{"id":"https://openalex.org/W4385686165","doi":"https://doi.org/10.4049/jimmunol.210.supp.154.25","title":"QRICH1 is a negative regulator of T cell activation via the CARD11 signalosome","display_name":"QRICH1 is a negative regulator of T cell activation via the CARD11 signalosome","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4385686165","doi":"https://doi.org/10.4049/jimmunol.210.supp.154.25"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.210.supp.154.25","doi":"https://doi.org/10.4049/jimmunol.210.supp.154.25","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.154.25","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/154.25/1631822/154_25.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/154.25/1631822/154_25.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101453069","display_name":"Nicole M. Carter","orcid":"https://orcid.org/0000-0003-4453-9027","observed_orcids":["https://orcid.org/0000-0003-4453-9027"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole M Carter","raw_affiliation_strings":["Johns Hopkins Univ. Sch. of Med","1Johns Hopkins Univ. Sch. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. Sch. of Med","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"1Johns Hopkins Univ. Sch. of Med","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039438049","display_name":"Joel L. Pomerantz","orcid":"https://orcid.org/0000-0002-5030-1018","observed_orcids":["https://orcid.org/0000-0002-5030-1018"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel L Pomerantz","raw_affiliation_strings":["Johns Hopkins Univ. Sch. of Med","1Johns Hopkins Univ. Sch. of Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Univ. Sch. of Med","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"1Johns Hopkins Univ. Sch. of Med","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"210","issue":"Supplement_1","first_page":"154.25","last_page":"154.25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.5859000086784363,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.5859000086784363,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.3743000030517578,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/card11","display_name":"CARD11","score":0.9739999771118164},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8019999861717224},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/t-cell-receptor-signaling","display_name":"T cell receptor signaling","score":0.7490000128746033},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.5920000076293945},{"id":"https://openalex.org/keywords/effector-memory-t-cells","display_name":"effector memory T cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7350000143051147},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/conditional-knockout-mice","display_name":"conditional knockout mice","score":0.6629999876022339},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.503000020980835},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C179464577","wikidata":"https://www.wikidata.org/wiki/Q1632589","display_name":"Jurkat cells","level":4,"score":0.84516441822052},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.6789417266845703},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.6737363338470459},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.6021584272384644},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5876369476318359},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5807600617408752},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5603755116462708},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5280473828315735},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3231881856918335},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.26572322845458984},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2513701617717743},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23487523198127747},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09580045938491821},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.210.supp.154.25","doi":"https://doi.org/10.4049/jimmunol.210.supp.154.25","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.154.25","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/154.25/1631822/154_25.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.210.supp.154.25","doi":"https://doi.org/10.4049/jimmunol.210.supp.154.25","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.154.25","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/154.25/1631822/154_25.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385686165.pdf","grobid_xml":"https://content.openalex.org/works/W4385686165.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4313407965","https://openalex.org/W4408423693","https://openalex.org/W4214739674","https://openalex.org/W4404170862","https://openalex.org/W2066177415","https://openalex.org/W2799631231","https://openalex.org/W4394575529","https://openalex.org/W2947604139","https://openalex.org/W2074768095","https://openalex.org/W2064558701"],"abstract_inverted_index":{"Abstract":[0],"Controlled":[1],"lymphocyte":[2],"activation":[3,34,89,110,236],"is":[4],"crucial":[5],"for":[6],"defending":[7],"against":[8],"pathogens":[9],"while":[10],"preventing":[11],"diseases":[12],"such":[13],"as":[14,46,93,95],"autoimmunity":[15],"and":[16,24,31,61,82,99,111,150,192,198,208,251],"lymphoma.":[17],"In":[18],"T":[19,37,75,84,105,142,152,163,168,173,187,212,234],"lymphocytes,":[20],"the":[21,54,120],"scaffold":[22],"protein":[23,65],"signaling":[25,240],"hub":[26],"CARD11":[27,50,55,92,101],"mediates":[28],"NF-\u03baB,":[29],"JNK,":[30],"mTOR":[32],"pathway":[33],"downstream":[35,57,114],"of":[36,58,78,115,124,194],"cell":[38,143,164,169,174,235],"receptor":[39],"(TCR)":[40],"engagement.":[41],"We":[42],"recently":[43],"identified":[44],"QRICH1":[45,64,79,125,132,141,172,231],"a":[47,130],"previously":[48],"unrecognized":[49],"interactor":[51],"recruited":[52],"to":[53,138,202,221],"complex":[56],"TCR":[59,116],"engagement":[60],"discovered":[62],"that":[63,230],"levels":[66],"are":[67],"upregulated":[68],"in":[69,80,121,126,157,171,200,219],"wild-type":[70,91],"activated":[71],"mouse":[72,135],"primary":[73,185],"CD8+":[74,151,167,186,211],"cells.":[76],"Overexpression":[77],"293T":[81],"Jurkat":[83,104],"cells":[85,106,188,213],"dose-dependently":[86],"inhibited":[87],"NF-\u03baB":[88,109],"by":[90,96,237,246],"well":[94],"constitutively":[97],"active":[98],"oncogenic":[100],"mutants.":[102],"QRICH1-deficient":[103,184,209],"had":[107,146,189,215],"increased":[108,190,216],"IL-2":[112],"secretion":[113],"stimulation.":[117],"To":[118],"study":[119],"vivo":[122,204],"role":[123],"immunity,":[127],"we":[128],"generated":[129],"novel":[131],"conditional":[133],"KO":[134,144,175],"model.":[136],"Compared":[137],"control":[139],"mice,":[140],"mice":[145,176],"decreased":[147],"splenic":[148],"CD4+":[149],"cells,":[153],"despite":[154],"no":[155],"differences":[156],"thymic":[158],"CD4+,":[159],"CD8+,":[160],"or":[161],"CD4+CD8+":[162],"populations.":[165],"The":[166],"population":[170],"was":[177,244],"skewed":[178],"towards":[179],"an":[180],"effector":[181],"memory":[182],"phenotype.":[183],"proliferation":[191],"production":[193,218],"pro-inflammatory":[195],"cytokines":[196],"IFN-\u03b3":[197],"TNF-\u03b1":[199],"response":[201,220],"ex":[203],"stimulation":[205,223],"with":[206,224],"anti-CD3/CD28,":[207],"OT-1":[210],"also":[214],"cytokine":[217],"antigen-specific":[222],"Ova":[225],"peptide.":[226],"Our":[227],"findings":[228],"reveal":[229],"negatively":[232],"regulates":[233],"modulating":[238],"CARD11\u2019s":[239],"output.":[241],"This":[242],"work":[243],"supported":[245],"NIH":[247],"grants":[248],"R01AI148143,":[249],"F31CA254167,":[250],"T32GM007445.":[252]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-08-10T00:00:00"}