27469998598098755,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.271699994802475,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.2703000009059906,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rosiglitazone","display_name":"rosiglitazone","score":1.0},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.9710000157356262},{"id":"https://openalex.org/keywords/chronic-alcohol-consumption","display_name":"chronic alcohol consumption","score":0.9509999752044678},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":0.9459999799728394},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.8889999985694885},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7889999747276306},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9390000104904175},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.7630000114440918},{"id":"https://openalex.org/keywords/pulmonary-infection","display_name":"pulmonary infection","score":0.8550000190734863},{"id":"https://openalex.org/keywords/tfam","display_name":"TFAM","score":0.8159999847412109},{"id":"https://openalex.org/keywords/drp1","display_name":"Drp1","score":0.8799999952316284},{"id":"https://openalex.org/keywords/mfn2","display_name":"mitofusin 2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.550000011920929},{"id":"https://openalex.org/keywords/bacterial-clearance","display_name":"bacterial clearance","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C169415338","wikidata":"https://www.wikidata.org/wiki/Q18031951","display_name":"TFAM","level":4,"score":0.8005805611610413},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6775438189506531},{"id":"https://openalex.org/C2777092462","wikidata":"https://www.wikidata.org/wiki/Q15334407","display_name":"MFN2","level":5,"score":0.6606364846229553},{"id":"https://openalex.org/C2780152017","wikidata":"https://www.wikidata.org/wiki/Q424771","display_name":"Rosiglitazone","level":3,"score":0.5789552927017212},{"id":"https://openalex.org/C2778012055","wikidata":"https://www.wikidata.org/wiki/Q448687","display_name":"Alveolar macrophage","level":4,"score":0.5265434384346008},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4855027198791504},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4607819616794586},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45786574482917786},{"id":"https://openalex.org/C2777591492","wikidata":"https://www.wikidata.org/wiki/Q18041951","display_name":"MFN1","level":5,"score":0.4360434114933014},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35972893238067627},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3594816327095032},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3397766947746277},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3200967311859131},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.26210784912109375},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.23169195652008057},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.180352121591568},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16247913241386414},{"id":"https://openalex.org/C2777229759","wikidata":"https://www.wikidata.org/wiki/Q6881848","display_name":"Mitochondrial biogenesis","level":3,"score":0.12404567003250122},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.210.supp.161.08","doi":"https://doi.org/10.4049/jimmunol.210.supp.161.08","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.161.08","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/161.08/1633550/161_08.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.210.supp.161.08","doi":"https://doi.org/10.4049/jimmunol.210.supp.161.08","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.161.08","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/161.08/1633550/161_08.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385686199.pdf","grobid_xml":"https://content.openalex.org/works/W4385686199.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3173336537","https://openalex.org/W4394740499","https://openalex.org/W4319433690","https://openalex.org/W2214511022","https://openalex.org/W4307739786","https://openalex.org/W7221347799","https://openalex.org/W3174847979","https://openalex.org/W2381915747","https://openalex.org/W7098037645","https://openalex.org/W2333910480"],"abstract_inverted_index":{"Abstract":[0],"Objective":[1],"People":[2],"with":[3,68,266],"alcohol":[4,24,58],"use":[5],"disorders":[6],"(AUDs)":[7],"are":[8],"2\u20134":[9],"times":[10],"more":[11],"likely":[12],"to":[13,34,77,137,193],"develop":[14],"lung":[15],"infections,":[16],"sepsis,":[17],"and":[18,66,142,150,155,168,175,202,205,218,234,240,259],"acute":[19,60],"respiratory":[20],"distress":[21],"syndrome.":[22],"Chronic":[23],"misuse":[25],"blunts":[26],"alveolar":[27],"macrophage":[28],"(AM)":[29],"immunity,":[30],"in":[31,98,112,128,209,222,230,238,262],"part,":[32],"due":[33],"decreased":[35,199],"peroxisome":[36],"proliferator-activated":[37],"receptor":[38],"(PPAR)\u03b3":[39],"which":[40],"increases":[41],"cellular":[42],"oxidative":[43,47,197],"stress.":[44],"Mitochondrial":[45],"(MT)":[46],"stress":[48],"may":[49,248],"impair":[50],"AM":[51,79,242,256],"phagocytosis;":[52],"thus,":[53],"we":[54],"posited":[55],"that":[56],"chronic":[57],"plus":[59],"Klebsiella":[61],"pneumoniae":[62],"(Kp)":[63],"dysregulates":[64],"MT":[65,140,156,196,214,236,257],"treatment":[67,229],"rosiglitazone":[69],"(RSG),":[70],"a":[71,250],"PPAR\u03b3":[72,154],"ligand,":[73],"reverses":[74],"these":[75],"effects":[76],"improve":[78],"phagocytosis":[80],"of":[81,110,120,153,244],"Kp.":[82,245,267],"Methods":[83],"AMs":[84,180,186,223,239],"were":[85,144,171],"isolated":[86],"from":[87],"8\u201310-month-old":[88],"male":[89],"C57BL/6J":[90],"mice":[91,194],"fed":[92],"\u00b1":[93,104,124,226],"ethanol":[94],"(EtOH,":[95],"20%":[96],"wt/vol":[97],"drinking":[99],"water)":[100],"for":[101,115,254],"12":[102],"wks":[103],"intratracheal":[105],"2":[106],"\u00d7":[107],"104":[108],"CFU":[109],"Kp":[111,177,211,220],"saline":[113],"vehicle":[114],"the":[116],"last":[117],"24":[118],"h":[119,135],"water":[121],"or":[122],"EtOH":[123,191],"RSG":[125,228,247],"(10":[126],"mg/kg/d":[127],"methylcellulose":[129],"vehicle)":[130],"via":[131],"oral":[132],"gavage":[133],"4":[134],"prior":[136],"sacrifice":[138],"(n=5/group).":[139],"O2\u2022\u2212":[141],"H2O2":[143],"assessed":[145],"by":[146,173,179,183,216,224],"fluorescence":[147],"microscopy.":[148],"mRNA":[149],"protein":[151,165],"levels":[152,208],"dynamics":[157],"mediators,":[158],"transcription":[159],"factor":[160],"A":[161],"mitochondrial":[162],"(TFAM),":[163],"dynamin-related":[164],"1":[166],"(DRP1),":[167],"mitofusin-2":[169],"(MFN2)":[170],"measured":[172],"qRT-PCR":[174],"cytoimmunostaining.":[176],"clearance":[178,221,243],"was":[181],"determined":[182],"plating":[184],"lysed":[185],"on":[187],"MacConkey":[188],"agar.":[189],"Results":[190],"feeding":[192],"increased":[195,206],"stress;":[198],"PPAR\u03b3,":[200],"TFAM,":[201],"MFN2":[203],"levels;":[204],"DRP1":[207],"AMs.":[210],"exacerbated":[212],"EtOH\u2019s":[213],"derangements":[215,237,258],"~51\u201363%":[217],"impaired":[219],"57.3":[225],"11.2%.":[227],"vivo":[231],"reversed":[232],"EtOH-":[233],"Kp-induced":[235],"restored":[241],"Conclusion":[246],"provide":[249],"novel":[251],"therapeutic":[252],"strategy":[253],"mitigating":[255],"immune":[260],"dysfunction":[261],"AUD":[263],"individuals":[264],"infected":[265],"NIAAA":[268],"R01-AA026086":[269]},"counts_by_year":[],"updated_date":"2026-09-06T09:10:53.072986","created_date":"2023-08-10T00:00:00"}